Clinical Analysis of Common Inhalant Allergens Causing Allergic Rhinitis in Underage Patients_West China Medical Journal

Authors：

 XILing

Department of Otolaryngology, Sichuan Academy of Medical Science & Sichuan Provincial Peoples'Hospital, Chengdu, Sichuan 610072, P. R. China;

Corresponding author：

Keywords：

Underage patients; Allergic rhinitis; Allergen; Skin prick test

DOI：

10.7507/1002-0179.20140212

Video：

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Objective To investigate the common inhalant allergens causing allergic rhinitis in underage patients, and provide references for clinical prevention of allergic rhinitis. Methods Underage patients with allergic rhinitis admitted to our hospital between January 2010 and June 2013 were screened and skin prick test (SPT) was applied to investigate the response intensity to 22 kinds of common inhalant allergens and analyze the correlation of the positive rates and grades of allergens with age and sex. Results A total of 402 patients were included, and 77.6% (312/402) of them reported positive reaction of SPT; and the top five allergens were dust mites (242/402, 60.2%), house dust (235/402, 58.5%), housefly (142/402, 35.3%), spring pollen Ⅲ (133/402, 33.1%) and mulberry silk (121/402, 30.1%), respectively. Compared with patients whose age was younger than 5 years, both the positive rates and grades of SPT were significantly higher in patients above 5 years old. Additionally, the higher positive rates and grades of SPT were also observed much more in male patients than female patients. Conclusion The most common inhalant allergens causing allergic rhinitis in underage patients are dust mites and house dust. And the SPT response intensity of inhalant allergens can be affected by age and gender.

Citation： XILing. Clinical Analysis of Common Inhalant Allergens Causing Allergic Rhinitis in Underage Patients. West China Medical Journal, 2014, 29(4): 710-713. doi: 10.7507/1002-0179.20140212 Copy

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3.	周艳, 周欣. 变态性鼻炎(过敏性鼻炎)病因与治疗[J]. 中国中医药现代远程教育, 2008, 6(12):1524-1525.
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12.	陈黎, 夏仕英, 张泓. 上海地区哮喘儿童过敏原调查[J]. 检验医学, 2006, 21(5):516, 520.
13.	张晓霞, 晏晓波, 杨秀云. 莱芜地区常见吸入性变应原皮肤点刺试验结果分析[J]. 齐鲁护理杂志, 2013, 19(20):16-18.
14.	Platts-Mills TA, Thomas WR, Aalberse RC, et al. Dust mite allergens and asthma:report of a second international workshop[J]. J Allergy Clin Immunol, 1992, 89(5):1046-1060.
15.	张宏誉. 变态反应学在中国[J]. 中华临床免疫和变态反应杂志, 2008, 2(4):255-260.
16.	Osman M, Hansell AL, Simpson CR, et al. Gender-specific presentations for asthma, allergic rhinitis and eczema in primary care[J]. Prim Care Respir J, 2007, 16(1):28-35.
17.	徐文飞, 刘恩梅, 周燕荣, 等. 重庆地区1105例变应性疾病患儿吸入性变应原临床分析[J]. 实用儿科临床杂志, 2008, 23(9):654-656.
18.	茅松, 刘光陵, 夏正坤, 等. 儿童支气管哮喘变应原检测与年龄、性别的关系探讨[J]. 实用医学杂志, 2011, 27(18):3366-3368.
19.	傅静芬, 俞怡, 苏亮, 等. 舟山地区儿童过敏性鼻炎主要变应原调查及护理[J]. 上海预防医学, 2013, 25(10):590-591, 594.
20.	赵卓慧, 张昕, 刘冉冉, 等. 太原市学龄前儿童哮喘、过敏性鼻炎及湿疹与出生前及早期家居环境的相关性[J]. 科学通报, 2013, 58(25):2582-2588.

1. Van Gysel D, Govaere E, Verhamme KM, et al. Messages from the Aalst Allergy Study[J]. World J Pediatr, 2009, 5(3):182-190.
2. 余艳云. 皮肤点刺在过敏性鼻炎与哮喘变应原检测中的应用[J]. 中国医药指南, 2012, 10(18):566-567.
3. 周艳, 周欣. 变态性鼻炎(过敏性鼻炎)病因与治疗[J]. 中国中医药现代远程教育, 2008, 6(12):1524-1525.
4. 张罗, 王成硕, 王向东. 过敏性鼻炎诊治进展[J]. 中国实用内科杂志, 2012, 32(2):86-88.
5. Johansson SG. ImmunoCAP specific IgE test:an objective tool for research and routine allergy diagnosis[J]. Expert Rev Mol Diagn, 2004, 4(3):273-279.
6. 刘飞, 徐艳, 潘现波, 等. 过敏性鼻炎吸入性变应原IgE检测分析[J]. 现代中西医结合杂志, 2013, 22(3):292-293.
7. 王元, 孔宪明, 曹兰芳, 等. 上海地区过敏性疾病患者过敏原研究[J]. 上海医学, 2008, 31(4):241-244.
8. 林英, 王波, 郭素华. 儿童910例变应原皮肤点刺试验结果分析[J]. 中国医师杂志, 2010, 12(11):1552-1555.
9. 艾涛, 罗荣华, 吴英, 等. 儿童哮喘1952例吸入变应原皮肤点刺结果分析[J]. 四川医学, 2010, 31(12):1742-1744.
10. 王刚, 陈建平, 汪万军, 等. 西南地区2071例变应性疾病患儿变应原临床分析[J]. 重庆医学, 2011, 40(19):1911-1914.
11. 方美善, 李景华, 窦逾常, 等. 531例变应性鼻炎吸入性变应原检测分析[J]. 中国实验诊断学, 2010, 14(8):1311-1312.
12. 陈黎, 夏仕英, 张泓. 上海地区哮喘儿童过敏原调查[J]. 检验医学, 2006, 21(5):516, 520.
13. 张晓霞, 晏晓波, 杨秀云. 莱芜地区常见吸入性变应原皮肤点刺试验结果分析[J]. 齐鲁护理杂志, 2013, 19(20):16-18.
14. Platts-Mills TA, Thomas WR, Aalberse RC, et al. Dust mite allergens and asthma:report of a second international workshop[J]. J Allergy Clin Immunol, 1992, 89(5):1046-1060.
15. 张宏誉. 变态反应学在中国[J]. 中华临床免疫和变态反应杂志, 2008, 2(4):255-260.
16. Osman M, Hansell AL, Simpson CR, et al. Gender-specific presentations for asthma, allergic rhinitis and eczema in primary care[J]. Prim Care Respir J, 2007, 16(1):28-35.
17. 徐文飞, 刘恩梅, 周燕荣, 等. 重庆地区1105例变应性疾病患儿吸入性变应原临床分析[J]. 实用儿科临床杂志, 2008, 23(9):654-656.
18. 茅松, 刘光陵, 夏正坤, 等. 儿童支气管哮喘变应原检测与年龄、性别的关系探讨[J]. 实用医学杂志, 2011, 27(18):3366-3368.
19. 傅静芬, 俞怡, 苏亮, 等. 舟山地区儿童过敏性鼻炎主要变应原调查及护理[J]. 上海预防医学, 2013, 25(10):590-591, 594.
20. 赵卓慧, 张昕, 刘冉冉, 等. 太原市学龄前儿童哮喘、过敏性鼻炎及湿疹与出生前及早期家居环境的相关性[J]. 科学通报, 2013, 58(25):2582-2588.

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Clinical Analysis of Common Inhalant Allergens Causing Allergic Rhinitis in Underage Patients

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