Mechanoresponsive microRNA_Journal of Biomedical Engineering

Authors：

WANGYang ,  GUOYong

College of Biotechnology Guilin Medical University, Guilin 541004, China;

Corresponding author：

GUOYong, Email: guoyong74@163.com

Keywords：

miRNA; mechanical stimulation; mechanoresponsive; clinical practice

DOI：

10.7507/1001-5515.20160097

Video：

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Abstract Full text Figures/Tables Video References Cited by

Mechanoresponsive microRNAs are a type of miRNAs which are sensitive or responsive to mechanical strain applied to them, their expression levels were changed after mechanical loading, thus affecting the expression levels of mRNA and proteins they regulated. Up to now, some mechanoresponsive miRNAs have been discovered in physiological or pathological tissues or organs. However, these discoveries are usually limited, and they are not able to guide clinical practice well. According to this situation, this paper summarizes research findings of mechanoresponsive miRNAs, and provides directions for clinical practice and further researches.

Citation： WANGYang, GUOYong. Mechanoresponsive microRNA. Journal of Biomedical Engineering, 2016, 33(3): 583-586. doi: 10.7507/1001-5515.20160097 Copy

1.	HA Minju, KIM V N. Regulation of microRNA biogenesis[J]. Nat Rev Mol Cell Biol, 2014, 15(8):509-524.
2.	WANG Jing, ZHANG Yifan, ZHANG Ning, et al. An updated review of mechanotransduction in skin disorders:transcriptional regulators, ion channels, and microRNAs[J]. Cell Mol Life Sci, 2015, 72(11):2091-2106.
3.	ZUO Bin, ZHU Junfeng, LI Jiao, et al. microRNA-103a functions as a mechanosensitive microRNA to inhibit bone formation through targeting Runx2[J]. J Bone Miner Res, 2015, 30(2):330-345.
4.	SON D J, KUMAR S, TAKABE W, et al. The atypical mechanosensitive microRNA-712 derived from pre-ribosomal RNA induces endothelial inflammation and atherosclerosis[J]. Atherosclerosis, 2013, 4(2):3000.
5.	MOHAMED J S, LOPEZ M A, BORIEK A M. Mechanical stretch up-regulates microRNA-26a and induces human airway smooth muscle hypertrophy by suppressing glycogen synthase kinase-3β[J]. J Biol Chem, 2010, 285(38):29336-29347.
6.	KUSUMBE A P, RAMASAMY S K, ADAMS R H. Coupling of angiogenesis and osteogenesis by a specific vessel subtype in bone[J]. Nature, 2014, 507(7492):323-328.
7.	CARRIERO A, ZIMMERMANN E A, PALUSZNY A, et al. How tough is brittle bone? Investigating osteogenesis imperfecta in mouse bone[J]. J Bone Miner Res, 2014, 29(6):1392-1401.
8.	CRANE J L, CAO Xu. Bone marrow mesenchymal stem cells and TGF-β signaling in bone remodeling[J]. J Clin Invest, 2014, 124(2):466-472.
9.	KOMORI T. The functions of Runx family transcription factors and Cbfb in skeletal development[J]. Oral Science International, 2015, 12(1):1-4.
10.	AZAGARSAMY M A, ANSETH K S. Light wavelengths to regulate the release of multiple growth factors[J]. Society For Biomaterials, 2014.
11.	COLLER H A. The runt-related transcription factor 1 in prostate cancer-associated fibroblasts[J]. Proc Natl Acad Sci U S A, 2014, 111(46):16238-16239.
12.	REN Xiaoyan, BISCHOFF D, WEISGERBER D W, et al. Osteogenesis on nanoparticulate mineralized collagen scaffolds via autogenous activation of the canonical BMP receptor signaling pathway[J]. Biomaterials, 2015, 50:107-114.
13.	MAI Zhihui, PENG Zhuli, ZHANG Jinglan, et al. miRNA expression profile during fluid shear stress-induced osteogenic differentiation in MC3T3-E1 cells[J]. Chin Med J (Engl), 2013, 126(8):1544-1550.
14.	NAGEL A K, BALL L E. O-GlcNAc modification of the runt-related transcription factor 2(Runx2) links osteogenesis and nutrient metabolism in bone marrow mesenchymal stem cells[J]. Mol Cell Proteomics, 2014, 13(12):3381-3395.
15.	BUDI E H, XU Jian, DERYNCK R. Regulation of TGF-β receptors[J]. Methods Mol Biol, 2016, 1344:1-33.
16.	OLSEN O E, WADER K F, HELLA H, et al. Activin a inhibits BMP-signaling by binding ACVR2A and ACVR2B[J]. Cell Commun Signal, 2015, 13:27.
17.	WEI Fulan, LIU Dongxu, FENG Cheng, et al. microRNA-21 mediates stretch-induced osteogenic differentiation in human periodontal ligament stem cells[J]. Stem Cells Dev, 2015, 24(3):312-319.
18.	FAN Wendong, FANG Rong, WU Xiaoyuan, et al. Shear-sensitive microRNA-34a modulates flow-dependent regulation of endothelial inflammation[J]. J Cell Sci, 2015, 128(1):70-80.
19.	HERBERT K J, COOK A L, SNOW E T. SIRT1 inhibition restores apoptotic sensitivity in p53-mutated human keratinocytes[J]. Toxicol Appl Pharmacol, 2014, 277(3):288-297.
20.	XIE Hong, LEE L, CARAMUTA S, et al. MicroRNA expression patterns related to merkel cell polyomavirus infection in human merkel cell carcinoma[J]. J Invest Dermatol, 2014, 134(2):507-517.
21.	LEFORT K, BROOKS Y, OSTANO P, et al. A miR-34a-SIRT6 axis in the squamous cell differentiation network[J]. EMBO J, 2013, 32(16):2248-2263.
22.	KUMAR S, KIM C W, SIMMONS R D, et al. Role of flow-sensitive microRNAs in endothelial dysfunction and atherosclerosis:mechanosensitive athero-miRs[J]. Arterioscler Thromb Vasc Biol, 2014, 34(10):2206-2216.
23.	WEBER M, BAKER M B, MOORE J P, et al. MiR-21 is induced in endothelial cells by shear stress and modulates apoptosis and eNOS activity[J]. Biochem Biophys Res Commun, 2010, 393(4):643-648.
24.	HUANG Ying, LI Jun. MicroRNA208 family in cardiovascular diseases:therapeutic implication and potential biomarker[J]. J Physiol Biochem, 2015, 71(3):479-486.
25.	WANG Baowei, WU G J, CHENG Wenpin, et al. Mechanical stretch via transforming growth factor-β1 activates microRNA-208a to regulate hypertrophy in cultured rat cardiac myocytes[J]. J Formos Med Assoc, 2013, 112(10):635-643.
26.	SONG Dongwoo, RYU J Y, KIM J O, et al. The miR-19a/b family positively regulates cardiomyocyte hypertrophy by targeting atrogin-1 and MuRF-1[J]. Biochem J, 2014, 457(1):151-162.
27.	程远, 赵建军.破血化瘀、填精补髓法对实验性脑出血大鼠血肿周围脑组织GSK-3β信号通路的作用研究[J].医学信息,2015,28(14):18-18.
28.	SUN X, MAPES B, WANG T, et al. Characterization of Cyclic-Stretch induced Dna demethylation in nampt/pbef promoter in the human lung endothelium[J]. Am J Respir Crit Care Med, 2014, 189:A3097.
29.	ADYSHEV D M, ELANGOVAN V R, MOLDOBAEVA N, et al. Mechanical stress induces pre-B-cell colony-enhancing factor/NAMPT expression via epigenetic regulation by miR-374a and miR-568 in human lung endothelium[J]. Am J Respir Cell Mol Biol, 2014, 50(2):409-418.

1. HA Minju, KIM V N. Regulation of microRNA biogenesis[J]. Nat Rev Mol Cell Biol, 2014, 15(8):509-524.
2. WANG Jing, ZHANG Yifan, ZHANG Ning, et al. An updated review of mechanotransduction in skin disorders:transcriptional regulators, ion channels, and microRNAs[J]. Cell Mol Life Sci, 2015, 72(11):2091-2106.
3. ZUO Bin, ZHU Junfeng, LI Jiao, et al. microRNA-103a functions as a mechanosensitive microRNA to inhibit bone formation through targeting Runx2[J]. J Bone Miner Res, 2015, 30(2):330-345.
4. SON D J, KUMAR S, TAKABE W, et al. The atypical mechanosensitive microRNA-712 derived from pre-ribosomal RNA induces endothelial inflammation and atherosclerosis[J]. Atherosclerosis, 2013, 4(2):3000.
5. MOHAMED J S, LOPEZ M A, BORIEK A M. Mechanical stretch up-regulates microRNA-26a and induces human airway smooth muscle hypertrophy by suppressing glycogen synthase kinase-3β[J]. J Biol Chem, 2010, 285(38):29336-29347.
6. KUSUMBE A P, RAMASAMY S K, ADAMS R H. Coupling of angiogenesis and osteogenesis by a specific vessel subtype in bone[J]. Nature, 2014, 507(7492):323-328.
7. CARRIERO A, ZIMMERMANN E A, PALUSZNY A, et al. How tough is brittle bone? Investigating osteogenesis imperfecta in mouse bone[J]. J Bone Miner Res, 2014, 29(6):1392-1401.
8. CRANE J L, CAO Xu. Bone marrow mesenchymal stem cells and TGF-β signaling in bone remodeling[J]. J Clin Invest, 2014, 124(2):466-472.
9. KOMORI T. The functions of Runx family transcription factors and Cbfb in skeletal development[J]. Oral Science International, 2015, 12(1):1-4.
10. AZAGARSAMY M A, ANSETH K S. Light wavelengths to regulate the release of multiple growth factors[J]. Society For Biomaterials, 2014.
11. COLLER H A. The runt-related transcription factor 1 in prostate cancer-associated fibroblasts[J]. Proc Natl Acad Sci U S A, 2014, 111(46):16238-16239.
12. REN Xiaoyan, BISCHOFF D, WEISGERBER D W, et al. Osteogenesis on nanoparticulate mineralized collagen scaffolds via autogenous activation of the canonical BMP receptor signaling pathway[J]. Biomaterials, 2015, 50:107-114.
13. MAI Zhihui, PENG Zhuli, ZHANG Jinglan, et al. miRNA expression profile during fluid shear stress-induced osteogenic differentiation in MC3T3-E1 cells[J]. Chin Med J (Engl), 2013, 126(8):1544-1550.
14. NAGEL A K, BALL L E. O-GlcNAc modification of the runt-related transcription factor 2(Runx2) links osteogenesis and nutrient metabolism in bone marrow mesenchymal stem cells[J]. Mol Cell Proteomics, 2014, 13(12):3381-3395.
15. BUDI E H, XU Jian, DERYNCK R. Regulation of TGF-β receptors[J]. Methods Mol Biol, 2016, 1344:1-33.
16. OLSEN O E, WADER K F, HELLA H, et al. Activin a inhibits BMP-signaling by binding ACVR2A and ACVR2B[J]. Cell Commun Signal, 2015, 13:27.
17. WEI Fulan, LIU Dongxu, FENG Cheng, et al. microRNA-21 mediates stretch-induced osteogenic differentiation in human periodontal ligament stem cells[J]. Stem Cells Dev, 2015, 24(3):312-319.
18. FAN Wendong, FANG Rong, WU Xiaoyuan, et al. Shear-sensitive microRNA-34a modulates flow-dependent regulation of endothelial inflammation[J]. J Cell Sci, 2015, 128(1):70-80.
19. HERBERT K J, COOK A L, SNOW E T. SIRT1 inhibition restores apoptotic sensitivity in p53-mutated human keratinocytes[J]. Toxicol Appl Pharmacol, 2014, 277(3):288-297.
20. XIE Hong, LEE L, CARAMUTA S, et al. MicroRNA expression patterns related to merkel cell polyomavirus infection in human merkel cell carcinoma[J]. J Invest Dermatol, 2014, 134(2):507-517.
21. LEFORT K, BROOKS Y, OSTANO P, et al. A miR-34a-SIRT6 axis in the squamous cell differentiation network[J]. EMBO J, 2013, 32(16):2248-2263.
22. KUMAR S, KIM C W, SIMMONS R D, et al. Role of flow-sensitive microRNAs in endothelial dysfunction and atherosclerosis:mechanosensitive athero-miRs[J]. Arterioscler Thromb Vasc Biol, 2014, 34(10):2206-2216.
23. WEBER M, BAKER M B, MOORE J P, et al. MiR-21 is induced in endothelial cells by shear stress and modulates apoptosis and eNOS activity[J]. Biochem Biophys Res Commun, 2010, 393(4):643-648.
24. HUANG Ying, LI Jun. MicroRNA208 family in cardiovascular diseases:therapeutic implication and potential biomarker[J]. J Physiol Biochem, 2015, 71(3):479-486.
25. WANG Baowei, WU G J, CHENG Wenpin, et al. Mechanical stretch via transforming growth factor-β1 activates microRNA-208a to regulate hypertrophy in cultured rat cardiac myocytes[J]. J Formos Med Assoc, 2013, 112(10):635-643.
26. SONG Dongwoo, RYU J Y, KIM J O, et al. The miR-19a/b family positively regulates cardiomyocyte hypertrophy by targeting atrogin-1 and MuRF-1[J]. Biochem J, 2014, 457(1):151-162.
27. 程远, 赵建军.破血化瘀、填精补髓法对实验性脑出血大鼠血肿周围脑组织GSK-3β信号通路的作用研究[J].医学信息,2015,28(14):18-18.
28. SUN X, MAPES B, WANG T, et al. Characterization of Cyclic-Stretch induced Dna demethylation in nampt/pbef promoter in the human lung endothelium[J]. Am J Respir Crit Care Med, 2014, 189:A3097.
29. ADYSHEV D M, ELANGOVAN V R, MOLDOBAEVA N, et al. Mechanical stress induces pre-B-cell colony-enhancing factor/NAMPT expression via epigenetic regulation by miR-374a and miR-568 in human lung endothelium[J]. Am J Respir Cell Mol Biol, 2014, 50(2):409-418.

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Mechanoresponsive microRNA

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