Properties of Hydrogel and Its Applications in Biomedicine_Journal of Biomedical Engineering

Authors：

GELi ¹ , LIULiwei ¹ , JIANGLina ² ,  SONGWengang ¹

1. School of Basic Medical Sciences, Taishan Medical University, Taian 271000, China;
2. School of Basic Medical Sciences, Weifang Medical University, Weifang 261053, China;

Corresponding author：

SONGWengang, Email: s.com@163.com

Keywords：

hydrogel; tissue engineering; drug delivery; stem cell culture

DOI：

10.7507/1001-5515.20150242

Video：

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Hydrogel is a creative polymeric biomaterial which can resemble extracellular matrix (ECM) in vitro. Hydrogel is also a material with intrinsic bioinert, but it can offer mechanical support and developmental guide for cell growth and new tissue organization by designing physicochemical and biological properties of hydrogels precisely. This review mainly introduces design of hydrogels, properties and applications in tissue engineering and regenerative medicine, drug delivery, stem cell culture and cell therapy.

Citation： GELi, LIULiwei, JIANGLina, SONGWengang. Properties of Hydrogel and Its Applications in Biomedicine. Journal of Biomedical Engineering, 2015, 32(6): 1369-1373. doi: 10.7507/1001-5515.20150242 Copy

1.	DISCHER D E, MOONEY D J, ZANDSTRA P W. Growth factors, matrices, and forces combine and control stem cells[J]. Science, 2009, 324(5935):1673-1677.
2.	WANG Ying, WEI Yueteng, ZU Zhaohui, et al. Combination of hyaluronic acid hydrogel scaffold and PLGA microspheres for supporting survival of neural stem cells[J]. Pharm Res, 2011, 28(6):1406-1414.
3.	MARTINO M M, MOCHIZUKI M, ROTHENFLUH D A, et al. Controlling integrin specificity and stem cell differentiation in 2D and 3D environments through regulation of fibronectin domain stability[J]. Biomaterials, 2009, 30(6):1089-1097.
4.	INO J M, CHEVALLIER P, LETOURNEUR D, et al. Plasma functionalization of poly(vinyl alcohol) hydrogel for cell adhesion enhancement[J]. Biomatter, 2013, 3(4):e25414.
5.	MURPHY C M, MATSIKO A, HAUGH M G, et al. Mesenchymal stem cell fate is regulated by the composition and mechanical properties of collagen-glycosaminoglycan scaffolds[J]. J Mech Behav Biomed Mater, 2012, 11:53-62.
6.	LIN C C, METTERS A T. Hydrogels in controlled release formulations:network design and mathematical modeling[J]. Adv Drug Deliv Rev, 2006, 58(12-13):1379-1408.
7.	CHIEN H W, TSAI W B, JIANG Shaoyi. Direct cell encapsulation in biodegradable and functionalizable carboxybetaine hydrogels[J]. Biomaterials, 2012, 33(23):5706-5712.
8.	GRÉGOIRE-LACOSTE F, JACQUEMET V, VINET A. Bifurcations, sustained oscillations and torus bursting involving ionic concentrations dynamics in a canine atrial cell model[J]. Math Biosci, 2014, 250:10-25.
9.	BARRETO E, CRESSMAN J R. Ion concentration dynamics as a mechanism for neuronal bursting[J]. J Biol Phys, 2011, 37(3):361-373.
10.	TURTURRO M V, CHRISTENSON M C, LARSON J C, et al. MMP-sensitive PEG diacrylate hydrogels with spatial variations in matrix properties stimulate directional vascular sprout formation[J]. PLoS One, 2013, 8(3):e58897.
11.	ANDERSON S B, LIN C C, KUNTZLER D V, et al. The performance of human mesenchymal stem cells encapsulated in cell-degradable polymer-peptide hydrogels[J]. Biomaterials, 2011, 32(14):3564-3574.
12.	LAU T T, HO L W, WANG Dong-an. Hepatogenesis of murine induced pluripotent stem cells in 3D micro-cavitary hydrogel system for liver regeneration[J]. Biomaterials, 2013, 34(28):6659-6669.
13.	YUAN Tun, ZHANG Li, LI Kuifeng, et al. Collagen hydrogel as an immunomodulatory scaffold in cartilage tissue engineering[J]. J Biomed Mater Res B Appl Biomater, 2014, 102(2):337-344.
14.	MEDEIROS J AU'U NIOR M D, CARVALHO E J, CATUNDA I S, et al. Hydrogel of polysaccharide of sugarcane molasses as carrier of bone morphogenetic protein in the reconstruction of critical bone defects in rats[J]. Acta Cir Bras, 2013, 28(4):233-238.
15.	HAKUBA N, TABATA Y, HATO N, et al. Gelatin hydrogel with basic fibroblast growth factor for tympanic membrane regeneration[J]. Otol Neurotol, 2014, 35(3):540-544.
16.	BENZ K, STIPPICH C, OSSWALD C, et al. Rheological and biological properties of a hydrogel support for cells intended for intervertebral disc repair[J]. BMC Musculoskelet Disord, 2012, 13:54.
17.	DIAB T, PRITCHARD E M, UHRIG B A, et al. A silk hydrogel-based delivery system of bone morphogenetic protein for the treatment of large bone defects[J]. J Mech Behav Biomed Mater, 2012, 11:123-131.
18.	MATYASH M, DESPANG F, IKONOMIDOU C, et al. Swelling and mechanical properties of alginate hydrogels with respect to promotion of neural growth[J]. Tissue Eng Part C Methods, 2014, 20(5):401-411.
19.	SUN Guoming, ZHANG Xianjie, SHEN Y I, et al. Dextran hydrogel scaffolds enhance angiogenic responses and promote complete skin regeneration during burn wound healing[J]. Proc Natl Acad Sci U S A, 2011, 108(52):20976-20981.
20.	PÉREZ E, FERNÁNDEZ A, OLMO R, et al. pH and glutathion-responsive hydrogel for localized delivery of paclitaxel[J]. Colloids Surf B Biointerfaces, 2014, 116:247-256.
21.	SACCHI V, MITTERMAYR R, HARTINGER J, et al. Long-lasting fibrin matrices ensure stable and functional angiogenesis by highly tunable, sustained delivery of recombinant VEGF164[J]. Proc Natl Acad Sci U S A, 2014, 111(19):6952-6957.
22.	NISHIKAWA M, OGAWA K, UMEKI Y, et al. Injectable, self-gelling, biodegradable, and immunomodulatory DNA hydrogel for antigen delivery[J]. J Control Release, 2014, 180:25-32.
23.	SEIDLITS S K, GOWER R M, SHEPARD J A. Hydrogels for lentiviral gene delivery[J]. Expert Opin Drug Deliv, 2013, 10(4):499-509.
24.	WANG Xiaobo, FERNANDEZ R, TSIVKOVSKAIA N, et al. OTO-201:nonclinical assessment of a sustained-release ciprofloxacin hydrogel for the treatment of otitis media[J]. Otol Neurotol, 2014, 35(3):459-469.
25.	LIU Jingping, ZHANG Lanlan, YANG Zehong, et al. Controlled release of paclitaxel from a self-assembling peptide hydrogel formed in situ and antitumor study in vitro[J]. Int J Nanomedicine, 2011, 6:2143-2153.
26.	KANG K S, LEE S I, HONG J M, et al. Hybrid scaffold composed of hydrogel/3D-framework and its application as a dopamine delivery system[J]. J Control Release, 2014, 175:10-16.
27.	LEE J, JUN I, PARK H J, et al. Genetically engineered myoblast sheet for therapeutic angiogenesis[J]. Biomacromolecules, 2014, 15(1):361-372.
28.	SERENA E, ZATTI S, REGHELIN E, et al. Soft substrates drive optimal differentiation of human healthy and dystrophic myotubes[J]. Integr Biol (Camb), 2010, 2(4):193-201.
29.	HAQUE M R, LEE D Y, AHN C H, et al. Local co-delivery of pancreatic islets and liposomal clodronate using injectable hydrogel to prevent acute immune reactions in a type 1 diabetes[J]. Pharm Res, 2014:DOI:10.1007/S11095-014-1340-4.
30.	LOU Yanru, KANNINEN L, KUISMA T, et al. The use of nanofibrillar cellulose hydrogel as a flexible three-dimensional model to culture human pluripotent stem cells[J]. Stem Cells Dev, 2014, 23(4):380-392.
31.	CHUNG J Y, SONG M J, HA C W, et al. Comparison of articular cartilage repair with different hydrogel-human umbilical cord blood-derived mesenchymal stem cell composites in a rat model[J]. Stem Cell Res Ther, 2014, 5(2):39.
32.	DE VRIES-VAN MELLE M L, TIHAYA M S, Kops N, et al. Chondrogenicdifferentiation of human bone marrow-derived mesenchymal stem cells in a simulated osteochondral environment is hydrogel dependent[J].Eur Cell Mater, 2014, 27:112-123.
33.	GILBERT P M, HAVENSTRITE K L, MAGNUSSON K E, et al. Substrate elasticity regulates skeletal muscle stem cell self-renewal in culture[J]. Science, 2010, 329(5995):1078-1081.
34.	HUEBSCH N, ARANY P R, MAO A S, et al. Harnessing traction-mediated manipulation of the cell/matrix interface to control stem-cell fate[J]. Nat Mater, 2010, 9(6):518-526.

1. DISCHER D E, MOONEY D J, ZANDSTRA P W. Growth factors, matrices, and forces combine and control stem cells[J]. Science, 2009, 324(5935):1673-1677.
2. WANG Ying, WEI Yueteng, ZU Zhaohui, et al. Combination of hyaluronic acid hydrogel scaffold and PLGA microspheres for supporting survival of neural stem cells[J]. Pharm Res, 2011, 28(6):1406-1414.
3. MARTINO M M, MOCHIZUKI M, ROTHENFLUH D A, et al. Controlling integrin specificity and stem cell differentiation in 2D and 3D environments through regulation of fibronectin domain stability[J]. Biomaterials, 2009, 30(6):1089-1097.
4. INO J M, CHEVALLIER P, LETOURNEUR D, et al. Plasma functionalization of poly(vinyl alcohol) hydrogel for cell adhesion enhancement[J]. Biomatter, 2013, 3(4):e25414.
5. MURPHY C M, MATSIKO A, HAUGH M G, et al. Mesenchymal stem cell fate is regulated by the composition and mechanical properties of collagen-glycosaminoglycan scaffolds[J]. J Mech Behav Biomed Mater, 2012, 11:53-62.
6. LIN C C, METTERS A T. Hydrogels in controlled release formulations:network design and mathematical modeling[J]. Adv Drug Deliv Rev, 2006, 58(12-13):1379-1408.
7. CHIEN H W, TSAI W B, JIANG Shaoyi. Direct cell encapsulation in biodegradable and functionalizable carboxybetaine hydrogels[J]. Biomaterials, 2012, 33(23):5706-5712.
8. GRÉGOIRE-LACOSTE F, JACQUEMET V, VINET A. Bifurcations, sustained oscillations and torus bursting involving ionic concentrations dynamics in a canine atrial cell model[J]. Math Biosci, 2014, 250:10-25.
9. BARRETO E, CRESSMAN J R. Ion concentration dynamics as a mechanism for neuronal bursting[J]. J Biol Phys, 2011, 37(3):361-373.
10. TURTURRO M V, CHRISTENSON M C, LARSON J C, et al. MMP-sensitive PEG diacrylate hydrogels with spatial variations in matrix properties stimulate directional vascular sprout formation[J]. PLoS One, 2013, 8(3):e58897.
11. ANDERSON S B, LIN C C, KUNTZLER D V, et al. The performance of human mesenchymal stem cells encapsulated in cell-degradable polymer-peptide hydrogels[J]. Biomaterials, 2011, 32(14):3564-3574.
12. LAU T T, HO L W, WANG Dong-an. Hepatogenesis of murine induced pluripotent stem cells in 3D micro-cavitary hydrogel system for liver regeneration[J]. Biomaterials, 2013, 34(28):6659-6669.
13. YUAN Tun, ZHANG Li, LI Kuifeng, et al. Collagen hydrogel as an immunomodulatory scaffold in cartilage tissue engineering[J]. J Biomed Mater Res B Appl Biomater, 2014, 102(2):337-344.
14. MEDEIROS J AU'U NIOR M D, CARVALHO E J, CATUNDA I S, et al. Hydrogel of polysaccharide of sugarcane molasses as carrier of bone morphogenetic protein in the reconstruction of critical bone defects in rats[J]. Acta Cir Bras, 2013, 28(4):233-238.
15. HAKUBA N, TABATA Y, HATO N, et al. Gelatin hydrogel with basic fibroblast growth factor for tympanic membrane regeneration[J]. Otol Neurotol, 2014, 35(3):540-544.
16. BENZ K, STIPPICH C, OSSWALD C, et al. Rheological and biological properties of a hydrogel support for cells intended for intervertebral disc repair[J]. BMC Musculoskelet Disord, 2012, 13:54.
17. DIAB T, PRITCHARD E M, UHRIG B A, et al. A silk hydrogel-based delivery system of bone morphogenetic protein for the treatment of large bone defects[J]. J Mech Behav Biomed Mater, 2012, 11:123-131.
18. MATYASH M, DESPANG F, IKONOMIDOU C, et al. Swelling and mechanical properties of alginate hydrogels with respect to promotion of neural growth[J]. Tissue Eng Part C Methods, 2014, 20(5):401-411.
19. SUN Guoming, ZHANG Xianjie, SHEN Y I, et al. Dextran hydrogel scaffolds enhance angiogenic responses and promote complete skin regeneration during burn wound healing[J]. Proc Natl Acad Sci U S A, 2011, 108(52):20976-20981.
20. PÉREZ E, FERNÁNDEZ A, OLMO R, et al. pH and glutathion-responsive hydrogel for localized delivery of paclitaxel[J]. Colloids Surf B Biointerfaces, 2014, 116:247-256.
21. SACCHI V, MITTERMAYR R, HARTINGER J, et al. Long-lasting fibrin matrices ensure stable and functional angiogenesis by highly tunable, sustained delivery of recombinant VEGF164[J]. Proc Natl Acad Sci U S A, 2014, 111(19):6952-6957.
22. NISHIKAWA M, OGAWA K, UMEKI Y, et al. Injectable, self-gelling, biodegradable, and immunomodulatory DNA hydrogel for antigen delivery[J]. J Control Release, 2014, 180:25-32.
23. SEIDLITS S K, GOWER R M, SHEPARD J A. Hydrogels for lentiviral gene delivery[J]. Expert Opin Drug Deliv, 2013, 10(4):499-509.
24. WANG Xiaobo, FERNANDEZ R, TSIVKOVSKAIA N, et al. OTO-201:nonclinical assessment of a sustained-release ciprofloxacin hydrogel for the treatment of otitis media[J]. Otol Neurotol, 2014, 35(3):459-469.
25. LIU Jingping, ZHANG Lanlan, YANG Zehong, et al. Controlled release of paclitaxel from a self-assembling peptide hydrogel formed in situ and antitumor study in vitro[J]. Int J Nanomedicine, 2011, 6:2143-2153.
26. KANG K S, LEE S I, HONG J M, et al. Hybrid scaffold composed of hydrogel/3D-framework and its application as a dopamine delivery system[J]. J Control Release, 2014, 175:10-16.
27. LEE J, JUN I, PARK H J, et al. Genetically engineered myoblast sheet for therapeutic angiogenesis[J]. Biomacromolecules, 2014, 15(1):361-372.
28. SERENA E, ZATTI S, REGHELIN E, et al. Soft substrates drive optimal differentiation of human healthy and dystrophic myotubes[J]. Integr Biol (Camb), 2010, 2(4):193-201.
29. HAQUE M R, LEE D Y, AHN C H, et al. Local co-delivery of pancreatic islets and liposomal clodronate using injectable hydrogel to prevent acute immune reactions in a type 1 diabetes[J]. Pharm Res, 2014:DOI:10.1007/S11095-014-1340-4.
30. LOU Yanru, KANNINEN L, KUISMA T, et al. The use of nanofibrillar cellulose hydrogel as a flexible three-dimensional model to culture human pluripotent stem cells[J]. Stem Cells Dev, 2014, 23(4):380-392.
31. CHUNG J Y, SONG M J, HA C W, et al. Comparison of articular cartilage repair with different hydrogel-human umbilical cord blood-derived mesenchymal stem cell composites in a rat model[J]. Stem Cell Res Ther, 2014, 5(2):39.
32. DE VRIES-VAN MELLE M L, TIHAYA M S, Kops N, et al. Chondrogenicdifferentiation of human bone marrow-derived mesenchymal stem cells in a simulated osteochondral environment is hydrogel dependent[J].Eur Cell Mater, 2014, 27:112-123.
33. GILBERT P M, HAVENSTRITE K L, MAGNUSSON K E, et al. Substrate elasticity regulates skeletal muscle stem cell self-renewal in culture[J]. Science, 2010, 329(5995):1078-1081.
34. HUEBSCH N, ARANY P R, MAO A S, et al. Harnessing traction-mediated manipulation of the cell/matrix interface to control stem-cell fate[J]. Nat Mater, 2010, 9(6):518-526.

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