The Expression of Inhibitor of Differentiation-1 in Hepatoma Tissues and Its Correlation with Prognosis_West China Medical Journal

Authors：

DENG Hongyu , ZHU Jie ,  YANG Li.

Gold Ward, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, P. R. China;

Corresponding author：

YANG Li., Email: realggyy@21cn.com

Keywords：

分化抑制因子1; 肝癌; 预后

DOI：

10.7507/1002-0179.20130273

Video：

Export PDF Favorites Scan Get Citation

Abstract Full text Figures/Tables Video References Cited by

目的　检测分化抑制因子1（Id-1）在肝细胞肝癌组织中和正常肝组织中的表达情况，了解Id-1与肝细胞肝癌患者预后关系。方法　对获得的19例肝细胞肝癌组织标本和8例正常肝组织进行免疫组织化学染色，并对染色结果进行分级。借助SPSS软件，分析肝细胞肝癌组织标本与正常肝组织标本中的Id-1表达强度区别，Id-1与甲胎蛋白（AFP）相关性，及Id-1表达强度与肝癌患者预后之间的关系。结果　免疫组织化学染色结果显示所有标本均表达为阳性，其中3例（+），7例（++），10例（+++）7例（++++），肝细胞肝癌组织标本与正常肝组织标本差异有统计学意义（P＜0.05）；Id-1表达与血液中AFP水平相关不显著（r=−0.121，P=0.621）；Spearman等级相关分析显示患者生存时间与Id-1表达呈负相关（r=−0.567，P=0.011）。结论　Id-1在肝癌组织中表达增高，Id-1表达水平与生存时间呈负相关，但和AFP无明显相关。

Citation： DENG Hongyu,ZHU Jie,YANG Li.. The Expression of Inhibitor of Differentiation-1 in Hepatoma Tissues and Its Correlation with Prognosis. West China Medical Journal, 2013, 28(6): 871-874. doi: 10.7507/1002-0179.20130273 Copy

1.	Siegel R, Naishadham D, Jemal A. Cancer statistics, 2012[J]. CA Cancer J Clin, 2012, 62(1): 10-29.
2.	Parkin DM, Bray FI, Devesa SS. Cancer burden in the year 2000. The global picture[J]. Eur J Cancer, 2001, 37(Supp18): 4-66.
3.	Block TM, Mehta AS, Fimmel CJ, et al. Molecular viral oncology of hepatocellular carcinoma[J]. Oncogene, 2003, 22(33): 5093-5107.
4.	Ruzinova MB, Benezra R. Id proteins in development, cell cycleand Cancer[J]. Trends Cell Biol, 2003, 13(8): 410-418.
5.	Norton JD. ID helix-loop-helix proteins in cell growth, differentiation and tumorigenesis[J]. J Cell Sci, 2000, 113(22): 3897-3905.
6.	Ding R, Han S, Lu Y, et al. Overexpressed Id-1 is associated with patient prognosis and HBx expression in hepatitis B virus-related hepatocellular carcinoma[J]. Cancer Biol Ther, 2010, 10(3): 299-307.
7.	Le Jossic C, Ilyin GP, Loyer P, et al. Expression of helix-loop-helix factor Id-1 is dependent on the hepatocyte proliferation and differentiation status in rat liver and in primary culture[J]. Cancer Res, 1994, 54(23): 6065-6068.
8.	Ohtani N, Zebedee Z, Huot TJ, et al. Opposing effects of Ets and Id proteins on p16INK4a expression during cellular senescence[J]. Nature, 2001, 409(6823): 1067-1070.
9.	Lee TK, Man K, Ling MT, et al. Over-expression of Id-1 induces cell proliferation in hepatocellular carcinoma through inactivation of p16INK4a/RB pathway[J]. Carcinogenesis, 2003, 24(11): 1729-1736.
10.	Alani RM, Young AZ, Shifflett CB. Id-1 regulation of cellular senescence through transcriptional repression of p16/Ink4a[J]. Proc Natl Acad Sci U S A, 2001, 98(14): 7812-7816.
11.	李晓军, 秦浚川. 分化抑制因子的研究进展[J]. 生物化学与生物物理学进展, 2004, 31(10): 865-869.
12.	Ao J, Meng J, Zhu L, et al. Activation of androgen receptor induces Id-1 and promotes hepatocellular carcinoma cell migration and invasion[J]. Mol Oncol, 2012, 6(5): 507-515.
13.	Fong S, Debs RJ, Desprez PY. Id genes and proteins as promising targets in Cancer therapy[J]. Trends Mol Med, 2004, 10(8): 387-392.
14.	宋光, 刘晶, 张男. 甲胎蛋白(AFP)与原发性肝癌早期诊断的关系[J]. 人人健康·医学导刊, 2008(5): 54-56.
15.	Forootan SS, Wong YC, Dodson A, et al. Increased Id-1 expression is significantly associated with poor survival of patients with prostate Cancer[J]. Hum Pathol, 2007, 38(9): 1321-1329.
16.	Perk J, Iavarone A, Benezra R, et al. Id family of helix-loop-helix proteins in Cancer[J]. Nat Rev Cancer, 2005, 5(8): 603-614.

1. 　Siegel R, Naishadham D, Jemal A. Cancer statistics, 2012[J]. CA Cancer J Clin, 2012, 62(1): 10-29.
2. 　Parkin DM, Bray FI, Devesa SS. Cancer burden in the year 2000. The global picture[J]. Eur J Cancer, 2001, 37(Supp18): 4-66.
3. 　Block TM, Mehta AS, Fimmel CJ, et al. Molecular viral oncology of hepatocellular carcinoma[J]. Oncogene, 2003, 22(33): 5093-5107.
4. 　Ruzinova MB, Benezra R. Id proteins in development, cell cycleand Cancer[J]. Trends Cell Biol, 2003, 13(8): 410-418.
5. 　Norton JD. ID helix-loop-helix proteins in cell growth, differentiation and tumorigenesis[J]. J Cell Sci, 2000, 113(22): 3897-3905.
6. 　Ding R, Han S, Lu Y, et al. Overexpressed Id-1 is associated with patient prognosis and HBx expression in hepatitis B virus-related hepatocellular carcinoma[J]. Cancer Biol Ther, 2010, 10(3): 299-307.
7. 　Le Jossic C, Ilyin GP, Loyer P, et al. Expression of helix-loop-helix factor Id-1 is dependent on the hepatocyte proliferation and differentiation status in rat liver and in primary culture[J]. Cancer Res, 1994, 54(23): 6065-6068.
8. 　Ohtani N, Zebedee Z, Huot TJ, et al. Opposing effects of Ets and Id proteins on p16INK4a expression during cellular senescence[J]. Nature, 2001, 409(6823): 1067-1070.
9. 　Lee TK, Man K, Ling MT, et al. Over-expression of Id-1 induces cell proliferation in hepatocellular carcinoma through inactivation of p16INK4a/RB pathway[J]. Carcinogenesis, 2003, 24(11): 1729-1736.
10. 　Alani RM, Young AZ, Shifflett CB. Id-1 regulation of cellular senescence through transcriptional repression of p16/Ink4a[J]. Proc Natl Acad Sci U S A, 2001, 98(14): 7812-7816.
11. 　李晓军, 秦浚川. 分化抑制因子的研究进展[J]. 生物化学与生物物理学进展, 2004, 31(10): 865-869.
12. 　Ao J, Meng J, Zhu L, et al. Activation of androgen receptor induces Id-1 and promotes hepatocellular carcinoma cell migration and invasion[J]. Mol Oncol, 2012, 6(5): 507-515.
13. 　Fong S, Debs RJ, Desprez PY. Id genes and proteins as promising targets in Cancer therapy[J]. Trends Mol Med, 2004, 10(8): 387-392.
14. 　宋光, 刘晶, 张男. 甲胎蛋白(AFP)与原发性肝癌早期诊断的关系[J]. 人人健康·医学导刊, 2008(5): 54-56.
15. 　Forootan SS, Wong YC, Dodson A, et al. Increased Id-1 expression is significantly associated with poor survival of patients with prostate Cancer[J]. Hum Pathol, 2007, 38(9): 1321-1329.
16. 　Perk J, Iavarone A, Benezra R, et al. Id family of helix-loop-helix proteins in Cancer[J]. Nat Rev Cancer, 2005, 5(8): 603-614.

West China Medical Journal

The Expression of Inhibitor of Differentiation-1 in Hepatoma Tissues and Its Correlation with Prognosis

Abstract Full text Figures/Tables Video References Cited by

Previous Article

Next Article

Format

Content