Simulation method of skull remodellingsurgeryfor infant with craniosynostosis_Journal of Biomedical Engineering

Authors：

LU Shenyu ¹ ,  LUO Yangyu ¹ , ZHENG Wenjian ² , GONG Jian ²

1. Institute of Automation, Chinese Academy of Sciences, Beijing 100190, P.R.China;
2. Beijing Tiantan Hospital, Capital Medical University, Beijing 100070, P.R.China;

Corresponding author：

LUO Yangyu, Email: yangyu.luo@ia.ac.cn

Keywords：

craniosynostosis; skull remodeling; point cloud registration; finite elements method

DOI：

10.7507/1001-5515.202101046

Video：

Export PDF Favorites Scan Get Citation

Abstract Full text Figures/Tables Video References Cited by

Craniofacial malformation caused by premature fusion of cranial suture of infants has a serious impact on their growth. The purpose of skull remodeling surgery for infants with craniosynostosis is to expand the skull and allow the brain to grow properly. There are no standardized treatments for skull remodeling surgery at the present, and the postoperative effect can be hardly assessed reasonably. Children with sagittal craniosynostosis were selected as the research objects. By analyzing the morphological characteristics of the patients, the point cloud registration of the skull distortion region with the ideal skull model was performed, and a plan of skull cutting and remodeling surgery was generated. A finite element model of the infant skull was used to predict the growth trend after remodeling surgery. Finally, an experimental study of surgery simulation was carried out with a child with a typical sagittal craniosynostosis. The evaluation results showed that the repositioning and stitching of bone plates effectively improved the morphology of the abnormal parts of the skull and had a normal growth trend. The child’s preoperative cephalic index was 65.31%, and became 71.50% after 9 months’ growth simulation. The simulation of the skull remodeling provides a reference for surgical plan design. The skull remodeling approach significantly improves postoperative effect, and it could be extended to the generation of cutting and remodeling plans and postoperative evaluations for treatment on other types of craniosynostosis.

Citation： LU Shenyu, LUO Yangyu, ZHENG Wenjian, GONG Jian. Simulation method of skull remodellingsurgeryfor infant with craniosynostosis. Journal of Biomedical Engineering, 2021, 38(5): 932-939. doi: 10.7507/1001-5515.202101046 Copy

1.	Malde O, Libby J, Moazen M. An overview of modelling craniosynostosis using the finite element method. Mol Syndromol, 2019, 10(1-2): 74-82.
2.	Zhang G, Tan H, Qian X, et al. A systematic approach to predicting spring force for sagittal craniosynostosis surgery. J Craniofac Surg, 2016, 27(3): 636-643.
3.	Hukki J, Saarinen P, Kangasniemi M. Single suture craniosynostosis: diagnosis and imaging. Front Oral Biol, 2008, 12: 79-90.
4.	沈卫民, 王刚, 吴玉新, 等. 先天性颅缝早闭的颅骨成形—附 6 例报道. 实用美容整形外科杂志, 2002(4): 15-18.
5.	冯胜之, 张涤生, 穆雄铮, 等. 先天性颅缝早闭症的治疗. 中华整形烧伤外科杂志, 1995(6): 406-411.
6.	贺佳宾. 基于模板匹配的颅缝早闭手术切割方案规划方法研究. 北京: 中国科学院大学, 2020.
7.	Borghi A, Rodriguez-Florez N, Rodgers W, et al. Spring assisted cranioplasty: A patient specific computational model. Med Eng Phys, 2018, 53: 58-65.
8.	Wolanski W, Larysz D, Gzik M, et al. Modeling and biomechanical analysis of craniosynostosis correction with the use of finite element method. Int J Numer Method Biomed Eng, 2014, 29(9): 916-925.
9.	Jiang X, Jia Y, Ning W, et al. Skull mechanics study of PI procedure plan for craniosynostosis correction based on finite element method// 4th International Conference on Bioinformatics and Biomedical Engineering. Chengdu: IEEE, 2010: 1-4.
10.	Malde O, Cross C, Lim L, et al. Predicting calvarial morphology in sagittal craniosynostosis. Sci Rep, 2020, 10(1): 3.
11.	Johnson D, Wilkie A. Craniosynostosis. Eur J Hum Genet, 2011, 19(4): 369-376.
12.	Heuzé Y, Boyadjiev S A, Marsh J L, et al. New insights into the relationship between suture closure and craniofacial dysmorphology in sagittal nonsyndromic craniosynostosis. J Anat, 2010, 217(2): 85-96.
13.	Kapp-Simon K A, Speltz M L, Cunningham M L, et al. Neurodevelopment of children with single suture craniosynostosis: a review. Childs Nerv Syst, 2007, 23(3): 269-281.
14.	Salti S, Tombari F, Stefano L D. SHOT: Unique signatures of histograms for surface and texture description. Comput Vis Image Underst, 2014, 125: 251-264.
15.	Rusu R B, Blodow N, Beetz M. Fast point feature histograms (FPFH) for 3D registration// IEEE International Conference on Robotics and Automation. Kobe: IEEE, 2009: 3212-3217.
16.	van Veelen M L C, Rooda O H J E, de Jong T, et al. Results of early surgery for sagittal suture synostosis: long-term follow-up and the occurrence of raised intracranial pressure. Childs Nerv Syst, 2013, 29(6): 997-1005.
17.	Vollmer D G, Jane J A, Park T S, et al. Variants of sagittal synostosis: strategies for surgical correction. J Neurosurg, 1984, 61(3): 557-562.
18.	Massimi L, Caldarelli M, Tamburrini G, et al. Isolated sagittal craniosynostosis: definition, classification, and surgical indications. Childs Nerv Syst, 2012, 28(9): 1311-1317.
19.	Libby J, Marghoub A, Johnson D, et al. Modelling human skull growth: a validated computational model. J Roy Soc Interf, 2017, 14(130): 20170202.
20.	Abbott A H, Netherway D J, Niemann D B, et al. CT-determined intracranial volume for a normal population. J Craniof Surg, 2000, 11(3): 211-223.
21.	赵波涛. 车辆碰撞事故中颅骨有限元精细建模及碰撞伤害研究. 长春: 吉林大学, 2015.
22.	陈丽丹, 杨斌, 倪健, 等. 单侧冠状缝早闭症整复手术的三维有限元生物力学分析. 中华整形外科杂志, 2019, 35(2): 117-123.
23.	Swider P, Delanoé F, Jalbert F, et al. Mechanical properties of fused sagittal sutures in scaphocephaly. Clin Biomechan, 2021, 86: 105369.
24.	何黎民. 头颈三维有限元模型构建及颅脑直接冲击伤致伤机制研究. 上海: 第二军医大学, 2004.
25.	倪健. 基于三维数字化技术的先天性颅缝早闭症整复外科治疗. 北京: 北京协和医学院, 2017.
26.	Li X, Zhu W, He J, et al. Application of computer assisted three-dimensional simulation operation and biomechanics analysis in the treatment of sagittal craniosynostosis. J Clin Neurosci, 2017, 44: 323-329.
27.	刘天甲. 基于 MIMICS 软件的婴幼儿颅缝早闭个性化手术设计研究. 上海: 上海交通大学, 2019.

1. Malde O, Libby J, Moazen M. An overview of modelling craniosynostosis using the finite element method. Mol Syndromol, 2019, 10(1-2): 74-82.
2. Zhang G, Tan H, Qian X, et al. A systematic approach to predicting spring force for sagittal craniosynostosis surgery. J Craniofac Surg, 2016, 27(3): 636-643.
3. Hukki J, Saarinen P, Kangasniemi M. Single suture craniosynostosis: diagnosis and imaging. Front Oral Biol, 2008, 12: 79-90.
4. 沈卫民, 王刚, 吴玉新, 等. 先天性颅缝早闭的颅骨成形—附 6 例报道. 实用美容整形外科杂志, 2002(4): 15-18.
5. 冯胜之, 张涤生, 穆雄铮, 等. 先天性颅缝早闭症的治疗. 中华整形烧伤外科杂志, 1995(6): 406-411.
6. 贺佳宾. 基于模板匹配的颅缝早闭手术切割方案规划方法研究. 北京: 中国科学院大学, 2020.
7. Borghi A, Rodriguez-Florez N, Rodgers W, et al. Spring assisted cranioplasty: A patient specific computational model. Med Eng Phys, 2018, 53: 58-65.
8. Wolanski W, Larysz D, Gzik M, et al. Modeling and biomechanical analysis of craniosynostosis correction with the use of finite element method. Int J Numer Method Biomed Eng, 2014, 29(9): 916-925.
9. Jiang X, Jia Y, Ning W, et al. Skull mechanics study of PI procedure plan for craniosynostosis correction based on finite element method// 4th International Conference on Bioinformatics and Biomedical Engineering. Chengdu: IEEE, 2010: 1-4.
10. Malde O, Cross C, Lim L, et al. Predicting calvarial morphology in sagittal craniosynostosis. Sci Rep, 2020, 10(1): 3.
11. Johnson D, Wilkie A. Craniosynostosis. Eur J Hum Genet, 2011, 19(4): 369-376.
12. Heuzé Y, Boyadjiev S A, Marsh J L, et al. New insights into the relationship between suture closure and craniofacial dysmorphology in sagittal nonsyndromic craniosynostosis. J Anat, 2010, 217(2): 85-96.
13. Kapp-Simon K A, Speltz M L, Cunningham M L, et al. Neurodevelopment of children with single suture craniosynostosis: a review. Childs Nerv Syst, 2007, 23(3): 269-281.
14. Salti S, Tombari F, Stefano L D. SHOT: Unique signatures of histograms for surface and texture description. Comput Vis Image Underst, 2014, 125: 251-264.
15. Rusu R B, Blodow N, Beetz M. Fast point feature histograms (FPFH) for 3D registration// IEEE International Conference on Robotics and Automation. Kobe: IEEE, 2009: 3212-3217.
16. van Veelen M L C, Rooda O H J E, de Jong T, et al. Results of early surgery for sagittal suture synostosis: long-term follow-up and the occurrence of raised intracranial pressure. Childs Nerv Syst, 2013, 29(6): 997-1005.
17. Vollmer D G, Jane J A, Park T S, et al. Variants of sagittal synostosis: strategies for surgical correction. J Neurosurg, 1984, 61(3): 557-562.
18. Massimi L, Caldarelli M, Tamburrini G, et al. Isolated sagittal craniosynostosis: definition, classification, and surgical indications. Childs Nerv Syst, 2012, 28(9): 1311-1317.
19. Libby J, Marghoub A, Johnson D, et al. Modelling human skull growth: a validated computational model. J Roy Soc Interf, 2017, 14(130): 20170202.
20. Abbott A H, Netherway D J, Niemann D B, et al. CT-determined intracranial volume for a normal population. J Craniof Surg, 2000, 11(3): 211-223.
21. 赵波涛. 车辆碰撞事故中颅骨有限元精细建模及碰撞伤害研究. 长春: 吉林大学, 2015.
22. 陈丽丹, 杨斌, 倪健, 等. 单侧冠状缝早闭症整复手术的三维有限元生物力学分析. 中华整形外科杂志, 2019, 35(2): 117-123.
23. Swider P, Delanoé F, Jalbert F, et al. Mechanical properties of fused sagittal sutures in scaphocephaly. Clin Biomechan, 2021, 86: 105369.
24. 何黎民. 头颈三维有限元模型构建及颅脑直接冲击伤致伤机制研究. 上海: 第二军医大学, 2004.
25. 倪健. 基于三维数字化技术的先天性颅缝早闭症整复外科治疗. 北京: 北京协和医学院, 2017.
26. Li X, Zhu W, He J, et al. Application of computer assisted three-dimensional simulation operation and biomechanics analysis in the treatment of sagittal craniosynostosis. J Clin Neurosci, 2017, 44: 323-329.
27. 刘天甲. 基于 MIMICS 软件的婴幼儿颅缝早闭个性化手术设计研究. 上海: 上海交通大学, 2019.

Journal of Biomedical Engineering

Simulation method of skull remodellingsurgeryfor infant with craniosynostosis

Abstract Full text Figures/Tables Video References Cited by

Previous Article

Next Article

Format

Content