A Review of Methods for Early Evaluation of Alzheimer's Disease_Journal of Biomedical Engineering

Authors：

 LIXin , CHENZetao , XIEJiali , YANGYadan

Institute of Biomedical Engineering of Yanshan University, Qinhuangdao 066004, China;

Corresponding author：

LIXin, Email: yddylixin@ysu.edu.cn

Keywords：

Alzheimer's disease; pathological mechanism; early evaluation; brain imaging; electroencephalogram

DOI：

10.7507/1001-5515.20150203

Video：

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With the intensified aging problem, the study of age-related diseases is becoming more and more significant. Alzheimer's disease is a kind of dementia, with senile plaques and neurofibrillary tangles as the main pathological features, and has become one of the major diseases that endanger the health of the elderly. This review is concentrated on the research of the early assessment of Alzheimer's disease. The current situation of early diagnosis of the disease is analyzed, and a prospect of the future development of early assessment means of the disease is also made in the paper.

Citation： LIXin, CHENZetao, XIEJiali, YANGYadan. A Review of Methods for Early Evaluation of Alzheimer's Disease. Journal of Biomedical Engineering, 2015, 32(5): 1146-1149,1154. doi: 10.7507/1001-5515.20150203 Copy

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10.	CHU L W. Alzheimer's disease:early diagnosis and treatment[J]. Hong Kong Med J, 2012, 18(3):228-237.
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14.	VENTURELLI M, SCARSINI R, SCHENA F. Six-month walking program changes cognitive and ADL performance in patients with Alzheimer[J]. Am J Alzheimers Dis Other Demen, 2011, 26(5):381-388.
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24.	NASRALLAH I, DUBROFF J. An overview of PET neuroimaging[J]. Semin Nucl Med, 2013, 43(6):449-461.
25.	徐梅松,陶华英.基于复杂度分析阿尔茨海默病、轻度认知功能障碍患者的脑电特点[J].中华神经科杂志,2013,46(10):687-691.
26.	马顺天,楼美珍,王晓玲,等.阿尔茨海默病的非匹配负波的实验研究[J].中国临床康复,2003,7(7):1102-1103.
27.	万柏坤,付小萌,杨春梅,等.老年痴呆脑电能谱分布特征[J].天津大学学报,2004,37(12):1077-1082.
28.	MORISON G, TIEGES Z, KILBORN K. Multiscale permutation statistical complexity measure analysis of EEG in patients with mild Alzheimer's disease[J].Alzheimer's & Dementia, 2013, 9(4):279-279.
29.	CARLINO E, SIGAUDO M, POLLO A, et al. Nonlinear analysis of electroencephalogram at rest and during cognitive tasks in patients with schizophrenia[J]. J Psychiatry Neurosci, 2012, 37(4):259-266.
30.	周菁,刘群,徐维安,等.老年抑郁症和阿尔茨海默症的听觉P300比较研究[J].神经病学与神经康复学杂志,2012,9(2):77-79.

1. LAUREYS S, TONONI G. The neurology of consciousness:cognitive neuroscience and neuropathology[M]. Amsterdam:Access Online via Elsevier, 2011:1-440.
2. SCHELLENBERG G D, MONTINE T J. The genetics and neuropathology of Alzheimer's disease[J]. Acta Neuropathol, 2012, 124(3):305-323.
3. GEFEN T, GASHO K, RADEMAKER A, et al. Clinically concordant variations of Alzheimer pathology in aphasic versus amnestic dementia[J]. Brain, 2012, 135(Pt 5):1554-1565.
4. DUYCKAERTS C, DICKSON D. Neurodegeneration:the molecular pathology of dementia and movement disorders[M]. New York:Wiley-Blackwell, 2011:1-496.
5. VISSCHER P M, BROWN M A, MCCARTHY M I, et al. Five years of GWAS discovery[J]. Am J Hum Genet, 2012, 90(1):7-24.
6. BERTRAM L, TANZI R E. Thirty years of Alzheimer's disease genetics:the implications of systematic meta-analyses[J]. Nat Rev Neurosci, 2008, 9(10):768-778.
7. STROOPER B, IWSTSUBOS T, WOLFE M. Presenilins and γ-secretase:structure, function, and role in Alzheimer disease[J]. Cold Spring Harb Perspect Med, 2012, 2(1):1-19.
8. ROWE C C, BOURGEAT P, ELLIS K A, et al. Predicting Alzheimer disease with β-amyloid imaging:results from the Australian imaging, biomarkers, and lifestyle study of ageing[J]. Ann Neurol, 2013, 74(6):905-913.
9. JONSSON T, ATWAL J K, STEINBERG S, et al. A mutation in APP protects against Alzheimer's disease and age-related cognitive decline[J]. Nature, 2012, 488(749):96-99.
10. CHU L W. Alzheimer's disease:early diagnosis and treatment[J]. Hong Kong Med J, 2012, 18(3):228-237.
11. NASREDDINE Z S, PHILLIPS N A, BÉDIRIAN V, et al. The Montreal Cognitive Assessment, MoCA:a brief screening tool for mild cognitive impairment[J]. J Am Geriatr Soc, 2005, 53(4):695-699.
12. GUO Qihao, CAO Xinyi, ZHOU Yan, et al. Application study of quick cognitive screening test in identifying mild cognitive impairment[J].Neurosci Bull,2010,26(1):47-54.
13. SPERING C C, HOBSON V, LUCAS J A, et al. Diagnostic accuracy of the MMSE in detecting probable and possible Alzheimer's disease in ethnically diverse highly educated individuals:an analysis of the NACC database[J]. J Gerontol A Biol Sci Med Sci, 2012, 67(8):890-896.
14. VENTURELLI M, SCARSINI R, SCHENA F. Six-month walking program changes cognitive and ADL performance in patients with Alzheimer[J]. Am J Alzheimers Dis Other Demen, 2011, 26(5):381-388.
15. 杨少华.CT对60例早期老年性痴呆的诊断价值分析[J].中外医疗,2012,31(7):175-175.
16. 陈建铭.低场强MRI在老年痴呆症诊断的创新预测与应用[J].中国保健营养:中旬刊,2012(6):328-329.
17. SABUNCU M R, DESIKAN R S, SEPULCRE J, et al. The dynamics of cortical and hippocampal atrophy in Alzheimer disease[J]. Arch Neurol, 2011, 68(8):1040-1048.
18. GREICIUS M. Network-based neurodegeneration in Alzheimer's disease:Evidence from resting-state fMRI[J]. Alzheimer's & Dementia, 2013, 9(4):313.
19. BARTRA O, MCGUIRE J T, KABLE J W. The valuation system:a coordinate-based meta-analysis of BOLD fMRI experiments examining neural correlates of subjective value[J]. Neuroimage, 2013, 76:412-427.
20. KOCH W, TEIPEL S, MUELLER S, et al. Diagnostic power of default mode network resting state fMRI in the detection of Alzheimer's disease[J]. Neurobiol Aging, 2012, 33(3):466-478.
21. LIM T S, HONG Y H, LEE H Y, et al. Metabolite investigation in both anterior and posterior cingulate gyri in Alzheimer's disease spectrum using 3-tesla MR spectroscopy[J]. Dement Geriatr Cogn Disord, 2012, 33(2-3):149-155.
22. 钱丽霞.Alzheimer病及轻度认知障碍的MRS、DWI和MTI随访研究及其与ApoE基因型关系的研究[D].天津:天津医科大学,2005.
23. REIMAN E M, JAGUST W J. Brain imaging in the study of Alzheimer's disease[J]. Neuroimage, 2012, 61(2):505-516.
24. NASRALLAH I, DUBROFF J. An overview of PET neuroimaging[J]. Semin Nucl Med, 2013, 43(6):449-461.
25. 徐梅松,陶华英.基于复杂度分析阿尔茨海默病、轻度认知功能障碍患者的脑电特点[J].中华神经科杂志,2013,46(10):687-691.
26. 马顺天,楼美珍,王晓玲,等.阿尔茨海默病的非匹配负波的实验研究[J].中国临床康复,2003,7(7):1102-1103.
27. 万柏坤,付小萌,杨春梅,等.老年痴呆脑电能谱分布特征[J].天津大学学报,2004,37(12):1077-1082.
28. MORISON G, TIEGES Z, KILBORN K. Multiscale permutation statistical complexity measure analysis of EEG in patients with mild Alzheimer's disease[J].Alzheimer's & Dementia, 2013, 9(4):279-279.
29. CARLINO E, SIGAUDO M, POLLO A, et al. Nonlinear analysis of electroencephalogram at rest and during cognitive tasks in patients with schizophrenia[J]. J Psychiatry Neurosci, 2012, 37(4):259-266.
30. 周菁,刘群,徐维安,等.老年抑郁症和阿尔茨海默症的听觉P300比较研究[J].神经病学与神经康复学杂志,2012,9(2):77-79.

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