Therapeutic Effect of Tizanidine Hydroehloride Combined with Non-steroidal Anti-inflammatory Drugs on Fibromyalgia versus Drug alone_West China Medical Journal

Authors：

 ZHANGDai-ying ,  LISen

Department of Anesthesiology, the Affiliated Hospitalof Luzhou Medical College, Luzhou, Sichuan 646000, P. R. China;

Corresponding author：

LISen, Email: jht187@163.com

Keywords：

Tizanidine hydroehloride; Fibromyalgia syndrome; Clinical efficacy

DOI：

10.7507/1002-0179.20140020

Video：

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Abstract Full text Figures/Tables Video References Cited by

Objective To observe the therapeutic effect of the Tizanidine hydroehloride combined with non-steroidal anti-inflammatory drugs (NSAIDs) on fibromyalgia syndrome. Methods A total of 166 patients collected from August 2011 to January 2013 were randomly divided into control group and treatment group (with 83 cases in each group), the NSAIDs was used for control group, and for the other group, the Tizanidine hydroehloride combined with NSAIDs was used. The patients in two groups were continuously treated for 2 weeks. And the first and second week after treatment, the psychological evaluation,visual analogue pain, activities of daily living were detected. During the treatment period, the average follow-up duration was 3 months. Results The clinical efficacy was better after treatment in both of the two groups. The clinical efficacy was more significant in treatment group than that in the control group, and the occurrence of gastrointestinal discomfort were less in the treatment group than that in the control group. Conclusion Tizanidine hydroehloride combined with NSAIDs is effective on fibromyalgia syndrome. And the Tizanidine hydroehloride can protect the gastrointestine from being injured.

Citation： ZHANGDai-ying, LISen. Therapeutic Effect of Tizanidine Hydroehloride Combined with Non-steroidal Anti-inflammatory Drugs on Fibromyalgia versus Drug alone. West China Medical Journal, 2014, 29(1): 73-76. doi: 10.7507/1002-0179.20140020 Copy

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1. Manchikanti L, Hirsch JA, Pampati V. Chronic low back pain of facet (zygapophysial) joint origin:is there a difference based on involvement of single or multiple spinal regions?[J]. Pain Physician, 2003, 6(4):399-405.
2. Manchikanti L, Singhv PV. Is there correlation of facejoint pain in lumbar and cervical spine[J]. Pain Physician, 2002, 4(5):365-371.
3. 王家良. 临床流行病学-临床科研设计,衡量与评价[M]. 2版. 上海:上海科学技术出版社, 2001:47-59.
4. 陈孝平. 外科学(下册)[M]. 2版. 北京:人民卫生出版社, 2010:1046-1047.
5. 刘云鹏, 刘沂. 骨与关节损伤和疾病的诊断分类及功能评定标准[M]. 北京:清华大学出版社, 2002:246.
6. Jennum PA, Orfilter YA. Department of clinical neurophysiology, hvidovre hospital, university of Copenhagen, Denmark[J]. J Rheumatol, 1993, 20(10):1756-1759.
7. Qiao ZG, Vaerøy H, Mørkrid L. Electrodermal and microcirculatory activity in patients with fibromyalgia during baseline, acoustic stimulation and cold pressor tests[J]. J Rheumatol, 1991, 18(9):1383-1389.
8. Sietsema KE, Cooper DM, Caro X, et al. Oxygen uptake during exercise in patients with primary fibromyalgia syndrome[J]. J Rheumatol, 1993, 20(5):860-865.
9. Yunus MB, Hussey FX, Aldag JC. Antinuclear antibodies and connective tissue disease features in fibromyalgia syndrome:a controlled study[J]. J Rheumatol, 1993, 20(9):1557-1560.
10. Leslie J, Michael C, Philip J, et al. Pregabalin for the treatment of fibromyalgia syndrome:results of a randomized, double-blind, placebo-controlled trial[J]. Arthritis Rheum, 2005, 4(52):1264-1273.
11. Philip J, Russell IJ, Lesley MA, et al. A randomized,double-blind, placebo-controlled, phase Ⅲ trial of pregabalin in the treatment of patients with fibromyalgia[J]. J Rheumatol, 2008, 3(35):502-514.
12. Michael R, Michael D, Judy F, et al. Efficacy of milnacipran in patients with fibromyalgia[J]. J Rheumatol, 2005, 10(32):1975-1985.
13. Gelber DA, Good DC, Dromerick A, et al. Open-label dose-titration safety and efficacy study of tizanidine hydrochloride in the treatment of spasticity associated with chronic stroke[J]. Stroke, 2001, 32(8):1841-1846.
14. Manfredini D, Romagnoli M, Cantini E, et al. Efficacy of tizanidine hydrochloride in the treatment of myofascial face pain[J]. Minerva Med, 2004, 95(2):165-171.

West China Medical Journal

Therapeutic Effect of Tizanidine Hydroehloride Combined with Non-steroidal Anti-inflammatory Drugs on Fibromyalgia versus Drug alone

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