Research Progress of the Regulation Function of Epigenetics on Bone Marrow Mesenchymal Stem Cells_Journal of Biomedical Engineering

Authors：

CHENZhihao ¹ , FANGShubin ¹ ,  TIANJing ²

1. Zhujiang Hospital of Southern Medical University, Guangzhou 510280, China;
2. Orthopedic Center, Zhujiang Hospital of Southern Medical University, Guangzhou 510280, China;

Corresponding author：

TIANJing, Email: tian_jing6723@aliyun.com

Keywords：

DNA methylation; histone acetylation; small interfering RNA; microRNA; bone marrow mesenchymal stem cell

DOI：

10.7507/1001-5515.20150123

Video：

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The regulation of epigenetics on bone marrow mesenchymal stem cells (BMSCs) has been a research hot spot in medical area. This paper mainly summarizes the progress of the regulation of DNA methylation, histone acetylation, small interfering RNA (siRNA) induced gene silence and microRNA (miRNA) on BMSCs. Our analysis shows that the regulation of epigenetics on BMSCs plays a significant role in the repair of bone tissue, nervous tissue and cardiac muscle.

Citation： CHENZhihao, FANGShubin, TIANJing. Research Progress of the Regulation Function of Epigenetics on Bone Marrow Mesenchymal Stem Cells. Journal of Biomedical Engineering, 2015, 32(3): 680-683. doi: 10.7507/1001-5515.20150123 Copy

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2.	PITTENGER M F, MACKAY A M, BECK S C, et al. Multilineage potential of adult human mesenchymal stem cells[J]. Science, 1999, 284(5411):143-147.
3.	EGGER G, LIANG Gangning, APARICIO A, et al. Epigenetics in human disease and prospects for epigenetic therapy[J]. Nature, 2004, 429(6990):457-463.
4.	CHOI M R, IN Y H, PARK J, et al. Genome-scale DNA methylation pattern profiling of human bone marrow mesenchymal stem cells in long-term culture[J]. Exp Mol Med, 2012, 44(8):503-512.
5.	NAEEM N, HANEEF K, KABIR N, et al. DNA methylation inhibitors, 5-azacytidine and zebularine potentiate the transdifferentiation of rat bone marrow mesenchymal stem cells into cardiomyocytes[J]. Cardiovasc Ther, 2013, 31(4):201-209.
6.	SMITH Z D, MEISSNER A. DNA methylation:roles in mammalian development[J]. Nat Rev Genet, 2013, 14(3):204-220.
7.	DONG Xuejun, PAN Ruolang, ZHANG Hui, et al. Modification of histone acetylation facilitates hepatic differentiation of human bone marrow mesenchymal stem cells[J]. PLoS One, 2013, 8(5):e63405.
8.	陆超, 陈吉庆, 周国平, 等.Par-4基因沉默对人骨髓间充质干细胞中Smac基因表达和半胱氨酸蛋白水解酶3酶活性的影响及其抗凋亡作用Par-4基因沉默对人骨髓间充质干细胞中Smac基因表达和半胱氨酸蛋白水解酶3酶活性的影响及其抗凋亡作用[J].中华医学杂志, 2008, 88(6):411-415.
9.	陆超, 陈吉庆, 周国平, 等.小RNA干扰靶向抑制Par-4基因表达对人骨髓间充质干细胞凋亡的影响[J].中华儿科杂志, 2008, 46(11):836-841.
10.	HUA Ping, LIU Libao, LIU Jialiang, et al. Inhibition of apoptosis by knockdown of caspase-3 with siRNA in rat bone marrow mesenchymal stem cells[J]. Exp Biol Med (Maywood), 2013, 238(9):991-998.
11.	周燕, 陈奎生, 高剑波, 等. miR-124-1促进大鼠骨髓间充质干细胞神经分化的实验研究[J].中国当代儿科杂志, 2012, 14(3):215-220.
12.	WU Rui, WANG Na, LI Min, et al. Experimental study on the facilitative effects of miR-125b on the differentiation of rat bone marrow mesenchymal stem cells into neuron-like cells[J]. Cell Biol Int, 2013, 37(8):812-819.
13.	JING Lijun, JIA Yonglin, LU Jingjing, et al. MicroRNA-9 promotes differentiation of mouse bone mesenchymal stem cells into neurons by Notch signaling[J]. Neuroreport, 2011, 22(5):206-211.
14.	HAN Rui, KAN Quancheng, SUN Yingpu, et al. MiR-9 promotes the neural differentiation of mouse bone marrow mesenchymal stem cells via targeting zinc finger protein 521[J]. Neurosci Lett, 2012, 515(2):147-152.
15.	魏均强, 张伯勋, 郑晓飞, 等.诱导hBMSCs成骨分化中微小RNA和靶基因表达水平的变化[J].中国修复重建外科杂志, 2012, 26(4):483-488.
16.	魏均强, 陈华, 郑晓飞, 等.hsa-miR-654-5p通过抑制骨形态发生蛋白2调控人骨髓基质干细胞成骨分化[J].南方医科大学学报, 2012, 32(3):291-295.
17.	陆细红, 邓敏, 贺洪辉, 等.miR-125b通过靶向抑制Smad4调控骨髓间充质干细胞成骨分化[J].中南大学学报(医学版), 2013, 38(4):341-346.
18.	BAGLÌO S R, DEVESCOVI V, GRANCHI D, et al. MicroRNA expression profiling of human bone marrow mesenchymal stem cells during osteogenic differentiation reveals Osterix regulation by miR-31[J]. Gene, 2013, 527(1):321-331.
19.	匡威, 谭家莉, 张红梅, 等.miR-146a调控骨髓间充质干细胞成骨分化的机制研究[J].生物医学工程与临床, 2011, 15(5):413-416, 封3.
20.	范龙坤, 华泽权, 金岩, 等.miR-26a对小鼠骨髓间充质干细胞成骨分化能力的调控作用[J].中国医科大学学报, 2012, 41(7):591-595, 606.
21.	王海鹏, 高杰, 张小平, 等.miR-30a-5P在人骨髓间充质干细胞向成骨细胞分化过程中的生物学功能及验证[J].中国医药导报, 2011, 8(16):23-26, 封3.
22.	LIU Ju-li, JIANG Li, LIN Qiu-xiong, et al. MicroRNA 16 enhances differentiation of human bone marrow mesenchymal stem cells in a cardiac niche toward myogenic phenotypes in vitro[J]. Life Sci, 2012, 90(25-26):1020-1026.
23.	高杰, 韩建伟, 朱洪繁, 等.miR-424在人骨髓间充质干细胞分化过程中的表达[J].中华创伤杂志, 2010, 26(8):752-756.
24.	张鹭鹭, 刘惊今, 王永顺, 等.microRNA499慢病毒载体转染诱导大鼠骨髓间充质干细胞向心肌样细胞分化[J].现代生物医学进展, 2012, 12(26):5027-5031.

1. INBAR-FEIGENBERG M, CHOUFANI S, BUTCHER D T, et al. Basic concepts of epigenetics[J]. Fertil Steril, 2013, 99(3):607-615.
2. PITTENGER M F, MACKAY A M, BECK S C, et al. Multilineage potential of adult human mesenchymal stem cells[J]. Science, 1999, 284(5411):143-147.
3. EGGER G, LIANG Gangning, APARICIO A, et al. Epigenetics in human disease and prospects for epigenetic therapy[J]. Nature, 2004, 429(6990):457-463.
4. CHOI M R, IN Y H, PARK J, et al. Genome-scale DNA methylation pattern profiling of human bone marrow mesenchymal stem cells in long-term culture[J]. Exp Mol Med, 2012, 44(8):503-512.
5. NAEEM N, HANEEF K, KABIR N, et al. DNA methylation inhibitors, 5-azacytidine and zebularine potentiate the transdifferentiation of rat bone marrow mesenchymal stem cells into cardiomyocytes[J]. Cardiovasc Ther, 2013, 31(4):201-209.
6. SMITH Z D, MEISSNER A. DNA methylation:roles in mammalian development[J]. Nat Rev Genet, 2013, 14(3):204-220.
7. DONG Xuejun, PAN Ruolang, ZHANG Hui, et al. Modification of histone acetylation facilitates hepatic differentiation of human bone marrow mesenchymal stem cells[J]. PLoS One, 2013, 8(5):e63405.
8. 陆超, 陈吉庆, 周国平, 等.Par-4基因沉默对人骨髓间充质干细胞中Smac基因表达和半胱氨酸蛋白水解酶3酶活性的影响及其抗凋亡作用Par-4基因沉默对人骨髓间充质干细胞中Smac基因表达和半胱氨酸蛋白水解酶3酶活性的影响及其抗凋亡作用[J].中华医学杂志, 2008, 88(6):411-415.
9. 陆超, 陈吉庆, 周国平, 等.小RNA干扰靶向抑制Par-4基因表达对人骨髓间充质干细胞凋亡的影响[J].中华儿科杂志, 2008, 46(11):836-841.
10. HUA Ping, LIU Libao, LIU Jialiang, et al. Inhibition of apoptosis by knockdown of caspase-3 with siRNA in rat bone marrow mesenchymal stem cells[J]. Exp Biol Med (Maywood), 2013, 238(9):991-998.
11. 周燕, 陈奎生, 高剑波, 等. miR-124-1促进大鼠骨髓间充质干细胞神经分化的实验研究[J].中国当代儿科杂志, 2012, 14(3):215-220.
12. WU Rui, WANG Na, LI Min, et al. Experimental study on the facilitative effects of miR-125b on the differentiation of rat bone marrow mesenchymal stem cells into neuron-like cells[J]. Cell Biol Int, 2013, 37(8):812-819.
13. JING Lijun, JIA Yonglin, LU Jingjing, et al. MicroRNA-9 promotes differentiation of mouse bone mesenchymal stem cells into neurons by Notch signaling[J]. Neuroreport, 2011, 22(5):206-211.
14. HAN Rui, KAN Quancheng, SUN Yingpu, et al. MiR-9 promotes the neural differentiation of mouse bone marrow mesenchymal stem cells via targeting zinc finger protein 521[J]. Neurosci Lett, 2012, 515(2):147-152.
15. 魏均强, 张伯勋, 郑晓飞, 等.诱导hBMSCs成骨分化中微小RNA和靶基因表达水平的变化[J].中国修复重建外科杂志, 2012, 26(4):483-488.
16. 魏均强, 陈华, 郑晓飞, 等.hsa-miR-654-5p通过抑制骨形态发生蛋白2调控人骨髓基质干细胞成骨分化[J].南方医科大学学报, 2012, 32(3):291-295.
17. 陆细红, 邓敏, 贺洪辉, 等.miR-125b通过靶向抑制Smad4调控骨髓间充质干细胞成骨分化[J].中南大学学报(医学版), 2013, 38(4):341-346.
18. BAGLÌO S R, DEVESCOVI V, GRANCHI D, et al. MicroRNA expression profiling of human bone marrow mesenchymal stem cells during osteogenic differentiation reveals Osterix regulation by miR-31[J]. Gene, 2013, 527(1):321-331.
19. 匡威, 谭家莉, 张红梅, 等.miR-146a调控骨髓间充质干细胞成骨分化的机制研究[J].生物医学工程与临床, 2011, 15(5):413-416, 封3.
20. 范龙坤, 华泽权, 金岩, 等.miR-26a对小鼠骨髓间充质干细胞成骨分化能力的调控作用[J].中国医科大学学报, 2012, 41(7):591-595, 606.
21. 王海鹏, 高杰, 张小平, 等.miR-30a-5P在人骨髓间充质干细胞向成骨细胞分化过程中的生物学功能及验证[J].中国医药导报, 2011, 8(16):23-26, 封3.
22. LIU Ju-li, JIANG Li, LIN Qiu-xiong, et al. MicroRNA 16 enhances differentiation of human bone marrow mesenchymal stem cells in a cardiac niche toward myogenic phenotypes in vitro[J]. Life Sci, 2012, 90(25-26):1020-1026.
23. 高杰, 韩建伟, 朱洪繁, 等.miR-424在人骨髓间充质干细胞分化过程中的表达[J].中华创伤杂志, 2010, 26(8):752-756.
24. 张鹭鹭, 刘惊今, 王永顺, 等.microRNA499慢病毒载体转染诱导大鼠骨髓间充质干细胞向心肌样细胞分化[J].现代生物医学进展, 2012, 12(26):5027-5031.

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