Research Progress of microRNA Influences on Colorectal Cancer_Journal of Biomedical Engineering

Authors：

ZHANGMengyi ¹ , HEJun ² , BIFeng ¹ ,  LIUMing ¹

1. West China Hospital, Sichuan University, Chengdu 610041, China;
2. The First Affiliated Hospital of Chengdu Medical college, Chengdu 610500, China;

Corresponding author：

LIUMing, Email: mingliu721@aliyun.com

Keywords：

microRNA; colorectal cancer; tumor metastasis

DOI：

10.7507/1001-5515.20160098

Video：

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microRNA (miRNA) is a kind of RNAs which involves in the regulation of proliferation, invasion and metastasis of tumors. It also closely connects to the colorectal cancer. This article reviews the relationship between miRNA and proliferation, invasion, metastasis, diagnosis and treatment of colorectal cancer.

Citation： ZHANGMengyi, HEJun, BIFeng, LIUMing. Research Progress of microRNA Influences on Colorectal Cancer. Journal of Biomedical Engineering, 2016, 33(3): 587-592. doi: 10.7507/1001-5515.20160098 Copy

1.	BARTEL D P. MicroRNAs:genomics, biogenesis, mechanism, and function[J]. Cell, 2004, 116(2):281-297.
2.	LAI E C. Micro RNAs are complementary to 3'UTR sequence motifs that mediate negative post-transcriptional regulation[J]. Nat Genet, 2002, 30(4):363-364.
3.	CHI S W, ZANG J B, MELE A, et al. Argonaute HITS-CLIP decodes microRNA-mRNA interaction maps[J]. Nature, 2009, 460(7254):479-486.
4.	ROSSI S, KOPETZ S, DAVULURI R, et al. MicroRNAs, ultraconserved genes and colorectal cancers[J]. Int J Biochem Cell Biol, 2010, 42(8):1291-1297.
5.	KIMELMAN D. XU W. β-Catenin destruction complex:insights and questions from a structural perspective[J]. Oncogene An International Journal, 2006, 25(57):7482-7491.
6.	LI V S W, NG S S, BOERSEMA P J, et al. Wnt signaling through inhibition of β-catenin degradation in an intact Axin1 complex[J]. Cell, 2012, 149(6):1245-1256.
7.	REYA T, CLEVERS H. Wnt signalling in stem cells and cancer[J]. Nature, 2005, 434(7035):843-850..
8.	SUN J Y, HUANG Y, LI J-p, et al. MicroRNA-320a suppresses human colon cancer cell proliferation by directly targeting β-catenin[J]. Biochem Biophys Res Commun, 2012, 420(4):787-792.
9.	YAMADA N, NOGUCHI S, MORI T, et al. Tumor-suppressive microRNA-145 targets catenin δ-1 to regulate Wnt/β-catenin signaling in human colon cancer cells[J]. Cancer Lett, 2013, 335(2):332-342.
10.	STRILLACCI A, VALERII M C, SANSONE P, et al. Loss of miR-101 expression promotes wnt/β-catenin signalling pathway activation and malignancy in colon cancer cells[J]. J Pathol, 2013, 229(3):379-389.
11.	ZHANG Z, KIM K H, LI X, et al. MicroRNA-26b represses colon cancer cell proliferation by inhibiting lymphoid enhancer factor 1 expression[J]. Mol Cancer Ther, 2014, 13(7):1942-1951.
12.	CIARDIELLO F, TORTORA G. EGFR antagonists in cancer treatment[J]. New Engl J Med, 2008, 358(11):1160-1174.
13.	LIAO W T, YE Y P, ZHANG N J, et al. MicroRNA-30b functions as a tumour suppressor in human colorectal cancer by targeting KRAS, PIK3CD and BCL2[J]. J Pathol, 2014, 232(4):415-427.
14.	SUN D, WANG C, LONG S, et al. C/EBP-β-activated microRNA-223 promotes tumour growth through targeting RASA1 in human colorectal cancer[J]. Br J Cancer, 2015, 112(9):1491-1500.
15.	WANG Q, HUANG Z, GUO W, et al. microRNA-202-3p inhibits cell proliferation by targeting ADP-ribosylation factor-like 5a in human colorectal carcinoma[J]. Clinical Cancer Research, 2014, 20(5):1146-1157.
16.	WANG Z, MA B, JI X, et al. MicroRNA-378-5p suppresses cell proliferation and induces apoptosis in colorectal cancer cells by targeting BRAF[J]. Cancer Cell Int, 2015, 15(1):40.
17.	VALERI N, BRACONI C, GASPARINI P, et al. MicroRNA-135b promotes cancer progression by acting as a downstream effector of oncogenic pathways in colon cancer[J]. Cancer Cell, 2014, 25(4):469-483.
18.	LIAO W T, LI T T, WANG Z G, et al. microRNA-224 promotes cell proliferation and tumor growth in human colorectal cancer by repressing PHLPP1 and PHLPP2[J]. Clinical Cancer Research, 2013, 19(17):4662-4672.
19.	TAKAYAMA T, MIYANISHI K, HAYASHI T, et al. Colorectal cancer:genetics of development and metastasis[J]. J Gastroenterol, 2006, 41(3):185-192.
20.	TANG W, ZHU Y, GAO J, et al. MicroRNA-29a promotes colorectal cancer metastasis by regulating matrix metalloproteinase 2 and E-cadherin via KLF4[J]. Br J Cancer, 2014, 110(2):450-458.
21.	ZHANG Q, YU L, QIN D, et al. Role of microRNA-30c targeting Adam19 in colorectal cancer[J]. PLoS One, 2015, 10(3):e0120698.
22.	QIN J, Luo M. MicroRNA-221 promotes colorectal cancer cell invasion and metastasis by targeting RECK[J]. FEBS Lett, 2014, 588(1):99-104.
23.	KE T W, WEI P L, YEH K T, et al. MiR-92a promotes cell metastasis of colorectal cancer through PTEN-Mediated PI3K/AKT pathway[J]. Ann Surg Oncol, 2015, 22(8):2649-2655.
24.	DEWS M, HOMAYOUNI A, YU D, et al. Augmentation of tumor angiogenesis by a Myc-activated microRNA cluster[J]. Nat Genet, 2006, 38(9):1060-1065.
25.	WU W, YANG J, XIAO F, et al. MicroRNA-32(miR-32) regulates phosphatase and tensin homologue (PTEN) expression and promotes growth, migration, and invasion in colorectal carcinoma cells[J]. Mol Cancer, 2013, 12(2):186-195.
26.	LI N, TANG A, HUANG S, et al. MiR-126 suppresses colon cancer cell proliferation and invasion via inhibiting RhoA/ROCK signaling pathway[J]. Mol Cell Biochem, 2013, 380(1-2):107-119.
27.	YUAN L, ZHOU C, LU Y, et al. IFN-γ-mediated IRF1/miR-29b feedback loop suppresses colorectal cancer cell growth and metastasis by repressing IGF1[J]. Cancer Lett, 2015, 359(1):136-147.
28.	ZHANG W, ZHANG T, JIN R, et al. MicroRNA-301a promotes migration and invasion by targeting TGFBR2 in human colorectal cancer[J]. Journal of Experimental & Clinical Cancer Research, 2014, 33(1):1-13.
29.	LING H, PICKARD K, IVAN C, et al. The clinical and biological significance of MIR-224 expression in colorectal cancer metastasis[J]. Gut, 2015, doi:10.1136/gutjnl-2015-309372.[Epubaheadofprint].
30.	BU P, WANG L, CHEN K Y, et al. miR-1269 promotes metastasis and forms a positive feedback loop with TGF-β[J]. Nat commun, 2015, 6:6879.
31.	LI Q, ZOU C, ZOU C, et al. MicroRNA-25 functions as a potential tumor suppressor in colon Cancer by targeting Smad7[J]. Cancer Lett, 2013, 335(1):168-174.
32.	LIU M, TANG Q, QIU M, et al. Mi-21 targets the tumor suppressor RhoB and regulates proliferation, invasion and apoptosis in colorectal cancer cells[J]. FEBS Lett, 2011, 585(19):2998-3005.
33.	LIU Ming, LANG Nan, QIU Meng, et al. miR-137 targets Cdc42 expression, induces cell cycle G1 arrest and inhibits invasion in colorectal cancer cells[J]. Int J Cancer, 2011, 128(6):1269-1279.
34.	LIU M, LANG N, CHEN X, et al. miR-185 targets RhoA and Cdc42 expression and inhibits the proliferation potential of human colorectal cells[J]. Cancer Lett, 2011, 301(2):151-160.
35.	RAMZY I, HASABALLAH M, MARZABAN R, et al. Evaluation of microRNAs-29a, 92a and 145 in colorectal carcinoma as candidate diagnostic markers:An Egyptian pilot study[J]. Clin Res Hepatol Gastroenterol, 2015, 39(4):508-551.
36.	YONG F L. LAW C W, WANG C W. Potentiality of a triple microRNA classifier:miR-193a-3p, miR-23a and miR-338-5p for early detection of colorectal cancer[J]. BMC Cancer, 2013, 13(1):280.
37.	WANG J, HUANG S K, ZHAO M, et al. Identification of a circulating microRNA signature for colorectal cancer detection[J]. PLoS One, 2014, 9(4):e87451.
38.	OGATA-KAWATA H, IZUMIYA M, KURIOKA D, et al. Circulating exosomal microRNAs as biomarkers of colon cancer[J]. PLoS One, 2014, 9(4):e92921.
39.	YIN J, BAI Z, SONG J, et al. Differential expression of serum miR-126, miR-141 and miR-21 as novel biomarkers for early detection of liver metastasis in colorectal cancer[J]. Chinese Journal of Cancer Research, 2014, 26(1):95.
40.	DENG J, LEI W, FU J C, et al. Targeting miR-21 enhances the sensitivity of human colon cancer HT-29 cells to chemoradiotherapy in vitro[J]. Biochem Biophys Res Commun, 2014, 443(3):789-795.
41.	WAN L Y, DENG J, XIANG X J, et al. miR-320 enhances the sensitivity of human colon cancer cells to chemoradiotherapy in vitro by targeting FOXM1[J]. Biochem Biophys Res Commun, 2015, 457(2):125-132.
42.	MOLINA-PINELO S, CARNERO A, RIVERA F, et al. MiR-107 and miR-99a-3p predict chemotherapy response in patients with advanced colorectal cancer[J]. BMC Cancer, 2014, 14(1):656.

1. BARTEL D P. MicroRNAs:genomics, biogenesis, mechanism, and function[J]. Cell, 2004, 116(2):281-297.
2. LAI E C. Micro RNAs are complementary to 3'UTR sequence motifs that mediate negative post-transcriptional regulation[J]. Nat Genet, 2002, 30(4):363-364.
3. CHI S W, ZANG J B, MELE A, et al. Argonaute HITS-CLIP decodes microRNA-mRNA interaction maps[J]. Nature, 2009, 460(7254):479-486.
4. ROSSI S, KOPETZ S, DAVULURI R, et al. MicroRNAs, ultraconserved genes and colorectal cancers[J]. Int J Biochem Cell Biol, 2010, 42(8):1291-1297.
5. KIMELMAN D. XU W. β-Catenin destruction complex:insights and questions from a structural perspective[J]. Oncogene An International Journal, 2006, 25(57):7482-7491.
6. LI V S W, NG S S, BOERSEMA P J, et al. Wnt signaling through inhibition of β-catenin degradation in an intact Axin1 complex[J]. Cell, 2012, 149(6):1245-1256.
7. REYA T, CLEVERS H. Wnt signalling in stem cells and cancer[J]. Nature, 2005, 434(7035):843-850..
8. SUN J Y, HUANG Y, LI J-p, et al. MicroRNA-320a suppresses human colon cancer cell proliferation by directly targeting β-catenin[J]. Biochem Biophys Res Commun, 2012, 420(4):787-792.
9. YAMADA N, NOGUCHI S, MORI T, et al. Tumor-suppressive microRNA-145 targets catenin δ-1 to regulate Wnt/β-catenin signaling in human colon cancer cells[J]. Cancer Lett, 2013, 335(2):332-342.
10. STRILLACCI A, VALERII M C, SANSONE P, et al. Loss of miR-101 expression promotes wnt/β-catenin signalling pathway activation and malignancy in colon cancer cells[J]. J Pathol, 2013, 229(3):379-389.
11. ZHANG Z, KIM K H, LI X, et al. MicroRNA-26b represses colon cancer cell proliferation by inhibiting lymphoid enhancer factor 1 expression[J]. Mol Cancer Ther, 2014, 13(7):1942-1951.
12. CIARDIELLO F, TORTORA G. EGFR antagonists in cancer treatment[J]. New Engl J Med, 2008, 358(11):1160-1174.
13. LIAO W T, YE Y P, ZHANG N J, et al. MicroRNA-30b functions as a tumour suppressor in human colorectal cancer by targeting KRAS, PIK3CD and BCL2[J]. J Pathol, 2014, 232(4):415-427.
14. SUN D, WANG C, LONG S, et al. C/EBP-β-activated microRNA-223 promotes tumour growth through targeting RASA1 in human colorectal cancer[J]. Br J Cancer, 2015, 112(9):1491-1500.
15. WANG Q, HUANG Z, GUO W, et al. microRNA-202-3p inhibits cell proliferation by targeting ADP-ribosylation factor-like 5a in human colorectal carcinoma[J]. Clinical Cancer Research, 2014, 20(5):1146-1157.
16. WANG Z, MA B, JI X, et al. MicroRNA-378-5p suppresses cell proliferation and induces apoptosis in colorectal cancer cells by targeting BRAF[J]. Cancer Cell Int, 2015, 15(1):40.
17. VALERI N, BRACONI C, GASPARINI P, et al. MicroRNA-135b promotes cancer progression by acting as a downstream effector of oncogenic pathways in colon cancer[J]. Cancer Cell, 2014, 25(4):469-483.
18. LIAO W T, LI T T, WANG Z G, et al. microRNA-224 promotes cell proliferation and tumor growth in human colorectal cancer by repressing PHLPP1 and PHLPP2[J]. Clinical Cancer Research, 2013, 19(17):4662-4672.
19. TAKAYAMA T, MIYANISHI K, HAYASHI T, et al. Colorectal cancer:genetics of development and metastasis[J]. J Gastroenterol, 2006, 41(3):185-192.
20. TANG W, ZHU Y, GAO J, et al. MicroRNA-29a promotes colorectal cancer metastasis by regulating matrix metalloproteinase 2 and E-cadherin via KLF4[J]. Br J Cancer, 2014, 110(2):450-458.
21. ZHANG Q, YU L, QIN D, et al. Role of microRNA-30c targeting Adam19 in colorectal cancer[J]. PLoS One, 2015, 10(3):e0120698.
22. QIN J, Luo M. MicroRNA-221 promotes colorectal cancer cell invasion and metastasis by targeting RECK[J]. FEBS Lett, 2014, 588(1):99-104.
23. KE T W, WEI P L, YEH K T, et al. MiR-92a promotes cell metastasis of colorectal cancer through PTEN-Mediated PI3K/AKT pathway[J]. Ann Surg Oncol, 2015, 22(8):2649-2655.
24. DEWS M, HOMAYOUNI A, YU D, et al. Augmentation of tumor angiogenesis by a Myc-activated microRNA cluster[J]. Nat Genet, 2006, 38(9):1060-1065.
25. WU W, YANG J, XIAO F, et al. MicroRNA-32(miR-32) regulates phosphatase and tensin homologue (PTEN) expression and promotes growth, migration, and invasion in colorectal carcinoma cells[J]. Mol Cancer, 2013, 12(2):186-195.
26. LI N, TANG A, HUANG S, et al. MiR-126 suppresses colon cancer cell proliferation and invasion via inhibiting RhoA/ROCK signaling pathway[J]. Mol Cell Biochem, 2013, 380(1-2):107-119.
27. YUAN L, ZHOU C, LU Y, et al. IFN-γ-mediated IRF1/miR-29b feedback loop suppresses colorectal cancer cell growth and metastasis by repressing IGF1[J]. Cancer Lett, 2015, 359(1):136-147.
28. ZHANG W, ZHANG T, JIN R, et al. MicroRNA-301a promotes migration and invasion by targeting TGFBR2 in human colorectal cancer[J]. Journal of Experimental & Clinical Cancer Research, 2014, 33(1):1-13.
29. LING H, PICKARD K, IVAN C, et al. The clinical and biological significance of MIR-224 expression in colorectal cancer metastasis[J]. Gut, 2015, doi:10.1136/gutjnl-2015-309372.[Epubaheadofprint].
30. BU P, WANG L, CHEN K Y, et al. miR-1269 promotes metastasis and forms a positive feedback loop with TGF-β[J]. Nat commun, 2015, 6:6879.
31. LI Q, ZOU C, ZOU C, et al. MicroRNA-25 functions as a potential tumor suppressor in colon Cancer by targeting Smad7[J]. Cancer Lett, 2013, 335(1):168-174.
32. LIU M, TANG Q, QIU M, et al. Mi-21 targets the tumor suppressor RhoB and regulates proliferation, invasion and apoptosis in colorectal cancer cells[J]. FEBS Lett, 2011, 585(19):2998-3005.
33. LIU Ming, LANG Nan, QIU Meng, et al. miR-137 targets Cdc42 expression, induces cell cycle G1 arrest and inhibits invasion in colorectal cancer cells[J]. Int J Cancer, 2011, 128(6):1269-1279.
34. LIU M, LANG N, CHEN X, et al. miR-185 targets RhoA and Cdc42 expression and inhibits the proliferation potential of human colorectal cells[J]. Cancer Lett, 2011, 301(2):151-160.
35. RAMZY I, HASABALLAH M, MARZABAN R, et al. Evaluation of microRNAs-29a, 92a and 145 in colorectal carcinoma as candidate diagnostic markers:An Egyptian pilot study[J]. Clin Res Hepatol Gastroenterol, 2015, 39(4):508-551.
36. YONG F L. LAW C W, WANG C W. Potentiality of a triple microRNA classifier:miR-193a-3p, miR-23a and miR-338-5p for early detection of colorectal cancer[J]. BMC Cancer, 2013, 13(1):280.
37. WANG J, HUANG S K, ZHAO M, et al. Identification of a circulating microRNA signature for colorectal cancer detection[J]. PLoS One, 2014, 9(4):e87451.
38. OGATA-KAWATA H, IZUMIYA M, KURIOKA D, et al. Circulating exosomal microRNAs as biomarkers of colon cancer[J]. PLoS One, 2014, 9(4):e92921.
39. YIN J, BAI Z, SONG J, et al. Differential expression of serum miR-126, miR-141 and miR-21 as novel biomarkers for early detection of liver metastasis in colorectal cancer[J]. Chinese Journal of Cancer Research, 2014, 26(1):95.
40. DENG J, LEI W, FU J C, et al. Targeting miR-21 enhances the sensitivity of human colon cancer HT-29 cells to chemoradiotherapy in vitro[J]. Biochem Biophys Res Commun, 2014, 443(3):789-795.
41. WAN L Y, DENG J, XIANG X J, et al. miR-320 enhances the sensitivity of human colon cancer cells to chemoradiotherapy in vitro by targeting FOXM1[J]. Biochem Biophys Res Commun, 2015, 457(2):125-132.
42. MOLINA-PINELO S, CARNERO A, RIVERA F, et al. MiR-107 and miR-99a-3p predict chemotherapy response in patients with advanced colorectal cancer[J]. BMC Cancer, 2014, 14(1):656.

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