Research progress of electrospinning polyurethane fiber in the field of biomedical tissue engineering_Journal of Biomedical Engineering

Authors：

JIAO Enxiang ^1,2,3 , SUN Ziru ¹ , XU Meihong ¹ , WU Ze ⁴ , LIU Yuanbiao ^1,2 , GUO Kai ^1,2 , REN Guiying ¹ ,  ZHANG Haijun ^1,2,3 , LIU Baichao ¹

1. College of Materials Science and Engineering, Shandong University of Technology, Zibo, Shandong 255000, P. R. China;
2. National Local Joint Engineering Laboratory of Biomedical Material Modification Technology, Dezhou, Shandong 253000, P. R. China;
3. School of Medicine, Tongji University, Shanghai 200000, P. R. China;
4. Department of Interventional Medicine, Affiliated Hospital of Qingdao University, Qingdao, Shandong 266000, P. R. China;

Corresponding author：

Keywords：

Electrostatic spinning; Polyurethane fiber; Tissue engineering; Extracellular matrix

DOI：

10.7507/1001-5515.202305051

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Polyurethane materials have good biocompatibility, blood compatibility, mechanical properties, fatigue resistance and processability, and have always been highly valued as medical materials. Polyurethane fibers prepared by electrostatic spinning technology can better mimic the structure of natural extracellular matrices (ECMs), and seed cells can adhere and proliferate better to meet the requirements of tissue repair and reconstruction. The purpose of this review is to present the research progress of electrostatically spun polyurethane fibers in bone tissue engineering, skin tissue engineering, neural tissue engineering, vascular tissue engineering and cardiac tissue engineering, so that researchers can understand the practical applications of electrostatically spun polyurethane fibers in tissue engineering and regenerative medicine.

Citation： JIAO Enxiang, SUN Ziru, XU Meihong, WU Ze, LIU Yuanbiao, GUO Kai, REN Guiying, ZHANG Haijun, LIU Baichao. Research progress of electrospinning polyurethane fiber in the field of biomedical tissue engineering. Journal of Biomedical Engineering, 2024, 41(4): 840-847. doi: 10.7507/1001-5515.202305051 Copy

1.	Zhang B, Xu Y, Ma S, et al. Small-diameter polyurethane vascular graft with high strength and excellent compliance. J Mech Behav Biomed Mater, 2021, 121: 104614.
2.	Rahmati M, Mills D K, Urbanska A M, et al. Electrospinning for tissue engineering applications. Prog Mater Sci, 2021, 117: 100721.
3.	Lu X, Zou H, Liao X, et al. Construction of PCL-collagen@PCL@PCL-gelatin three-layer small diameter artificial vascular grafts by electrospinning. Biomed Mater, 2022, 18(1): 015008.
4.	Moore M J, Tan R P, Yang N, et al. Bioengineering artificial blood vessels from natural materials. Trends Biotechnol, 2022, 40(6): 693-707.
5.	Jamil M, Mustafa I S, Ahmed N M, et al. Cytotoxicity evaluation of poly(ethylene) oxide nanofibre in MCF-7 breast cancer cell line. Biomater Adv, 2022, 143: 213178.
6.	Maliszewska I, Czapka T. Electrospun polymer nanofibers with antimicrobial activity. Polymers, 2022, 14(9): 1661.
7.	Jin J, Yeom S H, Lee H J, et al. The effect of nozzle spacing on the electric field and fiber size distribution in a multi‐nozzle electrospinning system. J Appl Polym Sci, 2023, 140(16): e53764.
8.	Zulkifli M Z A, Nordin D, Shaari N, et al. Overview of electrospinning for tissue engineering applications. Polymers (Basel), 2023, 15(11): 2418.
9.	Zhu Y, Goh C, Shrestha A. Biomaterial properties modulating bone regeneration. Macromol Biosci, 2021, 21(4): e2000365.
10.	Wu C, Wang H, Cao J. Tween-80 improves single/coaxial electrospinning of three-layered bioartificial blood vessel. J Mater Sci Mater Med, 2022, 34(1): 6.
11.	Shrestha B K, Shrestha S, Tiwari A P, et al. Bio-inspired hybrid scaffold of zinc oxide-functionalized multi-wall carbon nanotubes reinforced polyurethane nanofibers for bone tissue engineering. Mater Design, 2017, 133: 69-81.
12.	Ghorai S K, Roy T, Maji S, et al. A judicious approach of exploiting polyurethane-urea based electrospun nanofibrous scaffold for stimulated bone tissue regeneration through functionally nobbled nanohydroxyapatite. Chem Eng J, 2022, 429: 132179.
13.	Tang J, Zhang Y, Fang W, et al. Electrophysiological microenvironment and site-specific cell behaviors regulated by fibrous aniline trimer-based polyurethanes in bone progressive regeneration. Chem Eng J, 2023, 460: 141630.
14.	Jaganathan S K, Mani M P, Ismail A F, et al. Tailor‐made multicomponent electrospun polyurethane nanofibrous composite scaffold comprising olive oil, honey, and propolis for bone tissue engineering. Polym Composite, 2018, 40(5): 2039-2050.
15.	Jaganathan S K, Mani M P, Palaniappan S K, et al. Fabrication and characterisation of nanofibrous polyurethane scaffold incorporated with corn and neem oil using single stage electrospinning technique for bone tissue engineering applications. J Polym Res, 2018, 25(7): 146.
16.	Darvishi E, Kahrizi D, Arkan E, et al. Preparation of bio-nano bandage from quince seed mucilage/ZnO nanoparticles and its application for the treatment of burn. J Mol Liq, 2021, 339: 116598.
17.	Hsu K F, Chiu Y L, Chiao H Y, et al. Negative-pressure wound therapy combined with artificial dermis (Terudermis) followed by split-thickness skin graft might be an effective treatment option for wounds exposing tendon and bone: A retrospective observation study. Medicine (Baltimore), 2021, 100(14): e25395.
18.	Ghosh S, Haldar S, Gupta S, et al. Single unit functionally graded bioresorbable electrospun scaffold for scar-free full-thickness skin wound healing. Biomater Adv, 2022, 139: 212980.
19.	Sheikholeslam M, Wright M E E, Jeschke M G, et al. Biomaterials for skin substitutes. Adv Healthc Mater, 2018, 7(5): 1700897.
20.	Wang Y, Beekman J, Hew J, et al. Burn injury: Challenges and advances in burn wound healing, infection, pain and scarring. Adv Drug Deliv Rev, 2018, 123: 3-17.
21.	Chen X, Zhao R, Wang X, et al. Electrospun mupirocin loaded polyurethane fiber mats for anti-infection burn wound dressing application. J Biomater Sci Polym Ed, 2017, 28(2): 162-176.
22.	Sheikholeslam M, Wright M E E, Cheng N, et al. Electrospun polyurethane-gelatin composite: A new tissue-engineered scaffold for application in skin regeneration and repair of complex wounds. ACS Biomater Sci Eng, 2020, 6(1): 505-516.
23.	Wan X, Liu S, Xin X, et al. S-nitrosated keratin composite mats with NO release capacity for wound healing. Chem Eng J, 2020, 400: 125964.
24.	Sofi H S, Abdal-Hay A, Rashid R, et al. Electrospun polyurethane fiber mats coated with fish collagen layer to improve cellular affinity for skin repair. Sustain Mater Techno, 2022, 34: e00523.
25.	Zhang P X, Han N, Kou Y H, et al. Tissue engineering for the repair of peripheral nerve injury. Neural Regen Res, 2019, 14(1): 51-58.
26.	Shrestha S, Shrestha B K, Lee J, et al. A conducting neural interface of polyurethane/silk-functionalized multiwall carbon nanotubes with enhanced mechanical strength for neuroregeneration. Mater Sci Eng C Mater Biol Appl, 2019, 102: 511-523.
27.	Thampi S, Thekkuveettil A, Muthuvijayan V, et al. Accelerated outgrowth of neurites on graphene oxide-based hybrid electrospun fibro-porous polymeric substrates. ACS Appl Bio Mater, 2020, 3(4): 2160-2169.
28.	Nasab S T, Roodbari N H, Goodarzi V, et al. Nanobioglass enhanced polyurethane/collagen conduit in sciatic nerve regeneration. J Biomed Mater Res B, 2021, 110(5): 1093-1102.
29.	Alipour H, Alizadeh A, Azarpira N, et al. Incorporating fingolimod through poly(lactic‐co‐glycolic acid) nanoparticles in electrospun polyurethane/polycaprolactone/gelatin scaffold: An in vitro study for nerve tissue engineering. Polym Advan Technol, 2022, 33(8): 2589-2600.
30.	Lee D Y, Jang Y, Kim E, et al. Tissue-engineered vascular graft based on a bioresorbable tubular knit scaffold with flexibility, durability, and suturability for implantation. J Mater Chem B, 2023, 11(5): 1108-1114.
31.	Jaganathan S K, Mani M P, Ayyar M, et al. Engineered electrospun polyurethane and castor oil nanocomposite scaffolds for cardiovascular applications. J Mater Sci, 2017, 52(18): 10673-10685.
32.	Abdal-Hay A, Bartnikowski M, Hamlet S, et al. Electrospun biphasic tubular scaffold with enhanced mechanical properties for vascular tissue engineering. Mater Sci Eng C Mater Biol Appl, 2018, 82: 10-18.
33.	Post A, Kishan A P, Diaz-Rodriguez P, et al. Introduction of sacrificial bonds to hydrogels to increase defect tolerance during suturing of multilayer vascular grafts. Acta Biomater, 2018, 69: 313-322.
34.	Zhang Y, Jiao Y, Wang C, et al. Design and characterization of small-diameter tissue-engineered blood vessels constructed by electrospun polyurethane-core and gelatin-shell coaxial fiber. Bioengineered, 2021, 12(1): 5769-5788.
35.	Ul Haq A, Carotenuto F, Di Nardo P, et al. Extrinsically conductive nanomaterials for cardiac tissue engineering applications. Micromachines (Basel), 2021, 12(8): 914.
36.	Yao Y, Ding J, Wang Z, et al. ROS-responsive polyurethane fibrous patches loaded with methylprednisolone (MP) for restoring structures and functions of infarcted myocardium in vivo. Biomaterials, 2020, 232: 119726.
37.	Ahmadi P, Nazeri N, Derakhshan M A, et al. Preparation and characterization of polyurethane/chitosan/CNT nanofibrous scaffold for cardiac tissue engineering. Int J Biol Macromol, 2021, 180: 590-598.
38.	Feng J, Shi H, Yang X, et al. Self-adhesion conductive sub-micron fiber cardiac patch from shape memory polymers to promote electrical signal transduction function. ACS Appl Mater Interfaces, 2021, 13(17): 19593-19602.
39.	Ahmad Shiekh P, Anwar Mohammed S, Gupta S, et al. Oxygen releasing and antioxidant breathing cardiac patch delivering exosomes promotes heart repair after myocardial infarction. Chem Eng J, 2022, 428: 132490.

1. Zhang B, Xu Y, Ma S, et al. Small-diameter polyurethane vascular graft with high strength and excellent compliance. J Mech Behav Biomed Mater, 2021, 121: 104614.
2. Rahmati M, Mills D K, Urbanska A M, et al. Electrospinning for tissue engineering applications. Prog Mater Sci, 2021, 117: 100721.
3. Lu X, Zou H, Liao X, et al. Construction of PCL-collagen@PCL@PCL-gelatin three-layer small diameter artificial vascular grafts by electrospinning. Biomed Mater, 2022, 18(1): 015008.
4. Moore M J, Tan R P, Yang N, et al. Bioengineering artificial blood vessels from natural materials. Trends Biotechnol, 2022, 40(6): 693-707.
5. Jamil M, Mustafa I S, Ahmed N M, et al. Cytotoxicity evaluation of poly(ethylene) oxide nanofibre in MCF-7 breast cancer cell line. Biomater Adv, 2022, 143: 213178.
6. Maliszewska I, Czapka T. Electrospun polymer nanofibers with antimicrobial activity. Polymers, 2022, 14(9): 1661.
7. Jin J, Yeom S H, Lee H J, et al. The effect of nozzle spacing on the electric field and fiber size distribution in a multi‐nozzle electrospinning system. J Appl Polym Sci, 2023, 140(16): e53764.
8. Zulkifli M Z A, Nordin D, Shaari N, et al. Overview of electrospinning for tissue engineering applications. Polymers (Basel), 2023, 15(11): 2418.
9. Zhu Y, Goh C, Shrestha A. Biomaterial properties modulating bone regeneration. Macromol Biosci, 2021, 21(4): e2000365.
10. Wu C, Wang H, Cao J. Tween-80 improves single/coaxial electrospinning of three-layered bioartificial blood vessel. J Mater Sci Mater Med, 2022, 34(1): 6.
11. Shrestha B K, Shrestha S, Tiwari A P, et al. Bio-inspired hybrid scaffold of zinc oxide-functionalized multi-wall carbon nanotubes reinforced polyurethane nanofibers for bone tissue engineering. Mater Design, 2017, 133: 69-81.
12. Ghorai S K, Roy T, Maji S, et al. A judicious approach of exploiting polyurethane-urea based electrospun nanofibrous scaffold for stimulated bone tissue regeneration through functionally nobbled nanohydroxyapatite. Chem Eng J, 2022, 429: 132179.
13. Tang J, Zhang Y, Fang W, et al. Electrophysiological microenvironment and site-specific cell behaviors regulated by fibrous aniline trimer-based polyurethanes in bone progressive regeneration. Chem Eng J, 2023, 460: 141630.
14. Jaganathan S K, Mani M P, Ismail A F, et al. Tailor‐made multicomponent electrospun polyurethane nanofibrous composite scaffold comprising olive oil, honey, and propolis for bone tissue engineering. Polym Composite, 2018, 40(5): 2039-2050.
15. Jaganathan S K, Mani M P, Palaniappan S K, et al. Fabrication and characterisation of nanofibrous polyurethane scaffold incorporated with corn and neem oil using single stage electrospinning technique for bone tissue engineering applications. J Polym Res, 2018, 25(7): 146.
16. Darvishi E, Kahrizi D, Arkan E, et al. Preparation of bio-nano bandage from quince seed mucilage/ZnO nanoparticles and its application for the treatment of burn. J Mol Liq, 2021, 339: 116598.
17. Hsu K F, Chiu Y L, Chiao H Y, et al. Negative-pressure wound therapy combined with artificial dermis (Terudermis) followed by split-thickness skin graft might be an effective treatment option for wounds exposing tendon and bone: A retrospective observation study. Medicine (Baltimore), 2021, 100(14): e25395.
18. Ghosh S, Haldar S, Gupta S, et al. Single unit functionally graded bioresorbable electrospun scaffold for scar-free full-thickness skin wound healing. Biomater Adv, 2022, 139: 212980.
19. Sheikholeslam M, Wright M E E, Jeschke M G, et al. Biomaterials for skin substitutes. Adv Healthc Mater, 2018, 7(5): 1700897.
20. Wang Y, Beekman J, Hew J, et al. Burn injury: Challenges and advances in burn wound healing, infection, pain and scarring. Adv Drug Deliv Rev, 2018, 123: 3-17.
21. Chen X, Zhao R, Wang X, et al. Electrospun mupirocin loaded polyurethane fiber mats for anti-infection burn wound dressing application. J Biomater Sci Polym Ed, 2017, 28(2): 162-176.
22. Sheikholeslam M, Wright M E E, Cheng N, et al. Electrospun polyurethane-gelatin composite: A new tissue-engineered scaffold for application in skin regeneration and repair of complex wounds. ACS Biomater Sci Eng, 2020, 6(1): 505-516.
23. Wan X, Liu S, Xin X, et al. S-nitrosated keratin composite mats with NO release capacity for wound healing. Chem Eng J, 2020, 400: 125964.
24. Sofi H S, Abdal-Hay A, Rashid R, et al. Electrospun polyurethane fiber mats coated with fish collagen layer to improve cellular affinity for skin repair. Sustain Mater Techno, 2022, 34: e00523.
25. Zhang P X, Han N, Kou Y H, et al. Tissue engineering for the repair of peripheral nerve injury. Neural Regen Res, 2019, 14(1): 51-58.
26. Shrestha S, Shrestha B K, Lee J, et al. A conducting neural interface of polyurethane/silk-functionalized multiwall carbon nanotubes with enhanced mechanical strength for neuroregeneration. Mater Sci Eng C Mater Biol Appl, 2019, 102: 511-523.
27. Thampi S, Thekkuveettil A, Muthuvijayan V, et al. Accelerated outgrowth of neurites on graphene oxide-based hybrid electrospun fibro-porous polymeric substrates. ACS Appl Bio Mater, 2020, 3(4): 2160-2169.
28. Nasab S T, Roodbari N H, Goodarzi V, et al. Nanobioglass enhanced polyurethane/collagen conduit in sciatic nerve regeneration. J Biomed Mater Res B, 2021, 110(5): 1093-1102.
29. Alipour H, Alizadeh A, Azarpira N, et al. Incorporating fingolimod through poly(lactic‐co‐glycolic acid) nanoparticles in electrospun polyurethane/polycaprolactone/gelatin scaffold: An in vitro study for nerve tissue engineering. Polym Advan Technol, 2022, 33(8): 2589-2600.
30. Lee D Y, Jang Y, Kim E, et al. Tissue-engineered vascular graft based on a bioresorbable tubular knit scaffold with flexibility, durability, and suturability for implantation. J Mater Chem B, 2023, 11(5): 1108-1114.
31. Jaganathan S K, Mani M P, Ayyar M, et al. Engineered electrospun polyurethane and castor oil nanocomposite scaffolds for cardiovascular applications. J Mater Sci, 2017, 52(18): 10673-10685.
32. Abdal-Hay A, Bartnikowski M, Hamlet S, et al. Electrospun biphasic tubular scaffold with enhanced mechanical properties for vascular tissue engineering. Mater Sci Eng C Mater Biol Appl, 2018, 82: 10-18.
33. Post A, Kishan A P, Diaz-Rodriguez P, et al. Introduction of sacrificial bonds to hydrogels to increase defect tolerance during suturing of multilayer vascular grafts. Acta Biomater, 2018, 69: 313-322.
34. Zhang Y, Jiao Y, Wang C, et al. Design and characterization of small-diameter tissue-engineered blood vessels constructed by electrospun polyurethane-core and gelatin-shell coaxial fiber. Bioengineered, 2021, 12(1): 5769-5788.
35. Ul Haq A, Carotenuto F, Di Nardo P, et al. Extrinsically conductive nanomaterials for cardiac tissue engineering applications. Micromachines (Basel), 2021, 12(8): 914.
36. Yao Y, Ding J, Wang Z, et al. ROS-responsive polyurethane fibrous patches loaded with methylprednisolone (MP) for restoring structures and functions of infarcted myocardium in vivo. Biomaterials, 2020, 232: 119726.
37. Ahmadi P, Nazeri N, Derakhshan M A, et al. Preparation and characterization of polyurethane/chitosan/CNT nanofibrous scaffold for cardiac tissue engineering. Int J Biol Macromol, 2021, 180: 590-598.
38. Feng J, Shi H, Yang X, et al. Self-adhesion conductive sub-micron fiber cardiac patch from shape memory polymers to promote electrical signal transduction function. ACS Appl Mater Interfaces, 2021, 13(17): 19593-19602.
39. Ahmad Shiekh P, Anwar Mohammed S, Gupta S, et al. Oxygen releasing and antioxidant breathing cardiac patch delivering exosomes promotes heart repair after myocardial infarction. Chem Eng J, 2022, 428: 132490.

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