Additive Manufacturing and Its Medical Applications_Journal of Biomedical Engineering

Authors：

SONGZewen , WANGGuohui , GAOQin ,  ZHUShaihong

The Third Xiangya Hospital, Central South University, Changsha 410013, China;

Corresponding author：

ZHUShaihong, Email: zhushaihong@medmail.com.cn

Keywords：

additive manufacturing; medical application; tissue engineering; medical device

DOI：

10.7507/1001-5515.20150088

Video：

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Additive manufacturing (AM) is a collection of technologies based on the layer-by-layer manufacturing. Characterized by its direct manufacturing and rapidity, it has been regarded by the Economist Journal as one of the key techniques which will trigger the third industry reformation. The present article, beginning with a brief introduction of the history of AM and the process of its major technologies, focuses on the advantages and disadvantages and medical applications of the technique.

Citation： SONGZewen, WANGGuohui, GAOQin, ZHUShaihong. Additive Manufacturing and Its Medical Applications. Journal of Biomedical Engineering, 2015, 32(2): 485-488. doi: 10.7507/1001-5515.20150088 Copy

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2.	SOBRAL J M, CARIDADE S G, SOUSA R A, et al. Three-dimensional plotted scaffolds with controlled pore size gradients:effect of scaffold geometry on mechanical performance and cell seeding efficiency[J]. Acta Biomater, 2011, 7(3):1009-1018.
3.	BUTSCHER A, BOHNER M, ROTH C, et al. Printability of calcium phosphate powders for three-dimensional printing of tissue engineering scaffolds[J]. Acta Biomater, 2012, 8(1):373-385.
4.	GOMES S, LEONOR I B, MANO J F, et al. Natural and genetically engineered proteins for tissue engineering[J]. Prog Polym Sci, 2012, 37(1):1-17.
5.	KHODA A M, KOC B. Functionally heterogeneous porous scaffold design for tissue engineering[J]. Comput Aided Des, 2013, 45(11):1276-1293.
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7.	MCCULLOUGH E J, YADAVALLI V K. Surface modification of fused deposition modeling ABS to enable rapid prototyping of biomedical microdevices[J]. J Mater Proces Technol, 2013, 213(6):947-954.
8.	MIRONOV V, BOLAND T, TRUSK T, et al. Organ printing:computer-aided jet-based 3D tissue engineering[J]. Trends Biotechnol, 2003, 21(4):157-161.
9.	MIRONOV V, KASYANOV V, MARKWALD R R. Organ printing:from bioprinter to organ biofabrication line[J]. Curr Opin Biotechnol, 2011, 22(5):667-673.
10.	RENENDE R A, PEREIRA F S, KASYANOV V, et al. Scalable biofabrication of tissue spheroids for organ printing[J]. Procedia CIRP, 2013, 5:276-281.
11.	WANG J X, LIAO H, ZHU X H, et al. Real time 3D simulation for nose surgery and automatic individual prosthesis design[J]. Comput Methods Programs Biomed, 2011, 104(3):472-479.
12.	LIACOURAS P, GARNES J, ROMAN N, et al. Designing and manufacturing an auricular prosthesis using computed tomography, 3-dimensional photographic imaging, and additive manufacturing:a clinical report[J]. J Prosthet Dent, 2011, 105(2):78-82.
13.	VAN DER SMISSEN B, CLAEESSENS T, VERDONCK P, et al. Modelling the left ventricle using rapid prototyping techniques[J]. IRBM, 2013, 34(3):226-234.
14.	LI H, WANG L, MAO Y, et al. Revision of complex acetabular defects using cages with the aid of rapid prototyping[J]. J Arthroplasty, 2013, 28(10):1770-1775..
15.	MURR L E, AMATO K N, LI S J, et al. Microstructure and mechanical properties of open-cellular biomaterials prototypes for total knee replacement implants fabricated by electron beam melting[J]. J Mech Behav Biomed Mater, 2011, 4(7):1396-1411.
16.	KHANOKI S A, PASINI D. Fatigue design of a mechanically biocompatible lattice for a proof-of-concept femoral stem[J]. J Mech Behav Biomed Mater, 2013, 22:65-83.
17.	BAGARIA V, DESHPANDE S, RASALKAR D D, et al. Use of rapid prototyping and three-dimensional reconstruction modeling in the management of complex fractures[J]. Eur J Radiol, 2011, 80(3):814-820.
18.	ROHNER D, GUIJARRO-MARTÍNEZ R, BUCHER P, et al. Importance of patient-specific intraoperative guides in complex maxillofacial reconstruction[J]. J Craniomaxillofac Surg, 2013, 41(5):382-390.
19.	WEI R, LIU X Z, BING G, et al. Removal of a foreign body from the skull base using a customized computer-designed guide bar[J]. J Craniomaxillofac Surg, 2010, 38(4):279-283.
20.	CIOCCA L, MAZZONI S, FANTINI M, et al. CAD/CAM guided secondary mandibular Reconstruction of a discontinuity defect after ablative Cancer surgery[J]. J Craniomaxillofac Surg, 2012, 40(8):511-515.
21.	LETHAUS B, POORT L, BÖCKMANN R, et al. Additive manufacturing for microvascular Reconstruction of the mandible in 20 patients[J]. J Craniomaxillofac Surg, 2012, 40(1):43-46.
22.	GIBSON I, CHEUNG L K, CHOW S P, et al. The use of rapid prototyping to assist medical application[J]. Rapid Prototyping, 2006, 12(1):53-58.
23.	SALMI M, PALOHEIMO K S, TUOMI J, et al. Accuracy of medical models made by additive manufacturing (rapid manufacturing)[J]. J Craniomaxillofac Surg, 2013, 41(7):603-609.
24.	KARUNAKARAN K P, SREENATHBABU A, PUSHPA V. Hybrid layered manufacturing:direct rapid metal tool-making process[J]. Journal of Engineering Manufacture, 2004, 218(B12):1657-1665.
25.	SURYAKUMAR S, KARUNAKARAN K P, BERNARD A, et al. Weld bead modeling and process optimization in Hybrid Layered manufacturing[J]. Comput Aided Des, 2011, 43(4):331-344.

1. SUSAN L, CASEY K C, RAMAKRISHNA S. Stem cells and biomimetic materials strategies for tissue engineering[J]. Materials Science and Engineering C, 2008, 28(8):1189-1202.
2. SOBRAL J M, CARIDADE S G, SOUSA R A, et al. Three-dimensional plotted scaffolds with controlled pore size gradients:effect of scaffold geometry on mechanical performance and cell seeding efficiency[J]. Acta Biomater, 2011, 7(3):1009-1018.
3. BUTSCHER A, BOHNER M, ROTH C, et al. Printability of calcium phosphate powders for three-dimensional printing of tissue engineering scaffolds[J]. Acta Biomater, 2012, 8(1):373-385.
4. GOMES S, LEONOR I B, MANO J F, et al. Natural and genetically engineered proteins for tissue engineering[J]. Prog Polym Sci, 2012, 37(1):1-17.
5. KHODA A M, KOC B. Functionally heterogeneous porous scaffold design for tissue engineering[J]. Comput Aided Des, 2013, 45(11):1276-1293.
6. PODSHIVALOV L, GOMES C M, ZOCCA A, et al. Design, analysis and additive manufacturing of porous structures for biocompatible micro-scale scaffolds[J]. Procedia CIRP, 2013, 5:247-252.
7. MCCULLOUGH E J, YADAVALLI V K. Surface modification of fused deposition modeling ABS to enable rapid prototyping of biomedical microdevices[J]. J Mater Proces Technol, 2013, 213(6):947-954.
8. MIRONOV V, BOLAND T, TRUSK T, et al. Organ printing:computer-aided jet-based 3D tissue engineering[J]. Trends Biotechnol, 2003, 21(4):157-161.
9. MIRONOV V, KASYANOV V, MARKWALD R R. Organ printing:from bioprinter to organ biofabrication line[J]. Curr Opin Biotechnol, 2011, 22(5):667-673.
10. RENENDE R A, PEREIRA F S, KASYANOV V, et al. Scalable biofabrication of tissue spheroids for organ printing[J]. Procedia CIRP, 2013, 5:276-281.
11. WANG J X, LIAO H, ZHU X H, et al. Real time 3D simulation for nose surgery and automatic individual prosthesis design[J]. Comput Methods Programs Biomed, 2011, 104(3):472-479.
12. LIACOURAS P, GARNES J, ROMAN N, et al. Designing and manufacturing an auricular prosthesis using computed tomography, 3-dimensional photographic imaging, and additive manufacturing:a clinical report[J]. J Prosthet Dent, 2011, 105(2):78-82.
13. VAN DER SMISSEN B, CLAEESSENS T, VERDONCK P, et al. Modelling the left ventricle using rapid prototyping techniques[J]. IRBM, 2013, 34(3):226-234.
14. LI H, WANG L, MAO Y, et al. Revision of complex acetabular defects using cages with the aid of rapid prototyping[J]. J Arthroplasty, 2013, 28(10):1770-1775..
15. MURR L E, AMATO K N, LI S J, et al. Microstructure and mechanical properties of open-cellular biomaterials prototypes for total knee replacement implants fabricated by electron beam melting[J]. J Mech Behav Biomed Mater, 2011, 4(7):1396-1411.
16. KHANOKI S A, PASINI D. Fatigue design of a mechanically biocompatible lattice for a proof-of-concept femoral stem[J]. J Mech Behav Biomed Mater, 2013, 22:65-83.
17. BAGARIA V, DESHPANDE S, RASALKAR D D, et al. Use of rapid prototyping and three-dimensional reconstruction modeling in the management of complex fractures[J]. Eur J Radiol, 2011, 80(3):814-820.
18. ROHNER D, GUIJARRO-MARTÍNEZ R, BUCHER P, et al. Importance of patient-specific intraoperative guides in complex maxillofacial reconstruction[J]. J Craniomaxillofac Surg, 2013, 41(5):382-390.
19. WEI R, LIU X Z, BING G, et al. Removal of a foreign body from the skull base using a customized computer-designed guide bar[J]. J Craniomaxillofac Surg, 2010, 38(4):279-283.
20. CIOCCA L, MAZZONI S, FANTINI M, et al. CAD/CAM guided secondary mandibular Reconstruction of a discontinuity defect after ablative Cancer surgery[J]. J Craniomaxillofac Surg, 2012, 40(8):511-515.
21. LETHAUS B, POORT L, BÖCKMANN R, et al. Additive manufacturing for microvascular Reconstruction of the mandible in 20 patients[J]. J Craniomaxillofac Surg, 2012, 40(1):43-46.
22. GIBSON I, CHEUNG L K, CHOW S P, et al. The use of rapid prototyping to assist medical application[J]. Rapid Prototyping, 2006, 12(1):53-58.
23. SALMI M, PALOHEIMO K S, TUOMI J, et al. Accuracy of medical models made by additive manufacturing (rapid manufacturing)[J]. J Craniomaxillofac Surg, 2013, 41(7):603-609.
24. KARUNAKARAN K P, SREENATHBABU A, PUSHPA V. Hybrid layered manufacturing:direct rapid metal tool-making process[J]. Journal of Engineering Manufacture, 2004, 218(B12):1657-1665.
25. SURYAKUMAR S, KARUNAKARAN K P, BERNARD A, et al. Weld bead modeling and process optimization in Hybrid Layered manufacturing[J]. Comput Aided Des, 2011, 43(4):331-344.

Journal of Biomedical Engineering

Additive Manufacturing and Its Medical Applications

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