A Comparative Study between Dynamic Contrast-enhancement MRI and Magnetic Resonance Spectroscopy in Diagnosing Prostate Cancer_West China Medical Journal

Authors：

 PENGTao ¹ , XIAOJian-ming ¹ , YANGJin ²

1. Department of Radiology, Affiliated Hospital of Chengdu University, Chengdu, Sichuan 610081, P. R. China;
2. Department of Urology, Affiliated Hospital of Chengdu University, Chengdu, Sichuan 610081, P. R. China;

Corresponding author：

Keywords：

Magnetic resonance imaging; Dynamic enhancement; Magnetic resonance spectrum; Prostatic neoplasms; Prostate cancer

DOI：

10.7507/1002-0179.20140023

Video：

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Abstract Full text Figures/Tables Video References Cited by

Objective To compare the effectiveness of magnetic resonance spectroscopy (MRS) and Dynamic Contrast-enhancement (DCE-MRI) with 1.5 T MR scanner in diagnosing prostate cancer. Methods From April 2011 to December 2012, based on the results of biopsy, we measured 216 regions of interest (ROIs) in images of MRS and DCE-MRI, comprised of 131 ROIs from cancer zone and 85 ROIs from non-cancer zone. The data were analyzed with statistical methods, including receiver operating characteristic (ROC) curve. Results There were significant differences between the malignant group and the benign group (P<0.05) in Cit integral, Cho integral, CC/Cit ratio, the type of time-signal intensity curve, initial value, enhancement rate and ratio of enhancement. According to ROC curve, the area under curve (AUC) of CC/Cit and enhancement rate was 0.853 and 0.719, respectively. AUC of time to peak, time difference, enhancement rate and Cit integral was lower than 0.400. The optimal operating point (OOP) of CC/Cit was 0.775, with a specificity of 0.85 and a sensitivity of 0.79, and the AUC was 0.853. The OOP of the ratio of enhancement was 60.89, with a specificity of 0.66 and a sensitivity of 0.71, and the AUC was 0.719. Conclusion MRS is more sensitive and specific than DCE-MRI to diagnose prostate cancer when an 1.5 T MR scanner is used. On the other hand, MRS is susceptible to interference, but DCE-MRI can make up for these deficiencies.

Citation： PENGTao, XIAOJian-ming, YANGJin. A Comparative Study between Dynamic Contrast-enhancement MRI and Magnetic Resonance Spectroscopy in Diagnosing Prostate Cancer. West China Medical Journal, 2014, 29(1): 83-86. doi: 10.7507/1002-0179.20140023 Copy

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1. 徐莉, 谭绍恒, 梁长虹, 等. 静脉注射钆类对比剂及预饱和带对肾脏3.0T质子磁共振波谱匀场和抑水的影响[J]. 中国医学影像技术, 2010, 26(5):940-942.
2. 李春媚, 陈敏, 李飒英, 等. 前列腺癌的MRI诊断:T2WI、DWI、MRS及其综合应用[J]. 磁共振成像, 2010, 1(4):257-263.
3. Alonzi R, Padhani AR, Allen C. Dynamic contrast enhanced MRI in prostate cancer[J]. Eur J Radiol, 2007, 63(3):335-350.
4. Sciarra A, Panebianco V, Ciccariello M, et al. Magnetic resonance spectroscopic imaging (1H-MRSI) and dynamic contrastenhanced magnetic resonance (DCE-MRI):pattern changes from inflammation to prostate cancer[J]. Cancer Invest, 2010, 28(4):424-432.
5. 张盛箭, 彭卫军,周良平. 动态增强MRI基本原理及其在前列腺癌中的应用[J]. 中国医学影像技术, 2010, 26(2):378-380.
6. 周芳, 张同华, 陈建新, 等. 前列腺炎的MRI及MRS初步研究[J]. 临床放射学杂志, 2011, 30(9):1334-1336.
7. 高志国,肖新兰,尹建华. MRI、MRS联合PSA鉴别前列腺癌和前列腺增生的价值[J]. 临床放射学杂志, 2008, 27(12):1707-1710.
8. 李飞宇, 王霄英, 肖江喜, 等. 中国男性前列腺癌MRS体素诊断标准[J]. 中国医学影像技术, 2009, 25(5):833-836.
9. Prando A, Billis A. Focal prostatic atrophy:mimicry of prostatic cancer on TRUS and 3D-MRSI studies[J]. Abdom Imaging, 2009, 34(2):271-275.
10. Lee JY, Chang IH, Moon YT, et al. Effect of prostate biopsy hemorrhage on MRDW and MRS imaging[J]. Korean J Urol, 2011, 52(10):674-680.

West China Medical Journal

A Comparative Study between Dynamic Contrast-enhancement MRI and Magnetic Resonance Spectroscopy in Diagnosing Prostate Cancer

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