Research progress on anti-swelling hydrogels in biomedical field_Journal of Biomedical Engineering

Authors：

SONG Changlong ¹ , FU Xiang ¹ , TANG Lu ² ,  DONG Zhihong ¹

1. School of Mechanical Engineering, Chengdu University, Chengdu 610106, P. R. China;
2. Affiliated Hospital and Clinical College, Chengdu University, Chengdu 610031, P. R. China;

Corresponding author：

Keywords：

Hydrogel; Hydrophilicity; Anti-swelling; Biomedicine

DOI：

10.7507/1001-5515.202312008

Video：

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Hydrogel is a kind of degradable hydrophilic polymer, but excessive hydrophilicity leads to larger volume, lower elastic modulus and looser structure, which further affect its use. Especially in the field of biomedical engineering, excessive swelling of the hydrogel can compress the nerves and improve degradation rate resulting in mismatch of tissue growth and released ions. Therefore, anti-swelling hydrogel has been a research hotspot in recent years. This paper reviews the recent research progress on anti-swelling hydrogel, and expounds the application mechanism and preparation method of hydrogel in biomedical engineering, aiming to provide some references for researchers in the field of anti-swelling hydrogel.

Citation： SONG Changlong, FU Xiang, TANG Lu, DONG Zhihong. Research progress on anti-swelling hydrogels in biomedical field. Journal of Biomedical Engineering, 2024, 41(4): 848-853. doi: 10.7507/1001-5515.202312008 Copy

1.	Feinle A, Elsaesser M S, Huesing N. Sol–gel synthesis of monolithic materials with hierarchical porosity. Chem Soc Rev, 2016, 45(12): 3377-3399.
2.	Ullah F, Othman M B, Javed F, et al. Classification, processing and application of hydrogels: A review. Mater Sci Eng C Mater Biol Appl, 2015, 57: 414-433.
3.	Cai M H, Chen X Y, Fu L Q, et al. Design and development of hybrid hydrogels for biomedical applications: recent trends in anticancer drug delivery and tissue engineering. Front Bioeng Biotechnol, 2021, 9: 630943.
4.	Li L, Scheiger J M, Levkin P A. Design and applications of photoresponsive hydrogels. Adv Mater, 2019, 31(26): e1807333.
5.	Kaunisto E, Marucci M, Borgquist P, et al. Mechanistic modelling of drug release from polymer-coated and swelling and dissolving polymer matrix systems. Int J Pharm, 2011, 418(1): 54-77.
6.	Zhan Y, Fu W, Xing Y, et al. Advances in versatile anti-swelling polymer hydrogels. Mater Sci Eng C Mater Biol Appl, 2021, 127: 112208.
7.	Oryan A, Kamali A, Moshiri A, et al. Chemical crosslinking of biopolymeric scaffolds: current knowledge and future directions of crosslinked engineered bone scaffolds. Int J Biol Macromol, 2018, 107(Pt A): 678-688.
8.	Hennink W E, van Nostrum C F. Novel crosslinking methods to design hydrogels. Adv Drug Deliv Rev, 2012, 64: 223-236.
9.	Huang H, Shen J, Wan S, et al. Wet-adhesive multifunctional hydrogel with anti-swelling and a skin-seamless interface for underwater electrophysiological monitoring and communication. ACS Appl Mater Interfaces, 2023, 15(9): 11549-11562.
10.	Muir V G, Burdick J A. Chemically modified biopolymers for the formation of biomedical hydrogels. Chem Rev, 2021, 121(18): 10908-10949.
11.	Huang G, Tang Z F, Peng S W, et al. Modification of hydrophobic hydrogels into a strongly adhesive and tough hydrogel by electrostatic interaction. Macromolecules, 2021, 55(1): 156-165.
12.	Saunders L, Ma P X. Self-healing supramolecular hydrogels for tissue engineering applications. Macromol Biosci, 2019, 19(1): e1800313.
13.	Wang T, Ren X, Bai Y, et al. Adhesive and tough hydrogels promoted by quaternary chitosan for strain sensor. Carbohydr Polym, 2021, 254: 117298.
14.	Dai X, Zhang Y, Gao L, et al. A Mechanically strong, highly stable, thermoplastic, and self-healable supramolecular polymer hydrogel. Adv Mater, 2015, 27(23): 3566-3571.
15.	Qi C, Dong Z, Huang Y, et al. Tough, anti-swelling supramolecular hydrogels mediated by surfactant–polymer interactions for underwater sensors. ACS Appl Mater Interfaces, 2022, 14(26): 30385-30397.
16.	Pi M H, Qin S H, Wen S H, et al. Rapid gelation of tough and anti-swelling hydrogels under mild conditions for underwater communication. Adv Funct Mater, 2023, 33(1): 2210188.
17.	Pang J, Bi S, Kong T, et al. Mechanically and functionally strengthened tissue adhesive of chitin whisker complexed chitosan/dextran derivatives based hydrogel. Carbohydr Polym, 2020, 237: 116138.
18.	Fan H L, Wang J H, Jin Z X. Tough, swelling-resistant, self-healing, and adhesive dual-cross-linked hydrogels based on polymer–tannic acid multiple hydrogen bonds. Macromolecules, 2018, 51(5): 1696-1705.
19.	Lu S, Zhu L, Wang Q, et al. High-strength albumin hydrogels with hybrid cross-linking. Front Chem, 2020, 8: 106.
20.	Mackey A L, Kjaer M. Connective tissue regeneration in skeletal muscle after eccentric contraction-induced injury. J Appl Physiol (1985), 2017, 122(3): 533-540.
21.	Gendron R, Grenier D, Maheu-Robert L. The oral cavity as a reservoir of bacterial pathogens for focal infections. Microbes Infect, 2000, 2(8): 897-906.
22.	Wu J, Pan Z, Zhao Z Y, et al. Anti-swelling, robust, and adhesive extracellular matrix-mimicking hydrogel used as intraoral dressing. Adv Mater, 2022, 34(20): e2200115.
23.	Zhu J, Li Y, Xie W, et al. Low-swelling adhesive hydrogel with rapid hemostasis and potent anti-inflammatory capability for full-thickness oral mucosal defect repair. ACS Appl Mater Interfaces, 2022, 14(48): 53575-53592.
24.	Fleischer S, Tavakol D N, Vunjak-Novakovic G. From arteries to capillaries: approaches to engineering human vasculature. Adv Funct Mater, 2020, 30(37): 1910811.
25.	Hou J, Zhang X, Wu Y, et al. Amphiphilic and fatigue-resistant organohydrogels for small-diameter vascular grafts. Sci Adv, 2022, 8(30): eabn5360.
26.	Wang Xuebin, Mao Huanv, Xiang Yanxin, et al. Preliminary study on acrylated Pluronic F127-based hydrogels as artificial blood vessel materials. J Mater Sci, 2022, 57(37): 17735-17750.
27.	Gu Y, Wang P, Li H, et al. Chinese expert consensus on adult ventral abdominal wall defect repair and reconstruction. Am J Surg, 2021, 222(1): 86-98.
28.	Liang W, He W, Huang R, et al. Peritoneum-inspired Janus porous hydrogel with anti-deformation, anti-adhesion, and pro-healing characteristics for abdominal wall defect treatment. Adv Mater, 2022, 34(15): e2108992.
29.	Chen X, Zhang J, Chen G, et al. Hydrogel bioadhesives with extreme acid-tolerance for gastric perforation repairing. Adv Funct Mater, 2022, 32(29): 2202285.
30.	You Z, Yu Y, Wang T H, et al. Divalent anion-induced biohydrogels with high strength, anti-swelling, and bioactive capability for enhanced skull bone regeneration. ACS Appl Mater Interfaces, 2023, 15(26): 31243-31255.
31.	Zhang C, Wu H, Chen J, et al. La³⁺ modified poly (γ-glutamic acid) hydrogels with high strength and anti-swelling property for cartilage regeneration. J Appl Polym Sci, 2021, 138(38): 50978.
32.	Wu Y, Li X, Sun Y, et al. Multiscale design of stiffening and ROS scavenging hydrogels for the augmentation of mandibular bone regeneration. Bioact Mater, 2023, 20: 111-125.
33.	Zhao Y, Song S, Ren X, et al. Supramolecular adhesive hydrogels for tissue engineering applications. Chem Rev, 2022, 122(6): 5604-5640.
34.	Sun J, Xiao L, Li B, et al. Genetically engineered polypeptide adhesive coacervates for surgical applications. Angew Chem Int Ed Engl, 2021, 60(44): 23687-23694.
35.	Bian S Q, Hao L Z, Qiu X, et al. An injectable rapid-adhesion and anti-swelling adhesive hydrogel for hemostasis and wound sealing. Adv Funct Mater, 2022, 32(46): 2207741.
36.	Wei C, Tang P, Tang Y, et al. Sponge-like macroporous hydrogel with antibacterial and ROS scavenging capabilities for diabetic wound regeneration. Adv Healthc Mater, 2022, 11(20): e2200717.
37.	Zhu T, Ni Y, Biesold G M, et al. Recent advances in conductive hydrogels: classifications, properties, and applications. Chem Soc Rev, 2023, 52(2): 473-509.
38.	Xia X, Liang Q, Sun X, et al. Intrinsically electron conductive, antibacterial, and anti-swelling hydrogels as implantable sensors for bioelectronics. Adv Funct Mater, 2022, 32(48): 2208024.
39.	Gao Y, Wang Y, Dai Y, et al. Amylopectin based hydrogel strain sensor with good biocompatibility, high toughness and stable anti-swelling in multiple liquid media. Eur Polym J, 2022, 164: 110981.
40.	Di X, Hou J, Yang M, et al. A bio-inspired, ultra-tough, high-sensitivity, and anti-swelling conductive hydrogel strain sensor for motion detection and information transmission. Mater Horiz, 2022, 9(12): 3057-3069.

1. Feinle A, Elsaesser M S, Huesing N. Sol–gel synthesis of monolithic materials with hierarchical porosity. Chem Soc Rev, 2016, 45(12): 3377-3399.
2. Ullah F, Othman M B, Javed F, et al. Classification, processing and application of hydrogels: A review. Mater Sci Eng C Mater Biol Appl, 2015, 57: 414-433.
3. Cai M H, Chen X Y, Fu L Q, et al. Design and development of hybrid hydrogels for biomedical applications: recent trends in anticancer drug delivery and tissue engineering. Front Bioeng Biotechnol, 2021, 9: 630943.
4. Li L, Scheiger J M, Levkin P A. Design and applications of photoresponsive hydrogels. Adv Mater, 2019, 31(26): e1807333.
5. Kaunisto E, Marucci M, Borgquist P, et al. Mechanistic modelling of drug release from polymer-coated and swelling and dissolving polymer matrix systems. Int J Pharm, 2011, 418(1): 54-77.
6. Zhan Y, Fu W, Xing Y, et al. Advances in versatile anti-swelling polymer hydrogels. Mater Sci Eng C Mater Biol Appl, 2021, 127: 112208.
7. Oryan A, Kamali A, Moshiri A, et al. Chemical crosslinking of biopolymeric scaffolds: current knowledge and future directions of crosslinked engineered bone scaffolds. Int J Biol Macromol, 2018, 107(Pt A): 678-688.
8. Hennink W E, van Nostrum C F. Novel crosslinking methods to design hydrogels. Adv Drug Deliv Rev, 2012, 64: 223-236.
9. Huang H, Shen J, Wan S, et al. Wet-adhesive multifunctional hydrogel with anti-swelling and a skin-seamless interface for underwater electrophysiological monitoring and communication. ACS Appl Mater Interfaces, 2023, 15(9): 11549-11562.
10. Muir V G, Burdick J A. Chemically modified biopolymers for the formation of biomedical hydrogels. Chem Rev, 2021, 121(18): 10908-10949.
11. Huang G, Tang Z F, Peng S W, et al. Modification of hydrophobic hydrogels into a strongly adhesive and tough hydrogel by electrostatic interaction. Macromolecules, 2021, 55(1): 156-165.
12. Saunders L, Ma P X. Self-healing supramolecular hydrogels for tissue engineering applications. Macromol Biosci, 2019, 19(1): e1800313.
13. Wang T, Ren X, Bai Y, et al. Adhesive and tough hydrogels promoted by quaternary chitosan for strain sensor. Carbohydr Polym, 2021, 254: 117298.
14. Dai X, Zhang Y, Gao L, et al. A Mechanically strong, highly stable, thermoplastic, and self-healable supramolecular polymer hydrogel. Adv Mater, 2015, 27(23): 3566-3571.
15. Qi C, Dong Z, Huang Y, et al. Tough, anti-swelling supramolecular hydrogels mediated by surfactant–polymer interactions for underwater sensors. ACS Appl Mater Interfaces, 2022, 14(26): 30385-30397.
16. Pi M H, Qin S H, Wen S H, et al. Rapid gelation of tough and anti-swelling hydrogels under mild conditions for underwater communication. Adv Funct Mater, 2023, 33(1): 2210188.
17. Pang J, Bi S, Kong T, et al. Mechanically and functionally strengthened tissue adhesive of chitin whisker complexed chitosan/dextran derivatives based hydrogel. Carbohydr Polym, 2020, 237: 116138.
18. Fan H L, Wang J H, Jin Z X. Tough, swelling-resistant, self-healing, and adhesive dual-cross-linked hydrogels based on polymer–tannic acid multiple hydrogen bonds. Macromolecules, 2018, 51(5): 1696-1705.
19. Lu S, Zhu L, Wang Q, et al. High-strength albumin hydrogels with hybrid cross-linking. Front Chem, 2020, 8: 106.
20. Mackey A L, Kjaer M. Connective tissue regeneration in skeletal muscle after eccentric contraction-induced injury. J Appl Physiol (1985), 2017, 122(3): 533-540.
21. Gendron R, Grenier D, Maheu-Robert L. The oral cavity as a reservoir of bacterial pathogens for focal infections. Microbes Infect, 2000, 2(8): 897-906.
22. Wu J, Pan Z, Zhao Z Y, et al. Anti-swelling, robust, and adhesive extracellular matrix-mimicking hydrogel used as intraoral dressing. Adv Mater, 2022, 34(20): e2200115.
23. Zhu J, Li Y, Xie W, et al. Low-swelling adhesive hydrogel with rapid hemostasis and potent anti-inflammatory capability for full-thickness oral mucosal defect repair. ACS Appl Mater Interfaces, 2022, 14(48): 53575-53592.
24. Fleischer S, Tavakol D N, Vunjak-Novakovic G. From arteries to capillaries: approaches to engineering human vasculature. Adv Funct Mater, 2020, 30(37): 1910811.
25. Hou J, Zhang X, Wu Y, et al. Amphiphilic and fatigue-resistant organohydrogels for small-diameter vascular grafts. Sci Adv, 2022, 8(30): eabn5360.
26. Wang Xuebin, Mao Huanv, Xiang Yanxin, et al. Preliminary study on acrylated Pluronic F127-based hydrogels as artificial blood vessel materials. J Mater Sci, 2022, 57(37): 17735-17750.
27. Gu Y, Wang P, Li H, et al. Chinese expert consensus on adult ventral abdominal wall defect repair and reconstruction. Am J Surg, 2021, 222(1): 86-98.
28. Liang W, He W, Huang R, et al. Peritoneum-inspired Janus porous hydrogel with anti-deformation, anti-adhesion, and pro-healing characteristics for abdominal wall defect treatment. Adv Mater, 2022, 34(15): e2108992.
29. Chen X, Zhang J, Chen G, et al. Hydrogel bioadhesives with extreme acid-tolerance for gastric perforation repairing. Adv Funct Mater, 2022, 32(29): 2202285.
30. You Z, Yu Y, Wang T H, et al. Divalent anion-induced biohydrogels with high strength, anti-swelling, and bioactive capability for enhanced skull bone regeneration. ACS Appl Mater Interfaces, 2023, 15(26): 31243-31255.
31. Zhang C, Wu H, Chen J, et al. La³⁺ modified poly (γ-glutamic acid) hydrogels with high strength and anti-swelling property for cartilage regeneration. J Appl Polym Sci, 2021, 138(38): 50978.
32. Wu Y, Li X, Sun Y, et al. Multiscale design of stiffening and ROS scavenging hydrogels for the augmentation of mandibular bone regeneration. Bioact Mater, 2023, 20: 111-125.
33. Zhao Y, Song S, Ren X, et al. Supramolecular adhesive hydrogels for tissue engineering applications. Chem Rev, 2022, 122(6): 5604-5640.
34. Sun J, Xiao L, Li B, et al. Genetically engineered polypeptide adhesive coacervates for surgical applications. Angew Chem Int Ed Engl, 2021, 60(44): 23687-23694.
35. Bian S Q, Hao L Z, Qiu X, et al. An injectable rapid-adhesion and anti-swelling adhesive hydrogel for hemostasis and wound sealing. Adv Funct Mater, 2022, 32(46): 2207741.
36. Wei C, Tang P, Tang Y, et al. Sponge-like macroporous hydrogel with antibacterial and ROS scavenging capabilities for diabetic wound regeneration. Adv Healthc Mater, 2022, 11(20): e2200717.
37. Zhu T, Ni Y, Biesold G M, et al. Recent advances in conductive hydrogels: classifications, properties, and applications. Chem Soc Rev, 2023, 52(2): 473-509.
38. Xia X, Liang Q, Sun X, et al. Intrinsically electron conductive, antibacterial, and anti-swelling hydrogels as implantable sensors for bioelectronics. Adv Funct Mater, 2022, 32(48): 2208024.
39. Gao Y, Wang Y, Dai Y, et al. Amylopectin based hydrogel strain sensor with good biocompatibility, high toughness and stable anti-swelling in multiple liquid media. Eur Polym J, 2022, 164: 110981.
40. Di X, Hou J, Yang M, et al. A bio-inspired, ultra-tough, high-sensitivity, and anti-swelling conductive hydrogel strain sensor for motion detection and information transmission. Mater Horiz, 2022, 9(12): 3057-3069.

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Research progress on anti-swelling hydrogels in biomedical field

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