A numerical simulation of dendritic cells migration and induction of T cell specific proliferation during the initiation of skin inflammatory_Journal of Biomedical Engineering

Authors：

HU Wenhui ¹ , HUANG Wenzhu ^1,2 , HU Zuquan ^1,2 ,  ZENG Zhu ^1,2

1. School of Biology and Engineering, Guizhou Medical University, Guiyang 550025, P.R.China;
2. Key laboratory of Biology and Engineering, Guizhou Medical University, Guiyang 550025, P.R.China;

Corresponding author：

ZENG Zhu, Email: zengzhu100@sina.com

Keywords：

dendritic cells; skin inflammation; mathematical model; ordinary differential equations

DOI：

10.7507/1001-5515.201702050

Video：

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Abstract Full text Figures/Tables Video References Cited by

Dendritic cells (DCs) are the most potent and specialized antigen-presenting cells (APCs) currently known, which play a crucial role in initiating and amplifying both the innate and adaptive immune responses. During the process of immune function, migration ability of DCs and the number of effector T cells which activated by DCs are closely related to the efficiency of immune function. However, because of the complexity of immune system, in the immune response process caused by the skin chronic inflammatory, much is still unknown about the dynamic changes of cell count with time. Therefore, we created a differential equations model to reflect the initial stages of the immune response process caused by the skin chronic inflammatory via setting the function and initial conditions of parameters. The results showed that the model was able to simulate migration and proliferation of cells in vivo within realistic time scales in accordance with the proliferation and migration efficiency in real terms. In addition, the preliminary model can biologically predict the realistic dynamics of DCs and T cells at different time points. All these results may provide a theoretical reference for studying the immune function of DCs as well as guiding the clinical treatment for immune related diseases further.

Citation： HU Wenhui, HUANG Wenzhu, HU Zuquan, ZENG Zhu. A numerical simulation of dendritic cells migration and induction of T cell specific proliferation during the initiation of skin inflammatory. Journal of Biomedical Engineering, 2017, 34(5): 797-802. doi: 10.7507/1001-5515.201702050 Copy

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14.	Martin-Fontecha A, Sebastiani S, Höpken U E, et al. Regulation of dendritic cell migration to the draining lymph node: impact on T lymphocyte traffic and priming. J Exp Med, 2003, 198(4): 615-621.
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16.	Lin Erickson A H, Wise A, Fleming S, et al. A preliminary mathematical model of skin dendritic cell trafficking and induction of T cell immunity. Discrete Continuous Dyn Syst Ser B, 2009, 12(2): 323-336.

1. Steinman R M. Decisions about dendritic cells: past, present, and future. Annu Rev Immunol, 2012, 30: 1-22.
2. Steinman R M. Dendritic cells <italic>in vivo</italic>: a key target for a new vaccine science. Immunity, 2008, 29(3): 319-324.
3. Steinman R M, Banchereau J. Taking dendritic cells into medicine. Nature, 2007, 449(7161): 419-426.
4. Nestle F O, Di Meglio P, Qin Jianzhong, et al. Skin immune sentinels in health and disease. Nat Rev Immunol, 2009, 9(10): 679-691.
5. Di Meglio P, Perera G K, Nestle F O. The multitasking organ: recent insights into skin immune function. Immunity, 2011, 35(6): 857-869.
6. Pasparakis M, Haase I, Nestle F O. Mechanisms regulating skin immunity and inflammation. Nat Rev Immunol, 2014, 14(5): 289-301.
7. Cravens P D, Lipsky P E. Dendritic cells, chemokine receptors and autoimmune inflammatory diseases. Immunol Cell Biol, 2002, 80(5): 497-505.
8. Seyfizadeh N, Muthuswamy R, Mitchell D A, et al. Migration of dendritic cells to the lymph nodes and its enhancement to drive anti-tumor responses. Crit Rev Oncol Hematol, 2016, 107: 100-110.
9. Celli S, Day M, Müller A J, et al. How many dendritic cells are required to initiate a T-cell response? Blood, 2012, 120(19): 3945-3948.
10. Henrickson S E. von Andrian U H. single-cell dynamics of T-cell priming. Curr Opin Immunol, 2007, 19(3): 249-258.
11. Worbs T, Hammerschmidt S I, Förster R. Dendritic cell migration in health and disease. Nat Rev Immunol, 2017, 17(1): 30-48.
12. Kamath A T, Henri S, Battye F, et al. Developmental kinetics and lifespan of dendritic cells in mouse lymphoid organs. Blood, 2002, 100(5): 1734-1741.
13. Hommel M, Kyewski B. Dynamic changes during the immune response in T cell-antigen-presenting cell clusters isolated from lymph nodes. J Exp Med, 2003, 197(3): 269-280.
14. Martin-Fontecha A, Sebastiani S, Höpken U E, et al. Regulation of dendritic cell migration to the draining lymph node: impact on T lymphocyte traffic and priming. J Exp Med, 2003, 198(4): 615-621.
15. Mempel T R, Henrickson S E, von Andrian U H. T-cell priming by dendritic cells in lymph nodes occurs in three distinct phases. Nature, 2004, 427(6970): 154-159.
16. Lin Erickson A H, Wise A, Fleming S, et al. A preliminary mathematical model of skin dendritic cell trafficking and induction of T cell immunity. Discrete Continuous Dyn Syst Ser B, 2009, 12(2): 323-336.

Journal of Biomedical Engineering

A numerical simulation of dendritic cells migration and induction of T cell specific proliferation during the initiation of skin inflammatory

Abstract Full text Figures/Tables Video References Cited by

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