Research Progress in Genotoxic Effects of Degradation Products, Cobalt, Chromium Ions and Nanoparticles from Metal-on-metal Prostheses on Cells_Journal of Biomedical Engineering

Authors：

ZHOUHao , HANQinglin ,  LIUFan

Department of Orthopedics, Affiliated Hospital of Nantong University, Nantong 226001, China;

Corresponding author：

LIUFan, Email: liufan19575@yahoo.com.cn

Keywords：

cobalt; chromium; ions; nanoparticles; genotoxicity

DOI：

10.7507/1001-5515.20150089

Video：

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Cobalt or chromium alloys are the most common clinical materials of prosthesis and there have been some investigators at home and abroad have done related researches about the genotoxic effects of cobalt and chromium ions and nanoparticles. People have certain understanding about the mechanism of production of ions as well as their influence on cells. However, chromium or cobalt nanoparticles genotoxicity related research is still in its preliminary stage. In each stage, the mechanisms, from creating of the particles, through entering cells, until finally causing genotoxic, are still contained many problems to be solved. This article reviews the research progress in mechanisms of production and genotoxic effects of cobalt, chromium ions and nanoparticles.

Citation： ZHOUHao, HANQinglin, LIUFan. Research Progress in Genotoxic Effects of Degradation Products, Cobalt, Chromium Ions and Nanoparticles from Metal-on-metal Prostheses on Cells. Journal of Biomedical Engineering, 2015, 32(2): 489-492. doi: 10.7507/1001-5515.20150089 Copy

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2.	谭维琴, 杨士军, 崔建和.人工假体置换后的无菌性松动[J].中国组织工程研究与临床康复, 2011, 15(43):8133-8136.
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6.	GILBERT J L, MALI S, URBAN R M, et al. In vivo oxide-induced stress corrosion cracking of Ti-6Al-4V in a neck-stem modular taper:emergent behavior in a new mechanism of in vivo corrosion[J]. J Biomed Mater Res B Appl Biomater, 2012, 100:584-594.
7.	JULIAN L C, MUNOZ A I. Influence of microstructure of HC CoCrMo biomedical alloys on the corrosion and wear behavior in simulated body fluids[J]. Tribol Int, 2011, 44:318-329.
8.	AFOLARANMI G A, AKBAR M, BREWER J, et al. Distribution of metal released from cobalt-chromium alloy orthopaedic wear particles implanted into air pouches in mice[J]. J Biomed Mater Res Part A, 2012, 100(6):1529-1538.
9.	MILOSEV I, REMSKAR M. In vivo production of nanosized metal wear debris formed by tribochemical reaction as confirmed by high-resolution TEM and XPS analyses[J]. J Biomed Mater Res Part A, 2009, 91(4):1100-1110.
10.	DOORN P F, MIRRA J M, CAMPBELL P A, et al. Tissue reaction to metal on metal total hip prostheses[J]. Clin Orthop Relat Res, 1996, (329 Suppl):S187-S205.
11.	BROWN C, WILLIAMS S, TIPPER J L, et al. Characterisation of wear particles produced by metal on metal and ceramic on metal hip prostheses under standard and microseparation simulation[J]. J Mater Sci Mater Med, 2007, 18(5):819-827.
12.	PONTI J, SABBIONI E, MUNARO B, et al. Genotoxicity and morphological transformation induced by cobalt nanoparticles and cobalt chloride:an in vitro study in Balb/3T3 mouse fibroblasts[J]. Mutagenesis, 2009, 24(5):439-445.
13.	WALKEY C D, OLSEN J B, GUO H, et al. Nanoparticle size and surface chemistry determine serum protein adsorption and macrophage uptake[J]. J Am Chem Soc, 2012, 134(4):2139-2147.
14.	ALARIFI S, ALI D, SULIMAN Y A O, et al. Oxidative stress contributes to cobalt oxide nanoparticles-induced cytotoxicity and DNA damage in human hepatocarcinoma cells[J]. Int J Nanomedicine, 2013, 8:189-199.
15.	REINARDY H C, SYRETT J R, JEFFREE R A, et al. Cobalt-induced genotoxicity in male zebrafish (Danio rerio), with implications for reproduction and expression of DNA repair genes[J]. Aquat Toxicol, 2013, 126:224-230.
16.	HARRIS R M, WILLIAMS T D, HODGES N J, et al. Reactive oxygen species and oxidative DNA damage mediate the cytotoxicity of tungsten-nickel-cobalt alloysin vitro[J]. Toxicol Appl Pharmacol, 2011, 250(1):19-28.
17.	SABER A T, JACOBSEN N R, MORTENSEN A, et al. Nanotitanium dioxide toxicity in mouse lung is reduced in sanding dust from paint[J]. Part Fibre Toxicol, 2012, 9:4.
18.	MAGAYE R, ZHAO J, BOWMAN L, et al. Genotoxicity and carcinogenicity of cobalt-, nickel-and copper-based nanoparticles[J]. Exp Ther Med, 2012, 4(4):551-561.
19.	KVHNEL D, SCHEFFLER K, WELLNER P, et al. Comparative evaluation of particle properties, formation of reactive oxygen species and genotoxic potential of tungsten carbide based nanoparticles in vitro[J]. J Hazard Mater, 2012, 227-228:418-426.
20.	Gill H S, GRAMMATOPOULOS G, ADSHEAD S, et al. Molecular and immune toxicity of CoCr nanoparticles in MoM hip arthroplasty[J]. Trends Mol Med, 2012, 18(3):145-155.
21.	RAGHUNATHAN V K, DEVEY M, HAWKINS S, et al. Influence of particle size and reactive oxygen species on cobalt chromen an oparticle-mediated genotoxicity[J]. Biomaterials, 2013, 34(14):3559-3570.
22.	JIANG H, LIU F, YANG H, et al. Effects of cobalt nanop articles on human T cells in vitro[J]. Biol Trace Elem Res, 2012, 146(1):23-29.

1. CATELAS I, WIMMER M A, UTZSCHNEIDER S. Polyethylene and metal wear particles:characteristics and biological effects[J]. Semin Immunopathol, 2011, 33(3):257-271.
2. 谭维琴, 杨士军, 崔建和.人工假体置换后的无菌性松动[J].中国组织工程研究与临床康复, 2011, 15(43):8133-8136.
3. 王海, 宋科官.磨损颗粒诱导假体周围骨溶解的机制及基因治疗现状[J].哈尔滨医科大学学报, 2011, 45(1):95-98.
4. 张方杰, 雷光华.金属对金属全髋关节置换术后体内金属离子对机体的影响[J].现代生物医学进展, 2011, 13:2558-2561, 2583.
5. BAL W, PROTAS A M, KASPRZAK K S. Genotoxicity of metal ions:chemical insights[J]. Met Ions Life Sci, 2011, 8:319-373.
6. GILBERT J L, MALI S, URBAN R M, et al. In vivo oxide-induced stress corrosion cracking of Ti-6Al-4V in a neck-stem modular taper:emergent behavior in a new mechanism of in vivo corrosion[J]. J Biomed Mater Res B Appl Biomater, 2012, 100:584-594.
7. JULIAN L C, MUNOZ A I. Influence of microstructure of HC CoCrMo biomedical alloys on the corrosion and wear behavior in simulated body fluids[J]. Tribol Int, 2011, 44:318-329.
8. AFOLARANMI G A, AKBAR M, BREWER J, et al. Distribution of metal released from cobalt-chromium alloy orthopaedic wear particles implanted into air pouches in mice[J]. J Biomed Mater Res Part A, 2012, 100(6):1529-1538.
9. MILOSEV I, REMSKAR M. In vivo production of nanosized metal wear debris formed by tribochemical reaction as confirmed by high-resolution TEM and XPS analyses[J]. J Biomed Mater Res Part A, 2009, 91(4):1100-1110.
10. DOORN P F, MIRRA J M, CAMPBELL P A, et al. Tissue reaction to metal on metal total hip prostheses[J]. Clin Orthop Relat Res, 1996, (329 Suppl):S187-S205.
11. BROWN C, WILLIAMS S, TIPPER J L, et al. Characterisation of wear particles produced by metal on metal and ceramic on metal hip prostheses under standard and microseparation simulation[J]. J Mater Sci Mater Med, 2007, 18(5):819-827.
12. PONTI J, SABBIONI E, MUNARO B, et al. Genotoxicity and morphological transformation induced by cobalt nanoparticles and cobalt chloride:an in vitro study in Balb/3T3 mouse fibroblasts[J]. Mutagenesis, 2009, 24(5):439-445.
13. WALKEY C D, OLSEN J B, GUO H, et al. Nanoparticle size and surface chemistry determine serum protein adsorption and macrophage uptake[J]. J Am Chem Soc, 2012, 134(4):2139-2147.
14. ALARIFI S, ALI D, SULIMAN Y A O, et al. Oxidative stress contributes to cobalt oxide nanoparticles-induced cytotoxicity and DNA damage in human hepatocarcinoma cells[J]. Int J Nanomedicine, 2013, 8:189-199.
15. REINARDY H C, SYRETT J R, JEFFREE R A, et al. Cobalt-induced genotoxicity in male zebrafish (Danio rerio), with implications for reproduction and expression of DNA repair genes[J]. Aquat Toxicol, 2013, 126:224-230.
16. HARRIS R M, WILLIAMS T D, HODGES N J, et al. Reactive oxygen species and oxidative DNA damage mediate the cytotoxicity of tungsten-nickel-cobalt alloysin vitro[J]. Toxicol Appl Pharmacol, 2011, 250(1):19-28.
17. SABER A T, JACOBSEN N R, MORTENSEN A, et al. Nanotitanium dioxide toxicity in mouse lung is reduced in sanding dust from paint[J]. Part Fibre Toxicol, 2012, 9:4.
18. MAGAYE R, ZHAO J, BOWMAN L, et al. Genotoxicity and carcinogenicity of cobalt-, nickel-and copper-based nanoparticles[J]. Exp Ther Med, 2012, 4(4):551-561.
19. KVHNEL D, SCHEFFLER K, WELLNER P, et al. Comparative evaluation of particle properties, formation of reactive oxygen species and genotoxic potential of tungsten carbide based nanoparticles in vitro[J]. J Hazard Mater, 2012, 227-228:418-426.
20. Gill H S, GRAMMATOPOULOS G, ADSHEAD S, et al. Molecular and immune toxicity of CoCr nanoparticles in MoM hip arthroplasty[J]. Trends Mol Med, 2012, 18(3):145-155.
21. RAGHUNATHAN V K, DEVEY M, HAWKINS S, et al. Influence of particle size and reactive oxygen species on cobalt chromen an oparticle-mediated genotoxicity[J]. Biomaterials, 2013, 34(14):3559-3570.
22. JIANG H, LIU F, YANG H, et al. Effects of cobalt nanop articles on human T cells in vitro[J]. Biol Trace Elem Res, 2012, 146(1):23-29.

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