Advances in Researches on the Relations between miRNA-143/miRNA-145 and Colorectal Cancer_Journal of Biomedical Engineering

Authors：

CHENWei , WANGJin , MAYihan , WANGYiping ,  YANGJinlin

Department of Gastroenterology, West China Hospital, Sichuan University, Chengdu 610041, China;

Corresponding author：

YANGJinlin, Email: mouse-577@163.com

Keywords：

colorectal cancer; microRNAs; miRNA-143; miRNA-145

DOI：

10.7507/1001-5515.20160193

Video：

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Abstract Full text Figures/Tables Video References Cited by

Colorectal cancer is one of the most common malignant diseases that threatens human being's health. With researches on microRNAs (miRNAs) getting deeper and wider, more evidences revealed that a great many of miRNAs have been involved in the development of colorectal cancer and have the potential to become the biomarker for early diagnosis, prediction of prognosis and recurrence of colorectal cancer. MiRNA-143/miRNA-145 are significantly reduced in several cancers, including colorectal cancer, showing an antitumorigenic activity. In the present article, we make a brief review on the advances in the researches on miRNA-143/miRNA-145 and colorectal cancer to provide guidance for further explorations of the mechanism and target therapy of this disease.

Citation： CHENWei, WANGJin, MAYihan, WANGYiping, YANGJinlin. Advances in Researches on the Relations between miRNA-143/miRNA-145 and Colorectal Cancer. Journal of Biomedical Engineering, 2016, 33(6): 1220-1224. doi: 10.7507/1001-5515.20160193 Copy

1.	BRENNER H, KLOOR M, POX C P. Colorectal cancer[J]. Lancet, 2014, 383(9927): 1490-1502.
2.	CHEN Wanqing, ZHENG Rongshou, BAADE P D, et al. Cancer statistics in China, 2015[J]. CA Cancer J Clin, 2016, 66(2): 115-132.
3.	LIN Shuibin, GREGORY R I. MicroRNA biogenesis pathways in cancer[J]. Nat Rev Cancer, 2015, 15(6): 321-333.
4.	PENG Juan, XIE Zhengyong, CHENG Liyang, et al. Paired design study by real-time PCR: miR-378* and miR-145 are potent early diagnostic biomarkers of human colorectal cancer[J]. BMC Cancer, 2015, 15(1): 158.
5.	CHEN Xiangjian, SHI Keqing, WANG Yuqun, et al. Clinical value of integrated-signature miRNAs in colorectal cancer: miRNA expression profiling analysis and experimental validation[J]. Oncotarget, 2015, 6(35): 37544-37556.
6.	RISTAU J, STAFFA J, SCHROTZ-KING P, et al. Suitability of circulating miRNAs as potential prognostic markers in colorectal cancer[J]. Cancer Epidemiol Biomarkers Prev, 2014, 23(12): 2632-2637.
7.	DOW L E, O'ROURKE K P, SIMON J, et al. Apc restoration promotes cellular differentiation and reestablishes crypt homeostasis in colorectal cancer[J]. Cell, 2015, 161(7): 1539-1552.
8.	KAMATANI A, NAKAGAWA Y, AKAO Y, et al. Downregulation of anti-oncomirs miR-143/145 cluster occurs before APC gene aberration in the development of colorectal tumors[J]. Med Mol Morphol, 2013, 46(3): 166-171.
9.	朱林林, 陈薇,王瑾,等.正常结直肠组织、腺瘤、结直肠腺癌中miRNAs的表达差异[J].四川大学学报:医学版,2015,46(6):851-855.
10.	YIN Yuan, SONG Mingxu, GU Bing, et al. Systematic analysis of key miRNAs and related signaling pathways in colorectal tumorigenesis[J]. Gene, 2016, 578(2): 177-184.
11.	YUAN Fang, SUN Ruifen, LI Lijuan, et al. A functional variant rs353292 in the flanking region of miR-143/145 contributes to the risk of colorectal cancer[J]. Sci Rep, 2016, 6: 30195.
12.	BAUER K M, HUMMON A B. Effects of the miR-143/-145 microRNA cluster on the colon cancer proteome and transcriptome[J]. J Proteome Res, 2012, 11(9): 4744-4754.
13.	SU Jiaojiao, LIANG Hongwei, YAO Weiyan, et al. MiR-143 and MiR-145 regulate IGF1R to suppress cell proliferation in colorectal cancer[J]. PLoS One, 2014, 9(12): e114420.
14.	PAGLIUCA A, VALVO C, FABRIZI E, et al. Analysis of the combined action of miR-143 and miR-145 on oncogenic pathways in colorectal cancer cells reveals a coordinate program of gene repression[J]. Oncogene, 2013, 32(40): 4806-4813.
15.	CHIVUKULA R R, SHI Guanglu, ACHARYA A, et al. An essential mesenchymal function for miR-143/145 in intestinal epithelial regeneration[J]. Cell, 2014, 157(5): 1104-1116.
16.	SUN Guihua, CHENG Yawen, LAI L, et al. Signature miRNAs in colorectal cancers were revealed using a bias reduction small RNA deep sequencing protocol[J]. Oncotarget, 2016, 7(4): 3857-3872.
17.	GUO Haiyan, CHEN Ying, HU Xiaobo, et al. The regulation of Toll-like receptor 2 by miR-143 suppresses the invasion and migration of a subset of human colorectal carcinoma cells[J]. Mol Cancer, 2013, 12: 77.
18.	SIMÕES A S, RODRIGUES C P, BORRALHO P M. The MEK5/ERK5 signalling pathway in cancer: A promising novel therapeutic target[J]. Drug Discov Today, 2016. S1359-6446(16):30228.
19.	YAMADA Nami, NOGUCHI S, MORI Takashi, et al. Tumor-suppressive microRNA-145 targets catenin δ-1 to regulate Wnt/β-catenin signaling in human colon cancer cells[J]. Cancer Lett, 2013, 335(2): 332-342.
20.	FENG Y, ZHU J, OU C, et al. MicroRNA-145 inhibits tumour growth and metastasis in colorectal cancer by targeting fascin-1[J]. Br J Cancer, 2014, 110(9): 2300-2309.
21.	QIN Jun, WANG Feiran, JIANG Haiyan, et al. MicroRNA-145 suppresses cell migration and invasion by targeting paxillin in human colorectal cancer cells[J]. Int J Clin Exp Pathol, 2015, 8(2): 1328-1340.
22.	YUAN Wei, SUI C, LIU Qian, et al. Up-regulation of microRNA-145 associates with lymph node metastasis in colorectal cancer[J]. PLoS One, 2014, 9(7): e102017.
23.	GUARNERIO J, BEZZI M, JEONG J C, et al. Oncogenic role of fusion-circRNAs derived from cancer-associated chromosomal translocations[J]. Cell, 2016, 165(2): 289-302.
24.	XIE Huijun, REN Xiaoli, XIN Sainan, et al. Emerging roles of circRNA_001569 targeting miR-145 in the proliferation and invasion of colorectal cancer[J]. Oncotarget, 2016, 7(18): 26680-26691.
25.	SUNG J J, NG S C, CHAN F K, et al. An updated Asia Pacific Consensus Recommendations on colorectal cancer screening[J]. Gut, 2015, 64(1): 121-132.
26.	ROBERTSON D J, IMPERIALE T F. Stool testing for colorectal cancer screening[J]. Gastroenterology, 2015, 149(5): 1286-1293.
27.	TSIKITIS V L, WHITE I, MORI M, et al. Differential expression of microRNA-320a, -145, and -192 along the continuum of normal mucosa to high-grade dysplastic adenomas of the colorectum[J]. Am J Surg, 2014, 207(5): 717-722; discussion 722.
28.	LI Jinming, ZHAO Ronghua, LI Shaotang, et al. Down-regulation of fecal miR-143 and miR-145 as potential markers for colorectal cancer[J]. Saudi Med J, 2012, 33(1): 24-29.
29.	AHMED F E, AHMED N C, VOS P W, et al. Diagnostic microRNA markers to screen for sporadic human colon cancer in stool: I. Proof of principle[J]. Cancer Genomics Proteomics, 2013, 10(3): 93-113.
30.	GUSTAVSSON B, CARLSSON G, MACHOVER D, et al. A review of the evolution of systemic chemotherapy in the management of colorectal cancer[J]. Clin Colorectal Cancer, 2015, 14(1): 1-10.
31.	ZHANG Jian, ZHANG Kejun, BI Meisheng, et al. Circulating microRNA expressions in colorectal cancer as predictors of response to chemotherapy[J]. Anticancer Drugs, 2014, 25(3): 346-352.
32.	LIU Ruilei, DONG Ye, DENG Yanzhen, et al. Tumor suppressor miR-145 reverses drug resistance by directly targeting DNA damage-related gene RAD18 in colorectal cancer[J]. Tumour Biol, 2015, 36(7): 5011-5019.
33.	FEI Bingyuan, WANG Xiuying, FANG Xuedong. MicroRNA-143 replenishment re-sensitizes colorectal cancer cells harboring mutant, but not wild-type, KRAS to paclitaxel treatment[J]. Tumour Biol, 2016, 37(5): 5829-5835.
34.	GOMES S E, SIMÕES A E, PEREIRA D M, et al. miR-143 or miR-145 overexpression increases cetuximab-mediated antibody-dependent cellular cytotoxicity in human colon cancer cells[J]. Oncotarget, 2016, 7(8): 9368-9387.
35.	FINDLAY V J, WANG C, NOGUEIRA L M, et al. SNAI2 modulates colorectal cancer 5-fluorouracil sensitivity through miR145 repression[J]. Mol Cancer Ther, 2014, 13(11): 2713-2726.
36.	PENG Wei, HU Jian, ZHU Xiaodong, et al. Overexpression of miR-145 increases the sensitivity of vemurafenib in drug-resistant colo205 cell line[J]. Tumour Biol, 2014, 35(4): 2983-2988.

1. BRENNER H, KLOOR M, POX C P. Colorectal cancer[J]. Lancet, 2014, 383(9927): 1490-1502.
2. CHEN Wanqing, ZHENG Rongshou, BAADE P D, et al. Cancer statistics in China, 2015[J]. CA Cancer J Clin, 2016, 66(2): 115-132.
3. LIN Shuibin, GREGORY R I. MicroRNA biogenesis pathways in cancer[J]. Nat Rev Cancer, 2015, 15(6): 321-333.
4. PENG Juan, XIE Zhengyong, CHENG Liyang, et al. Paired design study by real-time PCR: miR-378* and miR-145 are potent early diagnostic biomarkers of human colorectal cancer[J]. BMC Cancer, 2015, 15(1): 158.
5. CHEN Xiangjian, SHI Keqing, WANG Yuqun, et al. Clinical value of integrated-signature miRNAs in colorectal cancer: miRNA expression profiling analysis and experimental validation[J]. Oncotarget, 2015, 6(35): 37544-37556.
6. RISTAU J, STAFFA J, SCHROTZ-KING P, et al. Suitability of circulating miRNAs as potential prognostic markers in colorectal cancer[J]. Cancer Epidemiol Biomarkers Prev, 2014, 23(12): 2632-2637.
7. DOW L E, O'ROURKE K P, SIMON J, et al. Apc restoration promotes cellular differentiation and reestablishes crypt homeostasis in colorectal cancer[J]. Cell, 2015, 161(7): 1539-1552.
8. KAMATANI A, NAKAGAWA Y, AKAO Y, et al. Downregulation of anti-oncomirs miR-143/145 cluster occurs before APC gene aberration in the development of colorectal tumors[J]. Med Mol Morphol, 2013, 46(3): 166-171.
9. 朱林林, 陈薇,王瑾,等.正常结直肠组织、腺瘤、结直肠腺癌中miRNAs的表达差异[J].四川大学学报:医学版,2015,46(6):851-855.
10. YIN Yuan, SONG Mingxu, GU Bing, et al. Systematic analysis of key miRNAs and related signaling pathways in colorectal tumorigenesis[J]. Gene, 2016, 578(2): 177-184.
11. YUAN Fang, SUN Ruifen, LI Lijuan, et al. A functional variant rs353292 in the flanking region of miR-143/145 contributes to the risk of colorectal cancer[J]. Sci Rep, 2016, 6: 30195.
12. BAUER K M, HUMMON A B. Effects of the miR-143/-145 microRNA cluster on the colon cancer proteome and transcriptome[J]. J Proteome Res, 2012, 11(9): 4744-4754.
13. SU Jiaojiao, LIANG Hongwei, YAO Weiyan, et al. MiR-143 and MiR-145 regulate IGF1R to suppress cell proliferation in colorectal cancer[J]. PLoS One, 2014, 9(12): e114420.
14. PAGLIUCA A, VALVO C, FABRIZI E, et al. Analysis of the combined action of miR-143 and miR-145 on oncogenic pathways in colorectal cancer cells reveals a coordinate program of gene repression[J]. Oncogene, 2013, 32(40): 4806-4813.
15. CHIVUKULA R R, SHI Guanglu, ACHARYA A, et al. An essential mesenchymal function for miR-143/145 in intestinal epithelial regeneration[J]. Cell, 2014, 157(5): 1104-1116.
16. SUN Guihua, CHENG Yawen, LAI L, et al. Signature miRNAs in colorectal cancers were revealed using a bias reduction small RNA deep sequencing protocol[J]. Oncotarget, 2016, 7(4): 3857-3872.
17. GUO Haiyan, CHEN Ying, HU Xiaobo, et al. The regulation of Toll-like receptor 2 by miR-143 suppresses the invasion and migration of a subset of human colorectal carcinoma cells[J]. Mol Cancer, 2013, 12: 77.
18. SIMÕES A S, RODRIGUES C P, BORRALHO P M. The MEK5/ERK5 signalling pathway in cancer: A promising novel therapeutic target[J]. Drug Discov Today, 2016. S1359-6446(16):30228.
19. YAMADA Nami, NOGUCHI S, MORI Takashi, et al. Tumor-suppressive microRNA-145 targets catenin δ-1 to regulate Wnt/β-catenin signaling in human colon cancer cells[J]. Cancer Lett, 2013, 335(2): 332-342.
20. FENG Y, ZHU J, OU C, et al. MicroRNA-145 inhibits tumour growth and metastasis in colorectal cancer by targeting fascin-1[J]. Br J Cancer, 2014, 110(9): 2300-2309.
21. QIN Jun, WANG Feiran, JIANG Haiyan, et al. MicroRNA-145 suppresses cell migration and invasion by targeting paxillin in human colorectal cancer cells[J]. Int J Clin Exp Pathol, 2015, 8(2): 1328-1340.
22. YUAN Wei, SUI C, LIU Qian, et al. Up-regulation of microRNA-145 associates with lymph node metastasis in colorectal cancer[J]. PLoS One, 2014, 9(7): e102017.
23. GUARNERIO J, BEZZI M, JEONG J C, et al. Oncogenic role of fusion-circRNAs derived from cancer-associated chromosomal translocations[J]. Cell, 2016, 165(2): 289-302.
24. XIE Huijun, REN Xiaoli, XIN Sainan, et al. Emerging roles of circRNA_001569 targeting miR-145 in the proliferation and invasion of colorectal cancer[J]. Oncotarget, 2016, 7(18): 26680-26691.
25. SUNG J J, NG S C, CHAN F K, et al. An updated Asia Pacific Consensus Recommendations on colorectal cancer screening[J]. Gut, 2015, 64(1): 121-132.
26. ROBERTSON D J, IMPERIALE T F. Stool testing for colorectal cancer screening[J]. Gastroenterology, 2015, 149(5): 1286-1293.
27. TSIKITIS V L, WHITE I, MORI M, et al. Differential expression of microRNA-320a, -145, and -192 along the continuum of normal mucosa to high-grade dysplastic adenomas of the colorectum[J]. Am J Surg, 2014, 207(5): 717-722; discussion 722.
28. LI Jinming, ZHAO Ronghua, LI Shaotang, et al. Down-regulation of fecal miR-143 and miR-145 as potential markers for colorectal cancer[J]. Saudi Med J, 2012, 33(1): 24-29.
29. AHMED F E, AHMED N C, VOS P W, et al. Diagnostic microRNA markers to screen for sporadic human colon cancer in stool: I. Proof of principle[J]. Cancer Genomics Proteomics, 2013, 10(3): 93-113.
30. GUSTAVSSON B, CARLSSON G, MACHOVER D, et al. A review of the evolution of systemic chemotherapy in the management of colorectal cancer[J]. Clin Colorectal Cancer, 2015, 14(1): 1-10.
31. ZHANG Jian, ZHANG Kejun, BI Meisheng, et al. Circulating microRNA expressions in colorectal cancer as predictors of response to chemotherapy[J]. Anticancer Drugs, 2014, 25(3): 346-352.
32. LIU Ruilei, DONG Ye, DENG Yanzhen, et al. Tumor suppressor miR-145 reverses drug resistance by directly targeting DNA damage-related gene RAD18 in colorectal cancer[J]. Tumour Biol, 2015, 36(7): 5011-5019.
33. FEI Bingyuan, WANG Xiuying, FANG Xuedong. MicroRNA-143 replenishment re-sensitizes colorectal cancer cells harboring mutant, but not wild-type, KRAS to paclitaxel treatment[J]. Tumour Biol, 2016, 37(5): 5829-5835.
34. GOMES S E, SIMÕES A E, PEREIRA D M, et al. miR-143 or miR-145 overexpression increases cetuximab-mediated antibody-dependent cellular cytotoxicity in human colon cancer cells[J]. Oncotarget, 2016, 7(8): 9368-9387.
35. FINDLAY V J, WANG C, NOGUEIRA L M, et al. SNAI2 modulates colorectal cancer 5-fluorouracil sensitivity through miR145 repression[J]. Mol Cancer Ther, 2014, 13(11): 2713-2726.
36. PENG Wei, HU Jian, ZHU Xiaodong, et al. Overexpression of miR-145 increases the sensitivity of vemurafenib in drug-resistant colo205 cell line[J]. Tumour Biol, 2014, 35(4): 2983-2988.

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