The application of nanotopography in the development of tissue engineered tissues using mesenchymal stem cells_Journal of Biomedical Engineering

Authors：

FANG Weiying ^1,2 , GU Tingyu ¹ , LIU Yi ¹ , XU Lan ¹ ,  CHEN Yuelei ¹

1. Cell Bank/Stem Cell Bank, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, P.R.China;
2. School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai 200240, P.R.China;

Corresponding author：

Keywords：

nanotopography; mesenchymal stem cell; tissue engineering; nanotechnology

DOI：

10.7507/1001-5515.201705077

Video：

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Tissue engineering has emerged as a promising approach for the repair and functional reconstruction of damaged tissues. The bionic and intelligentized scaffolds provide the structural support for cell growth and differentiation as well as tissue regeneration. The surface properties of the biological material implant, the nanotopology in particular, become key aspects in determining the success of the implant. Mesenchymal stem cells (MSC) are widely favored by researchers as the seed cells in tissue engineering. Recently, it has been shown that nanotopographical characteristics of biomaterials regulate a wide range of MSC properties from their cellular behavior and differentiation potential. Herein, this review will provide an update on studies investigating the roles of nanotopography in the development of tissue engineering using MSC.

Citation： FANG Weiying, GU Tingyu, LIU Yi, XU Lan, CHEN Yuelei. The application of nanotopography in the development of tissue engineered tissues using mesenchymal stem cells. Journal of Biomedical Engineering, 2018, 35(1): 145-150. doi: 10.7507/1001-5515.201705077 Copy

1.	Jiang Weicheng, Cheng Yuhao, Yen M H, et al. Cryo-chemical decellularization of the whole liver for mesenchymal stem cells-based functional hepatic tissue engineering. Biomaterials, 2014, 35(11): 3607-3617.
2.	Yang Lei, Liu Haipei, Lin Yuan. Biomaterial nanotopography-mediated cell responses: experiment and modeling. Int J Smart Nano Mater, 2015, 5(4): 227-256.
3.	Chen Weiqiang, Shao Yue, Li Xiang, et al. Nanotopographical surfaces for stem cell fate control: Engineering mechanobiology from the Bottom. Nano Today, 2014, 9(6): 759-784.
4.	Ao Chenghong, Niu Yan, Zhang Ximu, et al. Fabrication and characterization of electrospun cellulose/nano-hydroxyapatite nanofibers for bone tissue engineering. Int J Biol Macromol, 2017, 97: 568-573.
5.	Shahnavazi M, Ketabi M A, Fekrazad R, et al. Fabrication of Chitosan-nano hydroxyapatite scaffold for dental tissue engineering. Key Eng Mater, 2017, 720: 223-227.
6.	Atak B H, Buyuk B, Huysal M, et al. Preparation and characterization of amine functional nano-hydroxyapatite/chitosan bionanocomposite for bone tissue engineering applications. Carbohydr Polym, 2017, 164: 200-213.
7.	Oseni A O, Butler P E, Seifalian A M. The application of POSS nanostructures in cartilage tissue engineering: the chondrocyte response to nanoscale geometry. J Tissue Eng Regen Med, 2015, 9(11): E27-E38.
8.	Zulkifli F H, Hussain F S J, Zeyohannes S S, et al. A facile synthesis method of hydroxyethyl cellulose-silver nanoparticle scaffolds for skin tissue engineering applications. Mater Sci Eng C Mater Biol Appl, 2017, 79: 151-160.
9.	Yang H S, Lee B, Tsui J H, et al. Electroconductive nanopatterned substrates for enhanced myogenic differentiation and maturation. Adv Healthc Mater, 2016, 5(1): 137-145.
10.	Teo B K, Wong S T, Lim C K, et al. Nanotopography modulates mechanotransduction of stem cells and induces differentiation through focal adhesion kinase. ACS Nano, 2013, 7(6): 4785-4798.
11.	Biggs M J, Richards R G, Gadegaard N, et al. Interactions with nanoscale topography: adhesion quantification and signal transduction in cells of osteogenic and multipotent lineage. J Biomed Mater Res A, 2009, 91(1): 195-208.
12.	Loger K, Engel A, Haupt J, et al. Cell adhesion on NiTi thin film sputter-deposited meshes. Mater Sci Eng C Mater Biol Appl, 2016, 59: 611-616.
13.	Lin Manping, Wang Huaiyu, Ruan Changshun, et al. Adsorption force of fibronectin on various surface chemistries and its vital role in osteoblast adhesion. Biomacromolecules, 2015, 16(3): 973-984.
14.	Mcbeath R, Pirone D M, Nelson C M, et al. Cell shape, cytoskeletal tension, and RhoA regulate stem cell lineage commitment. Dev Cell, 2004, 6(4): 483-495.
15.	de Peppo G M, Agheli H, Karlsson C, et al. Osteogenic response of human mesenchymal stem cells to well-defined nanoscale topography in vitro. Int J Nanomedicine, 2014, 9(1): 2499-2515.
16.	Luo Yu, Shen He, Fang Yongxiang, et al. Enhanced proliferation and osteogenic differentiation of mesenchymal stem cells on graphene oxide-incorporated electrospun poly(lactic-co-glycolic acid) nanofibrous mats. ACS Appl Mater Interfaces, 2015, 7(11): 6331-6339.
17.	Hosseinkhani H, Hosseinkhani M, Kobayashi H. Proliferation and differentiation of mesenchymal stem cells using self-assembled peptide amphiphile nanofibers. Biomed Mater, 2006, 1(1): 8-15.
18.	Xiao Qianru, Zhang Ning, Wang Xi, et al. Oriented surface nanotopography promotes the osteogenesis of mesenchymal stem cells. Adv Mater Interface, 2016. DOI: 10.1002/admi.201600652.
19.	Abagnale G, Steger M, Nguyen V H, et al. Surface topography enhances differentiation of mesenchymal stem cells towards osteogenic and adipogenic lineages. Biomaterials, 2015, 61: 316-326.
20.	McCafferty M M, Burke G A, Meenan B J. Calcium phosphate thin films enhance the response of human mesenchymal stem cells to nanostructured Titanium surfaces. J Tissue Eng, 2014, 5: 2041731414537513. DOI: 10.1177/2041731414537513.
21.	Baboolal T G, Mastbergen S C, Jones E, et al. Synovial fluid hyaluronan mediates MSC attachment to cartilage, a potential novel mechanism contributing to cartilage repair in osteoarthritis using knee joint distraction. Ann Rheum Dis, 2016, 75(5): 908-915.
22.	Toh W S, Lai R C, Hui J H, et al. MSC exosome as a cell-free MSC therapy for cartilage regeneration: Implications for osteoarthritis treatment. Semin Cell Dev Biol, 2017, 67: 56-64.
23.	Gao Lin, Mcbeath R, Chen C S. Stem cell shape regulates a chondrogenic versus myogenic fate through Rac1 and N-cadherin. Stem Cells, 2010, 28(3): 564-572.
24.	Zhong Weiliang, Zhang Weiguo, Wang Shouyu, et al. Regulation of fibrochondrogenesis of mesenchymal stem cells in an integrated microfluidic platform embedded with biomimetic nanofibrous scaffolds. PLoS One, 2013, 8(4): e61283.
25.	Wu Yingnan, Law J B, He Aiyu, et al. Substrate topography determines the fate of chondrogenesis from human mesenchymal stem cells resulting in specific cartilage phenotype formation. Nanomedicine, 2014, 10(7): 1507-1516.
26.	Trujillo N A, Popat K C. Increased adipogenic and decreased chondrogenic differentiation of adipose derived stem cells on nanowire surfaces. Materials (Basel, Switzerland), 2014, 7(4): 2605-2630.
27.	Salmasi S, Kalaskar D M, Yoon W W, et al. Role of nanotopography in the development of tissue engineered 3D organs and tissues using mesenchymal stem cells. World J Stem Cells, 2015, 7(2): 266-280.
28.	Sundaramurthi D, Krishnan U M, Sethuraman S. Electrospun nanofibers as scaffolds for skin tissue engineering. Polymer Reviews, 2014, 54(2): 348-376.
29.	Kim J, Kim H N, Lim K T, et al. Designing nanotopographical density of extracellular matrix for controlled morphology and function of human mesenchymal stem cells. Sci Rep, 2013, 3: 3552.
30.	Jin G, Prabhakaran M P, Ramakrishna S. Stem cell differentiation to epidermal lineages on electrospun nanofibrous substrates for skin tissue engineering. Acta Biomater, 2011, 7(8): 3113-3122.
31.	Li Jingan, Qin Wei, Zhang Kun, et al. Controlling mesenchymal stem cells differentiate into contractile smooth muscle cells on a TiO₂ micro/nano interface: Towards benign pericytes environment for endothelialization. Colloids Surf B Biointerfaces, 2016, 145: 410-419.
32.	Moghadasi Boroujeni S, Mashayekhan S, Vakilian S, et al. The synergistic effect of surface topography and sustained release of TGF-β1 on myogenic differentiation of human mesenchymal stem cells. J Biomed Mater Res A, 2016, 104(7): 1610-1621.
33.	Khattak M, Pu Fanrong, Curran J M, et al. Human mesenchymal stem cell response to poly(ε-caprolactone/poly(methyl methacrylate) demixed thin films. J Mater Sci Mater Med, 2015, 26(5): 178.

1. Jiang Weicheng, Cheng Yuhao, Yen M H, et al. Cryo-chemical decellularization of the whole liver for mesenchymal stem cells-based functional hepatic tissue engineering. Biomaterials, 2014, 35(11): 3607-3617.
2. Yang Lei, Liu Haipei, Lin Yuan. Biomaterial nanotopography-mediated cell responses: experiment and modeling. Int J Smart Nano Mater, 2015, 5(4): 227-256.
3. Chen Weiqiang, Shao Yue, Li Xiang, et al. Nanotopographical surfaces for stem cell fate control: Engineering mechanobiology from the Bottom. Nano Today, 2014, 9(6): 759-784.
4. Ao Chenghong, Niu Yan, Zhang Ximu, et al. Fabrication and characterization of electrospun cellulose/nano-hydroxyapatite nanofibers for bone tissue engineering. Int J Biol Macromol, 2017, 97: 568-573.
5. Shahnavazi M, Ketabi M A, Fekrazad R, et al. Fabrication of Chitosan-nano hydroxyapatite scaffold for dental tissue engineering. Key Eng Mater, 2017, 720: 223-227.
6. Atak B H, Buyuk B, Huysal M, et al. Preparation and characterization of amine functional nano-hydroxyapatite/chitosan bionanocomposite for bone tissue engineering applications. Carbohydr Polym, 2017, 164: 200-213.
7. Oseni A O, Butler P E, Seifalian A M. The application of POSS nanostructures in cartilage tissue engineering: the chondrocyte response to nanoscale geometry. J Tissue Eng Regen Med, 2015, 9(11): E27-E38.
8. Zulkifli F H, Hussain F S J, Zeyohannes S S, et al. A facile synthesis method of hydroxyethyl cellulose-silver nanoparticle scaffolds for skin tissue engineering applications. Mater Sci Eng C Mater Biol Appl, 2017, 79: 151-160.
9. Yang H S, Lee B, Tsui J H, et al. Electroconductive nanopatterned substrates for enhanced myogenic differentiation and maturation. Adv Healthc Mater, 2016, 5(1): 137-145.
10. Teo B K, Wong S T, Lim C K, et al. Nanotopography modulates mechanotransduction of stem cells and induces differentiation through focal adhesion kinase. ACS Nano, 2013, 7(6): 4785-4798.
11. Biggs M J, Richards R G, Gadegaard N, et al. Interactions with nanoscale topography: adhesion quantification and signal transduction in cells of osteogenic and multipotent lineage. J Biomed Mater Res A, 2009, 91(1): 195-208.
12. Loger K, Engel A, Haupt J, et al. Cell adhesion on NiTi thin film sputter-deposited meshes. Mater Sci Eng C Mater Biol Appl, 2016, 59: 611-616.
13. Lin Manping, Wang Huaiyu, Ruan Changshun, et al. Adsorption force of fibronectin on various surface chemistries and its vital role in osteoblast adhesion. Biomacromolecules, 2015, 16(3): 973-984.
14. Mcbeath R, Pirone D M, Nelson C M, et al. Cell shape, cytoskeletal tension, and RhoA regulate stem cell lineage commitment. Dev Cell, 2004, 6(4): 483-495.
15. de Peppo G M, Agheli H, Karlsson C, et al. Osteogenic response of human mesenchymal stem cells to well-defined nanoscale topography in vitro. Int J Nanomedicine, 2014, 9(1): 2499-2515.
16. Luo Yu, Shen He, Fang Yongxiang, et al. Enhanced proliferation and osteogenic differentiation of mesenchymal stem cells on graphene oxide-incorporated electrospun poly(lactic-co-glycolic acid) nanofibrous mats. ACS Appl Mater Interfaces, 2015, 7(11): 6331-6339.
17. Hosseinkhani H, Hosseinkhani M, Kobayashi H. Proliferation and differentiation of mesenchymal stem cells using self-assembled peptide amphiphile nanofibers. Biomed Mater, 2006, 1(1): 8-15.
18. Xiao Qianru, Zhang Ning, Wang Xi, et al. Oriented surface nanotopography promotes the osteogenesis of mesenchymal stem cells. Adv Mater Interface, 2016. DOI: 10.1002/admi.201600652.
19. Abagnale G, Steger M, Nguyen V H, et al. Surface topography enhances differentiation of mesenchymal stem cells towards osteogenic and adipogenic lineages. Biomaterials, 2015, 61: 316-326.
20. McCafferty M M, Burke G A, Meenan B J. Calcium phosphate thin films enhance the response of human mesenchymal stem cells to nanostructured Titanium surfaces. J Tissue Eng, 2014, 5: 2041731414537513. DOI: 10.1177/2041731414537513.
21. Baboolal T G, Mastbergen S C, Jones E, et al. Synovial fluid hyaluronan mediates MSC attachment to cartilage, a potential novel mechanism contributing to cartilage repair in osteoarthritis using knee joint distraction. Ann Rheum Dis, 2016, 75(5): 908-915.
22. Toh W S, Lai R C, Hui J H, et al. MSC exosome as a cell-free MSC therapy for cartilage regeneration: Implications for osteoarthritis treatment. Semin Cell Dev Biol, 2017, 67: 56-64.
23. Gao Lin, Mcbeath R, Chen C S. Stem cell shape regulates a chondrogenic versus myogenic fate through Rac1 and N-cadherin. Stem Cells, 2010, 28(3): 564-572.
24. Zhong Weiliang, Zhang Weiguo, Wang Shouyu, et al. Regulation of fibrochondrogenesis of mesenchymal stem cells in an integrated microfluidic platform embedded with biomimetic nanofibrous scaffolds. PLoS One, 2013, 8(4): e61283.
25. Wu Yingnan, Law J B, He Aiyu, et al. Substrate topography determines the fate of chondrogenesis from human mesenchymal stem cells resulting in specific cartilage phenotype formation. Nanomedicine, 2014, 10(7): 1507-1516.
26. Trujillo N A, Popat K C. Increased adipogenic and decreased chondrogenic differentiation of adipose derived stem cells on nanowire surfaces. Materials (Basel, Switzerland), 2014, 7(4): 2605-2630.
27. Salmasi S, Kalaskar D M, Yoon W W, et al. Role of nanotopography in the development of tissue engineered 3D organs and tissues using mesenchymal stem cells. World J Stem Cells, 2015, 7(2): 266-280.
28. Sundaramurthi D, Krishnan U M, Sethuraman S. Electrospun nanofibers as scaffolds for skin tissue engineering. Polymer Reviews, 2014, 54(2): 348-376.
29. Kim J, Kim H N, Lim K T, et al. Designing nanotopographical density of extracellular matrix for controlled morphology and function of human mesenchymal stem cells. Sci Rep, 2013, 3: 3552.
30. Jin G, Prabhakaran M P, Ramakrishna S. Stem cell differentiation to epidermal lineages on electrospun nanofibrous substrates for skin tissue engineering. Acta Biomater, 2011, 7(8): 3113-3122.
31. Li Jingan, Qin Wei, Zhang Kun, et al. Controlling mesenchymal stem cells differentiate into contractile smooth muscle cells on a TiO₂ micro/nano interface: Towards benign pericytes environment for endothelialization. Colloids Surf B Biointerfaces, 2016, 145: 410-419.
32. Moghadasi Boroujeni S, Mashayekhan S, Vakilian S, et al. The synergistic effect of surface topography and sustained release of TGF-β1 on myogenic differentiation of human mesenchymal stem cells. J Biomed Mater Res A, 2016, 104(7): 1610-1621.
33. Khattak M, Pu Fanrong, Curran J M, et al. Human mesenchymal stem cell response to poly(ε-caprolactone/poly(methyl methacrylate) demixed thin films. J Mater Sci Mater Med, 2015, 26(5): 178.

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