Analysis of Risk Factors for Retinopathy in Patients with Type 2 Diabetes_West China Medical Journal

Authors：

 YANGHua ,  MALin , KANYan-min , ZHANGShu-hua , SUNMeng , LIXiao-song

Department of Ultrasound, Affiliated Hospital of Hebei United University, Tangshan, Hebei 063000, P. R. China;

Corresponding author：

MALin, Email: malintsh@163.com

Keywords：

Diabetes mellitus, type 2; Diabetic retinopathy; Risk factor

DOI：

10.7507/1002-0179.20140018

Video：

Export PDF Favorites Scan Get Citation

Abstract Full text Figures/Tables Video References Cited by

Objective To investigate the risk factors for retinopathy in type 2 diabetes patients. Methods A total of 112 patients with type 2 diabetes treated between December 2009 and December 2012 were divided into two groups. Fifty-two patients had no diabetic retinopathy (NDR group) and 60 had diabetic retinopathy (DR group). Blood pressure, blood lipids, and blood glucose were detected to analyze the correlation of retinopathy with disease course, blood pressure, blood lipid, and blood sugar. Results Disease course was longer and blood glucose level was higher in DR group than in NDR group (P<0.05). Logistic regression analysis results showed that the incidence of retinopathy was correlated with blood glucose[OR=1.490, 95% CI (1.123, 1.976), P=0.006] and disease course[OR=2.207, 95% CI (1.579, 3.085), P=0.000]. Conclusion Blood glucose and disease course may be the risk factors for DR. Active control of the blood glucose can be benefit for the prevention and treatment of DR.

Citation： YANGHua, MALin, KANYan-min, ZHANGShu-hua, SUNMeng, LIXiao-song. Analysis of Risk Factors for Retinopathy in Patients with Type 2 Diabetes. West China Medical Journal, 2014, 29(1): 64-66. doi: 10.7507/1002-0179.20140018 Copy

1.	高丽涛, 柳力敏, 张媛媛, 等. 糖尿病视网膜病变的危险因素分析[J]. 眼科新进展, 2011, 3l(8):742-744.
2.	Studholme S. Diabetic retinopathy[J]. J Perioper Pract, 2008, 18(5):205-210.
3.	王海红, 沈伟, 王智. 增殖性视网膜病变与血管新生的研究进展[J]. 国际眼科杂志, 2010, 10(10):1933-1936.
4.	郑大凤, 冯敏, 李琳玲. 糖尿病视网膜病变的防治[J]. 国际眼科杂志, 2012, 12(7):1289-1291.
5.	贾朝京. 糖尿病及高血压患者眼血流动力学研究[J]. 眼科新进展, 2002, 22(4):277-278.
6.	Hattori Y, Suzuki M, Hattori S, et al. Vascular smooth muscle cell activation by glycated albumin (Amadori adducts)[J]. Hypertension, 2002, 39(1):22-28.
7.	Ceriello A, Esposito K, Piconi L, et al. Oscillating glucose is more deleterious to endothelial function and oxidative stress than mean glucose in normal and type 2 diabetic patients[J]. Diabetes, 2008, 57(5):1349-1354.
8.	Kohnert KD, Augstein P, Zander E, et al. Glycemic variability correlates strongly with postprandial beta-cell dysfunction in a segment of type 2 diabetic patients using oral hypoglycemic agents[J]. Diabetes Care, 2009, 32(6):1058-1062.
9.	Monnier L, Mas E, Ginet C, et al. Activation of oxidative stress by acute glucose fluctuations compared with sustained chronic hyperglycemia in patients with type 2 diabetes[J]. JAMA, 2006, 295(14):168l-1687.
10.	Brownlee M. The pathobiology of diabetic complications:a unifying mechanism[J]. Diabetes, 2005, 54(6):1615-1625.
11.	Kowluru RS. Role of interleukin-1 beta in the pathogenesis of diabetic retinopathy[J]. Br J Ophthalmol, 2004, 88(10):1343-1347.
12.	Navarro JF, Mora-Fernandz C. The role of TNF-alpha in diabetic nephropathy:pathogenic and therapeatic implications[J]. Cytokine Growth Factor Rev, 2006, 17(6):441-450.
13.	吕茜. 糖尿病视网膜病变相关危险因素分析[J]. 河北医药, 2012, 34(9):1343-1344.
14.	Varma R, Macias GL, Torres M, et al. Biologic risk factors associated with diabetic retinopathy:the Los Angeles Latino Eye Study[J]. Ophthalmology, 2007, 114(7):1332-1340.
15.	黄晓波, 邹海东, 王宁, 等. 上海市北新泾街道60岁及其以上居民糖尿病视网膜病变患病情况调查[J]. 中华眼底病杂志, 2010, 26(2):105-108.
16.	何媛, 于德民, 周赛, 等. 糖尿病视网膜病变的相关危险因素分析[J]. 中华糖尿病杂志, 2012, 4(10):601-606.

1. 高丽涛, 柳力敏, 张媛媛, 等. 糖尿病视网膜病变的危险因素分析[J]. 眼科新进展, 2011, 3l(8):742-744.
2. Studholme S. Diabetic retinopathy[J]. J Perioper Pract, 2008, 18(5):205-210.
3. 王海红, 沈伟, 王智. 增殖性视网膜病变与血管新生的研究进展[J]. 国际眼科杂志, 2010, 10(10):1933-1936.
4. 郑大凤, 冯敏, 李琳玲. 糖尿病视网膜病变的防治[J]. 国际眼科杂志, 2012, 12(7):1289-1291.
5. 贾朝京. 糖尿病及高血压患者眼血流动力学研究[J]. 眼科新进展, 2002, 22(4):277-278.
6. Hattori Y, Suzuki M, Hattori S, et al. Vascular smooth muscle cell activation by glycated albumin (Amadori adducts)[J]. Hypertension, 2002, 39(1):22-28.
7. Ceriello A, Esposito K, Piconi L, et al. Oscillating glucose is more deleterious to endothelial function and oxidative stress than mean glucose in normal and type 2 diabetic patients[J]. Diabetes, 2008, 57(5):1349-1354.
8. Kohnert KD, Augstein P, Zander E, et al. Glycemic variability correlates strongly with postprandial beta-cell dysfunction in a segment of type 2 diabetic patients using oral hypoglycemic agents[J]. Diabetes Care, 2009, 32(6):1058-1062.
9. Monnier L, Mas E, Ginet C, et al. Activation of oxidative stress by acute glucose fluctuations compared with sustained chronic hyperglycemia in patients with type 2 diabetes[J]. JAMA, 2006, 295(14):168l-1687.
10. Brownlee M. The pathobiology of diabetic complications:a unifying mechanism[J]. Diabetes, 2005, 54(6):1615-1625.
11. Kowluru RS. Role of interleukin-1 beta in the pathogenesis of diabetic retinopathy[J]. Br J Ophthalmol, 2004, 88(10):1343-1347.
12. Navarro JF, Mora-Fernandz C. The role of TNF-alpha in diabetic nephropathy:pathogenic and therapeatic implications[J]. Cytokine Growth Factor Rev, 2006, 17(6):441-450.
13. 吕茜. 糖尿病视网膜病变相关危险因素分析[J]. 河北医药, 2012, 34(9):1343-1344.
14. Varma R, Macias GL, Torres M, et al. Biologic risk factors associated with diabetic retinopathy:the Los Angeles Latino Eye Study[J]. Ophthalmology, 2007, 114(7):1332-1340.
15. 黄晓波, 邹海东, 王宁, 等. 上海市北新泾街道60岁及其以上居民糖尿病视网膜病变患病情况调查[J]. 中华眼底病杂志, 2010, 26(2):105-108.
16. 何媛, 于德民, 周赛, 等. 糖尿病视网膜病变的相关危险因素分析[J]. 中华糖尿病杂志, 2012, 4(10):601-606.

West China Medical Journal

Analysis of Risk Factors for Retinopathy in Patients with Type 2 Diabetes

Abstract Full text Figures/Tables Video References Cited by

Previous Article

Next Article

Format

Content