Progress in Proteomic Study of the Penicillin Producer---<i>Penicillium Chrysogenum</i>_Journal of Biomedical Engineering

Authors：

WANGShun , WANGPeihong , ZHANGNan ,  GAORuichang

School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, China;

Corresponding author：

GAORuichang, Email: pharmacy@tju.edu.cn

Keywords：

penicillin; Penicillium chrysogenum; proteome; proteomics

DOI：

10.7507/1001-5515.20150239

Video：

Export PDF Favorites Scan Get Citation

Abstract Full text Figures/Tables Video References Cited by

Penicillin is a kind ofβ-lactam drug which has been applied in the clinical treatment firstly in the world, and it has still been widely used at present. The synthesis and regulation mechanism of Penicillium chrysogenum, which is used to produce penicillin, has been studied quite maturely, but its proteomics research started relatively late and fewer reports were published. This paper reviews the synthesis and application of penicillin, transformation of Penicillium chrysogenum, and the research progress of its proteomics. On this basis, the study highlights the advantages of proteomics in the research of protein expression.

Citation： WANGShun, WANGPeihong, ZHANGNan, GAORuichang. Progress in Proteomic Study of the Penicillin Producer---Penicillium Chrysogenum. Journal of Biomedical Engineering, 2015, 32(6): 1354-1358. doi: 10.7507/1001-5515.20150239 Copy

1.	刘丽华.β-内酰胺类抗生素的临床应用[J].中国药物经济学, 2013(6):245-246.
2.	VAN DEN BERG M A. Functional characterisation of penicillin production strains[J]. Fungal Biol Rev, 2010, 24(1-2):73-78.
3.	VOIGT K, KIRK P M. Recent developments in the taxonomic affiliation and phylogenetic positioning of fungi:impact in applied microbiology and environmental biotechnology[J]. Appl Microbiol Biotechnol, 2011, 90(1):41-57.
4.	SCHECKHUBER C Q, VEENHUIS M, VAN DER KLEI I J. Improving penicillin biosynthesis in Penicillium chrysogenum by glyoxalase overproduction[J]. Metab Eng, 2013, 18:36-43.
5.	OZCENGIZ G, DEMAIN A L. Recent advances in the biosynthesis of penicillins, cephalosporins and clavams and its regulation[J]. Biotechnol Adv, 2013, 31(2):287-311.
6.	VEIGA T, SOLIS-ESCALANTE D, ROMAGNOLI G, et al. Resolving phenylalanine metabolism sheds light on natural synthesis of penicillin G in Penicillium chrysogenum[J]. Eukaryot Cell, 2012, 11(2):238-249.
7.	MARTÍN J F, GARCÍA-ESTRADA C, ULLÁN R V. Transport of substrates into peroxisomes:the paradigm ofβ-lactam biosynthetic intermediates[J]. Biomol Concepts, 2013, 4(2):197-211.
8.	FERNÁNDEZ-AGUADO M, ULLÁN R V, TEIJEIRA F, et al. The transport of phenylacetic acid across the peroxisomal membrane is mediated by the PaaT protein in Penicillium chrysogenum[J]. Appl Microbiol Biotechnol, 2013, 97(7):3073-3084.
9.	钱小红.定量蛋白质组学分析方法[J].色谱, 2013, 31(8):719-723.
10.	姜丽丽, 郝欣霞, 张东泽.有关蛋白质组学概述[J].内蒙古科技与经济, 2013, 277(3):108-109.
11.	RAY S, REDDY P J, JAIN R, et al. Proteomic technologies for the identification of disease biomarkers in serum:advances and challenges ahead[J]. Proteomics, 2011, 11(11):2139-2161.
12.	VILLANUEVA J, CARRASCAL M, ABIAN J. Isotope dilution mass spectrometry for absolute quantification in proteomics:Concepts and strategies[J]. J Proteomics, 2014, 96:184-199.
13.	DÍEZ P, DASILVA N, GONZÁLEZ-GONZÁLEZ M, et al. Data analysis strategies for protein microarrays[J]. Microarrays, 2012, 1(2):64-83.
14.	张莹, 杨芃原, 陆豪杰.基于多级质谱的蛋白质组定量新方法新技术进展[J].色谱, 2013, 31(6):503-509.
15.	袁建丰, 李林林, 孙敏华, 等.iTRAQ标记技术及其在微生物比较蛋白质组学中的研究进展[J].中国预防兽医学报, 2013, 35(10):859-862.
16.	JIANG Yan, GUO Liang, XIE Li-qi, et al. Proteome profiling of mitotic clonal expansion during 3T3-L1 adipocyte differentiation using iTRAQ-2DLC-MS/MS[J]. J Proteome Res, 2014, 13(3):1307-1314.
17.	胡彬彬, 林连兵, 魏云林, 等.一种高效的真菌总蛋白质提取方法[J].中国生物工程杂志, 2013, 33(9):53-58.
18.	THIEDE B, KOEHLER C J, STROZYNSKI M, et al. High resolution quantitative proteomics of HeLa cells protein species using stable isotope labeling with amino acids in cell culture (SILAC), two-dimensional gel electrophoresis (2DE) and nano-liquid chromatograpohy coupled to an LTQ-OrbitrapMass spectrometer[J]. Mol Cell Proteomics, 2013, 12(2):529-538.
19.	WU Xiaolin, GONG Fangping, WANG Wei. Protein extraction from plant tissues for 2DE and its application in proteomic analysis[J]. Proteomics, 2014, 14(6):645-658.
20.	刘红, 刘艳, 谢丽萍, 等.顶头孢霉蛋白质组的制备[J].中国医药工业杂志, 2011, 42(6):412-415.
21.	MARTÍNEZ-ESTESO M J, VILELLA-ANTÓN M T, PEDREÑO M A, et al. iTRAQ-based protein profiling provides insights into the central metabolism changes driving grape berry development and ripening[J]. BMC Plant Biol, 2013, 13(167):1-20.
22.	崔少飞.利迪链霉菌对外源谷氨酸和脯氨酸的代谢响应研究[D].天津:天津大学, 2013.
23.	JAMI M S, BARREIRO C, GARCÍA-ESTRADA C, et al. Proteome analysis of the penicillin producer Penicillium chrysogenum: characterization of protein changes during the industrial strain improvement[J]. Molecular & Cellular Proteomics, 2010, 9(6):1182-1198.
24.	BARREIRO C, MARTÍN J F, GARCÍA-ESTRADA C. Proteomics shows new faces for the old penicillin producer Penicillium chrysogenum[J]. J Biomed Biotechnol, 2012, 2012:105109.
25.	GARCÍA-ESTRADA C, BARREIRO C, JAMI M S, et al. The inducers 1, 3-diaminopropane and spermidine cause the reprogramming of metabolism in Penicillium chrysogenum, leading to multiple vesicles and penicillin overproduction[J]. J Proteomics, 2013, 85:129-159.
26.	MARTÍN J, GARCÍA-ESTRADA C, RUMBERO A, et al. Characterization of an autoinducer of penicillin biosynthesis in Penicillium chrysogenum[J]. Appl Environ Microbiol, 2011, 77(16):5688-5696.
27.	GOODMAN V, MVLLER A, GRÖGER-ARNDT H, et al. Identification of spore specific allergens from Penicillium chrysogenum[J]. J Integr OMICS, 2011, 1(2):272-279.
28.	JAMI M S, GARCÍA-ESTRADA C, BARREIRO C, et al. The Penicillium chrysogenum extracellular proteome. Conversion from a food-rotting strain to a versatile cell factory for white biotechnology[J]. Mol Cell Proteomics, 2010, 9(12):2729-2744.
29.	NICKEL W, RABOUILLE C. Mechanisms of regulated unconventional protein secretion[J]. Nat Rev Mol Cell Biol, 2009, 10(2):148-155.
30.	KIEL J A, VAN DEN BERG M A, FUSETTI F, et al. Matching the proteome to the genome:the microbody of penicillin-producing Penicillium chrysogenum cells[J]. Funct Integr Genomics, 2009, 9(2):167-184.

1. 刘丽华.β-内酰胺类抗生素的临床应用[J].中国药物经济学, 2013(6):245-246.
2. VAN DEN BERG M A. Functional characterisation of penicillin production strains[J]. Fungal Biol Rev, 2010, 24(1-2):73-78.
3. VOIGT K, KIRK P M. Recent developments in the taxonomic affiliation and phylogenetic positioning of fungi:impact in applied microbiology and environmental biotechnology[J]. Appl Microbiol Biotechnol, 2011, 90(1):41-57.
4. SCHECKHUBER C Q, VEENHUIS M, VAN DER KLEI I J. Improving penicillin biosynthesis in Penicillium chrysogenum by glyoxalase overproduction[J]. Metab Eng, 2013, 18:36-43.
5. OZCENGIZ G, DEMAIN A L. Recent advances in the biosynthesis of penicillins, cephalosporins and clavams and its regulation[J]. Biotechnol Adv, 2013, 31(2):287-311.
6. VEIGA T, SOLIS-ESCALANTE D, ROMAGNOLI G, et al. Resolving phenylalanine metabolism sheds light on natural synthesis of penicillin G in Penicillium chrysogenum[J]. Eukaryot Cell, 2012, 11(2):238-249.
7. MARTÍN J F, GARCÍA-ESTRADA C, ULLÁN R V. Transport of substrates into peroxisomes:the paradigm ofβ-lactam biosynthetic intermediates[J]. Biomol Concepts, 2013, 4(2):197-211.
8. FERNÁNDEZ-AGUADO M, ULLÁN R V, TEIJEIRA F, et al. The transport of phenylacetic acid across the peroxisomal membrane is mediated by the PaaT protein in Penicillium chrysogenum[J]. Appl Microbiol Biotechnol, 2013, 97(7):3073-3084.
9. 钱小红.定量蛋白质组学分析方法[J].色谱, 2013, 31(8):719-723.
10. 姜丽丽, 郝欣霞, 张东泽.有关蛋白质组学概述[J].内蒙古科技与经济, 2013, 277(3):108-109.
11. RAY S, REDDY P J, JAIN R, et al. Proteomic technologies for the identification of disease biomarkers in serum:advances and challenges ahead[J]. Proteomics, 2011, 11(11):2139-2161.
12. VILLANUEVA J, CARRASCAL M, ABIAN J. Isotope dilution mass spectrometry for absolute quantification in proteomics:Concepts and strategies[J]. J Proteomics, 2014, 96:184-199.
13. DÍEZ P, DASILVA N, GONZÁLEZ-GONZÁLEZ M, et al. Data analysis strategies for protein microarrays[J]. Microarrays, 2012, 1(2):64-83.
14. 张莹, 杨芃原, 陆豪杰.基于多级质谱的蛋白质组定量新方法新技术进展[J].色谱, 2013, 31(6):503-509.
15. 袁建丰, 李林林, 孙敏华, 等.iTRAQ标记技术及其在微生物比较蛋白质组学中的研究进展[J].中国预防兽医学报, 2013, 35(10):859-862.
16. JIANG Yan, GUO Liang, XIE Li-qi, et al. Proteome profiling of mitotic clonal expansion during 3T3-L1 adipocyte differentiation using iTRAQ-2DLC-MS/MS[J]. J Proteome Res, 2014, 13(3):1307-1314.
17. 胡彬彬, 林连兵, 魏云林, 等.一种高效的真菌总蛋白质提取方法[J].中国生物工程杂志, 2013, 33(9):53-58.
18. THIEDE B, KOEHLER C J, STROZYNSKI M, et al. High resolution quantitative proteomics of HeLa cells protein species using stable isotope labeling with amino acids in cell culture (SILAC), two-dimensional gel electrophoresis (2DE) and nano-liquid chromatograpohy coupled to an LTQ-OrbitrapMass spectrometer[J]. Mol Cell Proteomics, 2013, 12(2):529-538.
19. WU Xiaolin, GONG Fangping, WANG Wei. Protein extraction from plant tissues for 2DE and its application in proteomic analysis[J]. Proteomics, 2014, 14(6):645-658.
20. 刘红, 刘艳, 谢丽萍, 等.顶头孢霉蛋白质组的制备[J].中国医药工业杂志, 2011, 42(6):412-415.
21. MARTÍNEZ-ESTESO M J, VILELLA-ANTÓN M T, PEDREÑO M A, et al. iTRAQ-based protein profiling provides insights into the central metabolism changes driving grape berry development and ripening[J]. BMC Plant Biol, 2013, 13(167):1-20.
22. 崔少飞.利迪链霉菌对外源谷氨酸和脯氨酸的代谢响应研究[D].天津:天津大学, 2013.
23. JAMI M S, BARREIRO C, GARCÍA-ESTRADA C, et al. Proteome analysis of the penicillin producer Penicillium chrysogenum: characterization of protein changes during the industrial strain improvement[J]. Molecular & Cellular Proteomics, 2010, 9(6):1182-1198.
24. BARREIRO C, MARTÍN J F, GARCÍA-ESTRADA C. Proteomics shows new faces for the old penicillin producer Penicillium chrysogenum[J]. J Biomed Biotechnol, 2012, 2012:105109.
25. GARCÍA-ESTRADA C, BARREIRO C, JAMI M S, et al. The inducers 1, 3-diaminopropane and spermidine cause the reprogramming of metabolism in Penicillium chrysogenum, leading to multiple vesicles and penicillin overproduction[J]. J Proteomics, 2013, 85:129-159.
26. MARTÍN J, GARCÍA-ESTRADA C, RUMBERO A, et al. Characterization of an autoinducer of penicillin biosynthesis in Penicillium chrysogenum[J]. Appl Environ Microbiol, 2011, 77(16):5688-5696.
27. GOODMAN V, MVLLER A, GRÖGER-ARNDT H, et al. Identification of spore specific allergens from Penicillium chrysogenum[J]. J Integr OMICS, 2011, 1(2):272-279.
28. JAMI M S, GARCÍA-ESTRADA C, BARREIRO C, et al. The Penicillium chrysogenum extracellular proteome. Conversion from a food-rotting strain to a versatile cell factory for white biotechnology[J]. Mol Cell Proteomics, 2010, 9(12):2729-2744.
29. NICKEL W, RABOUILLE C. Mechanisms of regulated unconventional protein secretion[J]. Nat Rev Mol Cell Biol, 2009, 10(2):148-155.
30. KIEL J A, VAN DEN BERG M A, FUSETTI F, et al. Matching the proteome to the genome:the microbody of penicillin-producing Penicillium chrysogenum cells[J]. Funct Integr Genomics, 2009, 9(2):167-184.

Journal of Biomedical Engineering

Progress in Proteomic Study of the Penicillin Producer---Penicillium Chrysogenum

Abstract Full text Figures/Tables Video References Cited by

Previous Article

Next Article

Format

Content