Recent Research Progress and Development Direction of Autofluorescence Diagnosis Technology_Journal of Biomedical Engineering

Authors：

 LIUGang , YANGuozheng

School of Electrical and Information Engineering, Shanghai Jiao Tong University, Shanghai 200240, China;

Corresponding author：

LIUGang, Email: liugang531557127@163.com

Keywords：

autofluorescence; premalignant lesion; endogenous fluorophores; fluorescence spectroscopy and imaging technology

DOI：

10.7507/1001-5515.20150238

Video：

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Abstract Full text Figures/Tables Video References Cited by

Autofluorescence has great advantage on detecting premalignant lesions and early cancers which are not detectable by conventional white light endoscopy (WLE). In this review, the recent advances in autofluorescence for diagnosis of precancerous lesions and early cancers are presented. Varieties of endogenous fluorophores in biological tissues, the potential mechanisms of the autofluorescence differences between normal and abnormal tissues, the selection of light source and optimal excitation wavelengths, and effective algorithms for processing autofluorescence data are highlighted. Finally, the shortages and improvement directions of autofluorescence technique for the diagnosis of precancerous lesions and early cancers are briefly discussed.

Citation： LIUGang, YANGuozheng. Recent Research Progress and Development Direction of Autofluorescence Diagnosis Technology. Journal of Biomedical Engineering, 2015, 32(6): 1348-1353. doi: 10.7507/1001-5515.20150238 Copy

1.	JEMAL A, BRAY F, CENTER M M, et al. Global cancer statistics[J]. CA Cancer J Clin, 2011, 61(2):69-90.
2.	JENKINSON F, STEELE R J C. Colorectal cancer screening-methodology[J]. The Surgeon, 2010, 8(3):164-171.
3.	YAO K. Basic Principles for the interpretation of magnified endoscopic (ME) findings:vessels (V) plus surface (S) classification system[M]//YAO K. Zoom Gastroscopy. Fukuoka:Springer Japan, 2014:1-2.
4.	DE PALMA G D, WALLACE M B, GIOVANNINI M. Confocal laser endomicroscopy[J]. Gastroenterol Res Pract, 2012, 2012:216209.
5.	OBA S, TANAKA S, SANO Y, et al. Current status of narrow-band imaging magnifying colonoscopy for colorectal neoplasia in Japan[J]. Digestion, 2011, 83(3):167-172.
6.	HAUG J T, HAUG C, KUTSCHERA V, et al. Autofluorescence imaging, an excellent tool for comparative morphology[J]. J Microsc, 2011, 244(3):259-272.
7.	ISHIHARA R, INOUE T, HANAOKA N, et al. Autofluorescence imaging endoscopy for screening of esophageal squamous mucosal high-grade neoplasia:A phaseⅡstudy[J]. J Gastroenterol Hepatol, 2012, 27(1):86-90.
8.	LIU Lina, NIE Yingbin, LIN Lisheng, et al. Pattern recognition of multiple excitation autofluorescence spectra for colon tissue classification[J]. Photodiagnosis Photodyn Ther, 2013, 10(2):111-119.
9.	HOLZ J A, BOERWINKEL D F, MEIJER S L, et al. Optimized endoscopic autofluorescence spectroscopy for the identification of premalignant lesions in Barrett's oesophagus[J]. Eur J Gastroenterol Hepatol, 2013, 25(12):1442-1449.
10.	BANERJEE B, MIEDEMA B, CHANDRASEKHAR H R. Emission spectra of colonic tissue and endogenous fluorophores[J]. Am J Med Sci, 1998, 316(3):220-226.
11.	BORISOVA E, PLAMENOVA L, KEREMEDCHIEV M, et al. Endogenous and exogenous fluorescence of gastrointestinal tumors:initial clinical observations[C]//Proceedings of Seventeenth International School on Quantum Electronics:Laser Physics and Applications, Nessebar, September 24, 2012. Nessebar:International Society for Optics and Photonics, 2013:87701-87709.
12.	KEEREWEER S, VAN DRIEL P B A A, SNOEKS T J A, et al. Optical image-guided cancer surgery:challenges and limitations[J]. Clin Cancer Res, 2013, 19(14):3745-3754.
13.	LEVITT J M, MCLAUGHLIN-DRUBIN M E, MVNGER K, et al. Automated biochemical, morphological, and organizational assessment of precancerous changes from endogenous two-photon fluorescence images[J]. PloS ONE, 2011, 6(9):e24765.
14.	GEORGAKOUDI I, QUINN K P. Optical imaging using endogenous contrast to assess metabolic state[J]. Annu Rev Biomed Eng, 2012, 14:351-367.
15.	GEORGAKOUDI I, FELD M S, ZHANG Q, et al. System and methods of fluorescence, reflectance and light scattering spectroscopy for measuring tissue characteristics:U.S. 8, 380, 268[P]. 2013-2-19.
16.	PANDEY K, PRADHAN A, AGARWAL A, et al. Fluorescence spectroscopy:a new approach in cervical cancer[J]. J Obstet Gynaecol India, 2012, 62(4):432-436.
17.	THEKKEK N, ANANDASABAPATHY S, RICHARDS-KORTUM R. Optical molecular imaging for detection of Barrett's-associated neoplasia[J]. World J Gastroenterol, 2011, 17(1):53-62.
18.	COTHREN R M, SIVAK M V Jr, VAN DAM J, et al. Detection of dysplasia at colonoscopy using laser-induced fluorescence:a blinded study[J]. Gastrointest Endosc, 1996, 44(2):168-176.
19.	SCHOMACKER K T, FRISOLI J K, COMPTON C C, et al. Ultraviolet laser-induced fluorescence of colonic tissue:Basic biology and diagnostic potential[J]. Lasers Surgery Med, 1992, 12(1):63-78.
20.	刘丽娜, 李步洪, 谢树森.自体荧光技术在早期肠癌诊断中的应用[J].激光生物学报, 2013, 22(1):1-12.
21.	SU Lei, FONSECA M B, ARYA S, et al. Laser-induced tissue fluorescence in radiofrequency tissue-fusion characterization[J]. J Biomed Opt, 2014, 19(1):015007-015007.
22.	ANGELOVA L, BORISOVA E, ZHELYAZKOVA A, et al. Fluorescence spectroscopy of gastrointestinal tumors:in vitro studies and in vivo clinical applications[C]//Proc SPIE 9032, Biophotonics-Riga 2013. Riga:2013:903209-1-903209-11.
23.	LUO Xiangjian, ZHANG Bo, LI Jianguo, et al. Autofluorescence spectroscopy for evaluating dysplasia in colorectal tissues[J]. Zeitschrift für Medizinische Physik, 2012, 22(1):40-47.
24.	曾堃, 虞震芬.内窥镜诊断癌前病变的装置:中国, 02137764.2[P]. 2004-05-05.
25.	TAKEUCHI Y, UEDO N, HANAFUSA M, et al. Endoscopic diagnosis of colorectal neoplasms using autofluorescence imaging[J]. Intest Res, 2012, 10(2):142-151.
26.	SCHEER M, NEUGEBAUER J, DERMAN A, et al. Autofluorescence imaging of potentially malignant mucosa lesions[J]. Oral Surg Oral Med Oral Pathol Oral Radiol Endod, 2011, 111(5):568-577.
27.	MATSUMOTO T, NAKAMURA S, MORIYAMA T, et al. Autofluorescence imaging colonoscopy for the detection of dysplastic lesions in ulcerative colitis:a pilot study[J]. Colorectal Dis, 2010, 12(10):E291-E297.
28.	ISSA P C, SINGH M S, LIPINSKI D M, et al. Optimization of in vivo confocal autofluorescence imaging of the ocular fundus in mice and its application to models of human retinal degeneration[J]. Invest Ophthalmol Vis Sci, 2012, 53(2):1066-1075.
29.	CHWIROT B W, KOWALSKA M, PLOCIENNIK N, et al. Variability of spectra of laser-induced fluorescence of colonic mucosa:its significance for fluorescence detection of colonic neoplasia[J]. Indian J Exp Biol, 2003, 41(5):500-510.
30.	ZHANG Lei, BI Liang-jia, SHI Jin-na, et al. A quantitative diagnostic method for oral mucous precancerosis by Rose Bengal fluorescence spectroscopy[J]. Lasers Med Sci, 2013, 28(1):241-246.

1. JEMAL A, BRAY F, CENTER M M, et al. Global cancer statistics[J]. CA Cancer J Clin, 2011, 61(2):69-90.
2. JENKINSON F, STEELE R J C. Colorectal cancer screening-methodology[J]. The Surgeon, 2010, 8(3):164-171.
3. YAO K. Basic Principles for the interpretation of magnified endoscopic (ME) findings:vessels (V) plus surface (S) classification system[M]//YAO K. Zoom Gastroscopy. Fukuoka:Springer Japan, 2014:1-2.
4. DE PALMA G D, WALLACE M B, GIOVANNINI M. Confocal laser endomicroscopy[J]. Gastroenterol Res Pract, 2012, 2012:216209.
5. OBA S, TANAKA S, SANO Y, et al. Current status of narrow-band imaging magnifying colonoscopy for colorectal neoplasia in Japan[J]. Digestion, 2011, 83(3):167-172.
6. HAUG J T, HAUG C, KUTSCHERA V, et al. Autofluorescence imaging, an excellent tool for comparative morphology[J]. J Microsc, 2011, 244(3):259-272.
7. ISHIHARA R, INOUE T, HANAOKA N, et al. Autofluorescence imaging endoscopy for screening of esophageal squamous mucosal high-grade neoplasia:A phaseⅡstudy[J]. J Gastroenterol Hepatol, 2012, 27(1):86-90.
8. LIU Lina, NIE Yingbin, LIN Lisheng, et al. Pattern recognition of multiple excitation autofluorescence spectra for colon tissue classification[J]. Photodiagnosis Photodyn Ther, 2013, 10(2):111-119.
9. HOLZ J A, BOERWINKEL D F, MEIJER S L, et al. Optimized endoscopic autofluorescence spectroscopy for the identification of premalignant lesions in Barrett's oesophagus[J]. Eur J Gastroenterol Hepatol, 2013, 25(12):1442-1449.
10. BANERJEE B, MIEDEMA B, CHANDRASEKHAR H R. Emission spectra of colonic tissue and endogenous fluorophores[J]. Am J Med Sci, 1998, 316(3):220-226.
11. BORISOVA E, PLAMENOVA L, KEREMEDCHIEV M, et al. Endogenous and exogenous fluorescence of gastrointestinal tumors:initial clinical observations[C]//Proceedings of Seventeenth International School on Quantum Electronics:Laser Physics and Applications, Nessebar, September 24, 2012. Nessebar:International Society for Optics and Photonics, 2013:87701-87709.
12. KEEREWEER S, VAN DRIEL P B A A, SNOEKS T J A, et al. Optical image-guided cancer surgery:challenges and limitations[J]. Clin Cancer Res, 2013, 19(14):3745-3754.
13. LEVITT J M, MCLAUGHLIN-DRUBIN M E, MVNGER K, et al. Automated biochemical, morphological, and organizational assessment of precancerous changes from endogenous two-photon fluorescence images[J]. PloS ONE, 2011, 6(9):e24765.
14. GEORGAKOUDI I, QUINN K P. Optical imaging using endogenous contrast to assess metabolic state[J]. Annu Rev Biomed Eng, 2012, 14:351-367.
15. GEORGAKOUDI I, FELD M S, ZHANG Q, et al. System and methods of fluorescence, reflectance and light scattering spectroscopy for measuring tissue characteristics:U.S. 8, 380, 268[P]. 2013-2-19.
16. PANDEY K, PRADHAN A, AGARWAL A, et al. Fluorescence spectroscopy:a new approach in cervical cancer[J]. J Obstet Gynaecol India, 2012, 62(4):432-436.
17. THEKKEK N, ANANDASABAPATHY S, RICHARDS-KORTUM R. Optical molecular imaging for detection of Barrett's-associated neoplasia[J]. World J Gastroenterol, 2011, 17(1):53-62.
18. COTHREN R M, SIVAK M V Jr, VAN DAM J, et al. Detection of dysplasia at colonoscopy using laser-induced fluorescence:a blinded study[J]. Gastrointest Endosc, 1996, 44(2):168-176.
19. SCHOMACKER K T, FRISOLI J K, COMPTON C C, et al. Ultraviolet laser-induced fluorescence of colonic tissue:Basic biology and diagnostic potential[J]. Lasers Surgery Med, 1992, 12(1):63-78.
20. 刘丽娜, 李步洪, 谢树森.自体荧光技术在早期肠癌诊断中的应用[J].激光生物学报, 2013, 22(1):1-12.
21. SU Lei, FONSECA M B, ARYA S, et al. Laser-induced tissue fluorescence in radiofrequency tissue-fusion characterization[J]. J Biomed Opt, 2014, 19(1):015007-015007.
22. ANGELOVA L, BORISOVA E, ZHELYAZKOVA A, et al. Fluorescence spectroscopy of gastrointestinal tumors:in vitro studies and in vivo clinical applications[C]//Proc SPIE 9032, Biophotonics-Riga 2013. Riga:2013:903209-1-903209-11.
23. LUO Xiangjian, ZHANG Bo, LI Jianguo, et al. Autofluorescence spectroscopy for evaluating dysplasia in colorectal tissues[J]. Zeitschrift für Medizinische Physik, 2012, 22(1):40-47.
24. 曾堃, 虞震芬.内窥镜诊断癌前病变的装置:中国, 02137764.2[P]. 2004-05-05.
25. TAKEUCHI Y, UEDO N, HANAFUSA M, et al. Endoscopic diagnosis of colorectal neoplasms using autofluorescence imaging[J]. Intest Res, 2012, 10(2):142-151.
26. SCHEER M, NEUGEBAUER J, DERMAN A, et al. Autofluorescence imaging of potentially malignant mucosa lesions[J]. Oral Surg Oral Med Oral Pathol Oral Radiol Endod, 2011, 111(5):568-577.
27. MATSUMOTO T, NAKAMURA S, MORIYAMA T, et al. Autofluorescence imaging colonoscopy for the detection of dysplastic lesions in ulcerative colitis:a pilot study[J]. Colorectal Dis, 2010, 12(10):E291-E297.
28. ISSA P C, SINGH M S, LIPINSKI D M, et al. Optimization of in vivo confocal autofluorescence imaging of the ocular fundus in mice and its application to models of human retinal degeneration[J]. Invest Ophthalmol Vis Sci, 2012, 53(2):1066-1075.
29. CHWIROT B W, KOWALSKA M, PLOCIENNIK N, et al. Variability of spectra of laser-induced fluorescence of colonic mucosa:its significance for fluorescence detection of colonic neoplasia[J]. Indian J Exp Biol, 2003, 41(5):500-510.
30. ZHANG Lei, BI Liang-jia, SHI Jin-na, et al. A quantitative diagnostic method for oral mucous precancerosis by Rose Bengal fluorescence spectroscopy[J]. Lasers Med Sci, 2013, 28(1):241-246.

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