Influence Factors on Monomer Conversion of Dental Composite Resin_Journal of Biomedical Engineering

Authors：

WANGShuang ^1,2 , GAOYan ¹ , WANGJing ¹ , ZHANGYan ¹ , ZHANGYuntao ¹ , WANGFanghui ¹ ,  WANGQingshan ¹

1. Department of Stomatology, Binzhou Medical University Hospital, Binzhou 256603, China;
2. Binzhou Vocational College, Binzhou 256603, China;

Corresponding author：

WANGQingshan, Email: wqsyahao@yahoo.com.cn

Keywords：

composite resin; residual monomer; monomer conversion; influence factors

DOI：

10.7507/1001-5515.20150090

Video：

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Dental composite resin is a kind of material which has been widely used in dental restoration. Research has found that the influence of residual monomer on the material mechanical, chemical and biological properties cannot be ignored. This paper elaborates these harms of residual monomers. The effects of resin matrix, inorganic filler and initiating system, illumination, secondarily treatment on the degree of conversion were also analyzed. The paper also discusses the effective measures to increase the conversion, and offers theoretical basis for the clinical application and development of composite resin.

Citation： WANGShuang, GAOYan, WANGJing, ZHANGYan, ZHANGYuntao, WANGFanghui, WANGQingshan. Influence Factors on Monomer Conversion of Dental Composite Resin. Journal of Biomedical Engineering, 2015, 32(2): 493-496. doi: 10.7507/1001-5515.20150090 Copy

1.	PARK J, YE Q, TOPP E M, et al. Effect of photoinitiator system and water content on dynamic mechanical properties of a light-cured bisGMA/HEMA dental resin[J]. J Biomed Mater Res A, 2010, 93(4):1245-1251.
2.	房俊艳, 凌均棨.树脂单体毒性机制的研究进展[J].国际口腔医学杂志, 2010, 37(3):302-305.
3.	FARIA-E-SILVA A L, PIVA E, MORAES R R. Time-dependent effect of refrigeration on viscosity and conversion kinetics of dental adhesive resins[J]. Eur J Dent, 2010, 4(2):150-155.
4.	AUSIELLO P, CASSESE A, MIELE C, et al. Cytotoxicity of dental resin composites:an in vitro evaluation[J]. J Appl Toxicol, 2013, 33(6):451-457.
5.	BLASIAK J, SYNOWIEC E, TARNAWSKA J, et al. Dental methacrylates may exert genotoxic effects via the oxidative induction of DNA double strand breaks and the inhibition of their repair[J]. Mol Biol Rep, 2012, 39(7):7487-7496.
6.	YANO J, KITAMURA C, NISHIHARA T, et al. Apoptosis and survivability of human dental pulp cells under exposure to Bis-GMA[J]. J Appl Oral Sci, 2011, 19(3):218-222.
7.	SZCZEPANSKA J, POPLAWSKI T, SYNOWIEC E, et al. 2-hydroxylethyl methacrylate (HEMA), a tooth restoration component, exerts its genotoxic effects in human gingival fibroblasts trough methacrylic acid, an immediate product of its degradation[J]. Mol Biol Rep, 2012, 39(2):1561-1574.
8.	ANIRUDHAN T S, RIJITH S. Synthesis and characterization of carboxyl terminated poly (methacrylic acid) grafted chitosan/bentonite composite and its application for the recovery of uranium (Ⅵ) from aqueous media[J]. J Eniron Radioact, 2012, 106:8-19.
9.	HATTORI N, SUZUKI T, JINNO S, et al. Methyl methacrylate activates the Gsta1 promoter[J]. J Dent Res, 2008, 87(12):1117-1121.
10.	CÓRDOBA S, GARCÍA-DONOSO C, VILLANUEVA C A, et al. Allergic contact dermatitis from a veterinary antiinflammatory gel containing 2-hydroxyethyl salicylate[J]. Dermatitis, 2011, 22(3):171-172.
11.	GOSAVI S S, GOSAVI S Y, ALLA R K. Local and systemic effects of unpolymerised monomers[J]. Dent Res J (Isfahan), 2010, 7(2):82-87.
12.	王军, 周平, 施长溪.过氧化物胺和阻聚剂含量对树脂固化和性能的影响[J].现代口腔医学杂志, 1997, 11(1):27-30.
13.	SOUZA R O, OZCAN M, MESQUITA A M, et al. Effect of different polymerization devices on the degree of conversion and the physical properties of an indirect resin composite[J]. Acta Odontol Latinoam, 2010, 23(2):129-135.
14.	GONÇALVES F, KAWANO Y, PFEIFER C, et al. Influence of BisGMA, TEGDMA, and BisEMA contents on viscosity, conversion, and flexural strength of experimental resins and composites[J]. Eur J Oral Sci, 2009, 117(4):442-446.
15.	NANDINI S. Indirect resin composites[J]. J Conserv Dent, 2010, 13(4):184-194.
16.	SUZUKI N, ZAKARIA M B, CHIANG Y D, et al. Thermally stable polymer composites with improved transparency by using colloidal mesoporous silica nanoparticles as inorganic fillers[J]. Phys Chem Chem Phys, 2012, 14(20):7427-7432.
17.	GUIRALDO R D, CONSANI S, CONSANI R L, et al. Evaluation of the light energy transmission and bottom/top rate in silorane and methacrylate-based composites with different photoactivation protocols[J]. J Contemp Dent Pract, 2011, 12(5):361-367.
18.	王云, 王青山.牙体修复性纳米羟基磷灰石复合材料的机械性能研究[J].现代口腔医学杂志, 2011, 25(2):115-117.
19.	李瑞, 王青山, 赵蒙蒙, 等.牙体修复性纳米羟基磷灰石复合材料生物相容性评价[J].牙体牙髓牙周病学杂志, 2012, 22(3):157-160.
20.	ALBUQUERQUE P P, MOREIRA A D, MORAES R R, et al. Colour stability, conversion, water sorption and solubility of dental composites formulated with different photoinitiator systems[J]. J Dent, 2013, 41(Suppl 3):e67-e72.
21.	PARK Y J, CHAE K H, RAWLS H R. Development of a new photoinitiation system for dental light-cure composite resins[J]. Dent Mater, 1999, 15(2):120-127.
22.	GIORGI M C, AGUIAR F H, SOARES L E, et al. Does an additional UV LED improve the degree of conversion and Knoop Hardness of light-shade composite resins?[J]. Eur J Dent, 2012, 6(4):396-401.
23.	PRATI C, CHERSONI S, MONTEBUGNOLI L, et al. Effect of air, dentin and resin-based composite thickness on light intensity reduction[J]. Am J Dent, 1999, 12(5):231-234.
24.	LIMA A F, DE ANDRADE K M, DA CRUZ ALVES L E, et al. Influence of light source and extended time of curing on microhardness and degree of conversion of different regions of a nanofilled composite resin[J]. Eur J Dent, 2012, 6(2):153-157.
25.	OLIVEIRA M, CESAR P F, GIANNINI M, et al. Effect of temperature on the degree of conversion and working time of dual-cured resin cements exposed to different curing conditions[J]. Oper Dent, 2012, 37(4):370-379.
26.	BURAL C, AKTAŞ E, DENIZ G, et al. Effect of post-polymerization heat-treatments on degree of conversion, leaching residual MMA and in vitro cytotoxicity of autopolymerizing acrylic repair resin[J]. Dent Mater, 2011, 27(11):1135-1143.
27.	GIACOMELLI L, DERCHI G, FRUSTACI A, et al. Surface roughness of commercial composites after different polishing protocols:an analysis with atomic force microscopy[J]. Open Dent J, 2010, 4:191-194.
28.	OYAMA K, TSUJIMOTO A, OTSUKA E, et al. Influence of oxygen inhibition on the surface free energy and enamel bond strength of self-etch adhesives[J]. Dent Mater J, 2012, 31(1):26-31.

1. PARK J, YE Q, TOPP E M, et al. Effect of photoinitiator system and water content on dynamic mechanical properties of a light-cured bisGMA/HEMA dental resin[J]. J Biomed Mater Res A, 2010, 93(4):1245-1251.
2. 房俊艳, 凌均棨.树脂单体毒性机制的研究进展[J].国际口腔医学杂志, 2010, 37(3):302-305.
3. FARIA-E-SILVA A L, PIVA E, MORAES R R. Time-dependent effect of refrigeration on viscosity and conversion kinetics of dental adhesive resins[J]. Eur J Dent, 2010, 4(2):150-155.
4. AUSIELLO P, CASSESE A, MIELE C, et al. Cytotoxicity of dental resin composites:an in vitro evaluation[J]. J Appl Toxicol, 2013, 33(6):451-457.
5. BLASIAK J, SYNOWIEC E, TARNAWSKA J, et al. Dental methacrylates may exert genotoxic effects via the oxidative induction of DNA double strand breaks and the inhibition of their repair[J]. Mol Biol Rep, 2012, 39(7):7487-7496.
6. YANO J, KITAMURA C, NISHIHARA T, et al. Apoptosis and survivability of human dental pulp cells under exposure to Bis-GMA[J]. J Appl Oral Sci, 2011, 19(3):218-222.
7. SZCZEPANSKA J, POPLAWSKI T, SYNOWIEC E, et al. 2-hydroxylethyl methacrylate (HEMA), a tooth restoration component, exerts its genotoxic effects in human gingival fibroblasts trough methacrylic acid, an immediate product of its degradation[J]. Mol Biol Rep, 2012, 39(2):1561-1574.
8. ANIRUDHAN T S, RIJITH S. Synthesis and characterization of carboxyl terminated poly (methacrylic acid) grafted chitosan/bentonite composite and its application for the recovery of uranium (Ⅵ) from aqueous media[J]. J Eniron Radioact, 2012, 106:8-19.
9. HATTORI N, SUZUKI T, JINNO S, et al. Methyl methacrylate activates the Gsta1 promoter[J]. J Dent Res, 2008, 87(12):1117-1121.
10. CÓRDOBA S, GARCÍA-DONOSO C, VILLANUEVA C A, et al. Allergic contact dermatitis from a veterinary antiinflammatory gel containing 2-hydroxyethyl salicylate[J]. Dermatitis, 2011, 22(3):171-172.
11. GOSAVI S S, GOSAVI S Y, ALLA R K. Local and systemic effects of unpolymerised monomers[J]. Dent Res J (Isfahan), 2010, 7(2):82-87.
12. 王军, 周平, 施长溪.过氧化物胺和阻聚剂含量对树脂固化和性能的影响[J].现代口腔医学杂志, 1997, 11(1):27-30.
13. SOUZA R O, OZCAN M, MESQUITA A M, et al. Effect of different polymerization devices on the degree of conversion and the physical properties of an indirect resin composite[J]. Acta Odontol Latinoam, 2010, 23(2):129-135.
14. GONÇALVES F, KAWANO Y, PFEIFER C, et al. Influence of BisGMA, TEGDMA, and BisEMA contents on viscosity, conversion, and flexural strength of experimental resins and composites[J]. Eur J Oral Sci, 2009, 117(4):442-446.
15. NANDINI S. Indirect resin composites[J]. J Conserv Dent, 2010, 13(4):184-194.
16. SUZUKI N, ZAKARIA M B, CHIANG Y D, et al. Thermally stable polymer composites with improved transparency by using colloidal mesoporous silica nanoparticles as inorganic fillers[J]. Phys Chem Chem Phys, 2012, 14(20):7427-7432.
17. GUIRALDO R D, CONSANI S, CONSANI R L, et al. Evaluation of the light energy transmission and bottom/top rate in silorane and methacrylate-based composites with different photoactivation protocols[J]. J Contemp Dent Pract, 2011, 12(5):361-367.
18. 王云, 王青山.牙体修复性纳米羟基磷灰石复合材料的机械性能研究[J].现代口腔医学杂志, 2011, 25(2):115-117.
19. 李瑞, 王青山, 赵蒙蒙, 等.牙体修复性纳米羟基磷灰石复合材料生物相容性评价[J].牙体牙髓牙周病学杂志, 2012, 22(3):157-160.
20. ALBUQUERQUE P P, MOREIRA A D, MORAES R R, et al. Colour stability, conversion, water sorption and solubility of dental composites formulated with different photoinitiator systems[J]. J Dent, 2013, 41(Suppl 3):e67-e72.
21. PARK Y J, CHAE K H, RAWLS H R. Development of a new photoinitiation system for dental light-cure composite resins[J]. Dent Mater, 1999, 15(2):120-127.
22. GIORGI M C, AGUIAR F H, SOARES L E, et al. Does an additional UV LED improve the degree of conversion and Knoop Hardness of light-shade composite resins?[J]. Eur J Dent, 2012, 6(4):396-401.
23. PRATI C, CHERSONI S, MONTEBUGNOLI L, et al. Effect of air, dentin and resin-based composite thickness on light intensity reduction[J]. Am J Dent, 1999, 12(5):231-234.
24. LIMA A F, DE ANDRADE K M, DA CRUZ ALVES L E, et al. Influence of light source and extended time of curing on microhardness and degree of conversion of different regions of a nanofilled composite resin[J]. Eur J Dent, 2012, 6(2):153-157.
25. OLIVEIRA M, CESAR P F, GIANNINI M, et al. Effect of temperature on the degree of conversion and working time of dual-cured resin cements exposed to different curing conditions[J]. Oper Dent, 2012, 37(4):370-379.
26. BURAL C, AKTAŞ E, DENIZ G, et al. Effect of post-polymerization heat-treatments on degree of conversion, leaching residual MMA and in vitro cytotoxicity of autopolymerizing acrylic repair resin[J]. Dent Mater, 2011, 27(11):1135-1143.
27. GIACOMELLI L, DERCHI G, FRUSTACI A, et al. Surface roughness of commercial composites after different polishing protocols:an analysis with atomic force microscopy[J]. Open Dent J, 2010, 4:191-194.
28. OYAMA K, TSUJIMOTO A, OTSUKA E, et al. Influence of oxygen inhibition on the surface free energy and enamel bond strength of self-etch adhesives[J]. Dent Mater J, 2012, 31(1):26-31.

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