Comparison between Butorphanol and Fentanyl Used for Patient-controlled Intravenous Analgesia after Abdominal Surgery_West China Medical Journal

Authors：

LUO Xiongying , LI Lingling , CHEN Tao , TAO Yanzhi , LEI Da.

Department of Anesthesia, Sichuan Hospital of Integrated Traditional and Western Medicine, Chengdu, Sichuan 610041, P. R. China;

Corresponding author：

Keywords：

酒石酸布托啡诺; 舒芬太尼; 自控静脉镇痛; 不良反应

DOI：

10.7507/1002-0179.20130272

Video：

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目的　通过对腹部手术后自控静脉镇痛（PCIA）不同药物配方的研究，探讨酒石酸布托啡诺与舒芬太尼用于术后PCIA临床效果。方法　将2012年2月－8月收治的60例麻醉分级为Ⅰ～Ⅲ级需术后镇痛的腹部手术患者（均无心、肺、肝、肾、脑、内分泌疾病及过敏史）随机分成两组：酒石酸布托啡诺组（N组，n=30），舒芬太尼组（S组，n=30）。观察镇痛效果和不良反应发生率。结果　两组镇痛效果差异无统计学意义（P＞0.05），不良反应（包括恶心、呕吐、头晕、嗜睡、皮肤瘙痒、呼吸抑制、尿潴留等），N组发生率均低于S组（P＜0.05）。结论　酒石酸布托啡诺用于PCIA安全、有效，不良反应少。

Citation： LUO Xiongying,LI Lingling,CHEN Tao,TAO Yanzhi,LEI Da.. Comparison between Butorphanol and Fentanyl Used for Patient-controlled Intravenous Analgesia after Abdominal Surgery. West China Medical Journal, 2013, 28(6): 868-870. doi: 10.7507/1002-0179.20130272 Copy

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1. 　毕娜, 姚梅芳, 徐美英. 术后疼痛及止痛的进展[J]. 国外医学护理学分册, 1999, 18(5): 211-214.
2. 　连庆泉, 李军. 围术期疼痛治疗的新理念[J]. 现代实用医学, 2005, 17(2): 116-118.
3. 　耿莉华, 宋雁宾. 外科手术后疼痛的控制进展[J]. 实用护理杂志, 1999, 15(9): 12.
4. 　刘俊杰, 赵俊, 译. 现代麻醉学[M]. 2版. 北京: 人民卫生出版社, 1997: 1431.
5. 　蒋宗滨, 谭冠先, 胡振快, 等. 手术病人对术后镇痛认识程度的调查[J]. 中国疼痛医学杂志, 1998, 4(4): 197-201.
6. 　金昔陆. μ阿片受体激动剂舒芬太尼的药理作用与应用[J]. 中国现代应用药学杂志, 1999, 16(1): 57-62.
7. 　Bonnet F, Vésinet C. A review of the use of fentanyl analgesia in the management of acute pain in adults[J]. Anesthesiology, 1999, 90(2): 576-599.
8. 　Butelman ER, Winger G, Zernig G, et al. Butorphanol: characterization of agonist and antagonist effects in rhesus monkeys[J]. J Pharmacol Exp Ther, 1995, 272(2): 845-853.
9. 　Preston KL, Bigelow GE, Liebson IA. Discrimination of butorphanol and nalbuphine in opioid-dependent humans[J]. Pharmacol Biochem Behav, 1990, 37(3): 511-522.
10. 　Vogelsang J, Butorphanoltartrate HS. (stado1):a review[J]. J Post AnesthNuts, 1991, 6(2): 129-135.
11. 　戴体俊, 喻田, 译. 麻醉药理学[M]. 3版. 北京: 人民卫生出版社, 2011: 53.
12. 　杭燕南. 当代麻醉与复苏[M]. 上海: 上海科技出版社, 1994: 115-120.
13. 　李慧禄, 王少超, 孙梅杰. 布托啡诺剖宫产术后硬膜外镇痛效果[J]. 临床麻醉学杂志, 2006, 22(6): 473.
14. 　Chang KJ, Wei ET, Killian A, et al. Potent morphiceptin analogs: structure activity relationships and morphine-like activities[J]. J Pharmacol Exp Ther, 1983, 227(2): 403-408.
15. 　Garner HR, Burke TF, Lawhorn CD, et al. Butorphanol-mediated antinociception in mice: partial agonist effects and mu receptor involvement[J]. J Pharmacol Exp Ther, 1997, 282(3): 1253-1261.
16. 　Gilman AG, Goodman LS, Gilman A, et al. Pharmacological basis of therapeutics[M]. 8th ed. 1990: 508-513.
17. 　Bowdle TA, Greichen SL, Bjurstrom RL, et al. Butorphanol improves CO2 response and ventilation after fentanyl anesthesia[J]. Anesth Analg, 1987, 66(6): 517-522.
18. 　何蕾, 张小洺, 徐亮. 酒石酸布托啡诺与芬太尼联合用于妇科患者术后静脉自控镇痛的临床研究[J]. 华西医学, 2012, 27(3): 63-66.

West China Medical Journal

Comparison between Butorphanol and Fentanyl Used for Patient-controlled Intravenous Analgesia after Abdominal Surgery

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