Prevalence of Chronic Obstructive Pulmonary Disease with Lipid Metabolism Disorders in Chengdu_West China Medical Journal

Authors：

 WUJia , LIAOXiao-yang , PENGDa-qing , LIUXian-yuan ,  LEIYi

Department of General Practice, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, P. R. China;

Corresponding author：

LEIYi, Email: 3371842@qq.com

Keywords：

Chronic obstructive pulmonary disease; Lipid metabolism disorders; Body mass index; Waistline

DOI：

10.7507/1002-0179.20140247

Video：

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Objective To investigate the prevalence of chronic obstructive pulmonary disease (COPD) with lipid metabolism disorders patients in Chengdu. Methods We randomly selected four communities from urban and rural areas in Chengdu between February and December, 2010, with multistage cluster random sampling method; 1 931 residents aged from 40 to 70 received special questionnaire from the BOLD Study, lung examination, blood biochemical examination, and physical examination. Results The prevalence of COPD was 60.26% (91/151) with dyslipidemia; while non-COPD was 68.17% (972/1 428), and the difference was significant (P<0.05), in which the most obvious difference is triglycerides (TG). The prevalence of COPD was 6.62% (10/151) with underweight; while non-COPD was 4.97% (71/1 428), and the difference was significant (P<0.001). The prevalence of COPD was 21.19% (32/151) with abdominal obesity; while non-COPD was 30.81% (440/1 428), and the difference was significant (P<0.05). Conclusion The prevalence of COPD with lipid metabolism disorders is lower than which with non-COPD in Chengdu. It provides an evidence for the nutrition support therapy in the treatment of COPD.

Citation： WUJia, LIAOXiao-yang, PENGDa-qing, LIUXian-yuan, LEIYi. Prevalence of Chronic Obstructive Pulmonary Disease with Lipid Metabolism Disorders in Chengdu. West China Medical Journal, 2014, 29(5): 806-808. doi: 10.7507/1002-0179.20140247 Copy

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1. 中华医学会呼吸病学分会慢性阻塞性肺疾病学组. 慢性阻塞性肺疾病诊治指南(2013年修订版)(二)[J]. 全科医学临床与教育, 2013, 36(6):603-607.
2. Zhong N, Wang C, Yao W, et al. Prevalence of chronic obstructive pulmonary disease in China:a large, population-based survey[J]. Am J Respir Crit Care Med, 2007, 176(8):753-760.
3. 曾雪峰, 王晓霞, 包勇, 等. 成都市社区慢性阻塞性肺疾病流行病学调查[J]. 中国呼吸与危重监护杂志, 2011, 10(1):30-32.
4. Feary JR, Rodrigues LC, Smith CJ, et al. Prevalence of major comorbidities in subjects with COPD and incidence of myocardial infarction and stroke:a comprehensive analysis using data from primary care[J]. Thorax, 2010, 65(11):956-962.
5. 常春, 姚婉贞, 方天舒. 慢性阻塞性肺疾病患者死因构成及其生存时间的影响因素[J]. 中华医学杂志, 2011, 91(12):824-827.
6. 王曾礼. 重视慢性阻塞性肺疾病的共病[J]. 中华内科杂志, 2011, 50(6):456-458.
7. Buist AS, Mcburnie MA, Vollmer WM, et al. International variation in the prevalence of COPD (the BOLD Study):a population-based prevalence study[J]. Lancet, 2007, 370(9589):741-750.
8. 中华医学会呼吸病学分会慢性阻塞性肺疾病学组. 慢性阻塞性肺疾病诊治指南(2007年修订版)[J]. 中华内科杂志, 2007, 30(3):254-261.
9. Miller MR, Hankinson J, Brusasco V, et al. Standardisation of spirometry[J]. Eur Respir J, 2005, 26(2):319-338.
10. 中国成人血脂异常防治指南制订联合委员会. 中国成人血脂异常防治指南[J]. 中华心血管病杂志, 2007, 35(5):390-419.
11. 中华医学会糖尿病分会. 2007年版中国2型糖尿病防治指南[J]. 中华内分泌代谢杂志, 2008, 24(2):增录1-附录26.
12. 吴文彬. 慢性阻塞性肺疾病糖脂代谢的研究现状[J]. 内科, 2011, 6(3):245-248.
13. 赵华昌, 李晓萍, 张倩. 慢性阻塞性肺疾病与血脂关系的临床探讨[J]. 现代预防医学, 2007, 34(6):1194-1195.
14. Zhang Y, Proenca R, Maffei M, et al. Positional cloning of the mouse obese gene and its human homologue[J]. Nature, 1994, 372(655):425-432.
15. Wouters EF, Groenewegen KH, Dentener MA, et al. Systemic inflammation in chronic obstructive pulmonary disease:the role of exacerbations[J]. Proc Am Thorac Soc, 2007, 4(8):626-634.
16. 程静, 叶碧绿, 李春洋. 小剂量激素替代治疗对绝经后妇女心血管系统的影响[J]. 中国老年学杂志, 2005, 25(11):1308-1310.
17. 崔华, 魏致民, 蔡建芳, 等. 2000~2010年间4960例慢性阻塞性肺病住院患者合并高血压和糖/脂代谢紊乱情况调查[J]. 南方医科大学学报, 2011, 31(9):1498-1503.
18. 黄志俭, 罗琴, 凌敏, 等. 慢性阻塞性肺病体重指数与肺功能的相关性研究[J]. 临床肺科杂志, 2009, 14(1):14-16.
19. Celli BR, Cote CG, Marin JM, et al. The body-mass index, airflow obstruction, dyspnea, and exercise capacity index in chronic obstructive pulmonary disease[J]. N England Med, 2004, 350(10):1005-1012.
20. 张明科, 徐治波, 谭珂, 等. 慢性阻塞性肺疾病患者肺功能与体重指数的关系研究[J]. 华西医学, 2008, 23(4):744-745.

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