Clinicopathological Analysis of Primary Signet Ring Cell Adenocarcinoma of the Lung_West China Medical Journal

Authors：

Department of Pathology, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, P. R. China;

Corresponding author：

Keywords：

肺肿瘤; 癌，印戒细胞; 免疫组织化学; 诊断; 存活率分析; 预后

DOI：

10.7507/1002-0179.20130222

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目的　探讨原发性肺印戒细胞腺癌（PSRCACL）的临床病理学特点、诊断与鉴别诊断及其预后因素等。方法　收集2000年1月－2012年6月间50例PSRCACL患者的临床资料，进行组织学及免疫组织化学检测观察，并进行随访和结合文献复习分析。结果　 PSRCACL的临床症状及影像学表现与非小细胞肺癌无明显差异，其诊断与鉴别诊断依据其特殊的细胞形态学及免疫组织化学检测。PSRCACL的发病率约占肺腺癌的1.20%，平均发病年龄为53.3岁，中位年龄为54.5岁，男女比例为1.17︰1。患者的中位生存时间约为56个月，1年生存率约为85.4%，3年生存率约为67.4%，5年生存率约为40.9%。患者的生存率与患者的性别、年龄无关（P＞0.05），与肿瘤的大小、是否伴有癌转移及TNM分期有关（P＜0.05）。结论　PSRCACL是一种比较罕见的、好发于中青年人、恶性程度较高、易发生侵袭和转移、预后较差的恶性上皮性肿瘤，除手术治疗外，目前尚无标准化疗方案。

Citation： HE Xin,LIANG Dongni,CAO Yidan,YE Yunxia,JIANG Lili,ZHANG Shangfu.. Clinicopathological Analysis of Primary Signet Ring Cell Adenocarcinoma of the Lung. West China Medical Journal, 2013, 28(5): 710-714. doi: 10.7507/1002-0179.20130222 Copy

1.	Tsuta K, Ishii G, Yoh K, et al. Primary lung carcinoma with signet-ring cell carcinoma components: clinicopathological analysis of 39 cases[J]. Am J Surg Pathol, 2004, 28(7): 868-874.
2.	Shimosato Y, Suemasu K, Suzuki A. Morphology of bronchial gland tumors, with special reference to adenocarcinomas[J]. Gan No Rinsho, 1973, 19(2): 170-179.
3.	Kish JK, Ro JY, Ayala AG, et al. Primary mucinous adenocarcinoma of the lung with signet-ring cells: a histochemical comparison with signet-ring cell carcinomas of other sites[J]. Hum Pathol, 1989, 20(11): 1097-1102.
4.	Travis WD, Brambilla E, Müller-Hermelink HK, et al. Pathology and genetics of tumours of the lung, pleura, thymus and heart[M]. Lyon: IARC Press, 2004: 10.
5.	Castro CY, Moran CA, Flieder DG, et al. Primary signet ring cell adenocarcinomas of the lung: Aclinicopathological study of 15 cases[J]. Histopathology, 2001, 39(4): 397-401.
6.	Yoshida A, Tsuta K, Watanabe S, et al. Frequent ALK rearrangement and TTF-1/p63 co-expression in lung adenocarcinoma with signet-ring cell component[J]. Lung Cancer, 2011, 72(3): 309-315.
7.	Wang YJ, Liu CT, Li HX, et al. A clinical study of 12 patients with primary signet ring cell carcinoma of lung and literature review[J]. Med J China PAPF, 2010, 21(4): 324-326.
8.	Merchant SH, Amin MB, Tamboli P, et al. Primary signet-ring cell arcinoma of lung: immunohistochemical study and comparison with on-pulmonary signet-ring cell carcinomas[J]. Am J Surg Pathol, 2001, 25(12): 1515-1519.
9.	Hayashi H, Kitamura H, Nakatani Y, et al. Primary signet-ring cell carcinoma of the lung: histochemical and immunohistochemical characterization[J]. Hum Pathol, 1999, 30(4): 378-383.
10.	郑玉龙, 丁伟, 周建英．原发性肺印戒细胞癌临床表现[J]．浙江预防医学, 2008, 20(5): 87-88．.
11.	杨柳青, 秦叔逵, 华海清．原发性右肺印戒细胞癌1例[J]．临床肿瘤学杂志, 2005, 10(3): 335．.
12.	王琳, 张楚, 赵建华, 等．国人原发性肺印戒细胞癌伴EML4-ALK融合基因阳性1例[J]．临床肿瘤学杂志, 2012, 17(4): 381-382．.

1. 　Tsuta K, Ishii G, Yoh K, et al. Primary lung carcinoma with signet-ring cell carcinoma components: clinicopathological analysis of 39 cases[J]. Am J Surg Pathol, 2004, 28(7): 868-874.
2. 　Shimosato Y, Suemasu K, Suzuki A. Morphology of bronchial gland tumors, with special reference to adenocarcinomas[J]. Gan No Rinsho, 1973, 19(2): 170-179.
3. 　Kish JK, Ro JY, Ayala AG, et al. Primary mucinous adenocarcinoma of the lung with signet-ring cells: a histochemical comparison with signet-ring cell carcinomas of other sites[J]. Hum Pathol, 1989, 20(11): 1097-1102.
4. 　Travis WD, Brambilla E, Müller-Hermelink HK, et al. Pathology and genetics of tumours of the lung, pleura, thymus and heart[M]. Lyon: IARC Press, 2004: 10.
5. 　Castro CY, Moran CA, Flieder DG, et al. Primary signet ring cell adenocarcinomas of the lung: Aclinicopathological study of 15 cases[J]. Histopathology, 2001, 39(4): 397-401.
6. 　Yoshida A, Tsuta K, Watanabe S, et al. Frequent ALK rearrangement and TTF-1/p63 co-expression in lung adenocarcinoma with signet-ring cell component[J]. Lung Cancer, 2011, 72(3): 309-315.
7. 　Wang YJ, Liu CT, Li HX, et al. A clinical study of 12 patients with primary signet ring cell carcinoma of lung and literature review[J]. Med J China PAPF, 2010, 21(4): 324-326.
8. 　Merchant SH, Amin MB, Tamboli P, et al. Primary signet-ring cell arcinoma of lung: immunohistochemical study and comparison with on-pulmonary signet-ring cell carcinomas[J]. Am J Surg Pathol, 2001, 25(12): 1515-1519.
9. 　Hayashi H, Kitamura H, Nakatani Y, et al. Primary signet-ring cell carcinoma of the lung: histochemical and immunohistochemical characterization[J]. Hum Pathol, 1999, 30(4): 378-383.
10. 　郑玉龙, 丁伟, 周建英．原发性肺印戒细胞癌临床表现[J]．浙江预防医学, 2008, 20(5): 87-88．.
11. 　杨柳青, 秦叔逵, 华海清．原发性右肺印戒细胞癌1例[J]．临床肿瘤学杂志, 2005, 10(3): 335．.
12. 　王琳, 张楚, 赵建华, 等．国人原发性肺印戒细胞癌伴EML4-ALK融合基因阳性1例[J]．临床肿瘤学杂志, 2012, 17(4): 381-382．.

West China Medical Journal

Clinicopathological Analysis of Primary Signet Ring Cell Adenocarcinoma of the Lung

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