Expression of Monocyte Chemoattractant Protein-4 in Patients with Systemic Lupus Erythematosus and Its Clinical Significance_West China Medical Journal

Authors：

ZHANG Jie ¹ ,  LI Jiangtao ¹ , YANG Nanping. ²

1. Department of Rheumatology and Immunology, the First People’s Hospital of Yibin, Yibin, Sichuan 644000, P. R. China; 2. Department of Rheumatology and Immunology, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, P. R. China;

Corresponding author：

LI Jiangtao, Email: 810934482@qq.com

Keywords：

单核细胞趋化蛋白-4; 红斑狼疮，系统性; 表达

DOI：

10.7507/1002-0179.20130009

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目的　研究C-C亚族趋化因子单核细胞趋化蛋白-4（MCP-4/CCL13）在系统性红斑狼疮（SLE）患者外周血的表达水平，并分析MCP-4的水平与狼疮肾炎的关系，以探讨MCP-4在SLE发病机制中可能起的作用。方法　选取2007年9月－2010年8月在四川大学华西医院和宜宾市第一人民医院诊断明确的SLE及类风湿关节炎（RA）患者各40例。另收入正常健康对照组（20例），应用酶联免疫吸附试验定量方法测定SLE组、RA患者和正常健康对照者血清中MCP-4的水平，SLE患者根据有无肾脏受累分为非狼疮肾炎组和狼疮肾炎组，其中非狼疮肾炎组20例，狼疮肾炎组20例，并分析SLE组血清MCP-4水平是否与抗核抗体、补体C3、C4等指标及SLE疾病活动指数SLEDAI评分相关性，血清MCP-4水平采用方差分析、LSD-t检验和Spearman相关进行统计分析。结果　血清MCP-4水平SLE组为（216.32 ± 12.65）pg/mL，RA组为（203.79 ± 18.64）pg/mL，正常健康对照组为（125.13 ± 11.08）pg/mL。SLE组、RA组血清MCP-4水平与正常健康对照组相比均有统计学意义（P＜0.05），SLE组与RA组比较血清MCP-4水平无统计学意义（P＞0.05）；SLE患者中狼疮肾炎组与非狼疮肾炎组比较血清MCP-4水平无统计学意义（P＞0.05）。SLE组血清MCP-4水平与抗核抗体、补体C3、C4等指标及SLEDAI评分无相关性。结论　MCP-4在SLE组患者血清中表达增高，MCP-4可能参与了SLE的发病过程，可能成为SLE新的血清学有用指标并作为治疗的靶点。

Citation： ZHANG Jie,LI Jiangtao,YANG Nanping.. Expression of Monocyte Chemoattractant Protein-4 in Patients with Systemic Lupus Erythematosus and Its Clinical Significance. West China Medical Journal, 2013, 28(1): 32-35. doi: 10.7507/1002-0179.20130009 Copy

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2.	Iikuni N, Okamoto H, Yoshio T, et al. Raised monocyte chemotactic protein-1 (MCP-1)/CCL2 in cerebrospinal fluid of patients with neuropsychiatric lupus[J]. Ann Rheum Dis, 2006, 65(2): 253-256.
3.	刘杰, 孙晗笑. 单核细胞趋化蛋白-1生物学特性及应用研究[J]. 生命的化学，2001, 21(6): 445-447.
4.	Radstake TR, van der Voort R, ten Brummelhuis M, et al. Increased expression of CCL18, CCL19, and CCL17 by dendritic cells from patients with rheumatoid arthritis, and regulation by Fc gamma receptors[J]. Ann Rheumatic Dis, 2005, 64(3): 359-367.
5.	Eriksson C, Eneslatt K, Ivanoff J, et al. Abnormal expression of chemokine receptors on T-cells from patients with systemic lupus erythematosus[J]. Lupus, 2003,12(10): 766-774.
6.	Lit LC, Wong CK, Tam LS, et al. Raised plasma concentration and ex vivo production of inflammatory chemokines in patients with systemic lupus erythematosus[J]. Ann Rheum Dis, 2006, 65(2): 209-215.
7.	Lu XY, Zhu CQ, Qian J, et al. Intrathecal cytokine and chemokine profiling in neuropsychiatric lupus or lupus complicated with central nervous system infection[J]. Lupus, 2010, 19(6): 689-695.
8.	郝伟丽, 周晓鸿, 邓丹琪, 等. 治疗干预对SLE患者血清和尿液MCP-1水平的影响[J]. 中国皮肤性病学杂志, 2010, 24(8): 705-707.
9.	摇顺华. MCP-1及IL-10在狼疮性肾炎及其相关疾病活动度的临床意义[J]. 放射免疫学杂志, 2012, 25(2): 199-201.
10.	Singh RG, Usha, Rathore SS, et al. Urinary MCP-1 as diagnostic and prognostic marker in patients with lupus nephritis flare[J]. Lupus, 2012, 21(11): 1214-1218.
11.	Malafronte P, Vieira JM Jr, Pereira AC, et al. Association of the MCP-1 –2518 A/G polymorphism and no association of its receptor CCR2 –64 V/I polymorphism with lupus nephritis[J]. J Rheumatol, 2010, 37(4): 776-782.
12.	Lamkhioued B, Garcia-Zepeda EA, Abi-Younes S, et al. Monocyte chemoattractant protein (MCP)-4 expression in the airways of patients with induction in epithelial cells and mononuclear cells by proinflammatory cytokines[J]. Am J Respir Crit Care Med, 2000, 162(2): 723-732.
13.	Taha RA, Minshall EM, Leung DY, et al. Evidence for increased expression of eotaxin and monocyte chemotactic protein-4 in atopic dermatitis[J]. J Allergy Clin Immunol, 2000, 105(5): 1002-1007.
14.	Taha RA, Laberge S, Hamid Q, et al. Increased expression of the chemoattractant cytokines eotaxin, monocyte chemotactic protein-4, and interleukin-16 in induced sputum in asthmatic patients[J]. Chest, 2001, 120(2): 595-601.
15.	Iwamoto T, Okamoto H, Iikuni N, et al. Monocyte chemoattractant protein-4 (MCP-4)/CCL13 is highly expressed in cartilage from patients with rheumatoid arthritis[J]. Rheumatology, 2006, 45(4): 421-424.
16.	徐婷，顾志峰，吴敏，等. 脐带间质干细胞移植治疗对MRL/lpr狼疮鼠单核细胞趋化蛋白-1的影响[J]. 交通医学, 2011, 25(4): 325-332.

1. 　Kulkarni O, Pawar RD, Purschke W, et al. Spiegelmer inhibition of CCL2/MCP-1 ameliorates lupus nephritis in MRL-(Fas)lpr mice[J]. J Am Soc Nephrol, 2007, 18(8): 2350-2358.
2. 　Iikuni N, Okamoto H, Yoshio T, et al. Raised monocyte chemotactic protein-1 (MCP-1)/CCL2 in cerebrospinal fluid of patients with neuropsychiatric lupus[J]. Ann Rheum Dis, 2006, 65(2): 253-256.
3. 　刘杰, 孙晗笑. 单核细胞趋化蛋白-1生物学特性及应用研究[J]. 生命的化学，2001, 21(6): 445-447.
4. 　Radstake TR, van der Voort R, ten Brummelhuis M, et al. Increased expression of CCL18, CCL19, and CCL17 by dendritic cells from patients with rheumatoid arthritis, and regulation by Fc gamma receptors[J]. Ann Rheumatic Dis, 2005, 64(3): 359-367.
5. 　Eriksson C, Eneslatt K, Ivanoff J, et al. Abnormal expression of chemokine receptors on T-cells from patients with systemic lupus erythematosus[J]. Lupus, 2003,12(10): 766-774.
6. 　Lit LC, Wong CK, Tam LS, et al. Raised plasma concentration and ex vivo production of inflammatory chemokines in patients with systemic lupus erythematosus[J]. Ann Rheum Dis, 2006, 65(2): 209-215.
7. 　Lu XY, Zhu CQ, Qian J, et al. Intrathecal cytokine and chemokine profiling in neuropsychiatric lupus or lupus complicated with central nervous system infection[J]. Lupus, 2010, 19(6): 689-695.
8. 　郝伟丽, 周晓鸿, 邓丹琪, 等. 治疗干预对SLE患者血清和尿液MCP-1水平的影响[J]. 中国皮肤性病学杂志, 2010, 24(8): 705-707.
9. 　摇顺华. MCP-1及IL-10在狼疮性肾炎及其相关疾病活动度的临床意义[J]. 放射免疫学杂志, 2012, 25(2): 199-201.
10. 　Singh RG, Usha, Rathore SS, et al. Urinary MCP-1 as diagnostic and prognostic marker in patients with lupus nephritis flare[J]. Lupus, 2012, 21(11): 1214-1218.
11. 　Malafronte P, Vieira JM Jr, Pereira AC, et al. Association of the MCP-1 –2518 A/G polymorphism and no association of its receptor CCR2 –64 V/I polymorphism with lupus nephritis[J]. J Rheumatol, 2010, 37(4): 776-782.
12. 　Lamkhioued B, Garcia-Zepeda EA, Abi-Younes S, et al. Monocyte chemoattractant protein (MCP)-4 expression in the airways of patients with induction in epithelial cells and mononuclear cells by proinflammatory cytokines[J]. Am J Respir Crit Care Med, 2000, 162(2): 723-732.
13. 　Taha RA, Minshall EM, Leung DY, et al. Evidence for increased expression of eotaxin and monocyte chemotactic protein-4 in atopic dermatitis[J]. J Allergy Clin Immunol, 2000, 105(5): 1002-1007.
14. 　Taha RA, Laberge S, Hamid Q, et al. Increased expression of the chemoattractant cytokines eotaxin, monocyte chemotactic protein-4, and interleukin-16 in induced sputum in asthmatic patients[J]. Chest, 2001, 120(2): 595-601.
15. 　Iwamoto T, Okamoto H, Iikuni N, et al. Monocyte chemoattractant protein-4 (MCP-4)/CCL13 is highly expressed in cartilage from patients with rheumatoid arthritis[J]. Rheumatology, 2006, 45(4): 421-424.
16. 　徐婷，顾志峰，吴敏，等. 脐带间质干细胞移植治疗对MRL/lpr狼疮鼠单核细胞趋化蛋白-1的影响[J]. 交通医学, 2011, 25(4): 325-332.

West China Medical Journal

Expression of Monocyte Chemoattractant Protein-4 in Patients with Systemic Lupus Erythematosus and Its Clinical Significance

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