Study on the Relationship among Hepatitis B Virus PreS1, Human Hepatitis B e Antigen and Liver Fuction in Serum of Hepatitis B Patients_West China Medical Journal

Authors：

 DUANWen-bing , JUYing , WANGZi-e , SONGXiao-fei , LIUYi-qing , YANZhuang-min ,  ZHANGBing-chang

Department of Laboratory Medicine, Provincial Hospital Affiliated to Shandong University, Jinan, Shandong 250021, P. R. China;

Corresponding author：

ZHANGBing-chang, Email: zhangbingchangb@163.com

Keywords：

Viral hepatitis type B; PreS1 antigen; Human hepatitis B e antigen; Alanine transaminase

DOI：

10.7507/1002-0179.20140016

Video：

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Objective To evaluate the relationship between hepatitis B virus (HBV) preS1 antigen and the virus replication index human hepatitis B e antigen (HBeAg) and liver function. Methods A total of 310 cases of serum samples from patients with chronic HBV treated in our hospital between May and July 2012 were examined and studied. HBV preS1 antigen was detected by ELISA; HBeAg was detected by the Architect i2000 system; and alanine transaminase (ALT) was detected by kinetic method. Results The detection rate of HBV preS1 antigen was higher in HBeAg positive group. HBV preS1 antigen was correlated with HBeAg which was an index of virus replication. HBV preS1 antigen was correlated with ALT levels. Conclusion The levels of HBV preS1 antigen may reflect the replication of HBV and the reactiveness condition of chronic hepatitis.

Citation： DUANWen-bing, JUYing, WANGZi-e, SONGXiao-fei, LIUYi-qing, YANZhuang-min, ZHANGBing-chang. Study on the Relationship among Hepatitis B Virus PreS1, Human Hepatitis B e Antigen and Liver Fuction in Serum of Hepatitis B Patients. West China Medical Journal, 2014, 29(1): 57-59. doi: 10.7507/1002-0179.20140016 Copy

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3.	Echevarria JM, Avellón A. Hepatitis B virus genetic diversity[J]. J Med Virol, 2006, 78(Suppl 1):S36-S42.
4.	Ingman M, Lindqvist B, Kidd-Ljunggren K. Novel mutation in hepatitis B virus preventing HBsAg production and resembling primate strains[J]. J Gen Virol, 2006, 87(Pt 2):307-310.
5.	Taliani G, Rapicetta M, Francisci D, et al. Correlation of preS antigens and clinical status during chronic hepatitis B virus infection[J]. Med Microbil Im munol, 1991, 180(5):239-248.
6.	徐文丽. 联合检测乙肝病毒前Sl抗原临床意义[J]. 上海预防医学杂志, 2009, 21(2):76.
7.	Lee YI, Hur GM, Suh DJ, et al. Novel pre2C/C gene mutants of hepatitisis B virus in chronic active hepatitis:naturally occwrring escape mutants[J]. J Gen Virol, 1996, 77(Pt 6):1129-1138.
8.	Tonetto PA, Gonçales NS, Fais VC, et al. Hepatitis B virus:molecular genotypes and HBeAg serological status among HBV-infected patients in the southeast of Brazil[J]. BMC Infec Dis, 2009, 9:149-155.
9.	李小平, 朱卫平, 李若冰. 乙型肝炎表面抗原阳性肝硬化患者前S1抗原、e抗原及乙型肝炎病毒DNA结果分析[J]. 华西医学, 2012, 27(1):63-65.
10.	Pichoud C, Berby F, Stuyver L, et al. Persistence of viral replication after anti-HBe seroconversion during antiviral therapy for chronic hepatitis B[J]. J Hepatol, 2000, 32(2):307-316.
11.	姚光弼,陆选永,张利民,等. 前S1和前S2蛋白-HBV复制的新标志[J]. 中华传染病杂志, 1988, 6(4):193.
12.	Delfini C, Colloca S, Taitiani G, et al. Clearance of hepatitis B virus, DNA and pre S1 surface antigens in patients with markers of acute viral replication[J]. J Med Viral, 1989, 28(2):169-175.

1. Hu WG, Wei J, Yang XX, et al. Expression of overlapping PreS1 fragment recombinant proteins for the determination of immunogenic domains in HBsAg PreS1 region[J]. Acta Biochim Biophys Sin, 2004, 36(6):397-404.
2. 闵福援,孙桂珍,王健,等. 前S1蛋白在乙型肝炎诊断及判断预后中的作用[J]. 中华检验医学杂志, 2004, 27(4):224-226.
3. Echevarria JM, Avellón A. Hepatitis B virus genetic diversity[J]. J Med Virol, 2006, 78(Suppl 1):S36-S42.
4. Ingman M, Lindqvist B, Kidd-Ljunggren K. Novel mutation in hepatitis B virus preventing HBsAg production and resembling primate strains[J]. J Gen Virol, 2006, 87(Pt 2):307-310.
5. Taliani G, Rapicetta M, Francisci D, et al. Correlation of preS antigens and clinical status during chronic hepatitis B virus infection[J]. Med Microbil Im munol, 1991, 180(5):239-248.
6. 徐文丽. 联合检测乙肝病毒前Sl抗原临床意义[J]. 上海预防医学杂志, 2009, 21(2):76.
7. Lee YI, Hur GM, Suh DJ, et al. Novel pre2C/C gene mutants of hepatitisis B virus in chronic active hepatitis:naturally occwrring escape mutants[J]. J Gen Virol, 1996, 77(Pt 6):1129-1138.
8. Tonetto PA, Gonçales NS, Fais VC, et al. Hepatitis B virus:molecular genotypes and HBeAg serological status among HBV-infected patients in the southeast of Brazil[J]. BMC Infec Dis, 2009, 9:149-155.
9. 李小平, 朱卫平, 李若冰. 乙型肝炎表面抗原阳性肝硬化患者前S1抗原、e抗原及乙型肝炎病毒DNA结果分析[J]. 华西医学, 2012, 27(1):63-65.
10. Pichoud C, Berby F, Stuyver L, et al. Persistence of viral replication after anti-HBe seroconversion during antiviral therapy for chronic hepatitis B[J]. J Hepatol, 2000, 32(2):307-316.
11. 姚光弼,陆选永,张利民,等. 前S1和前S2蛋白-HBV复制的新标志[J]. 中华传染病杂志, 1988, 6(4):193.
12. Delfini C, Colloca S, Taitiani G, et al. Clearance of hepatitis B virus, DNA and pre S1 surface antigens in patients with markers of acute viral replication[J]. J Med Viral, 1989, 28(2):169-175.

West China Medical Journal

Study on the Relationship among Hepatitis B Virus PreS1, Human Hepatitis B e Antigen and Liver Fuction in Serum of Hepatitis B Patients

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