• 1. Department of Respiratory Medicine, Second Affiliated Hospital, Chongqing Medical University, Chengdu, Sichuan 610031, P. R. China;
  • 2. Department of Respiratory, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, P. R. China;
BAOYong, Email: cd_baoyong@sina.com
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Objective To investigate diagnostic and prognostic value of pulmonary embolism severity index (PESI), troponin I (cTnI) and brain natriuretic peptide (BNP) in patients with acute pulmonary embolism (APE). Methods A total of 96 patients confirmed with APE were collected from January 2010 to January 2013, and 50 cases of non-APE controls were also selected in the same period. According to the PESI scores, patients were divided into low-risk, mid-risk, and highrisk group. According to the results of cTnI and BNP, patients were divided into positive group and negative group. Then, we evaluated the diagnostic and prognostic value of the PESI score, cTnI and BNP for patients with APE. Results For the APE patients, the higher the risk was, the higher the constituent ratio of massive and sub-massive APE was (P<0.01). In the cTnI positive group, massive and sub-massive APE accounted for 82.9%, and in the cTnI negative group, non-massive APE was up to 81.9%; in the BNP positive group, massive and sub-massive APE accounted for 73.3%, and in the BNP negative group, non-massive APE was up to 86.3%. The patients with positive cTnI and BNP had a higher rate of right ventricular dysfunction, cardiogenic shock and mortality than the negative group (P<0.01). Conclusion The combined detection of cTnI, BNP and PESI score is important in the diagnosis and risk stratification in APE patients.

Citation: LIQun, WANGXiao-xia, GUOHong-xia, BAOYong, LIWei-min. Research of Cardiac Biomarkers and Pulmonary Embolism Severity Index for the Diagnosis of Acute Pulmonary Embolism and Its Risk Stratification. West China Medical Journal, 2014, 29(7): 1208-1212. doi: 10.7507/1002-0179.20140373 Copy

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