Research Progress of Graphene and Derivatives Nanocomposite in Orthopedics Application_Journal of Biomedical Engineering

Authors：

ZHAOWeikang , ZHANGShiyang , YANGQiming ,  JIANGDianming

The Firsr Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China;

Corresponding author：

JIANGDianming, Email: jdm571026@vip.163.com

Keywords：

graphene; orthopedics; nanocomposite material

DOI：

10.7507/1001-5515.20160101

Video：

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Graphene and its derivatives have good physical and chemical properties and biological properties, which can promote stem cell proliferation and osteogenic differentiation, and it has antibacterial properties and drug release property. Therefore, it has broad application prospects in the field of orthopedic biomaterials. This paper mainly introduces the research progress of graphene nanocomposite materials applied in the aspects of bone tissue engineering scaffold, bone repair, bone graft materials, etc. in order to provide desirable information for the future application basis and clinical research.

Citation： ZHAOWeikang, ZHANGShiyang, YANGQiming, JIANGDianming. Research Progress of Graphene and Derivatives Nanocomposite in Orthopedics Application. Journal of Biomedical Engineering, 2016, 33(3): 604-608. doi: 10.7507/1001-5515.20160101 Copy

1.	中国科学院金属研究所、东南大学、泰州石墨烯研究及检测平台、中国科学院半导体研究所、泰州巨纳新能源有限公司.Q/LM01CGS001-2013石墨烯材料的名称术语和定义[S]//中国石墨烯产业技术创新战略联盟.北京:2013.
2.	NOVOSELOV K S, GEIM A K, MOROZOV S V, et al. Electric field effect in atomically thin carbon films[J]. Science, 2004, 306(5696):666-669.
3.	BALANDIN A A, GHOSH S, BAO W, et al. Superior thermal conductivity of single-layer grapheme[J]. Nano Lett, 2008, 8(3):902-907.
4.	SAHNI D, JEA A, MATA J A, et al. Biocompatibility of pristine graphene for neuronal interface laboratory investigation[J]. J Neurosurg Pediatr, 2013, 11(5):575-583.
5.	NEZAKATI T, COUSINS B G, SEIFALIAN A M. Toxicology of chemically modified graphene-based materials for medical application[J]. Arch Toxicol, 2014, 88(11):1987-2012.
6.	HUSSAIN S, IQBAL M W, PARK J, et al. Physical and electrical properties of graphene grown under different hydrogen flow in low pressure chemical vapor deposition[J]. Nanoscale Res Lett, 2014, 9(1):546.0.
7.	GOENKA S, SANT V, SANT S. Graphene-based nanomaterials for drug delivery and tissue engineering[J]. J Control Release, 2014, 173(10):75-88.
8.	GONÇALVES G, VILA M, PORTOLÉS M T, et al. Nano-graphene oxide:a potential multifunctional platform for cancer therapy[J]. Adv Healthc Mater, 2013, 2(8):1072-1090.
9.	RADOI A, OBREJA A C, EREMIA S V, et al. L-lactic acid biosensor based on multi-layered graphene[J]. Journal of Applied Electrochemistry, 2013, 43(10):985-994.
10.	GU Ming, LIU Yunsong, CHEN Tong, et al. Is graphene a promising nano-material for promoting surface modification of implants or scaffold materials in bone tissue engineering?[J]. Tissue Eng Part B Rev, 2014, 20(5):477-491.
11.	LEE W C, LIM C H, SHI Hui, et al. Origin of enhanced stem cell growth and differentiation on graphene and graphene oxide[J]. ACS Nano, 2011, 5(9):7334-7341.
12.	ARYAEI A, JAYATISSA A H, JAYASURIYA A C. The effect of graphene substrate on osteoblast cell adhesion and proliferation[J]. J Biomed Mater Res A, 2014, 102(9):3282-3290.
13.	ELKHENANY H, AMELSE L, LAFONT A, et al. Graphene supports in vitro proliferation and osteogenic differentiation of goat adult mesenchymal stem cells:potential for bone tissue engineering[J]. J Appl Toxicol, 2015, 35(4):367-374.
14.	NISHIDA E, MIYAJI H, TAKITA H, et al. Graphene oxide coating facilitates the bioactivity of scaffold material for tissue engineering[J]. Jpn J Appl Phys, 2014, 53(6, SI):06JD04.
15.	TALUKDAR Y, RASHKOW J T, LALWANI G, et al. The effects of graphene nanostructures on mesenchymal stem cells[J]. Biomaterials, 2014, 35(18):4863-4877.
16.	KUMAR S, RAJ S, KOLANTHAI E, et al. Chemical functionalization of graphene to augment stem cell osteogenesis and inhibit biofilm formation on polymer composites for orthopedic applications[J]. ACS Appl Mater Interfaces, 2015, 7(5):3237-3252.
17.	LI Jinhua, WANG Gang, ZHU Hongqin, et al. Antibacterial activity of large-area monolayer graphene film manipulated by charge transfer[J]. Sci Rep, 2014, 4:4359.
18.	TANG Jia, CHEN Qian, XU Ligeng, et al. Graphene oxide-silver nanocomposite as a highly effective antibacterial agent with species-specific mechanisms[J]. ACS Appl Mater Interfaces, 2013, 5(9):3867-3874.
19.	LA W G, PARK S, YOON H H, et al. Delivery of a therapeutic protein for bone regeneration from a substrate coated with graphene oxide[J]. Small, 2013, 9(23):4051-4060.
20.	JUSTIN R, CHEN Biqiong. Characterisation and drug release performance of biodegradable chitosan-graphene oxide nanocomposites[J]. Carbohydr Polym, 2014, 103:70-80.
21.	FAN Zengjie, WANG Jinqing, WANG Zhaofeng, et al. One-pot synthesis of graphene/hydroxyapatite nanorod composite for tissue engineering[J]. Carbon N Y, 2014, 66:407-416.
22.	OYEFUSI A, OLANIPEKUN O, NEELGUND G M, et al. Hydroxyapatite grafted carbon nanotubes and graphene nanosheets:promising bone implant materials[J]. Spectrochim Acta A Mol Biomol Spectrosc, 2014, 132:410-416.
23.	RAMANI D, SASTRY T P. Bacterial cellulose-reinforced hydroxyapatite functionalized graphene oxide:a potential osteoinductive composite[J]. Cellulose, 2014, 21(5):3585-3595.
24.	MA Haibin, SU Wenxin, TAI Zhixin, et al. Preparation and cytocompatibility of polylactic acid/hydroxyapatite/graphene oxide nanocomposite fibrous membrane[J]. 科学通报, 2012, 57(23):3051-3058.
25.	PORWAL H, GRASSO S, REECE M, et al. Review of graphene-ceramic matrix composites[J]. Advances in Applied Ceramics, 2013, 112(8):443-454.
26.	GAO Chengde, LIU Tingting, SHUAI Cijun, et al. Enhancement mechanisms of graphene in nano-58S bioactive glass scaffold:mechanical and biological performance[J]. Sci Rep, 2014, 4:4712.
27.	PORWAL H, GRASSO S, CORDERO-ARIAS L, et al. Processing and bioactivity of 45S5 Bioglass^®-graphene nanoplatelets composites[J]. J Mater Sci Mater Med, 2014, 25(6):1403-1413.
28.	SHUAI Cijun, GAO Chengde, FENG Pei, et al. Graphene-reinforced mechanical properties of calcium silicate scaffolds by laser sintering[J]. RSC Adv, 2014, 4(25):12782-12788.
29.	XIE Youtao, LI Hongqing, ZHANG Chi, et al. Graphene-reinforced calcium silicate coatings for load-bearing implants[J]. Biomed Mater, 2014, 9(2):025009.
30.	MEHRALI M, MOGHADDAM E, SHIRAZI S F, et al. Synthesis, mechanical properties, and in vitro biocompatibility with osteoblasts of calcium silicate-reduced graphene oxide composites[J]. ACS Appl Mater Interfaces, 2014, 6(6):3947-3962.
31.	DEPAN D, GIRASE B, SHAH J S, et al. Structure-process-property relationship of the polar graphene oxide-mediated cellular response and stimulated growth of osteoblasts on hybrid chitosan network structure nanocomposite scaffolds[J]. Acta Biomater, 2011, 7(9):3432-3445.
32.	DINESCU S, IONITA M, PANDELE A M, et al. In vitro cytocompatibility evaluation of chitosan/graphene oxide 3D scaffold composites designed for bone tissue engineering[J]. Biomed Mater Eng, 2014, 24(6):2249-2256.
33.	LIU Hongyan, CHENG Ju, CHEN Fengjuan, et al. Gelatin functionalized graphene oxide for mineralization of hydroxyapatite:biomimetic and in vitro evaluation[J]. Nanoscale, 2014, 6(10):5315-5322.
34.	BRACH DEL PREVER E M, BISTOLFI A, BRACCO P, et al. UHMWPE for arthroplasty:past or future?[J]. J Orthop Traumatol, 2009, 10(1):1-8.
35.	LAHIRI D, DUA R, ZHANG Cheng, et al. Graphene nanoplatelet-induced strengthening of ultrahigh molecular weight polyethylene and biocompatibility in vitro[J]. ACS Appl Mater Interfaces, 2012, 4(4):2234-2241.
36.	CHEN Yuanfeng, QI Yuanyuan, TAI Zhixin, et al. Preparation, mechanical properties and biocompatibility of graphene oxide/ultrahigh molecular weight polyethylene composites[J]. Eur Polym J, 2012, 48(6):1026-1033.
37.	QI Y Y, TAI Z X, SUN D F, et al. Fabrication and characterization of poly(vinyl alcohol)/graphene oxide nanofibrous biocomposite scaffolds[J]. J Appl Polym Sci, 2013, 127(3):1885-1894.
38.	GONÇALVES G, PORTOLÉS M T, RAMÍREZ-SANTILLÁN C, et al. Evaluation of the in vitro biocompatibility of PMMA/high-load HA/carbon nanostructures bone cement formulations[J]. J Mater Sci Mater Med, 2013, 24(12):2787-2796.

1. 中国科学院金属研究所、东南大学、泰州石墨烯研究及检测平台、中国科学院半导体研究所、泰州巨纳新能源有限公司.Q/LM01CGS001-2013石墨烯材料的名称术语和定义[S]//中国石墨烯产业技术创新战略联盟.北京:2013.
2. NOVOSELOV K S, GEIM A K, MOROZOV S V, et al. Electric field effect in atomically thin carbon films[J]. Science, 2004, 306(5696):666-669.
3. BALANDIN A A, GHOSH S, BAO W, et al. Superior thermal conductivity of single-layer grapheme[J]. Nano Lett, 2008, 8(3):902-907.
4. SAHNI D, JEA A, MATA J A, et al. Biocompatibility of pristine graphene for neuronal interface laboratory investigation[J]. J Neurosurg Pediatr, 2013, 11(5):575-583.
5. NEZAKATI T, COUSINS B G, SEIFALIAN A M. Toxicology of chemically modified graphene-based materials for medical application[J]. Arch Toxicol, 2014, 88(11):1987-2012.
6. HUSSAIN S, IQBAL M W, PARK J, et al. Physical and electrical properties of graphene grown under different hydrogen flow in low pressure chemical vapor deposition[J]. Nanoscale Res Lett, 2014, 9(1):546.0.
7. GOENKA S, SANT V, SANT S. Graphene-based nanomaterials for drug delivery and tissue engineering[J]. J Control Release, 2014, 173(10):75-88.
8. GONÇALVES G, VILA M, PORTOLÉS M T, et al. Nano-graphene oxide:a potential multifunctional platform for cancer therapy[J]. Adv Healthc Mater, 2013, 2(8):1072-1090.
9. RADOI A, OBREJA A C, EREMIA S V, et al. L-lactic acid biosensor based on multi-layered graphene[J]. Journal of Applied Electrochemistry, 2013, 43(10):985-994.
10. GU Ming, LIU Yunsong, CHEN Tong, et al. Is graphene a promising nano-material for promoting surface modification of implants or scaffold materials in bone tissue engineering?[J]. Tissue Eng Part B Rev, 2014, 20(5):477-491.
11. LEE W C, LIM C H, SHI Hui, et al. Origin of enhanced stem cell growth and differentiation on graphene and graphene oxide[J]. ACS Nano, 2011, 5(9):7334-7341.
12. ARYAEI A, JAYATISSA A H, JAYASURIYA A C. The effect of graphene substrate on osteoblast cell adhesion and proliferation[J]. J Biomed Mater Res A, 2014, 102(9):3282-3290.
13. ELKHENANY H, AMELSE L, LAFONT A, et al. Graphene supports in vitro proliferation and osteogenic differentiation of goat adult mesenchymal stem cells:potential for bone tissue engineering[J]. J Appl Toxicol, 2015, 35(4):367-374.
14. NISHIDA E, MIYAJI H, TAKITA H, et al. Graphene oxide coating facilitates the bioactivity of scaffold material for tissue engineering[J]. Jpn J Appl Phys, 2014, 53(6, SI):06JD04.
15. TALUKDAR Y, RASHKOW J T, LALWANI G, et al. The effects of graphene nanostructures on mesenchymal stem cells[J]. Biomaterials, 2014, 35(18):4863-4877.
16. KUMAR S, RAJ S, KOLANTHAI E, et al. Chemical functionalization of graphene to augment stem cell osteogenesis and inhibit biofilm formation on polymer composites for orthopedic applications[J]. ACS Appl Mater Interfaces, 2015, 7(5):3237-3252.
17. LI Jinhua, WANG Gang, ZHU Hongqin, et al. Antibacterial activity of large-area monolayer graphene film manipulated by charge transfer[J]. Sci Rep, 2014, 4:4359.
18. TANG Jia, CHEN Qian, XU Ligeng, et al. Graphene oxide-silver nanocomposite as a highly effective antibacterial agent with species-specific mechanisms[J]. ACS Appl Mater Interfaces, 2013, 5(9):3867-3874.
19. LA W G, PARK S, YOON H H, et al. Delivery of a therapeutic protein for bone regeneration from a substrate coated with graphene oxide[J]. Small, 2013, 9(23):4051-4060.
20. JUSTIN R, CHEN Biqiong. Characterisation and drug release performance of biodegradable chitosan-graphene oxide nanocomposites[J]. Carbohydr Polym, 2014, 103:70-80.
21. FAN Zengjie, WANG Jinqing, WANG Zhaofeng, et al. One-pot synthesis of graphene/hydroxyapatite nanorod composite for tissue engineering[J]. Carbon N Y, 2014, 66:407-416.
22. OYEFUSI A, OLANIPEKUN O, NEELGUND G M, et al. Hydroxyapatite grafted carbon nanotubes and graphene nanosheets:promising bone implant materials[J]. Spectrochim Acta A Mol Biomol Spectrosc, 2014, 132:410-416.
23. RAMANI D, SASTRY T P. Bacterial cellulose-reinforced hydroxyapatite functionalized graphene oxide:a potential osteoinductive composite[J]. Cellulose, 2014, 21(5):3585-3595.
24. MA Haibin, SU Wenxin, TAI Zhixin, et al. Preparation and cytocompatibility of polylactic acid/hydroxyapatite/graphene oxide nanocomposite fibrous membrane[J]. 科学通报, 2012, 57(23):3051-3058.
25. PORWAL H, GRASSO S, REECE M, et al. Review of graphene-ceramic matrix composites[J]. Advances in Applied Ceramics, 2013, 112(8):443-454.
26. GAO Chengde, LIU Tingting, SHUAI Cijun, et al. Enhancement mechanisms of graphene in nano-58S bioactive glass scaffold:mechanical and biological performance[J]. Sci Rep, 2014, 4:4712.
27. PORWAL H, GRASSO S, CORDERO-ARIAS L, et al. Processing and bioactivity of 45S5 Bioglass^®-graphene nanoplatelets composites[J]. J Mater Sci Mater Med, 2014, 25(6):1403-1413.
28. SHUAI Cijun, GAO Chengde, FENG Pei, et al. Graphene-reinforced mechanical properties of calcium silicate scaffolds by laser sintering[J]. RSC Adv, 2014, 4(25):12782-12788.
29. XIE Youtao, LI Hongqing, ZHANG Chi, et al. Graphene-reinforced calcium silicate coatings for load-bearing implants[J]. Biomed Mater, 2014, 9(2):025009.
30. MEHRALI M, MOGHADDAM E, SHIRAZI S F, et al. Synthesis, mechanical properties, and in vitro biocompatibility with osteoblasts of calcium silicate-reduced graphene oxide composites[J]. ACS Appl Mater Interfaces, 2014, 6(6):3947-3962.
31. DEPAN D, GIRASE B, SHAH J S, et al. Structure-process-property relationship of the polar graphene oxide-mediated cellular response and stimulated growth of osteoblasts on hybrid chitosan network structure nanocomposite scaffolds[J]. Acta Biomater, 2011, 7(9):3432-3445.
32. DINESCU S, IONITA M, PANDELE A M, et al. In vitro cytocompatibility evaluation of chitosan/graphene oxide 3D scaffold composites designed for bone tissue engineering[J]. Biomed Mater Eng, 2014, 24(6):2249-2256.
33. LIU Hongyan, CHENG Ju, CHEN Fengjuan, et al. Gelatin functionalized graphene oxide for mineralization of hydroxyapatite:biomimetic and in vitro evaluation[J]. Nanoscale, 2014, 6(10):5315-5322.
34. BRACH DEL PREVER E M, BISTOLFI A, BRACCO P, et al. UHMWPE for arthroplasty:past or future?[J]. J Orthop Traumatol, 2009, 10(1):1-8.
35. LAHIRI D, DUA R, ZHANG Cheng, et al. Graphene nanoplatelet-induced strengthening of ultrahigh molecular weight polyethylene and biocompatibility in vitro[J]. ACS Appl Mater Interfaces, 2012, 4(4):2234-2241.
36. CHEN Yuanfeng, QI Yuanyuan, TAI Zhixin, et al. Preparation, mechanical properties and biocompatibility of graphene oxide/ultrahigh molecular weight polyethylene composites[J]. Eur Polym J, 2012, 48(6):1026-1033.
37. QI Y Y, TAI Z X, SUN D F, et al. Fabrication and characterization of poly(vinyl alcohol)/graphene oxide nanofibrous biocomposite scaffolds[J]. J Appl Polym Sci, 2013, 127(3):1885-1894.
38. GONÇALVES G, PORTOLÉS M T, RAMÍREZ-SANTILLÁN C, et al. Evaluation of the in vitro biocompatibility of PMMA/high-load HA/carbon nanostructures bone cement formulations[J]. J Mater Sci Mater Med, 2013, 24(12):2787-2796.

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