心房钠尿肽及其受体在内耳的研究进展_West China Medical Journal

Authors：

 赵超 ,  唐玥玓

四川大学华西医院耳鼻咽喉头颈外科（成都，610041）;

Corresponding author：

唐玥玓, Email: tangyd@hotmail.com

Keywords：

心房钠尿肽; 受体; 内耳; 综述

DOI：

10.7507/1002-0179.20140598

Video：

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内耳是重要的听觉与平衡觉感受器官，由骨迷路和膜迷路构成，含有2套互不相通的内外淋巴系统，内耳中淋巴液的生成、声信号的传导以及耳蜗血流量的调节等方面的机制仍不清楚，但多种物质如肾上腺素、血管加压素、内皮素、醛固酮、一氧化氮、心房钠尿肽等各自或相互的作用与上述机制有关。现将近年来多肽类信号分子心房钠尿肽在内耳中的研究状况综述如下。

Citation： 赵超, 唐玥玓. 心房钠尿肽及其受体在内耳的研究进展. West China Medical Journal, 2014, 29(10): 1975-1978. doi: 10.7507/1002-0179.20140598 Copy

1.	De Bold AJ, Borenstein HB, Veress AT, et al. A rapid and potent natriuretic response to intravenous injection of atrial myocardial extract in rats[J]. Life Sci, 1981, 28(1):89-94.
2.	Vink S, Jin AH, Poth KJ, et al. Natriuretic peptide drug leads from snake venom[J]. Toxicon, 2012, 59(4, SI):434-445.
3.	Chen BY, Tie R, Qu P, et al. Vasonatrin peptide, a new regulator of adiponectin and interleukin-6 production in adipocytes[J]. J Endocrinol Invest, 2011, 34(10):742-746.
4.	Potter LR, Yoder AR, Flora DR, et al. Natriuretic peptides:their structures, receptors, physiologic functions and therapeutic applications[J]. Handb Exp Pharmacol, 2009(191):341-366.
5.	Potter LR, Hunter T. Guanylyl cyclase-linked natriuretic peptide receptors:structure and regulation[J]. J Biol Chem, 2001, 276(9):6057-6060.
6.	Misono KS, Philo JS, Arakawa T, et al. Structure, signaling mechanism and regulation of the natriuretic peptide receptor guanylate cyclase[J]. FEBS Journal, 2011, 278(11):1818-1829.
7.	Suga S, Nakao K, Hosoda K, et al. Receptor selectivity of natriuretic peptide family, atrial natriuretic peptide, brain natriuretic peptide, and C-type natriuretic peptide[J]. Endocrinology, 1992, 130(1):229-239.
8.	Van Den Akker F. Structural insights into the ligand binding domains of membrane bound guanylyl cyclases and natriuretic peptide receptors[J]. J Mol Biol, 2001, 311(5):923-937.
9.	Misono KS, Ogawa H, Qiu Y, et al. Structural studies of the natriuretic peptide receptor:a novel hormone-induced rotation mechanism for transmembrane signal transduction[J]. Peptides, 2005, 26(6):957-968.
10.	Rubattu S, Sciarretta S, Morriello AA, et al. NPR-C:a component of the natriuretic peptide family with implications in human diseases[J]. J Mol Med, 2010, 88(9):889-897.
11.	Pandey KN. Guanylyl cyclase/atrial natriuretic peptide receptor-A:role in the pathophysiology of cardiovascular regulation[J]. Can J Physiol Pharmacol, 2011, 89(8):557-573.
12.	Lamprecht J. Meyer zum gottesberge AM.the presence and localization of receptors for atrial natriuretic peptide in the inner ear of the Guinea pig[J]. Arch Otorhinolaryngo, 1988, 245(5):300-301.
13.	Yoon YJ, Lee EJ, Kim SH. Synthesis of atrial natriuretic peptide in the rabbit inner ear[J]. Laryngoscope, 2012, 122(7):1605-1608.
14.	陈合新, 史剑波, 邱建华, 等. 心钠素免疫反应在豚鼠耳蜗中的整体分布[J]. 中国临床解剖学杂志, 2002, 20(4):290-291.
15.	陈合新, 邱建华. 心钠素在豚鼠耳蜗螺旋神经节中的分布及定位[J]. 中华医学杂志, 1996, 76(2):147-148.
16.	陈合新, 王锦玲. 豚鼠耳蜗心钠素免疫反应阳性颗粒的超微结构观察[J]. 临床耳鼻咽喉科杂志, 1998, 12(9):415-417.
17.	张鹏志, 陈俊, 薛涛, 等. 大鼠耳蜗血管纹边缘细胞原代培养及心钠素的表达[J]. 中华耳科学杂志, 2008, 6(3):325-330.
18.	Qiao L, Han Y, Zhang PZ, et al. Detection of atrial natriuretic peptide and its receptor in marginal cells and cochlea tissues from the developing rats[J]. Neuro Endocrinol Lett, 2011, 32(2):187-192.
19.	周柯, 孙菲, 邱建华, 等. 心钠素在原代培养大鼠耳蜗螺旋神经元细胞中的表达[J]. 中华耳科学杂志, 2010, 8(2):225-230.
20.	Yoon YJ, Hellstrom S. Immunohistochemical localization of alpha-atrial natriuretic polypeptide in the rat cochlea[J]. Acta Otolaryngol, 1992, 112(4):604-610.
21.	李雪梅, 周庆华, 张军桥. 心房利钠肽在大鼠蜗管外侧壁及螺旋神经节的定位-RNA斑点杂交和免疫组织化学研究[J]. 中国医药导刊, 2009, 11(1):90-91.
22.	Long LL, Tang YE, Xia QJ, et al. Detection of atrial natriuretic peptide receptor in the labyrinth of the mouse inner ear[J]. Neuro Endocrinol Lett, 2008, 29(4):577-580.
23.	Long LL, Tang YE, Xia QJ, et al. The expression of atrial natriuretic peptide receptor in the mouse inner ear labyrinth[J]. Neuro Endocrinol Lett, 2010, 31(1):126-130.
24.	Sun F, Zhou K, Wang SJ, et al. Expression and localization of atrial natriuretic peptide and its receptors in rat spiral ganglion neurons[J]. Brain Res Bull, 2013, 95:28-32.
25.	Koch T, Gloddek B, Gutzke S. Binding sites of atrial natriuretic peptide (ANP) in the mammalian cochlea and stimulation of cyclic GMP synthesis[J]. Hear Res, 1992, 63(1/2):197-202.
26.	Furuta H, Mori N, Luo L, et al. Detection of mRNA encoding guanylate cyclase A atrial natriuretic peptide receptor in the rat cochlea by competitive polymerase chain reaction and in situ hybridization[J]. Hear Res, 1995, 92(1/2):78-84.
27.	Dornhoffer JL, Danner C, Li SL. Natriuretic peptide receptors in the human endolymphatic sac[J]. Arch Otolaryngol Head Neck Surg, 2002, 128(4):379-383.
28.	Cao LH, Yang XL. Natriuretic peptides and their receptors in the central nervous system[J]. Prog Neurobiol, 2008, 84(3):234-248.
29.	陈合新, 邱建华, 王锦玲. 心钠素免疫反应物质在豚鼠耳蜗Corti器中的分布[J]. 听力学及言语疾病杂志, 2000, 8(4):213-214.
30.	Yoon YJ, Anniko M. Distribution of alpha-ANP in the cochlea and the vestibular organs[J]. Otorhinolaryngol, 1994, 56(2):73-77.
31.	Nakashima T, Naganawa S, Sone M, et al. Disorders of cochlear blood flow[J]. Brain Res Rev, 2003, 43(1):17-28.
32.	Carlisle L, Aberdeen J, Forge A, et al. Neural basis for regulation of cochlear blood flow:peptidergic and adrenergic innervation of the spiral modiolar artery of the Guinea pig[J]. Hear Res, 1990, 43(2/3):107-113.
33.	熊巍, 邱建华, 林颖, 等. 心钠素对耳蜗缺血再灌注损伤的影响[J]. 中华耳鼻咽喉头颈外科杂志, 2006, 41(4):293-296.
34.	林颖, 邱建华, 乔莉, 等. 心钠素对耳蜗微循环的影响[J]. 听力学及言语疾病杂志, 2006, 14(5):347-350.
35.	林颖, 邱建华. 心钠素在豚鼠耳蜗微血管的分布[J]. 第四军医大学学报, 2005, 26(7):581-583.
36.	Rachel JD, Dziadziola JK, Quirk WS. Atrial natriuretic peptide participates in the regulation of vestibular blood flow[J]. Hear Res, 1995, 89(1/2):181-186.
37.	Seebacher T, Beitz E, Kumagami H, et al. Expression of membrane-bound and cytosolic guanylyl cyclases in the rat inner ear[J]. Hear Res, 1999, 127(1/2):95-102.
38.	Suzuki M, Kitallo H, Kitanishi T, et al. RT-PCR analysis of mRNA expression of natriuretic peptide family and their receptors in rat inner ear[J]. Brain Res Mol Brain Res, 1998, 55(1):165-168.
39.	Hibino H, Nin F, Tsuzuki C, et al. How is the highly positive endocochelear potential formed? The specific architecture of the stria vascularis and theroles of the ion-transport apparatus[J]. Pflugers Arch, 2010, 459(4):521-533.

1. De Bold AJ, Borenstein HB, Veress AT, et al. A rapid and potent natriuretic response to intravenous injection of atrial myocardial extract in rats[J]. Life Sci, 1981, 28(1):89-94.
2. Vink S, Jin AH, Poth KJ, et al. Natriuretic peptide drug leads from snake venom[J]. Toxicon, 2012, 59(4, SI):434-445.
3. Chen BY, Tie R, Qu P, et al. Vasonatrin peptide, a new regulator of adiponectin and interleukin-6 production in adipocytes[J]. J Endocrinol Invest, 2011, 34(10):742-746.
4. Potter LR, Yoder AR, Flora DR, et al. Natriuretic peptides:their structures, receptors, physiologic functions and therapeutic applications[J]. Handb Exp Pharmacol, 2009(191):341-366.
5. Potter LR, Hunter T. Guanylyl cyclase-linked natriuretic peptide receptors:structure and regulation[J]. J Biol Chem, 2001, 276(9):6057-6060.
6. Misono KS, Philo JS, Arakawa T, et al. Structure, signaling mechanism and regulation of the natriuretic peptide receptor guanylate cyclase[J]. FEBS Journal, 2011, 278(11):1818-1829.
7. Suga S, Nakao K, Hosoda K, et al. Receptor selectivity of natriuretic peptide family, atrial natriuretic peptide, brain natriuretic peptide, and C-type natriuretic peptide[J]. Endocrinology, 1992, 130(1):229-239.
8. Van Den Akker F. Structural insights into the ligand binding domains of membrane bound guanylyl cyclases and natriuretic peptide receptors[J]. J Mol Biol, 2001, 311(5):923-937.
9. Misono KS, Ogawa H, Qiu Y, et al. Structural studies of the natriuretic peptide receptor:a novel hormone-induced rotation mechanism for transmembrane signal transduction[J]. Peptides, 2005, 26(6):957-968.
10. Rubattu S, Sciarretta S, Morriello AA, et al. NPR-C:a component of the natriuretic peptide family with implications in human diseases[J]. J Mol Med, 2010, 88(9):889-897.
11. Pandey KN. Guanylyl cyclase/atrial natriuretic peptide receptor-A:role in the pathophysiology of cardiovascular regulation[J]. Can J Physiol Pharmacol, 2011, 89(8):557-573.
12. Lamprecht J. Meyer zum gottesberge AM.the presence and localization of receptors for atrial natriuretic peptide in the inner ear of the Guinea pig[J]. Arch Otorhinolaryngo, 1988, 245(5):300-301.
13. Yoon YJ, Lee EJ, Kim SH. Synthesis of atrial natriuretic peptide in the rabbit inner ear[J]. Laryngoscope, 2012, 122(7):1605-1608.
14. 陈合新, 史剑波, 邱建华, 等. 心钠素免疫反应在豚鼠耳蜗中的整体分布[J]. 中国临床解剖学杂志, 2002, 20(4):290-291.
15. 陈合新, 邱建华. 心钠素在豚鼠耳蜗螺旋神经节中的分布及定位[J]. 中华医学杂志, 1996, 76(2):147-148.
16. 陈合新, 王锦玲. 豚鼠耳蜗心钠素免疫反应阳性颗粒的超微结构观察[J]. 临床耳鼻咽喉科杂志, 1998, 12(9):415-417.
17. 张鹏志, 陈俊, 薛涛, 等. 大鼠耳蜗血管纹边缘细胞原代培养及心钠素的表达[J]. 中华耳科学杂志, 2008, 6(3):325-330.
18. Qiao L, Han Y, Zhang PZ, et al. Detection of atrial natriuretic peptide and its receptor in marginal cells and cochlea tissues from the developing rats[J]. Neuro Endocrinol Lett, 2011, 32(2):187-192.
19. 周柯, 孙菲, 邱建华, 等. 心钠素在原代培养大鼠耳蜗螺旋神经元细胞中的表达[J]. 中华耳科学杂志, 2010, 8(2):225-230.
20. Yoon YJ, Hellstrom S. Immunohistochemical localization of alpha-atrial natriuretic polypeptide in the rat cochlea[J]. Acta Otolaryngol, 1992, 112(4):604-610.
21. 李雪梅, 周庆华, 张军桥. 心房利钠肽在大鼠蜗管外侧壁及螺旋神经节的定位-RNA斑点杂交和免疫组织化学研究[J]. 中国医药导刊, 2009, 11(1):90-91.
22. Long LL, Tang YE, Xia QJ, et al. Detection of atrial natriuretic peptide receptor in the labyrinth of the mouse inner ear[J]. Neuro Endocrinol Lett, 2008, 29(4):577-580.
23. Long LL, Tang YE, Xia QJ, et al. The expression of atrial natriuretic peptide receptor in the mouse inner ear labyrinth[J]. Neuro Endocrinol Lett, 2010, 31(1):126-130.
24. Sun F, Zhou K, Wang SJ, et al. Expression and localization of atrial natriuretic peptide and its receptors in rat spiral ganglion neurons[J]. Brain Res Bull, 2013, 95:28-32.
25. Koch T, Gloddek B, Gutzke S. Binding sites of atrial natriuretic peptide (ANP) in the mammalian cochlea and stimulation of cyclic GMP synthesis[J]. Hear Res, 1992, 63(1/2):197-202.
26. Furuta H, Mori N, Luo L, et al. Detection of mRNA encoding guanylate cyclase A atrial natriuretic peptide receptor in the rat cochlea by competitive polymerase chain reaction and in situ hybridization[J]. Hear Res, 1995, 92(1/2):78-84.
27. Dornhoffer JL, Danner C, Li SL. Natriuretic peptide receptors in the human endolymphatic sac[J]. Arch Otolaryngol Head Neck Surg, 2002, 128(4):379-383.
28. Cao LH, Yang XL. Natriuretic peptides and their receptors in the central nervous system[J]. Prog Neurobiol, 2008, 84(3):234-248.
29. 陈合新, 邱建华, 王锦玲. 心钠素免疫反应物质在豚鼠耳蜗Corti器中的分布[J]. 听力学及言语疾病杂志, 2000, 8(4):213-214.
30. Yoon YJ, Anniko M. Distribution of alpha-ANP in the cochlea and the vestibular organs[J]. Otorhinolaryngol, 1994, 56(2):73-77.
31. Nakashima T, Naganawa S, Sone M, et al. Disorders of cochlear blood flow[J]. Brain Res Rev, 2003, 43(1):17-28.
32. Carlisle L, Aberdeen J, Forge A, et al. Neural basis for regulation of cochlear blood flow:peptidergic and adrenergic innervation of the spiral modiolar artery of the Guinea pig[J]. Hear Res, 1990, 43(2/3):107-113.
33. 熊巍, 邱建华, 林颖, 等. 心钠素对耳蜗缺血再灌注损伤的影响[J]. 中华耳鼻咽喉头颈外科杂志, 2006, 41(4):293-296.
34. 林颖, 邱建华, 乔莉, 等. 心钠素对耳蜗微循环的影响[J]. 听力学及言语疾病杂志, 2006, 14(5):347-350.
35. 林颖, 邱建华. 心钠素在豚鼠耳蜗微血管的分布[J]. 第四军医大学学报, 2005, 26(7):581-583.
36. Rachel JD, Dziadziola JK, Quirk WS. Atrial natriuretic peptide participates in the regulation of vestibular blood flow[J]. Hear Res, 1995, 89(1/2):181-186.
37. Seebacher T, Beitz E, Kumagami H, et al. Expression of membrane-bound and cytosolic guanylyl cyclases in the rat inner ear[J]. Hear Res, 1999, 127(1/2):95-102.
38. Suzuki M, Kitallo H, Kitanishi T, et al. RT-PCR analysis of mRNA expression of natriuretic peptide family and their receptors in rat inner ear[J]. Brain Res Mol Brain Res, 1998, 55(1):165-168.
39. Hibino H, Nin F, Tsuzuki C, et al. How is the highly positive endocochelear potential formed? The specific architecture of the stria vascularis and theroles of the ion-transport apparatus[J]. Pflugers Arch, 2010, 459(4):521-533.

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心房钠尿肽及其受体在内耳的研究进展

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