Research Progress of Feasibility of Dendritic Cell Antifungal Vaccines_Journal of Biomedical Engineering

Authors：

FANGuoxin , WANGLong , WANGYueye ,  ZHAOPeilin

School of Medicine, Tongji University, Shanghai 200092, China;

Corresponding author：

ZHAOPeilin, Email: plzhao@yahoo.com

Keywords：

dendritic cell; antifungal vaccine; immunotherapy

DOI：

10.7507/1001-5515.20150124

Video：

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Fungal infection is an important clinical problem for patients with immune deficiency or immunosuppression. With deadly fungus infection case increasing, the development of antifungal vaccine attracts the attention of researchers. Dendritic cell (DC) is the unique antigen presenting cell (APC) to trigger the antifungal immune reaction, and recent studies indicate that the targeted vaccination strategy based on DC have prospective antifungal potentials. In this paper, we review the antifungal immunity mechanism and recent development of the targeted DC antifungal strategy.

Citation： FANGuoxin, WANGLong, WANGYueye, ZHAOPeilin. Research Progress of Feasibility of Dendritic Cell Antifungal Vaccines. Journal of Biomedical Engineering, 2015, 32(3): 684-687. doi: 10.7507/1001-5515.20150124 Copy

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2.	RAMIREZ-ORTIZ Z G, MEANS T K. The role of dendritic cells in the innate recognition of pathogenic fungi (A. fumigatus, C. neoformans and C. albicans)[J]. Virulence, 2012, 3(7):635-646.
3.	VAN SPRIEL A B, CAMBI A. Binding and uptake of Candida albicans by human monocyte-derived dendritic cells[J]. Methods Mol Biol, 2012, 845:319-331.
4.	PARK S J, BURDICK M D, MEHRAD B. Neutrophils mediate maturation and efflux of lung dendritic cells in response to Aspergillus fumigatus germ tubes[J]. Infect Immun, 2012, 80(5):1759-1765.
5.	CASSONE A, CASADEVALL A. Recent progress in vaccines against fungal diseases[J]. Curr Opin Microbiol, 2012, 15(4):427-433.
6.	FRANKENBERGER B, SCHENDEL D J. Third generation dendritic cell vaccines for tumor immunotherapy[J]. Eur J Cell Biol, 2012, 91(1):53-58.
7.	HAMMERSTROM A E, CAULEY D H, ATKINSON B J, et al. Cancer immunotherapy:sipuleucel-T and beyond[J]. Pharmacotherapy, 2011, 31(8):813-828.
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13.	BOURGEOIS C, MAJER O, FROHNER I E, et al. Conventional dendritic cells mount a typeⅠIFN response against Candida spp. requiring novel phagosomal TLR7-mediated IFN-βsignaling[J]. J Immunol, 2011, 186(5):3104-3112.
14.	WEVERS B A, GEIJTENBEEK T B, GRINGHUIS S I. C-type lectin receptors orchestrate antifungal immunity[J]. Future Microbiol, 2013, 8(7):839-854.
15.	KERSCHER B, WILLMENT J A, BROWN G D. The dectin-2 family of c-type lectin-like receptors:an update[J]. Int Immunol, 2013, 25(5):271-277.
16.	NETEA M G, VAN DER MEER J W. Immunodeficiency and genetic defects of pattern-recognition receptors[J]. N Engl J Med, 2011, 364(1):60-70.
17.	CASADEVALL A, PIROFSKI L A. Immunoglobulins in defense, pathogenesis, and therapy of fungal diseases[J]. Cell Host Microbe, 2012, 11(5):447-456.
18.	CASADEVALL A, PIROFSKI L A. A new synthesis for antibody-mediated immunity[J]. Nat Immunol, 2012, 13(1):21-28.
19.	WVTHRICH M, DEEPE G S Jr, KLEIN B. Adaptive immunity to fungi[J]. Annu Rev Immunol, 2012, 30:115-148.
20.	KHADER S A, GAFFEN S L, KOLLS J K. Th17 cells at the crossroads of innate and adaptive immunity against infectious diseases at the mucosa[J]. Mucosal Immunol, 2009, 2(5):403-411.
21.	WÜTHRICH M, GERN B, HUNG C Y, et al. Vaccine-induced protection against 3 systemic mycoses endemic to North America requires Th17 cells in mice[J]. J Clin Invest, 2011, 121(2):554-568.
22.	STUEHLER C, KHANNA N, BOZZA S, et al. Cross-protective TH1 immunity against Aspergillus fumigatus and Candida albicans[J]. Blood, 2011, 117(22):5881-5891.
23.	XIN Hong, CUTLER J E. Vaccine and monoclonal antibody that enhance mouse resistance to candidiasis[J]. Clin Vaccine Immunol, 2011, 18(10):1656-1667.
24.	BELSHE R B, NEWMAN F K, CANNON J, et al. Serum antibody responses after intradermal vaccination against influenza[J]. N Engl J Med, 2004, 351(22):2286-2294.
25.	SANDINI S, LA VALLE R, DEAGLIO S, et al. A highly immunogenic recombinant and truncated protein of the secreted aspartic proteases family (rSap2t) of Candida albicans as a mucosal anticandidal vaccine[J]. FEMS Immunol Med Microbiol, 2011, 62(2):215-224.
26.	HU Wei, TROUTMAN T D, EDUKULLA R, et al. Priming microenvironments dictate cytokine requirements for T helper 17 cell lineage commitment[J]. Immunity, 2011, 35(6):1010-1022.
27.	LAM J S, HUANG Haibin, LEVITZ S M. Effect of differential N-linked and O-linked mannosylation on recognition of fungal antigens by dendritic cells[J]. PLoS One, 2007, 2(10):e1009.
28.	HUANG Haibin, OSTROFF G R, LEE C K, et al. Robust stimulation of humoral and cellular immune responses following vaccination with antigen-loaded beta-glucan particles[J]. mBio, 2010, 1(3):e00164-10.
29.	TACKEN P J, ZEELENBERG I S, CRUZ L J, et al. Targeted delivery of TLR ligands to human and mouse dendritic cells strongly enhances adjuvanticity[J]. Blood, 2011, 118(26):6836-6844.
30.	AVCI F Y, LI Xiangming, TSUJI M, et al. A mechanism for glycoconjugate vaccine activation of the adaptive immune system and its implications for vaccine design[J]. Nat Med, 2011, 17(12):1602-1609.

1. BROWN G D, NETEA M G. Exciting developments in the immunology of fungal infections[J]. Cell Host Microbe, 2012, 11(5):422-424.
2. RAMIREZ-ORTIZ Z G, MEANS T K. The role of dendritic cells in the innate recognition of pathogenic fungi (A. fumigatus, C. neoformans and C. albicans)[J]. Virulence, 2012, 3(7):635-646.
3. VAN SPRIEL A B, CAMBI A. Binding and uptake of Candida albicans by human monocyte-derived dendritic cells[J]. Methods Mol Biol, 2012, 845:319-331.
4. PARK S J, BURDICK M D, MEHRAD B. Neutrophils mediate maturation and efflux of lung dendritic cells in response to Aspergillus fumigatus germ tubes[J]. Infect Immun, 2012, 80(5):1759-1765.
5. CASSONE A, CASADEVALL A. Recent progress in vaccines against fungal diseases[J]. Curr Opin Microbiol, 2012, 15(4):427-433.
6. FRANKENBERGER B, SCHENDEL D J. Third generation dendritic cell vaccines for tumor immunotherapy[J]. Eur J Cell Biol, 2012, 91(1):53-58.
7. HAMMERSTROM A E, CAULEY D H, ATKINSON B J, et al. Cancer immunotherapy:sipuleucel-T and beyond[J]. Pharmacotherapy, 2011, 31(8):813-828.
8. VOLCHENKOV R, SPRATER F, VOGELSANG P, et al. The 2011 Nobel Prize in physiology or medicine[J]. Scand J Immunol, 2012, 75(1):1-4.
9. ANTACHOPOULOS C, KATRAGKOU A, ROILIDES E. Immunotherapy against invasive mold infections[J]. Immunotherapy, 2012, 4(1):107-120.
10. ROMANI L. Immunity to fungal infections[J]. Nat Rev Immunol, 2011, 11(4):275-288.
11. ROY R M, KLEIN B S. Dendritic cells in antifungal immunity and vaccine design[J]. Cell Host Microbe, 2012, 11(5):436-446.
12. HERNÁNDEZ-SANTOS N, GAFFEN S L. Th17 cells in immunity to Candida albicans[J]. Cell Host Microbe, 2012, 11(5):425-435.
13. BOURGEOIS C, MAJER O, FROHNER I E, et al. Conventional dendritic cells mount a typeⅠIFN response against Candida spp. requiring novel phagosomal TLR7-mediated IFN-βsignaling[J]. J Immunol, 2011, 186(5):3104-3112.
14. WEVERS B A, GEIJTENBEEK T B, GRINGHUIS S I. C-type lectin receptors orchestrate antifungal immunity[J]. Future Microbiol, 2013, 8(7):839-854.
15. KERSCHER B, WILLMENT J A, BROWN G D. The dectin-2 family of c-type lectin-like receptors:an update[J]. Int Immunol, 2013, 25(5):271-277.
16. NETEA M G, VAN DER MEER J W. Immunodeficiency and genetic defects of pattern-recognition receptors[J]. N Engl J Med, 2011, 364(1):60-70.
17. CASADEVALL A, PIROFSKI L A. Immunoglobulins in defense, pathogenesis, and therapy of fungal diseases[J]. Cell Host Microbe, 2012, 11(5):447-456.
18. CASADEVALL A, PIROFSKI L A. A new synthesis for antibody-mediated immunity[J]. Nat Immunol, 2012, 13(1):21-28.
19. WVTHRICH M, DEEPE G S Jr, KLEIN B. Adaptive immunity to fungi[J]. Annu Rev Immunol, 2012, 30:115-148.
20. KHADER S A, GAFFEN S L, KOLLS J K. Th17 cells at the crossroads of innate and adaptive immunity against infectious diseases at the mucosa[J]. Mucosal Immunol, 2009, 2(5):403-411.
21. WÜTHRICH M, GERN B, HUNG C Y, et al. Vaccine-induced protection against 3 systemic mycoses endemic to North America requires Th17 cells in mice[J]. J Clin Invest, 2011, 121(2):554-568.
22. STUEHLER C, KHANNA N, BOZZA S, et al. Cross-protective TH1 immunity against Aspergillus fumigatus and Candida albicans[J]. Blood, 2011, 117(22):5881-5891.
23. XIN Hong, CUTLER J E. Vaccine and monoclonal antibody that enhance mouse resistance to candidiasis[J]. Clin Vaccine Immunol, 2011, 18(10):1656-1667.
24. BELSHE R B, NEWMAN F K, CANNON J, et al. Serum antibody responses after intradermal vaccination against influenza[J]. N Engl J Med, 2004, 351(22):2286-2294.
25. SANDINI S, LA VALLE R, DEAGLIO S, et al. A highly immunogenic recombinant and truncated protein of the secreted aspartic proteases family (rSap2t) of Candida albicans as a mucosal anticandidal vaccine[J]. FEMS Immunol Med Microbiol, 2011, 62(2):215-224.
26. HU Wei, TROUTMAN T D, EDUKULLA R, et al. Priming microenvironments dictate cytokine requirements for T helper 17 cell lineage commitment[J]. Immunity, 2011, 35(6):1010-1022.
27. LAM J S, HUANG Haibin, LEVITZ S M. Effect of differential N-linked and O-linked mannosylation on recognition of fungal antigens by dendritic cells[J]. PLoS One, 2007, 2(10):e1009.
28. HUANG Haibin, OSTROFF G R, LEE C K, et al. Robust stimulation of humoral and cellular immune responses following vaccination with antigen-loaded beta-glucan particles[J]. mBio, 2010, 1(3):e00164-10.
29. TACKEN P J, ZEELENBERG I S, CRUZ L J, et al. Targeted delivery of TLR ligands to human and mouse dendritic cells strongly enhances adjuvanticity[J]. Blood, 2011, 118(26):6836-6844.
30. AVCI F Y, LI Xiangming, TSUJI M, et al. A mechanism for glycoconjugate vaccine activation of the adaptive immune system and its implications for vaccine design[J]. Nat Med, 2011, 17(12):1602-1609.

Journal of Biomedical Engineering

Research Progress of Feasibility of Dendritic Cell Antifungal Vaccines

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