Research Progress and Development Prospect of Biomedical Plate_Journal of Biomedical Engineering

Authors：

LIXiao ¹ , LIUJing ¹ , WUQiang ¹ , WANGYanjie ¹ , XIAOTao ² , LIULihong ² ,  YUShu ¹

1. Key Laboratory for Powder Metallurgy, Central South University, Changsha 410083, China;
2. Department of Orthopedics, Second Xiangya Hospital, Central South University, Changsha 410011, China;

Corresponding author：

YUShu, Email: yushu@csu.edu.cn

Keywords：

bone plate; biomedical materials; carbon/carbon composites

DOI：

10.7507/1001-5515.20160192

Video：

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Different generations of biomedical materials are analyzed in this paper. The current clinical uses of plates made of metals, polymers or composite materials are evaluated, and nano hydroxyapatite/polylactic acid composites and carbon/carbon composite plates are introduced as emphasis. It is pointed out that the carbon/carbon composites are of great feasibility and advantage as a new generation of biomedical materials, especially in the field of bone plate. Compared to other biomaterials, carbon/carbon composites have a good biocompatibility and mechanical compatibility because they have similar elastic modulus, porosity and density to that of human bones. With the development of the technology in knitting and material preparation, carbon/carbon composite plates have a good application prospect.

Citation： LIXiao, LIUJing, WUQiang, WANGYanjie, XIAOTao, LIULihong, YUShu. Research Progress and Development Prospect of Biomedical Plate. Journal of Biomedical Engineering, 2016, 33(6): 1214-1219. doi: 10.7507/1001-5515.20160192 Copy

1.	李明. 锁定加压接骨板治疗30例胫骨平台骨折临床疗效观察[J].现代诊断与治疗,2013(20):4690-4691.
2.	RÜEDI T P, SOMMER C. From the classical AO compression plate to the new internal fixator principle[J]. 中华创伤骨科杂志, 2003, 5(3): 212-217.
3.	关薇, 翟伟,刘斌,等.接骨板固有风险浅析[J].中国药物警戒,2013,10(12):752-754.
4.	刘昌星, 卢通成.消除人工髋关节应力遮挡等问题的理论分析与研究[J].中国组织工程研究,2013,17(39):6875-6880.
5.	赖金平, 魏刚,李秀波,等.低应力遮挡效应接骨板的研究与设计[J].生物骨科材料与临床研究,2007,4(3):51-52.
6.	BEAUPRE G S, CSONGRADI J J. Refracture risk after plate removal in the forearm[J]. J Orthop Trauma, 1996, 10(2): 87-92.
7.	吴炜, 王立军,徐蓬,等.犬下颌骨骨折小型接骨板内固定术后应力遮挡作用导致骨密度变化的实验研究[J].医学信息,2013,26(4):285-286.
8.	HENCH L L. Bioactive materials: the potential for tissue regeneration[J]. J Biomed Mater Res, 1998, 41(4): 511-518.
9.	RADE K, MARTIN AČU I AČU A, NOVAK S, et al. Feasibility study of SiC-ceramics as a potential material for bone implants[J]. Journal of Materials Science, 2013, 48(15): 5295-5301.
10.	AZEM F A, KISS A, BIRLIK I, et al. The corrosion and bioactivity behavior of SiC doped hydroxyapatite for dental applications[J]. Ceramics International, 2014, 40(10, A): 15881-15887.
11.	VLADESCU A, BIRLIK I, BRAIC V, et al. Enhancement of the mechanical properties of hydroxyapatite by SiC addition[J]. J Mech Behav Biomed Mater, 2014, 40: 362-368.
12.	徐小平, 倪卫东,高仕长,等.新型人工生物活性接骨板治疗犬股骨骨折[J].中国组织工程研究,2012,16(21):3838-3842.
13.	杨红胜, 刘跃辉,张斌,等.可变刚度可降解-DL-聚乳酸泡沫衬垫材料与钛合金组成接骨板系统治疗胫骨骨折[J].中国组织工程研究与临床康复,2011,15(12):2100-2104.
14.	王展, 张军,张堃,等.内固定材料修复后踝骨折及其生物力学特性[J].中国组织工程研究,2015,19(44):7182-7187.
15.	董双鹏, 王成焘,齐宝芬,等.肱骨内植物材料选择及预紧力影响的参数化研究[J].中国骨与关节外科,2014,7(1):35-39.
16.	杜建, 丁元法,苏向东,等.医用镍钛形状记忆合金的表面改性及生物相容性[J].中国组织工程研究,2012,16(25):4686-4691.
17.	徐晓宇, 高琨.生物材料学[M].北京:科学出版社,2016:105-106.
18.	于成, 赵卫生,贾伟.生物医用复合材料的研究进展[J].玻璃钢/复合材料,2012(2):78-81.
19.	杨明. 纳米羟基磷灰石/聚乳酸可吸收椎间融合器的生物力学研究[D].长沙:中南大学,2009.
20.	许哲武, 张志光.乳酸骨内固定材料在正颌外科的应用及改性研究[J].口腔颌面修复学杂志,2014,15(2):110-113.
21.	吕桂浩, 蒋练,满城.颌面部骨折手术治疗的发展现状[J].医学美学美容,2015(3):643.
22.	白晓东, 杨冬梅,钟应权,等.GRAND FIXTM可吸收骨固定系统在颌骨骨折治疗中的应用[J].中国保健营养,2013,33(5):2379.
23.	张建伟, 周昌龙,王永盛,等.可吸收内固定微型板在颌面骨折中的应用[J].口腔医学,2013,33(5):357-358.
24.	程俊秋, 段可,翁杰,等.多孔纳米羟基磷灰石-聚乳酸复合材料的制备及其界面研究[J].化学研究与应用,2001,13(5):518-521.
25.	李敏, 唐元,SHAIKH A B,等.聚乳酸/羟基磷灰石纳米复合物对MC3T3-E1细胞增殖活性的影响[J].中国组织工程研究,2014,18(43):6929-6934.
26.	冯志海, 樊桢,孔清,等.热处理温度对二维高导热炭/炭复合材料结构及热导率的影响[J].新型炭材料,2014,29(5):357-362.
27.	EVANS S L, GREGSON P J. Composite technology in load-bearing orthopaedic implants[J]. Biomaterials, 1998, 19(15): 1329-1342.
28.	WANG Guohui, YU Shu, ZHU Shaihong, et al. Biological properties of carbon/carbon implant composites with unique manufacturing processes[J]. J Mater Sci Mater Med, 2009, 20(12): 2487-2492.
29.	倪听晔, 李爱军,钟萍,等.不同高温处理工艺对C/C复合材料生物相容性的影响[J].材料工程,2014(6):62-67.
30.	刘京, 肖鹏,于澍,等.炭基复合材料与人骨的力学性能对比分析[J/OL].复合材料学报.(2016-03-11)[2016-07-17].http://www.cnki.net/kcms/detail/11.1801.TB.20160311.1456.002.html.
31.	马艺林. 医用C/C复合材料力学性能和体外相容性研究[D].长沙:中南大学,2014.
32.	吴琪琳, 潘鼎.炭材料在医学领域的应用[J].材料导报,2003,17(8):54-56.
33.	BRANDWOOD A, NOBLE K R, SCHINDHELM K. Phagocytosis of carbon particles by macrophages in vitro[J]. Biomaterials, 1992, 13(9): 646-648.
34.	MUKHERJEE D P, SAHA S. The application of new composite materials for total joint arthroplasty[J]. J Long Term Eff Med Implants, 1993, 3(2): 131-141.
35.	LEWANDOWSKA-SZUMIEŁ M, KOMENDER J, GÓRECKI A, et al. Fixation of carbon fibre-reinforced carbon composite implanted into bone[J]. J Mater Sci Mater Med, 1997, 8(8): 485-488.
36.	PESÁKOVÁ V, KLÉZL Z, BALÍK K, et al. Biomechanical and biological properties of the implant material carbon-carbon composite covered with pyrolytic carbon[J]. J Mater Sci Mater Med, 2000, 11(12): 793-798.
37.	LEWANDOWSKA-SZUMIEŁ M, KOMENDER J, CHŁOPEK J. Interaction between carbon composites and bone after intrabone implantation[J]. J Biomed Mater Res, 1999, 48(3): 289-296.
38.	陈永强, 戴克戎,方如华,等.混杂复合材料接骨板的实验研究[J].中华骨科杂志,1995,15(8):529-531.
39.	方如华, 袁旬华,采林春,等.混杂复合材料接骨板的研制[J].医用生物力学,1993,8(1):1-8.
40.	LI S, ZHENG Z, LIU Q, et al. Collage/apatite coating on 3-dimensional carbon/carbon composite[J]. J Biomed Mater Res, 1998, 40(4): 520-529.
41.	STOCH A, JASTRZEBSKI W, BROZBEK A, et al. FTIR monitoring of the growth of the carbonate containing apatite layers from simulated and natural body fluids[J]. J Mol Struct, 1999, 511: 287-294.
42.	PIETAK A M, REID J W, STOTT M J, et al. Silicon substitution in the calcium phosphate bioceramics[J]. Biomaterials, 2007, 28(28): 4023-4032.
43.	LAI W, GARINO J, DUCHEYNE P. Silicon excretion from bioactive glass implanted in rabbit bone[J]. Biomaterials, 2002, 23(1): 213-217.

1. 李明. 锁定加压接骨板治疗30例胫骨平台骨折临床疗效观察[J].现代诊断与治疗,2013(20):4690-4691.
2. RÜEDI T P, SOMMER C. From the classical AO compression plate to the new internal fixator principle[J]. 中华创伤骨科杂志, 2003, 5(3): 212-217.
3. 关薇, 翟伟,刘斌,等.接骨板固有风险浅析[J].中国药物警戒,2013,10(12):752-754.
4. 刘昌星, 卢通成.消除人工髋关节应力遮挡等问题的理论分析与研究[J].中国组织工程研究,2013,17(39):6875-6880.
5. 赖金平, 魏刚,李秀波,等.低应力遮挡效应接骨板的研究与设计[J].生物骨科材料与临床研究,2007,4(3):51-52.
6. BEAUPRE G S, CSONGRADI J J. Refracture risk after plate removal in the forearm[J]. J Orthop Trauma, 1996, 10(2): 87-92.
7. 吴炜, 王立军,徐蓬,等.犬下颌骨骨折小型接骨板内固定术后应力遮挡作用导致骨密度变化的实验研究[J].医学信息,2013,26(4):285-286.
8. HENCH L L. Bioactive materials: the potential for tissue regeneration[J]. J Biomed Mater Res, 1998, 41(4): 511-518.
9. RADE K, MARTIN AČU I AČU A, NOVAK S, et al. Feasibility study of SiC-ceramics as a potential material for bone implants[J]. Journal of Materials Science, 2013, 48(15): 5295-5301.
10. AZEM F A, KISS A, BIRLIK I, et al. The corrosion and bioactivity behavior of SiC doped hydroxyapatite for dental applications[J]. Ceramics International, 2014, 40(10, A): 15881-15887.
11. VLADESCU A, BIRLIK I, BRAIC V, et al. Enhancement of the mechanical properties of hydroxyapatite by SiC addition[J]. J Mech Behav Biomed Mater, 2014, 40: 362-368.
12. 徐小平, 倪卫东,高仕长,等.新型人工生物活性接骨板治疗犬股骨骨折[J].中国组织工程研究,2012,16(21):3838-3842.
13. 杨红胜, 刘跃辉,张斌,等.可变刚度可降解-DL-聚乳酸泡沫衬垫材料与钛合金组成接骨板系统治疗胫骨骨折[J].中国组织工程研究与临床康复,2011,15(12):2100-2104.
14. 王展, 张军,张堃,等.内固定材料修复后踝骨折及其生物力学特性[J].中国组织工程研究,2015,19(44):7182-7187.
15. 董双鹏, 王成焘,齐宝芬,等.肱骨内植物材料选择及预紧力影响的参数化研究[J].中国骨与关节外科,2014,7(1):35-39.
16. 杜建, 丁元法,苏向东,等.医用镍钛形状记忆合金的表面改性及生物相容性[J].中国组织工程研究,2012,16(25):4686-4691.
17. 徐晓宇, 高琨.生物材料学[M].北京:科学出版社,2016:105-106.
18. 于成, 赵卫生,贾伟.生物医用复合材料的研究进展[J].玻璃钢/复合材料,2012(2):78-81.
19. 杨明. 纳米羟基磷灰石/聚乳酸可吸收椎间融合器的生物力学研究[D].长沙:中南大学,2009.
20. 许哲武, 张志光.乳酸骨内固定材料在正颌外科的应用及改性研究[J].口腔颌面修复学杂志,2014,15(2):110-113.
21. 吕桂浩, 蒋练,满城.颌面部骨折手术治疗的发展现状[J].医学美学美容,2015(3):643.
22. 白晓东, 杨冬梅,钟应权,等.GRAND FIXTM可吸收骨固定系统在颌骨骨折治疗中的应用[J].中国保健营养,2013,33(5):2379.
23. 张建伟, 周昌龙,王永盛,等.可吸收内固定微型板在颌面骨折中的应用[J].口腔医学,2013,33(5):357-358.
24. 程俊秋, 段可,翁杰,等.多孔纳米羟基磷灰石-聚乳酸复合材料的制备及其界面研究[J].化学研究与应用,2001,13(5):518-521.
25. 李敏, 唐元,SHAIKH A B,等.聚乳酸/羟基磷灰石纳米复合物对MC3T3-E1细胞增殖活性的影响[J].中国组织工程研究,2014,18(43):6929-6934.
26. 冯志海, 樊桢,孔清,等.热处理温度对二维高导热炭/炭复合材料结构及热导率的影响[J].新型炭材料,2014,29(5):357-362.
27. EVANS S L, GREGSON P J. Composite technology in load-bearing orthopaedic implants[J]. Biomaterials, 1998, 19(15): 1329-1342.
28. WANG Guohui, YU Shu, ZHU Shaihong, et al. Biological properties of carbon/carbon implant composites with unique manufacturing processes[J]. J Mater Sci Mater Med, 2009, 20(12): 2487-2492.
29. 倪听晔, 李爱军,钟萍,等.不同高温处理工艺对C/C复合材料生物相容性的影响[J].材料工程,2014(6):62-67.
30. 刘京, 肖鹏,于澍,等.炭基复合材料与人骨的力学性能对比分析[J/OL].复合材料学报.(2016-03-11)[2016-07-17].http://www.cnki.net/kcms/detail/11.1801.TB.20160311.1456.002.html.
31. 马艺林. 医用C/C复合材料力学性能和体外相容性研究[D].长沙:中南大学,2014.
32. 吴琪琳, 潘鼎.炭材料在医学领域的应用[J].材料导报,2003,17(8):54-56.
33. BRANDWOOD A, NOBLE K R, SCHINDHELM K. Phagocytosis of carbon particles by macrophages in vitro[J]. Biomaterials, 1992, 13(9): 646-648.
34. MUKHERJEE D P, SAHA S. The application of new composite materials for total joint arthroplasty[J]. J Long Term Eff Med Implants, 1993, 3(2): 131-141.
35. LEWANDOWSKA-SZUMIEŁ M, KOMENDER J, GÓRECKI A, et al. Fixation of carbon fibre-reinforced carbon composite implanted into bone[J]. J Mater Sci Mater Med, 1997, 8(8): 485-488.
36. PESÁKOVÁ V, KLÉZL Z, BALÍK K, et al. Biomechanical and biological properties of the implant material carbon-carbon composite covered with pyrolytic carbon[J]. J Mater Sci Mater Med, 2000, 11(12): 793-798.
37. LEWANDOWSKA-SZUMIEŁ M, KOMENDER J, CHŁOPEK J. Interaction between carbon composites and bone after intrabone implantation[J]. J Biomed Mater Res, 1999, 48(3): 289-296.
38. 陈永强, 戴克戎,方如华,等.混杂复合材料接骨板的实验研究[J].中华骨科杂志,1995,15(8):529-531.
39. 方如华, 袁旬华,采林春,等.混杂复合材料接骨板的研制[J].医用生物力学,1993,8(1):1-8.
40. LI S, ZHENG Z, LIU Q, et al. Collage/apatite coating on 3-dimensional carbon/carbon composite[J]. J Biomed Mater Res, 1998, 40(4): 520-529.
41. STOCH A, JASTRZEBSKI W, BROZBEK A, et al. FTIR monitoring of the growth of the carbonate containing apatite layers from simulated and natural body fluids[J]. J Mol Struct, 1999, 511: 287-294.
42. PIETAK A M, REID J W, STOTT M J, et al. Silicon substitution in the calcium phosphate bioceramics[J]. Biomaterials, 2007, 28(28): 4023-4032.
43. LAI W, GARINO J, DUCHEYNE P. Silicon excretion from bioactive glass implanted in rabbit bone[J]. Biomaterials, 2002, 23(1): 213-217.

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