Analysis on the Risk Factors of Infection in Late-onset Systemic Lupus Erythematosus Patients_West China Medical Journal

Authors：

LIU Yi , TANG Honghu ,  ZHAO Yi

Department of Rheumatology and Immunology, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, P. R. China;

Corresponding author：

ZHAO Yi, Email: year61@163.com

Keywords：

老年; 红斑狼疮，系统性; 感染; 危险因素

DOI：

10.7507/1002-0179.20130008

Video：

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目的　回顾性研究老年系统性红斑狼疮（SLE）患者合并感染的危险因素。方法　选取1995年1月－2009年12月间在四川大学华西医院确诊为SLE，起病年龄为50周岁以上的158例患者，收集性别、临床表现、疾病活动度、实验室检查指标、合并症以及并发症等进行单因素分析或多因素非条件logistic回归分析。结果　所纳入的158例患者中，合并感染53例（占33.5%），采用单因素分析显示疾病活动性（P=0.001）、低蛋白血症（P=0.030）、糖尿病（P=0.003）、肺间质病变（P=0.000）与老年SLE患者感染发生有关。经logistic回归分析显示，疾病活动性（OR=7.533，P=0.000）、肺间质病变（OR=19.762，P=0.000）、糖尿病（OR=6.862，P=0.025）是老年SLE患者感染发生的危险因素。结论　积极控制老年SLE的疾病活动度，减少危险因素的发生是控制老年SLE患者并发感染的有效手段。

Citation： LIU Yi,TANG Honghu,ZHAO Yi. Analysis on the Risk Factors of Infection in Late-onset Systemic Lupus Erythematosus Patients. West China Medical Journal, 2013, 28(1): 28-31. doi: 10.7507/1002-0179.20130008 Copy

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1. 　Rovensky J, Tuchynová A. Systemic lupus erythematosus in the elderly[J]. Autoimmun Rev, 2008, 7(3): 235-239.
2. 　Padovan M, Govoni M, Castellino G, et al. Late onset systemic lupus erythematosus: no substantial differences using different cut-off ages[J]. Rheumatol Int, 2007, 27(8): 735-741.
3. 　Boddaert J, Huong DL, Amoura Z, et al. Late-onset systemic lupus erythematosus: a personal series of 47 patients and pooled analysis of 714 cases in the literature[J]. Medicine (Baltimore), 2004, 83(6): 348-359.
4. 　Ho CT, Mok CC, Lau CS, et al. Late onset systemic lupus erythematosus in southern Chinese[J]. Ann Rheum Dis, 1998, 57(7): 437-440.
5. 　Appenzeller S, Pereira DA, Costallat LT. Greater accrual damage in late-onset systemic lupus erythematosus: a long-term follow-up study[J]. Lupus, 2008, 17(11): 1023-1028.
6. 　Lalani S, Pope J, de Leon F, et al. Clinical features and prognosis of late-onset systemic lupus erythematosus: results from the 1000 faces of lupus study[J]. J Rheumatol, 2010, 37(1): 38-44.
7. 　Chen TL, Wong CH, Lee CH, et al. Systemic lupus erythematosus in the elderly[J]. Int J Gerontol, 2009, 3(2): 108-113.
8. 　Hochberg MC. Updating the American College of Rheumatology revised criteria for the classification of systemic lupus erythematosus[J]. Arthritis Rheum, 1997, 40(9): 1725.
9. 　Bernatsky S, Boivin JF, Joseph L, et al. Mortality in systemic lupus erythematosus[J]. Arthritis Rheum, 2006, 54(8): 2550-2557.
10. 　Gladman DD, Hussain F, Ibañez D, et al. The nature and outcome of infection in systemic lupus erythematosus[J]. Lupus, 2002, 11(4): 234-239.
11. 　裘昊旻, 宣丹旦, 邹和建. 系统性红斑狼疮合并感染130例回顾性分析[J]. 中华风湿病学杂志, 2009, 13(6): 390-393.
12. 　郑莉, 王忠明, 林辉. 系统性红斑狼疮（SLE）患者合并感染临床分析[J].华西医学, 2007, 22(1): 33-34.

West China Medical Journal

Analysis on the Risk Factors of Infection in Late-onset Systemic Lupus Erythematosus Patients

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