Effect of Zinc Doped Calcium Phosphate Coating on Bone Formation and the Underlying Biological Mechanism_Journal of Biomedical Engineering

Authors：

LUOWenjing ¹ , ZHAOJinghui ¹ , MENGXing ¹ , MAShanshan ¹ , SUNQianyue ¹ , GUOTianqi ¹ , WANGYufeng ² ,  ZHOUYanmin ¹

1. Center of Implantation, Hospital of Stomatology, Jilin University, Changchun 130021, China;
2. Department of Prosthodontics, Hospital of Stomatology, Jilin University, Changchun 130021, China;

Corresponding author：

ZHOUYanmin, Email: zhouym62@126.com

Keywords：

calcium ions; inorganic phosphorus; zinc ions; osteogenesis; osteoinductivity

DOI：

10.7507/1001-5515.20150240

Video：

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Implant surface modified coating can improve its osteoinductivity, about which simple calcium phosphate coating has been extensively studied. But it has slow osteointegration speed and poor antibacterial property, while other metal ions added, such as nano zinc ion, can compensate for these deficiencies. This paper describes the incorporation form, the effect on physical and chemical properties of the material and the antibacterial property of nano zinc, and summarizes the material's biological property given by calcium ion, zinc ion and inorganic phosphate (Pi), mainly focusing on the influence of these three inorganic ions on osteoblast proliferation, differentiation, protein synthesis and matrix mineralization in order to present the positive function of zinc doped calcium phosphate in the field of bone formation.

Citation： LUOWenjing, ZHAOJinghui, MENGXing, MAShanshan, SUNQianyue, GUOTianqi, WANGYufeng, ZHOUYanmin. Effect of Zinc Doped Calcium Phosphate Coating on Bone Formation and the Underlying Biological Mechanism. Journal of Biomedical Engineering, 2015, 32(6): 1359-1363. doi: 10.7507/1001-5515.20150240 Copy

1.	TANG Yuanzhi, CHAPPELL H F, DOVE M T, et al. Zinc incorporation into hydroxylapatite[J]. Biomaterials, 2009, 30(15):2864-2872.
2.	MATSUNAGA K, MURATA H, MIZOGUCHI T, et al. Mechanism of incorporation of zinc into hydroxyapatite[J]. Acta Biomater, 2010, 6(6):2289-2293.
3.	BAZIN D, CARPENTIER X, BROCHERIOU I, et al. Revisiting the localisation of Zn(2+) cations sorbed on pathological apatite calcifications made through X-ray absorption spectroscopy[J]. Biochimie, 2009, 91(10):1294-1300.
4.	王丹宁.微弧氧化法制备不同锌含量的钙磷活性涂层的体外实验研究[D].沈阳:中国医科大学, 2012.
5.	GARDIN C, CHIARA G, FERRONI L, et al. Nanostructured biomaterials for tissue engineered bone tissue reconstruction[J]. Int J Mol Sci, 2012, 13(1):737-757.
6.	MENG Jie, XIAO Bo, ZHANG Yu, et al. Super-paramagnetic responsive nanofibrous scaffolds under static magnetic field enhance osteogenesis for bone repair in vivo[J]. Sci Rep, 2013, 3:2655-2661.
7.	CLAES L, RECKNAGEL S, IGNATIUS A. Fracture healing under healthy and inflammatory conditions[J]. Nat Rev Rheumatol, 2012, 8(3):133-143.
8.	LEE J H, RYU M Y, BAEK H R, et al. Fabrication and evaluation of porous beta-tricalcium phosphate/hydroxyapatite (60/40) composite as a bone graft extender using rat calvarial bone defect model[J]. Sci World, 2013:doi:10.1155/2013/481789.
9.	ROKN A, MOSLEMI N, ESLAMI B, et al. Histologic evaluation of bone healing following application of anorganic bovine bone andβ-tricalcium phosphate in rabbit calvaria[J]. J Dent (Tehran), 2012, 9(1):35-40.
10.	CHEN Zetao, WU Chengtie, YUEN J, et al. Influence of osteocytes in the in vitro and in vivoβ-tricalcium phosphate-stimulated osteogenesis[J]. J Biomed Mater Res A, 2014, 102(8):2813-2823.
11.	BARRADAS A M, FERNANDES H A, GROEN N, et al. A calcium-induced signaling cascade leading to osteogenic differentiation of human bone marrow-derived mesenchymal stromal cells[J]. Biomaterials, 2012, 33(11):3205-3215.
12.	FAN Qiming, YUE Bing, BIAN Zhenyu, et al. The CREB-Smad6-Runx2 axis contributes to the impaired osteogenesis potential of bone marrow stromal cells in fibrous dysplasia of bone[J]. J Pathol, 2012, 228(1):45-55.
13.	WU Mingyue, LI Quanli, CHEN Lianzi. Cytompatibility assessment of the surface of titanium after phosphorylation[J]. Biomed Mater Eng, 2014, 24(1):659-671.
14.	YANG Fan, DONG Wenjing, HE Fuming, et al. Osteoblast response to porous titanium surfaces coated with zinc-substituted hydroxyapatite[J]. Oral Surg Oral Med Oral Pathol Oral Radiol, 2012, 113(3):313-318.
15.	ZOFKOVÁ I, NEMCIKOVA P, MATUCHA P. Trace elements and bone health[J]. Clin Chem Lab Med, 2013, 51(8):1555-1561.
16.	OH S A, WON J E, KIM H W. Composite membranes of poly(lactic acid) with zinc-added bioactive glass as a guiding matrix for osteogenic differentiation of bone marrow mesenchymal stem cells[J]. J Biomater Appl, 2012, 27(4):413-422.
17.	ALVAREZ K, FUKUDA M, YAMAMOTO O. Titanium implants after alkali heating treatment with a[Zn(OH)₄]₂-complex:analysis of interfacial bond strength using push-out tests[J]. Clin Implant Dent Relat Res, 2010, 12(Suppl 1):e114-e125.
18.	LI Xia, SOGO Y, ITO A, et al. The optimum zinc content in set calcium phosphate cement for promoting bone formation in vivo[J]. Mater Sci Eng C Mater Biol Appl, 2009, 29(3):969-975.
19.	JONES J R. Review of bioactive glass:from Hench to hybrids[J]. Acta Biomater, 2013, 9(1):4457-4486.
20.	SHARMA V, ANDERSON D, DHAWAN A. Zinc oxide nanoparticles induce oxidative DNA damage and ROS-triggered mitochondria mediated apoptosis in human liver cells (HepG2)[J]. Apoptosis, 2012, 17(8):852-870.
21.	LIANG Dan, YANG Maowei, GUO Baolei, et al. Zinc upregulates the expression of osteoprotegerin in mouse osteoblasts MC3T3-E1 through PKC/MAPK pathways[J]. Biol Trace Elem Res, 2012, 146(3):340-348.
22.	LEIDI M, DELLERA F, MARIOTTI M, et al. Nitric oxide mediates low magnesium inhibition of osteoblast-like cell proliferation[J]. J Nutr Biochem, 2012, 23(10):1224-1229.
23.	GUO Baolei, YANG Maowei, LIANG Dan, et al. Cell apoptosis induced by Zinc deficiency in osteoblastic MC3T3-E1 cells via a mitochondrial-mediated pathway[J]. Mol Cell Biochem, 2012, 361(1-2):209-216.
24.	FUKADA T, HOJYO S, FURUICHI T. Zinc signal:a new player in osteobiology[J]. J Bone Miner Metab, 2013, 31(2):129-135.
25.	FIELDING G A, ROY M, BANDYOPADHYAY A, et al. Antibacterial and biological characteristics of plasma sprayed silver and strontium doped hydroxyapatite coatings[J]. Acta Biomater, 2012, 8(8):3144-3152.
26.	YAMASAKI S, HASEGAWA A, HOJYO S, et al. A novel role of the L-type calcium channelα1D subunit as a gatekeeper for intracellular Zinc signaling:Zinc wave[J]. PLoS One, 2012, 7(6):e39654.
27.	ROY M, FIELDING G A, BANDYOPADHYAY A, et al. Effects of Zinc and Strontium substitution in tricalcium phosphate on osteoclast differentiation and resorption[J]. Biomater Sci, 2013, 1(1):74-82.

1. TANG Yuanzhi, CHAPPELL H F, DOVE M T, et al. Zinc incorporation into hydroxylapatite[J]. Biomaterials, 2009, 30(15):2864-2872.
2. MATSUNAGA K, MURATA H, MIZOGUCHI T, et al. Mechanism of incorporation of zinc into hydroxyapatite[J]. Acta Biomater, 2010, 6(6):2289-2293.
3. BAZIN D, CARPENTIER X, BROCHERIOU I, et al. Revisiting the localisation of Zn(2+) cations sorbed on pathological apatite calcifications made through X-ray absorption spectroscopy[J]. Biochimie, 2009, 91(10):1294-1300.
4. 王丹宁.微弧氧化法制备不同锌含量的钙磷活性涂层的体外实验研究[D].沈阳:中国医科大学, 2012.
5. GARDIN C, CHIARA G, FERRONI L, et al. Nanostructured biomaterials for tissue engineered bone tissue reconstruction[J]. Int J Mol Sci, 2012, 13(1):737-757.
6. MENG Jie, XIAO Bo, ZHANG Yu, et al. Super-paramagnetic responsive nanofibrous scaffolds under static magnetic field enhance osteogenesis for bone repair in vivo[J]. Sci Rep, 2013, 3:2655-2661.
7. CLAES L, RECKNAGEL S, IGNATIUS A. Fracture healing under healthy and inflammatory conditions[J]. Nat Rev Rheumatol, 2012, 8(3):133-143.
8. LEE J H, RYU M Y, BAEK H R, et al. Fabrication and evaluation of porous beta-tricalcium phosphate/hydroxyapatite (60/40) composite as a bone graft extender using rat calvarial bone defect model[J]. Sci World, 2013:doi:10.1155/2013/481789.
9. ROKN A, MOSLEMI N, ESLAMI B, et al. Histologic evaluation of bone healing following application of anorganic bovine bone andβ-tricalcium phosphate in rabbit calvaria[J]. J Dent (Tehran), 2012, 9(1):35-40.
10. CHEN Zetao, WU Chengtie, YUEN J, et al. Influence of osteocytes in the in vitro and in vivoβ-tricalcium phosphate-stimulated osteogenesis[J]. J Biomed Mater Res A, 2014, 102(8):2813-2823.
11. BARRADAS A M, FERNANDES H A, GROEN N, et al. A calcium-induced signaling cascade leading to osteogenic differentiation of human bone marrow-derived mesenchymal stromal cells[J]. Biomaterials, 2012, 33(11):3205-3215.
12. FAN Qiming, YUE Bing, BIAN Zhenyu, et al. The CREB-Smad6-Runx2 axis contributes to the impaired osteogenesis potential of bone marrow stromal cells in fibrous dysplasia of bone[J]. J Pathol, 2012, 228(1):45-55.
13. WU Mingyue, LI Quanli, CHEN Lianzi. Cytompatibility assessment of the surface of titanium after phosphorylation[J]. Biomed Mater Eng, 2014, 24(1):659-671.
14. YANG Fan, DONG Wenjing, HE Fuming, et al. Osteoblast response to porous titanium surfaces coated with zinc-substituted hydroxyapatite[J]. Oral Surg Oral Med Oral Pathol Oral Radiol, 2012, 113(3):313-318.
15. ZOFKOVÁ I, NEMCIKOVA P, MATUCHA P. Trace elements and bone health[J]. Clin Chem Lab Med, 2013, 51(8):1555-1561.
16. OH S A, WON J E, KIM H W. Composite membranes of poly(lactic acid) with zinc-added bioactive glass as a guiding matrix for osteogenic differentiation of bone marrow mesenchymal stem cells[J]. J Biomater Appl, 2012, 27(4):413-422.
17. ALVAREZ K, FUKUDA M, YAMAMOTO O. Titanium implants after alkali heating treatment with a[Zn(OH)₄]₂-complex:analysis of interfacial bond strength using push-out tests[J]. Clin Implant Dent Relat Res, 2010, 12(Suppl 1):e114-e125.
18. LI Xia, SOGO Y, ITO A, et al. The optimum zinc content in set calcium phosphate cement for promoting bone formation in vivo[J]. Mater Sci Eng C Mater Biol Appl, 2009, 29(3):969-975.
19. JONES J R. Review of bioactive glass:from Hench to hybrids[J]. Acta Biomater, 2013, 9(1):4457-4486.
20. SHARMA V, ANDERSON D, DHAWAN A. Zinc oxide nanoparticles induce oxidative DNA damage and ROS-triggered mitochondria mediated apoptosis in human liver cells (HepG2)[J]. Apoptosis, 2012, 17(8):852-870.
21. LIANG Dan, YANG Maowei, GUO Baolei, et al. Zinc upregulates the expression of osteoprotegerin in mouse osteoblasts MC3T3-E1 through PKC/MAPK pathways[J]. Biol Trace Elem Res, 2012, 146(3):340-348.
22. LEIDI M, DELLERA F, MARIOTTI M, et al. Nitric oxide mediates low magnesium inhibition of osteoblast-like cell proliferation[J]. J Nutr Biochem, 2012, 23(10):1224-1229.
23. GUO Baolei, YANG Maowei, LIANG Dan, et al. Cell apoptosis induced by Zinc deficiency in osteoblastic MC3T3-E1 cells via a mitochondrial-mediated pathway[J]. Mol Cell Biochem, 2012, 361(1-2):209-216.
24. FUKADA T, HOJYO S, FURUICHI T. Zinc signal:a new player in osteobiology[J]. J Bone Miner Metab, 2013, 31(2):129-135.
25. FIELDING G A, ROY M, BANDYOPADHYAY A, et al. Antibacterial and biological characteristics of plasma sprayed silver and strontium doped hydroxyapatite coatings[J]. Acta Biomater, 2012, 8(8):3144-3152.
26. YAMASAKI S, HASEGAWA A, HOJYO S, et al. A novel role of the L-type calcium channelα1D subunit as a gatekeeper for intracellular Zinc signaling:Zinc wave[J]. PLoS One, 2012, 7(6):e39654.
27. ROY M, FIELDING G A, BANDYOPADHYAY A, et al. Effects of Zinc and Strontium substitution in tricalcium phosphate on osteoclast differentiation and resorption[J]. Biomater Sci, 2013, 1(1):74-82.

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