Research Progress of Proton Transfer Reaction Mass Spectrometry in the Field of Breathing Gas Detection_Journal of Biomedical Engineering

Authors：

ZHAOXuehong ^1,2 , LIWeikang ¹ , DUKang ¹ , SUNYun ¹ , YANGWen ³ ,  WANGYan ^1,2

1. School of Precision Instrument and Optoelectronics Engineering, Tianjin University, Tianjin 300072, China;
2. Tianjin Key Laboratory of Biomedical Detecting Techniques and Instruments, Tianjin 300072, China;
3. Institute of Atmospheric Environment, Chinese Research Academy of Environmental Sciences, Beijing 100012, China;

Corresponding author：

WANGYan, Email: wangyan@tju.edu.cn

Keywords：

breathing gas detection; proton transfer reaction mass spectrometry; volatile organic compounds; breath biomarker

DOI：

10.7507/1001-5515.20150243

Video：

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Breathing gas carries important physiological information. Technology for detection of breathing gas has become a research focus because of the advantages of nondestructive sampling and convenient operation. Proton transfer reaction mass spectrometry (PTR-MS) plays an irreplaceable role because of the advantages of high sensitivity, fast response and good specificity. In this paper, the principle of PTR-MS is introduced first, followed by research progress of PTR-MS in the field of breathing gas detection. Factors influencing the test results are analyzed. Finally, future prospects of development for PTR-MS in the field of breathing gas detection are discussed.

Citation： ZHAOXuehong, LIWeikang, DUKang, SUNYun, YANGWen, WANGYan. Research Progress of Proton Transfer Reaction Mass Spectrometry in the Field of Breathing Gas Detection. Journal of Biomedical Engineering, 2015, 32(6): 1374-1379. doi: 10.7507/1001-5515.20150243 Copy

1.	SMOLINSKA A, HAUSCHILD A-Ch, FIJTEN R R R, et al. Current breathomics-a review on data pre-processing techniques and machine learning in metabolomics breath analysis[J]. J Breath Res, 2014, 8(2):027105.
2.	WHITE I R, WILLIS K, WHYTE C, et al. Real-time multi-marker measurement of organic compounds in human breath:towards fingerprinting breath[J]. J Breath Res, 2013, 7(1):017112.
3.	VAN DE KANT K D, VAN DER SANDE L J, JÖBSIS Q, et al. Clinical use of exhaled volatile organic compounds in pulmonary diseases:a systematic review[J]. Respir Res, 2012, 13(1):117.
4.	GILCHRIST F J, BRIGHT-THOMAS R J, JONES A M, et al. Hydrogen cyanide concentrations in the breath of adult cystic fibrosis patients with and without Pseudomonas aeruginosa infection[J]. J Breath Res, 2013, 7(2):026010.
5.	FILIPIAK W, RUZSANYI V, MOCHALSKI P, et al. Dependence of exhaled breath composition on exogenous factors, smoking habits and exposure to air pollutants[J]. J Breath Res, 2012, 6(3):036008.
6.	WANG Zhennan, WANG Chuji. Is breath acetone a biomarker of diabetes? A historical review on breath acetone measurements[J]. J Breath Res, 2013, 7(3):037109.
7.	WANG Changsong, KE Chaofu, WANG Xiaoyang, et al. Noninvasive detection of colorectal cancer by analysis of exhaled breath[J]. Anal Bioanal Chem, 2014, 406(19):4757-4763.
8.	张燕, 潘素素, 朱志强, 等.电喷雾萃取电离质谱直接检测人体呼出气体中的乙腈[J].分析化学, 2013, 41(8):1220-1225.
9.	PHILLIPS C, MAC PARTHALÁIN N, SYED Y, et al. Short-term intra-subject variation in exhaled volatile organic compounds (VOCs) in COPD patients and healthy controls and its effect on disease classification[J]. Metabolites, 2014, 4(2):300-318.
10.	PORTILLO-ESTRADA M. Advantages of PTR-MS and PTR-TOF-MS techniques for measuring volatile organic compounds (VOCs)[J]. Scientific Bulletin of ESCORENA, 2013, 8:65-67.
11.	BEAUCHAMP J, HERBIG J, DUNKL J, et al. On the performance of proton-transfer-reaction mass spectrometry for breath-relevant gas matrices[J]. Meas Sci Technol, 2013, 24(12):125003.
12.	CAPPELLIN L, MAKHOUL S, SCHUHFRIED E, et al. Ethylene:absolute real-time high-sensitivity detection with PTR/SRI-MS. The example of fruits, leaves and bacteria[J]. Int J Mass Spectrom, 2014, 365-366:33-41.
13.	ZHAN Xuefang, DUAN Jiana, DUAN Yixiang. Recent developments of proton-transfer reaction mass spectrometry (PTR-MS) and its applications in medical research[J]. Mass Spectrom Rev, 2013, 32(2):143-165.
14.	LECHNER M, KARLSEDER A, NIEDERSEER D, et al. H. pylori infection increases levels of exhaled nitrate[J]. Helicobacter, 2005, 10(5):385-390.
15.	KARL T, PRAZELLER P, MAYR D, et al. Human breath isoprene and its relation to blood cholesterol levels:new measurements and modeling[J]. J Appl Physiol, 2001, 91(2):762-770.
16.	WEHINGER A, SCHMID A, MECHTCHERIAKOV S A, et al. Lung cancer detection by proton transfer reaction mass-spectrometric analysis of human breath gas[J]. Int J Mass Spectrom, 2007, 265(1):49-59.
17.	KOHL I, BEAUCHAMP J, CAKAR-BECK F, et al. First observation of a potential non-invasive breath gas biomarker for kidney function[J]. J Breath Res, 2013, 7(1):017110.
18.	KAMYSEK S, FUCHS P, SCHWOEBEL H, et al. Drug detection in breath:effects of pulmonary blood flow and cardiac output on propofol exhalation[J]. Anal Bioanal Chem, 2011, 401(7):2093-2102.
19.	APREA E, MORISCO F, BIASIOLI F A, et al. Analysis of breath by proton transfer reaction time of flight mass spectrometry in rats with steatohepatitis induced by high-fat diet[J]. Biol Mass Spectrom, 2012, 47(9, SI):1098-1103.
20.	APREA E, CAPPELLIN L, GASPERI F, et al. Application of PTR-TOF-MS to investigate metabolites in exhaled breath of patients affected by coeliac disease under gluten free diet[J]. J Chromatogr B Analyt Technol Biomed Life Sci, 2014, 966(SI):208-213.
21.	KISTLER M, SZYMCZAK W, FEDRIGO M, et al. Effects of diet-matrix on volatile organic compounds in breath in diet-induced obese mice[J]. J Breath Res, 2014, 8(1):016004.
22.	沈成银, 李建权, 王宏志, 等.呼气中痕量挥发性有机物的质子转移反应质谱在线检测研究[J].分析化学, 2012, 40(5):773-777.
23.	杨彬, 沈成银, 王宏志, 等.高血糖人群呼气标志物的质子转移反应质谱研究[J].分析测试学报, 2013, 32(5):553-558.
24.	KECK L, HOESCHEN C, OEH U. Effects of carbon dioxide in breath gas on proton transfer reaction-mass spectrometry (PTR-MS) measurements[J]. Int J Mass Spectrom, 2008, 270(3):156-165.
25.	BEAUCHAMP J, HERBIG J, DUNKL J, et al. On the performance of proton-transfer-reaction mass spectrometry for breath-relevant gas matrices[J]. Meas Sci Technol, 2013, 24(12):125003.
26.	TREFZ P, SCHMIDT M, OERTEL P, et al. Continuous real time breath gas monitoring in the clinical environment by proton-transfer-reaction-time-of-flight-mass spectrometry[J]. Anal Chem, 2013, 85(21):10321-10329.

1. SMOLINSKA A, HAUSCHILD A-Ch, FIJTEN R R R, et al. Current breathomics-a review on data pre-processing techniques and machine learning in metabolomics breath analysis[J]. J Breath Res, 2014, 8(2):027105.
2. WHITE I R, WILLIS K, WHYTE C, et al. Real-time multi-marker measurement of organic compounds in human breath:towards fingerprinting breath[J]. J Breath Res, 2013, 7(1):017112.
3. VAN DE KANT K D, VAN DER SANDE L J, JÖBSIS Q, et al. Clinical use of exhaled volatile organic compounds in pulmonary diseases:a systematic review[J]. Respir Res, 2012, 13(1):117.
4. GILCHRIST F J, BRIGHT-THOMAS R J, JONES A M, et al. Hydrogen cyanide concentrations in the breath of adult cystic fibrosis patients with and without Pseudomonas aeruginosa infection[J]. J Breath Res, 2013, 7(2):026010.
5. FILIPIAK W, RUZSANYI V, MOCHALSKI P, et al. Dependence of exhaled breath composition on exogenous factors, smoking habits and exposure to air pollutants[J]. J Breath Res, 2012, 6(3):036008.
6. WANG Zhennan, WANG Chuji. Is breath acetone a biomarker of diabetes? A historical review on breath acetone measurements[J]. J Breath Res, 2013, 7(3):037109.
7. WANG Changsong, KE Chaofu, WANG Xiaoyang, et al. Noninvasive detection of colorectal cancer by analysis of exhaled breath[J]. Anal Bioanal Chem, 2014, 406(19):4757-4763.
8. 张燕, 潘素素, 朱志强, 等.电喷雾萃取电离质谱直接检测人体呼出气体中的乙腈[J].分析化学, 2013, 41(8):1220-1225.
9. PHILLIPS C, MAC PARTHALÁIN N, SYED Y, et al. Short-term intra-subject variation in exhaled volatile organic compounds (VOCs) in COPD patients and healthy controls and its effect on disease classification[J]. Metabolites, 2014, 4(2):300-318.
10. PORTILLO-ESTRADA M. Advantages of PTR-MS and PTR-TOF-MS techniques for measuring volatile organic compounds (VOCs)[J]. Scientific Bulletin of ESCORENA, 2013, 8:65-67.
11. BEAUCHAMP J, HERBIG J, DUNKL J, et al. On the performance of proton-transfer-reaction mass spectrometry for breath-relevant gas matrices[J]. Meas Sci Technol, 2013, 24(12):125003.
12. CAPPELLIN L, MAKHOUL S, SCHUHFRIED E, et al. Ethylene:absolute real-time high-sensitivity detection with PTR/SRI-MS. The example of fruits, leaves and bacteria[J]. Int J Mass Spectrom, 2014, 365-366:33-41.
13. ZHAN Xuefang, DUAN Jiana, DUAN Yixiang. Recent developments of proton-transfer reaction mass spectrometry (PTR-MS) and its applications in medical research[J]. Mass Spectrom Rev, 2013, 32(2):143-165.
14. LECHNER M, KARLSEDER A, NIEDERSEER D, et al. H. pylori infection increases levels of exhaled nitrate[J]. Helicobacter, 2005, 10(5):385-390.
15. KARL T, PRAZELLER P, MAYR D, et al. Human breath isoprene and its relation to blood cholesterol levels:new measurements and modeling[J]. J Appl Physiol, 2001, 91(2):762-770.
16. WEHINGER A, SCHMID A, MECHTCHERIAKOV S A, et al. Lung cancer detection by proton transfer reaction mass-spectrometric analysis of human breath gas[J]. Int J Mass Spectrom, 2007, 265(1):49-59.
17. KOHL I, BEAUCHAMP J, CAKAR-BECK F, et al. First observation of a potential non-invasive breath gas biomarker for kidney function[J]. J Breath Res, 2013, 7(1):017110.
18. KAMYSEK S, FUCHS P, SCHWOEBEL H, et al. Drug detection in breath:effects of pulmonary blood flow and cardiac output on propofol exhalation[J]. Anal Bioanal Chem, 2011, 401(7):2093-2102.
19. APREA E, MORISCO F, BIASIOLI F A, et al. Analysis of breath by proton transfer reaction time of flight mass spectrometry in rats with steatohepatitis induced by high-fat diet[J]. Biol Mass Spectrom, 2012, 47(9, SI):1098-1103.
20. APREA E, CAPPELLIN L, GASPERI F, et al. Application of PTR-TOF-MS to investigate metabolites in exhaled breath of patients affected by coeliac disease under gluten free diet[J]. J Chromatogr B Analyt Technol Biomed Life Sci, 2014, 966(SI):208-213.
21. KISTLER M, SZYMCZAK W, FEDRIGO M, et al. Effects of diet-matrix on volatile organic compounds in breath in diet-induced obese mice[J]. J Breath Res, 2014, 8(1):016004.
22. 沈成银, 李建权, 王宏志, 等.呼气中痕量挥发性有机物的质子转移反应质谱在线检测研究[J].分析化学, 2012, 40(5):773-777.
23. 杨彬, 沈成银, 王宏志, 等.高血糖人群呼气标志物的质子转移反应质谱研究[J].分析测试学报, 2013, 32(5):553-558.
24. KECK L, HOESCHEN C, OEH U. Effects of carbon dioxide in breath gas on proton transfer reaction-mass spectrometry (PTR-MS) measurements[J]. Int J Mass Spectrom, 2008, 270(3):156-165.
25. BEAUCHAMP J, HERBIG J, DUNKL J, et al. On the performance of proton-transfer-reaction mass spectrometry for breath-relevant gas matrices[J]. Meas Sci Technol, 2013, 24(12):125003.
26. TREFZ P, SCHMIDT M, OERTEL P, et al. Continuous real time breath gas monitoring in the clinical environment by proton-transfer-reaction-time-of-flight-mass spectrometry[J]. Anal Chem, 2013, 85(21):10321-10329.

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