Comparison between Pulsed Electromagnetic Field and Alendronate in the Treatment of Postmenopausal Osteoporosis_West China Medical Journal

Authors：

 LIUYing ^1,2 , WANGChun-yan ³ , LIUHui-fang ¹ ,  HECheng-qi ¹

1. Department of Rehabilitation Medicine, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, P. R. China;
2. Department of Geriatric Medicine, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, P. R. China;
3. Department of Rehabilitation, Tianjin Medical University General Hospital, Tianjin 300052, P. R. China;

Corresponding author：

HECheng-qi, Email: hxkfhcq@126.com

Keywords：

Pulsed electromagnetic fields; Postmenopausal osteoporosis; Bone mineral density; Pain; Muscle strength

DOI：

10.7507/1002-0179.20140019

Video：

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Objective To compare the clinical effects of pulsed electromagnetic fields (PEMFs) with oral alendronate in the treatment of postmenopausal osteoporosis. Methods Fourty patients diagnosed to have postmenopausal osteoporosis (OP) from September 2009 to September 2010 were included in our study. They were randomly divided into the experimental group and the control group. All patients were administered the same basic drugs:Caltrate 600 mg and Alfacalcidol 0.5 μg per day. For the experimental group, PEMFs were offered 6 times per week for 5 weeks (30 times in total), and patients in this group were followed up for 12 weeks. For the control group, alendronate was given at a dose of 70 mg per week for 12 weeks. Bone mineral density (BMD), visual analogue scale, and manual muscle testing (MMT) scale were evaluated before, 1 week, 5 weeks, and 12 weeks after intervention. Results Increasing of BMD, pain relieving, and improvement of MMT had a trend of increasing values after 5 weeks of treatment in the experimental group (P<0.05), but there was no significant difference between the two groups (P>0.05). However, there was a significant difference between the two groups in patients' lower back muscle strength after treatment (P<0.05). Conclusion PEMFs have the same effect as alendronate in pain relief, and bone mass and muscle strength improvement, and are even advantageous in increasing back muscle strength compared with alendronate.

Citation： LIUYing, WANGChun-yan, LIUHui-fang, HECheng-qi. Comparison between Pulsed Electromagnetic Field and Alendronate in the Treatment of Postmenopausal Osteoporosis. West China Medical Journal, 2014, 29(1): 67-72. doi: 10.7507/1002-0179.20140019 Copy

1.	Reginster JY, Burlet N. Osteoporosis:a still increasing prevalence[J]. Bone, 2006, 38(2):4-9.
2.	Melton LJ, Atkinson EJ, Cooper C, et al. Vertebral fractures predict subsequent fractures[J]. Osteoporos Int, 1999, 10(3):214-221.
3.	Gronholz MJ. Prevention、diagnosis and management of osteoporosis-related fracture:a multifactoral osteopathic approach[J]. Am Osteopath Assoc, 2008, 108(10):575-585.
4.	余雷, 罗二平, 申广浩, 等. 低频脉冲电磁场治疗骨质疏松的作用[J]. 中国临床康复, 2003, 7(12):1801-1802.
5.	Watts NB, Bilezikian JP, Camacho PM, et al. American Association of Clinical Endocrinologists Medical Guidelines for Clinical Practice for the diagnosis and treatment of postmenopausal osteoporosis:executive summary of recommendations[J]. Endocr Pract, 2010, 16(3):1-37.
6.	Reid DM, Hosking D, Kendler D, et al. A comparison of the effect of alendronate and risedronate on bone mineral density in postmenopausal women with osteoporosis:24-month results from FACTS-International[J]. Int J Clin Pract, 2008, 62(4):575-584.
7.	Markov MS. Magnetic field therapy:a review[J]. Electromagn Biol Med, 2007, 26(8):1-23.
8.	Ehatjfulelhan G, Festa MA, Angelete JE. Reproducibility of DXA absorp-tiometry:a model for bone loss estimates[J]. Bone Miner Res, 1995, 10(7):1004-1014.
9.	Miller PD. Guidelines for the diagnosis of osteoporosis:T-scores vs fractures[J]. Rev Endocr Metab Disord, 2006, 7(1-2):75-89.
10.	Chang WH, Chen LT, Sun JS, et al. Effect of pulse-burst electromagnetic field stimulation on osteoblast cell activities[J]. Bioelectromagnetics, 2004, 25(6):457-465.
11.	Bassett CAL, Pilla AA, Pawluk RJ. A nonoperative salvage of surgically-resist antpseudarthroses and non-unions by pulsing elecromagnetic fields:a preliminary report[J]. Clin Orth op, 1977, 12(124):128-143.
12.	Sert C, Mustafa D, Duz MZ, et al. The preventive effect on bone loss of 50 Hz, 1mT electrom agnetic field in ovariectomized rats[J]. Bone Miner Metab, 2002, 20(6):345-349.
13.	Giavaresi G, Fini M, Gnudi S, et al. Giardino. Effect of pulsed electromagnetic fields on ovariectomized rats[J]. Electro-Magnetobiol, 1998(18):119-131.
14.	黄礼群, 王维, 何成奇, 等. 不同治疗时间脉冲电磁场对去势大鼠股骨骨密度的影响[J]. 中国修复重建外科杂志, 2008, 22(5):548-550.
15.	高堪达, 俞永林, 周建伟. 脉冲电磁场治疗骨质疏松症研究进展[J]. 国外医学·骨科学分册, 2004, 25(5):307-309.
16.	Tabrah FL, Ross P, Hoffmeier M, et al. Clinical report on long-term bone density after short-term EMF application[J]. Bioelectromagnetics, 1998, 19:75-78.
17.	肖登, 杨霖, 雷中杰, 等. 不同治疗时间脉冲电磁场对去卵巢大鼠股骨生物力学性能的影响[J]. 四川大学学报·医学版, 2010, 41(2):296-298.
18.	Weintraub MI, Herrmann DN, Smith AG, et al. Pulsed electromagnetic fields to reduce diabetic neuropathic pain and stimulate neuronal repair:a randomized controlled trial[J]. Arch Phys Med Rehabil, 2009, 9(8):1102-1109.
19.	Ay S, Evcik D. The effects of pulsed electromagnetic fields in the treatment of knee osteoarthritis:a randomized, placebo-controlled trial[J]. Rheumatol Int, 2009, 29(6):663-666.
20.	郝双林, 田宝斌, 王玲, 等. VAS测痛法的临床初步评估[J]. 中国医学科学院学报, 1994, 16(5):397-399.
21.	胡一顺, 史玲, 鲍志民, 等. 低频脉冲电磁场治疗骨质疏松症骨痛症状疗效观察[J]. 上海医药, 2012, 33(6):46-47.
22.	Snow S, Kirwan JR. Visual analogue scales:a source of error[J]. Ann Rheum Dis, 1988, 47(6):526.
23.	郝双林. 临床疼痛的测定方法及其评价[J]. 国外医学·麻醉学与复苏分册, 1993, 14(4):228-230.
24.	张权, 黄煌渊. 降钙素治疗骨质疏松性疼痛的短期疗效评估[J]. 上海医科大学学报, 2000, 11(1):27-29.
25.	Smith TL, Wong-Gi bbons D, Maultsby J. Microcirculatory effects of pulse electromagnetic fields[J]. Orthop Res, 2004, 22(1):80-84.
26.	周万松. 新编磁疗学[M]. 北京:科学出版社, 1995:50-58, 130-151.
27.	Greenough CG. The effects of pulsed electromagnetic fields on blood vessel growth in the rabbit ear chamber[J]. Orthop Res, 1992, 10(2):256-262.
28.	张小云, 罗振国, 马永键. 磁场对血浆B-内啡肽的影响[J]. 中华物理医学与康复杂志, 1998, 20(3):129-132.
29.	Blain H, Vuillemin A, Teissier A, et al. Influence of muscle strength and body weight and composition on regional bone mineral density in healthy women aged 60 years and over[J]. Gerontology, 2001, 47(4):207-212.
30.	杨霖, 雷中杰, 何成奇. 低频脉冲电磁场治疗骨质疏松症的临床观察[J]. 中国骨质疏松杂志, 2006, 12(6):592-593.
31.	Zhao FZ, Han XS, Tao TZ. The treatment of primary osteoporosis by salmon calcitonin and physical therapy[J]. Chin J Osteoporos, 2007, 13(4):281-283.
32.	Weinans H, Huiskes R, Grootenboer HJ. The behavior of adaptive bone-remodeling simulation models[J]. Biomech, 1992, 25(12):1425-1441.
33.	李国新, 温健, 汤晨达, 等. 低频脉冲电磁场治疗原发性骨质疏松症的短期疗效观察[J]. 齐齐哈尔医学院学报, 2010, 13(14):2203-2204.
34.	Forgacs Z, Somosy Z, Kubinyi G, et al. Effects of whole-body 50-Hz magnetic field exposure on mouse Leydig cell[J]. Sci World J, 2004, 4(2):83-90.
35.	Fitzsimmons R, Strong D, Mohan S, et al. Low-amplitude, low-frequency electric field-stimulated cell proliferation may in part be mediated by increased IGF-Ⅱ release[J]. Cell Physiol, 1992, 150(1):326-334.

1. Reginster JY, Burlet N. Osteoporosis:a still increasing prevalence[J]. Bone, 2006, 38(2):4-9.
2. Melton LJ, Atkinson EJ, Cooper C, et al. Vertebral fractures predict subsequent fractures[J]. Osteoporos Int, 1999, 10(3):214-221.
3. Gronholz MJ. Prevention、diagnosis and management of osteoporosis-related fracture:a multifactoral osteopathic approach[J]. Am Osteopath Assoc, 2008, 108(10):575-585.
4. 余雷, 罗二平, 申广浩, 等. 低频脉冲电磁场治疗骨质疏松的作用[J]. 中国临床康复, 2003, 7(12):1801-1802.
5. Watts NB, Bilezikian JP, Camacho PM, et al. American Association of Clinical Endocrinologists Medical Guidelines for Clinical Practice for the diagnosis and treatment of postmenopausal osteoporosis:executive summary of recommendations[J]. Endocr Pract, 2010, 16(3):1-37.
6. Reid DM, Hosking D, Kendler D, et al. A comparison of the effect of alendronate and risedronate on bone mineral density in postmenopausal women with osteoporosis:24-month results from FACTS-International[J]. Int J Clin Pract, 2008, 62(4):575-584.
7. Markov MS. Magnetic field therapy:a review[J]. Electromagn Biol Med, 2007, 26(8):1-23.
8. Ehatjfulelhan G, Festa MA, Angelete JE. Reproducibility of DXA absorp-tiometry:a model for bone loss estimates[J]. Bone Miner Res, 1995, 10(7):1004-1014.
9. Miller PD. Guidelines for the diagnosis of osteoporosis:T-scores vs fractures[J]. Rev Endocr Metab Disord, 2006, 7(1-2):75-89.
10. Chang WH, Chen LT, Sun JS, et al. Effect of pulse-burst electromagnetic field stimulation on osteoblast cell activities[J]. Bioelectromagnetics, 2004, 25(6):457-465.
11. Bassett CAL, Pilla AA, Pawluk RJ. A nonoperative salvage of surgically-resist antpseudarthroses and non-unions by pulsing elecromagnetic fields:a preliminary report[J]. Clin Orth op, 1977, 12(124):128-143.
12. Sert C, Mustafa D, Duz MZ, et al. The preventive effect on bone loss of 50 Hz, 1mT electrom agnetic field in ovariectomized rats[J]. Bone Miner Metab, 2002, 20(6):345-349.
13. Giavaresi G, Fini M, Gnudi S, et al. Giardino. Effect of pulsed electromagnetic fields on ovariectomized rats[J]. Electro-Magnetobiol, 1998(18):119-131.
14. 黄礼群, 王维, 何成奇, 等. 不同治疗时间脉冲电磁场对去势大鼠股骨骨密度的影响[J]. 中国修复重建外科杂志, 2008, 22(5):548-550.
15. 高堪达, 俞永林, 周建伟. 脉冲电磁场治疗骨质疏松症研究进展[J]. 国外医学·骨科学分册, 2004, 25(5):307-309.
16. Tabrah FL, Ross P, Hoffmeier M, et al. Clinical report on long-term bone density after short-term EMF application[J]. Bioelectromagnetics, 1998, 19:75-78.
17. 肖登, 杨霖, 雷中杰, 等. 不同治疗时间脉冲电磁场对去卵巢大鼠股骨生物力学性能的影响[J]. 四川大学学报·医学版, 2010, 41(2):296-298.
18. Weintraub MI, Herrmann DN, Smith AG, et al. Pulsed electromagnetic fields to reduce diabetic neuropathic pain and stimulate neuronal repair:a randomized controlled trial[J]. Arch Phys Med Rehabil, 2009, 9(8):1102-1109.
19. Ay S, Evcik D. The effects of pulsed electromagnetic fields in the treatment of knee osteoarthritis:a randomized, placebo-controlled trial[J]. Rheumatol Int, 2009, 29(6):663-666.
20. 郝双林, 田宝斌, 王玲, 等. VAS测痛法的临床初步评估[J]. 中国医学科学院学报, 1994, 16(5):397-399.
21. 胡一顺, 史玲, 鲍志民, 等. 低频脉冲电磁场治疗骨质疏松症骨痛症状疗效观察[J]. 上海医药, 2012, 33(6):46-47.
22. Snow S, Kirwan JR. Visual analogue scales:a source of error[J]. Ann Rheum Dis, 1988, 47(6):526.
23. 郝双林. 临床疼痛的测定方法及其评价[J]. 国外医学·麻醉学与复苏分册, 1993, 14(4):228-230.
24. 张权, 黄煌渊. 降钙素治疗骨质疏松性疼痛的短期疗效评估[J]. 上海医科大学学报, 2000, 11(1):27-29.
25. Smith TL, Wong-Gi bbons D, Maultsby J. Microcirculatory effects of pulse electromagnetic fields[J]. Orthop Res, 2004, 22(1):80-84.
26. 周万松. 新编磁疗学[M]. 北京:科学出版社, 1995:50-58, 130-151.
27. Greenough CG. The effects of pulsed electromagnetic fields on blood vessel growth in the rabbit ear chamber[J]. Orthop Res, 1992, 10(2):256-262.
28. 张小云, 罗振国, 马永键. 磁场对血浆B-内啡肽的影响[J]. 中华物理医学与康复杂志, 1998, 20(3):129-132.
29. Blain H, Vuillemin A, Teissier A, et al. Influence of muscle strength and body weight and composition on regional bone mineral density in healthy women aged 60 years and over[J]. Gerontology, 2001, 47(4):207-212.
30. 杨霖, 雷中杰, 何成奇. 低频脉冲电磁场治疗骨质疏松症的临床观察[J]. 中国骨质疏松杂志, 2006, 12(6):592-593.
31. Zhao FZ, Han XS, Tao TZ. The treatment of primary osteoporosis by salmon calcitonin and physical therapy[J]. Chin J Osteoporos, 2007, 13(4):281-283.
32. Weinans H, Huiskes R, Grootenboer HJ. The behavior of adaptive bone-remodeling simulation models[J]. Biomech, 1992, 25(12):1425-1441.
33. 李国新, 温健, 汤晨达, 等. 低频脉冲电磁场治疗原发性骨质疏松症的短期疗效观察[J]. 齐齐哈尔医学院学报, 2010, 13(14):2203-2204.
34. Forgacs Z, Somosy Z, Kubinyi G, et al. Effects of whole-body 50-Hz magnetic field exposure on mouse Leydig cell[J]. Sci World J, 2004, 4(2):83-90.
35. Fitzsimmons R, Strong D, Mohan S, et al. Low-amplitude, low-frequency electric field-stimulated cell proliferation may in part be mediated by increased IGF-Ⅱ release[J]. Cell Physiol, 1992, 150(1):326-334.

West China Medical Journal

Comparison between Pulsed Electromagnetic Field and Alendronate in the Treatment of Postmenopausal Osteoporosis

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