System Analysis of Cytoreductive Surgery for the Treatment of Recurrent Epithelial Ovarian Carcinoma_West China Medical Journal

Authors：

DANG Cailing ^1,2 , ZHAO Dan ³ , YANG Zhijun ¹ ,  LI Li. ¹

1. Department of Gynecologic Oncology, Affiliated Cancer Hospital of Guangxi Medical University, Nanning, Guangxi 530021, P. R. China; 2. Department of Gynecology, the Second People’ s Hospital of Yibin, Yibin, Sichuan 644000, P. R. China; 3. Deparmtne of Hematology, the First People’ s Hospital of Yibin, Yibin, Sichuan 644000, P. R. China;

Corresponding author：

LI Li., Email: cailingdang@163.com

Keywords：

复发上皮性卵巢癌; 肿瘤细胞减灭术; 系统评价

DOI：

10.7507/1002-0179.20130531

Video：

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目的　评价肿瘤细胞减灭术治疗复发上皮性卵巢癌（EOC）的作用，分析影响生存时间的因素。方法　按Cochrane系统评价方法，计算机检索PubMed、EMbase、Medline、Cochrane Library、循证医学数据库（EBMR）、中国生物医学文献数据库（CBM）、中国期刊全文数据库（CJFD）、清华同方等数据库，并手工检索相关领域杂志。检索时间从1985年1月1日－2011年11月30日，查找手术治疗复发EOC患者的回顾性、非随机前瞻性、病例对照研究，由两位研究者按照纳入排除标准筛选文献、评价质量并提取资料后，采用SPSS软件进行线性回归分析。结果　共纳入48篇文献（回顾性文献40篇，非随机前瞻性文献7篇，病例对照研究1篇）共2 605例。简单线性回归分析结果显示满意切除比例与中位生存时间回归模型成立，有统计学意义（F=7.346，P=0.009），浆液性病理类型比例与中位生存时间回归模型成立，有统计学意义（F=5.537，P=0.025），残留病灶大小与中位生存时间回归模型成立，有统计学意义（F=4.249，P=0.045），多重逐步线性回归分析显示仅有满意切除比率对术后中位生存时间的影响有统计学意义（P=0.009）。结论　二次肿瘤细胞减灭术主要适用于铂类敏感型可切除及孤立结节复发EOC患者，要获得明确二次肿瘤细胞减灭术治疗复发EOC对中位生存时间的影响，尚需进行大样本随机对照的研究。

Citation： DANG Cailing,ZHAO Dan,YANG Zhijun,LI Li.. System Analysis of Cytoreductive Surgery for the Treatment of Recurrent Epithelial Ovarian Carcinoma. West China Medical Journal, 2013, 28(11): 1678-1685. doi: 10.7507/1002-0179.20130531 Copy

1.	Jemal A, Siegel R, Xu J, et al. Cancer statistics, 2010[J]. CA Cancer J Clin, 2010, 60(5): 277-300.
2.	Griffiths CT. Surgical resection of tumor bulk in the primary treatment of ovarian carcinoma[J]. Natl Cancer Inst Monogr, 1975, 42: 101-104.
3.	Hoskins WJ, Bundy BN, Thigpen JT, et al. The influence of cytoreductive surgery on recurrence-free interval and survival in small-volume stageⅢ epithelial ovarian cancer: a gynecologic oncology group study[J]. Gynecol Oncol, 1992, 47(2): 159-166.
4.	Hoskins WJ, Mcguire WP, Brady MF, et al. The effect of diameter of largest residual disease on survival after primary cytoreductive surgery in patients with suboptimal residual epithelial ovarian carcinoma[J]. Am J Obstet Gynecol, 1994, 170(4): 974-980.
5.	Berek JS, Hacker NF, Lagasse LD, et al. Survival of patients following secondary cytoreductive surgery in ovarian cancer[J]. Obstet Gynecol, 1983, 61(2): 189-193.
6.	Morris M, Gershenson DM, Wharton JT, et al. Secondary cytoreductive surgery for recurrent epithelial ovarian cancer[J]. Gynecol Oncol, 1989, 34(3): 334-338.
7.	Janicke F, Holscher M, Kuhn W, et al. Radical surgical procedure improves survival time in patients with recurrent ovarian cancer[J]. Cancer, 1992, 70(8): 2129-2136.
8.	Segna RA, Dottino PR, Mandeli JP, et al. Secondary cytoreduction for ovarian cancer following cisplatin therapy[J]. J Clin Oncol, 1993, 11(3): 434-439.
9.	Eisenkop SM, Friedman RL, Wang HJ. Secondary cytoreductive surgery for recurrent ovarian cancer. A prospective study[J]. Cancer, 1995, 76(9): 1606-1614.
10.	Landoni F, Pellegrino A, Cormio G, et al. Platin-based chemotherapy and salvage surgery in recurrent ovarian cancer following negative second-look laparotomy[J]. Acta Obstet Gynecol Scand, 1998, 77(2): 233-237.
11.	Cormio G, di Vagno G, Cazzolla A, et al. Surgical treatment of recurrent ovarian cancer: report of 21 cases and a review of the literature[J]. Eur J Obstet Gynecol Reprod Biol, 1999, 86(2): 185-188.
12.	Zang RY, Zhang ZY, Li ZT, et al. Effect of cytoreductive surgery on survival of patients with recurrent epithelial ovarian cancer[J]. J Surg Oncol, 2000, 75(1): 24-30.
13.	Eisenkop SM, Friedman RL, Spirtos NM. The role of secondary cytoreductive surgery in the treatment of patients with recurrent epithelial ovarian carcinoma[J]. Cancer, 2000, 88(1): 144-153.
14.	Gadducci A, Iacconi P, Cosio S, et al. Complete salvage surgical cytoreduction improves further survival of patients with late recurrent ovarian cancer[J]. Gynecol Oncol, 2000, 79(3): 344-349.
15.	Zylberberg B, Dormont D, Janklewicz S, et al. Secondary cytoreductions in the treatment of ovarian cancers[J]. Gynecol Obstet Fertil, 2000, 28(2): 127-136.
16.	Tay EH, Grant PT, Gebski V, et al. Secondary cytoreductive surgery for recurrent epithelial ovarian cancer[J]. Obstet Gynecol, 2002, 99(6): 1008-1013.
17.	Bristow RE, Gossett DR, Shook DR, et al. Recurrent micropapillary serous ovarian carcinoma[J]. Cancer, 2002, 95(4): 791-800.
18.	Merideth MA, Cliby WA, Keeney GL, et al. Hepatic resection for metachronous metastases from ovarian carcinoma[J]. Gynecol Oncol, 2003, 89(1): 16-21.
19.	Yoon SS, Jarnagin WR, Fong Y, et al. Resection of recurrent ovarian or fallopian tube carcinoma involving the liver[J]. Gynecol Oncol, 2003, 91(2): 383-388.
20.	Look M, Chang D, Sugarbaker PH. Long-term results of cytoreductive surgery for advanced and recurrent epithelial ovarian cancers and papillary serous carcinoma of the peritoneum[J]. Int J Gynecol Cancer, 2003, 13(6): 764-770.
21.	Zanon C, Clara R, Chiappino I, et al. Cytoreductive surgery and intraperitoneal chemohyperthermia for recurrent peritoneal carcinomatosis from ovarian cancer[J]. World J Surg, 2004, 28(10): 1040-1045.
22.	Uzan C, Morice P, Rey A, et al. Outcomes after combined therapy including surgical resection in patients with epithelial ovarian cancer recurrence(s) exclusively in lymph nodes[J]. Ann Surg Oncol, 2004, 11(7): 658-664.
23.	Zang RY, Li ZT, Tang J, et al. Secondary cytoreductive surgery for patients with relapsed epithelial ovarian carcinoma: who benefits?[J]. Cancer, 2004, 100(6): 1152-1161.
24.	Leitao MJ, Kardos S, Barakat RR, et al. Tertiary cytoreduction in patients with recurrent ovarian carcinoma[J]. Gynecol Oncol, 2004, 95(1): 181-188.
25.	Onda T, Yoshikawa H, Yasugi T, et al. Secondary cytoreductive surgery for recurrent epithelial ovarian carcinoma: proposal for patients selection[J]. Br J Cancer, 2005, 92(6): 1026-1032.
26.	Gungor M, Ortac F, Arvas M, et al. The role of secondary cytoreductive surgery for recurrent ovarian cancer[J]. Gynecol Oncol, 2005, 97(1): 74-79.
27.	Gronlund B, Lundvall L, Christensen IJ, et al. Surgical cytoreduction in recurrent ovarian carcinoma in patients with complete response to paclitaxel-platinum[J]. Eur J Surg Oncol, 2005, 31(1): 67-73.
28.	Ayhan A, Gultekin M, Taskiran C, et al. The role of secondary cytoreduction in the treatment of ovarian cancer: Hacettepe University experience[J]. Am J Obstet Gynecol, 2006, 194(1): 49-56.
29.	Chi DS, Mccaughty K, Diaz JP, et al. Guidelines and selection criteria for secondary cytoreductive surgery in patients with recurrent, platinum-sensitive epithelial ovarian carcinoma[J]. Cancer, 2006, 106(9): 1933-1939.
30.	Manci N, Bellati F, Muzii L, et al. Splenectomy during secondary cytoreduction for ovarian cancer disease recurrence: surgical and survival data[J]. Ann Surg Oncol, 2006, 13(12): 1717-1723.
31.	Matsumoto A, Higuchi T, Yura S, et al. Role of salvage cytoreductive surgery in the treatment of patients with recurrent ovarian cancer after platinum-based chemotherapy[J]. J Obstet Gynaecol Res, 2006, 32(6): 580-587.
32.	Harter P, du Bois A, Hahmann M, et al. Surgery in recurrent ovarian cancer: the Arbeitsgemeinschaft Gynaekologische Onkologie (AGO) DESKTOP OVAR trial[J]. Ann Surg Oncol, 2006, 13(12): 1702-1710.
33.	Park JY, Seo SS, Kang S, et al. The benefits of low anterior en bloc resection as part of cytoreductive surgery for advanced primary and recurrent epithelial ovarian cancer patients outweigh morbidity concerns[J]. Gynecol Oncol, 2006, 103(3): 977-984.
34.	Bosquet JG, Merideth MA, Podratz KC, et al. Hepatic resection for metachronous metastases from ovarian carcinoma[J]. HPB (Oxford), 2006, 8(2): 93-96.
35.	Cotte E, Glehen O, Mohamed F, et al. Cytoreductive surgery and intraperitoneal chemo-hyperthermia for chemo-resistant and recurrent advanced epithelial ovarian cancer: prospective study of 81 patients[J]. World J Surg, 2007, 31(9): 1813-1820.
36.	Santillan A, Karam AK, Li AJ, et al. Secondary cytoreductive surgery for isolated nodal recurrence in patients with epithelial ovarian cancer[J]. Gynecol Oncol, 2007, 104(3): 686-690.
37.	Salani R, Santillan A, Zahurak ML, et al. Secondary cytoreductive surgery for localized, recurrent epithelial ovarian cancer: analysis of prognostic factors and survival outcome[J]. Cancer, 2007, 109(4): 685-691.
38.	Benedetti PP, Perniola G, Angioli R, et al. Bulky lymph node resection in patients with recurrent epithelial ovarian cancer: impact of surgery[J]. Int J Gynecol Cancer, 2007, 17(6): 1245-1251.
39.	Benedetti PP, de Vivo A, Bellati F, et al. Secondary cytoreductive surgery in patients with platinum-sensitive recurrent ovarian cancer[J]. Ann Surg Oncol, 2007, 14(3): 1136-1142.
40.	Helm CW, Randall-Whitis L, Martin RR, et al. Hyperthermic intraperitoneal chemotherapy in conjunction with surgery for the treatment of recurrent ovarian carcinoma[J]. Gynecol Oncol, 2007, 105(1): 90-96.
41.	Tebes SJ, Sayer RA, Palmer JM, et al. Cytoreductive surgery for patients with recurrent epithelial ovarian carcinoma[J]. Gynecol Oncol, 2007, 106(3): 482-487.
42.	Cheng X, Jiang R, Li ZT, et al. The role of secondary cytoreductive surgery for recurrent mucinous epithelial ovarian cancer (mEOC)[J]. Eur J Surg Oncol, 2009, 35(10): 1105-1108.
43.	Bristow RE, Peiretti M, Gerardi M, et al. Secondary cytoreductive surgery including rectosigmoid colectomy for recurrent ovarian cancer: operative technique and clinical outcome[J]. Gynecol Oncol, 2009, 114(2): 173-177.
44.	Fotiou S, Aliki T, Petros Z, et al. Secondary cytoreductive surgery in patients presenting with isolated nodal recurrence of epithelial ovarian cancer[J]. Gynecol Oncol, 2009, 114(2): 178-182.
45.	Pavlov MJ, Kovacevic PA, Ceranic MS, et al. Cytoreductive surgery and modified heated intraoperative intraperitoneal chemotherapy (HIPEC) for advanced and recurrent ovarian cancer: 12-year single center experience[J]. Eur J Surg Oncol, 2009, 35(11): 1186-1191.
46.	Oksefjell H, Sandstad B, Trope C. The role of secondary cytoreduction in the management of the first relapse in epithelial ovarian cancer[J]. Ann Oncol, 2009, 20(2): 286-293.
47.	Woelber L, Jung S, Eulenburg C, et al. Perioperative morbidity and outcome of secondary cytoreduction for recurrent epithelial ovarian cancer[J]. Eur J Surg Oncol, 2010, 36(6): 583-588.
48.	Tian WJ, Jiang R, Cheng X, et al. Surgery in recurrent epithelial ovarian cancer: benefits on survival for patients with residual disease of 0.1-1 cm after secondary cytoreduction[J]. J Surg Oncol, 2010, 101(3): 244-250.
49.	Fanfani F, Fagotti A, Gallotta V, et al. Upper abdominal surgery in advanced and recurrent ovarian cancer: role of diaphragmatic surgery[J]. Gynecol Oncol, 2010, 116(3): 497-501.
50.	Gadducci A, Cosio S, Zola P, et al. The clinical outcome of epithelial ovarian cancer patients with apparently isolated lymph node recurrence: a multicenter retrospective Italian study[J]. Gynecol Oncol, 2010, 116(3): 358-363.
51.	Schorge JO, Wingo SN, Bhore R, et al. Secondary cytoreductive surgery for recurrent platinum-sensitive ovarian cancer[J]. Int J Gynaecol Obstet, 2010, 108(2): 123-127.
52.	Frenel JS, Leux C, Pouplin L, et al. Oxaliplatin-based hyperthermic intraperitoneal chemotherapy in primary or recurrent epithelial ovarian cancer: a pilot study of 31 patients[J]. J Surg Oncol, 2011, 103(1): 10-16.
53.	Fotopoulou C, Richter R, Braicu IE, et al. Clinical outcome of tertiary surgical cytoreduction in patients with recurrent epithelial ovarian cancer[J]. Ann Surg Oncol, 2011, 18(1): 49-57.
54.	Bristow RE, Puri I, Chi DS. Cytoreductive surgery for recurrent ovarian cancer: a meta-analysis[J]. Gynecol Oncol, 2009, 112(1): 265-274.
55.	Zang RY, Harter P, Chi DS, et al. Predictors of survival in patients with recurrent ovarian cancer undergoing secondary cytoreductive surgery based on the pooled analysis of an international collaborative cohort[J]. Br J Cancer, 2011, 105(7): 890-896.
56.	Park JY, Eom JM, Kim DY, et al. Secondary cytoreductive surgery in the management of platinum-sensitive recurrent epithelial ovarian cancer[J]. J Surg Oncol, 2010, 101(5): 418-424.

1. 　Jemal A, Siegel R, Xu J, et al. Cancer statistics, 2010[J]. CA Cancer J Clin, 2010, 60(5): 277-300.
2. 　Griffiths CT. Surgical resection of tumor bulk in the primary treatment of ovarian carcinoma[J]. Natl Cancer Inst Monogr, 1975, 42: 101-104.
3. 　Hoskins WJ, Bundy BN, Thigpen JT, et al. The influence of cytoreductive surgery on recurrence-free interval and survival in small-volume stageⅢ epithelial ovarian cancer: a gynecologic oncology group study[J]. Gynecol Oncol, 1992, 47(2): 159-166.
4. 　Hoskins WJ, Mcguire WP, Brady MF, et al. The effect of diameter of largest residual disease on survival after primary cytoreductive surgery in patients with suboptimal residual epithelial ovarian carcinoma[J]. Am J Obstet Gynecol, 1994, 170(4): 974-980.
5. 　Berek JS, Hacker NF, Lagasse LD, et al. Survival of patients following secondary cytoreductive surgery in ovarian cancer[J]. Obstet Gynecol, 1983, 61(2): 189-193.
6. 　Morris M, Gershenson DM, Wharton JT, et al. Secondary cytoreductive surgery for recurrent epithelial ovarian cancer[J]. Gynecol Oncol, 1989, 34(3): 334-338.
7. 　Janicke F, Holscher M, Kuhn W, et al. Radical surgical procedure improves survival time in patients with recurrent ovarian cancer[J]. Cancer, 1992, 70(8): 2129-2136.
8. 　Segna RA, Dottino PR, Mandeli JP, et al. Secondary cytoreduction for ovarian cancer following cisplatin therapy[J]. J Clin Oncol, 1993, 11(3): 434-439.
9. 　Eisenkop SM, Friedman RL, Wang HJ. Secondary cytoreductive surgery for recurrent ovarian cancer. A prospective study[J]. Cancer, 1995, 76(9): 1606-1614.
10. 　Landoni F, Pellegrino A, Cormio G, et al. Platin-based chemotherapy and salvage surgery in recurrent ovarian cancer following negative second-look laparotomy[J]. Acta Obstet Gynecol Scand, 1998, 77(2): 233-237.
11. 　Cormio G, di Vagno G, Cazzolla A, et al. Surgical treatment of recurrent ovarian cancer: report of 21 cases and a review of the literature[J]. Eur J Obstet Gynecol Reprod Biol, 1999, 86(2): 185-188.
12. 　Zang RY, Zhang ZY, Li ZT, et al. Effect of cytoreductive surgery on survival of patients with recurrent epithelial ovarian cancer[J]. J Surg Oncol, 2000, 75(1): 24-30.
13. 　Eisenkop SM, Friedman RL, Spirtos NM. The role of secondary cytoreductive surgery in the treatment of patients with recurrent epithelial ovarian carcinoma[J]. Cancer, 2000, 88(1): 144-153.
14. 　Gadducci A, Iacconi P, Cosio S, et al. Complete salvage surgical cytoreduction improves further survival of patients with late recurrent ovarian cancer[J]. Gynecol Oncol, 2000, 79(3): 344-349.
15. 　Zylberberg B, Dormont D, Janklewicz S, et al. Secondary cytoreductions in the treatment of ovarian cancers[J]. Gynecol Obstet Fertil, 2000, 28(2): 127-136.
16. 　Tay EH, Grant PT, Gebski V, et al. Secondary cytoreductive surgery for recurrent epithelial ovarian cancer[J]. Obstet Gynecol, 2002, 99(6): 1008-1013.
17. 　Bristow RE, Gossett DR, Shook DR, et al. Recurrent micropapillary serous ovarian carcinoma[J]. Cancer, 2002, 95(4): 791-800.
18. 　Merideth MA, Cliby WA, Keeney GL, et al. Hepatic resection for metachronous metastases from ovarian carcinoma[J]. Gynecol Oncol, 2003, 89(1): 16-21.
19. 　Yoon SS, Jarnagin WR, Fong Y, et al. Resection of recurrent ovarian or fallopian tube carcinoma involving the liver[J]. Gynecol Oncol, 2003, 91(2): 383-388.
20. 　Look M, Chang D, Sugarbaker PH. Long-term results of cytoreductive surgery for advanced and recurrent epithelial ovarian cancers and papillary serous carcinoma of the peritoneum[J]. Int J Gynecol Cancer, 2003, 13(6): 764-770.
21. 　Zanon C, Clara R, Chiappino I, et al. Cytoreductive surgery and intraperitoneal chemohyperthermia for recurrent peritoneal carcinomatosis from ovarian cancer[J]. World J Surg, 2004, 28(10): 1040-1045.
22. 　Uzan C, Morice P, Rey A, et al. Outcomes after combined therapy including surgical resection in patients with epithelial ovarian cancer recurrence(s) exclusively in lymph nodes[J]. Ann Surg Oncol, 2004, 11(7): 658-664.
23. 　Zang RY, Li ZT, Tang J, et al. Secondary cytoreductive surgery for patients with relapsed epithelial ovarian carcinoma: who benefits?[J]. Cancer, 2004, 100(6): 1152-1161.
24. 　Leitao MJ, Kardos S, Barakat RR, et al. Tertiary cytoreduction in patients with recurrent ovarian carcinoma[J]. Gynecol Oncol, 2004, 95(1): 181-188.
25. 　Onda T, Yoshikawa H, Yasugi T, et al. Secondary cytoreductive surgery for recurrent epithelial ovarian carcinoma: proposal for patients selection[J]. Br J Cancer, 2005, 92(6): 1026-1032.
26. 　Gungor M, Ortac F, Arvas M, et al. The role of secondary cytoreductive surgery for recurrent ovarian cancer[J]. Gynecol Oncol, 2005, 97(1): 74-79.
27. 　Gronlund B, Lundvall L, Christensen IJ, et al. Surgical cytoreduction in recurrent ovarian carcinoma in patients with complete response to paclitaxel-platinum[J]. Eur J Surg Oncol, 2005, 31(1): 67-73.
28. 　Ayhan A, Gultekin M, Taskiran C, et al. The role of secondary cytoreduction in the treatment of ovarian cancer: Hacettepe University experience[J]. Am J Obstet Gynecol, 2006, 194(1): 49-56.
29. 　Chi DS, Mccaughty K, Diaz JP, et al. Guidelines and selection criteria for secondary cytoreductive surgery in patients with recurrent, platinum-sensitive epithelial ovarian carcinoma[J]. Cancer, 2006, 106(9): 1933-1939.
30. 　Manci N, Bellati F, Muzii L, et al. Splenectomy during secondary cytoreduction for ovarian cancer disease recurrence: surgical and survival data[J]. Ann Surg Oncol, 2006, 13(12): 1717-1723.
31. 　Matsumoto A, Higuchi T, Yura S, et al. Role of salvage cytoreductive surgery in the treatment of patients with recurrent ovarian cancer after platinum-based chemotherapy[J]. J Obstet Gynaecol Res, 2006, 32(6): 580-587.
32. 　Harter P, du Bois A, Hahmann M, et al. Surgery in recurrent ovarian cancer: the Arbeitsgemeinschaft Gynaekologische Onkologie (AGO) DESKTOP OVAR trial[J]. Ann Surg Oncol, 2006, 13(12): 1702-1710.
33. 　Park JY, Seo SS, Kang S, et al. The benefits of low anterior en bloc resection as part of cytoreductive surgery for advanced primary and recurrent epithelial ovarian cancer patients outweigh morbidity concerns[J]. Gynecol Oncol, 2006, 103(3): 977-984.
34. 　Bosquet JG, Merideth MA, Podratz KC, et al. Hepatic resection for metachronous metastases from ovarian carcinoma[J]. HPB (Oxford), 2006, 8(2): 93-96.
35. 　Cotte E, Glehen O, Mohamed F, et al. Cytoreductive surgery and intraperitoneal chemo-hyperthermia for chemo-resistant and recurrent advanced epithelial ovarian cancer: prospective study of 81 patients[J]. World J Surg, 2007, 31(9): 1813-1820.
36. 　Santillan A, Karam AK, Li AJ, et al. Secondary cytoreductive surgery for isolated nodal recurrence in patients with epithelial ovarian cancer[J]. Gynecol Oncol, 2007, 104(3): 686-690.
37. 　Salani R, Santillan A, Zahurak ML, et al. Secondary cytoreductive surgery for localized, recurrent epithelial ovarian cancer: analysis of prognostic factors and survival outcome[J]. Cancer, 2007, 109(4): 685-691.
38. 　Benedetti PP, Perniola G, Angioli R, et al. Bulky lymph node resection in patients with recurrent epithelial ovarian cancer: impact of surgery[J]. Int J Gynecol Cancer, 2007, 17(6): 1245-1251.
39. 　Benedetti PP, de Vivo A, Bellati F, et al. Secondary cytoreductive surgery in patients with platinum-sensitive recurrent ovarian cancer[J]. Ann Surg Oncol, 2007, 14(3): 1136-1142.
40. 　Helm CW, Randall-Whitis L, Martin RR, et al. Hyperthermic intraperitoneal chemotherapy in conjunction with surgery for the treatment of recurrent ovarian carcinoma[J]. Gynecol Oncol, 2007, 105(1): 90-96.
41. 　Tebes SJ, Sayer RA, Palmer JM, et al. Cytoreductive surgery for patients with recurrent epithelial ovarian carcinoma[J]. Gynecol Oncol, 2007, 106(3): 482-487.
42. 　Cheng X, Jiang R, Li ZT, et al. The role of secondary cytoreductive surgery for recurrent mucinous epithelial ovarian cancer (mEOC)[J]. Eur J Surg Oncol, 2009, 35(10): 1105-1108.
43. 　Bristow RE, Peiretti M, Gerardi M, et al. Secondary cytoreductive surgery including rectosigmoid colectomy for recurrent ovarian cancer: operative technique and clinical outcome[J]. Gynecol Oncol, 2009, 114(2): 173-177.
44. 　Fotiou S, Aliki T, Petros Z, et al. Secondary cytoreductive surgery in patients presenting with isolated nodal recurrence of epithelial ovarian cancer[J]. Gynecol Oncol, 2009, 114(2): 178-182.
45. 　Pavlov MJ, Kovacevic PA, Ceranic MS, et al. Cytoreductive surgery and modified heated intraoperative intraperitoneal chemotherapy (HIPEC) for advanced and recurrent ovarian cancer: 12-year single center experience[J]. Eur J Surg Oncol, 2009, 35(11): 1186-1191.
46. 　Oksefjell H, Sandstad B, Trope C. The role of secondary cytoreduction in the management of the first relapse in epithelial ovarian cancer[J]. Ann Oncol, 2009, 20(2): 286-293.
47. 　Woelber L, Jung S, Eulenburg C, et al. Perioperative morbidity and outcome of secondary cytoreduction for recurrent epithelial ovarian cancer[J]. Eur J Surg Oncol, 2010, 36(6): 583-588.
48. 　Tian WJ, Jiang R, Cheng X, et al. Surgery in recurrent epithelial ovarian cancer: benefits on survival for patients with residual disease of 0.1-1 cm after secondary cytoreduction[J]. J Surg Oncol, 2010, 101(3): 244-250.
49. 　Fanfani F, Fagotti A, Gallotta V, et al. Upper abdominal surgery in advanced and recurrent ovarian cancer: role of diaphragmatic surgery[J]. Gynecol Oncol, 2010, 116(3): 497-501.
50. 　Gadducci A, Cosio S, Zola P, et al. The clinical outcome of epithelial ovarian cancer patients with apparently isolated lymph node recurrence: a multicenter retrospective Italian study[J]. Gynecol Oncol, 2010, 116(3): 358-363.
51. 　Schorge JO, Wingo SN, Bhore R, et al. Secondary cytoreductive surgery for recurrent platinum-sensitive ovarian cancer[J]. Int J Gynaecol Obstet, 2010, 108(2): 123-127.
52. 　Frenel JS, Leux C, Pouplin L, et al. Oxaliplatin-based hyperthermic intraperitoneal chemotherapy in primary or recurrent epithelial ovarian cancer: a pilot study of 31 patients[J]. J Surg Oncol, 2011, 103(1): 10-16.
53. 　Fotopoulou C, Richter R, Braicu IE, et al. Clinical outcome of tertiary surgical cytoreduction in patients with recurrent epithelial ovarian cancer[J]. Ann Surg Oncol, 2011, 18(1): 49-57.
54. 　Bristow RE, Puri I, Chi DS. Cytoreductive surgery for recurrent ovarian cancer: a meta-analysis[J]. Gynecol Oncol, 2009, 112(1): 265-274.
55. 　Zang RY, Harter P, Chi DS, et al. Predictors of survival in patients with recurrent ovarian cancer undergoing secondary cytoreductive surgery based on the pooled analysis of an international collaborative cohort[J]. Br J Cancer, 2011, 105(7): 890-896.
56. 　Park JY, Eom JM, Kim DY, et al. Secondary cytoreductive surgery in the management of platinum-sensitive recurrent epithelial ovarian cancer[J]. J Surg Oncol, 2010, 101(5): 418-424.

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