活性氧簇对创口愈合过程中血管新生的影响_West China Medical Journal

Authors：

 谢飞 ,  何延政 , 刘勇

泸州医学院附属医院血管外科（四川泸州，646000）;

Corresponding author：

何延政, Email: heyanzheng@163.com

Keywords：

活性氧; 创口愈合; 血管发生; 血管生成

DOI：

10.7507/1002-0179.20140599

Video：

Export PDF Favorites Scan Get Citation

Abstract Full text Figures/Tables Video References Cited by

活性氧族是一类氧衍生的代谢物，被广泛地认为是多种生理过程以及病理状态下关键的调节剂，在血管系统中主要由还原型辅酶Ⅱ氧化酶生成。慢性创口的愈合涉及2种不同形式的血管新生：血管发生（骨髓来源分化而成的循环内皮祖细胞形成）和血管生成（已存在血管局部内皮细胞的芽生而形成）。活性氧族通过对血管新生过程中所涉及的内皮祖细胞、内皮细胞和血管平滑肌细胞功能的调节，影响创口愈合。

Citation： 谢飞, 何延政, 刘勇. 活性氧簇对创口愈合过程中血管新生的影响. West China Medical Journal, 2014, 29(10): 1979-1982. doi: 10.7507/1002-0179.20140599 Copy

1.	Coant N, Mkaddem SB, Pedruzzi E, et al. NADPH oxidase 1 modulates WNT and NOTCH1 signaling to control the fate of proliferative progenitor cells in the colon[J]. Mol Cell Biol, 2010, 30(11):2636-2650.
2.	Kajla S, Mondol AS, Nagasawa A, et al. A crucial role for Nox 1 in redox-dependent regulation of Wnt-beta-catenin signaling[J]. FASEB J, 2012, 26(5):2049-2059.
3.	Carmeliet P, Jain RK. Molecular mechanisms and clinical applications of angiogenesis[J]. Nature, 2011, 473(7347):298-307.
4.	Haddad P, Dussault S, Groleau J, et al. Nox2-derived reactive oxygen species contribute to hypercholesterolemia-induced inhibition of neovascularization:effects on endothelial progenitor cells and mature endothelial cells[J]. Atherosclerosis, 2011, 217(2):340-349.
5.	Urao N, Inomata H, Razvi M et al. Role of nox2-based NADPH oxidase in bone marrow and progenitor cell function involved in neovascularization induced by hindlimb ischemia[J]. Circ Res, 2008, 103(2):212-220.
6.	Schroeter MR, Stein S, Heida NM, et al. Leptin promotes the mobilization of vascular progenitor cells and neovascularization by NOX2-mediated activation of MMP9[J]. Cardiovasc Res, 2012, 93(1):170-180.
7.	Lewandowski D, Barroca V, Ducongé F, et al. In vivo cellular imaging pinpoints the role of reactive oxygen species in the early steps of adult hematopoietic reconstitution[J]. Blood, 2010, 115(3):443-452.
8.	Tojo T, Ushio-Fukai M, Yamaoka-Tojo M et al. Role of gp91phox (Nox2)-containing NADPH oxidase in angiogenesis in response to hindlimb ischemia[J]. Circulation, 2005, 111(18):2347-2355.
9.	White CD, Erdemir HH, Sacks DB, et al. IQGAP1 and its binding proteins control diverse biological functions[J]. Cell Signal, 2012, 24(4):826-834.
10.	Sun Z, Li X, Massena S, et al. VEGFR2 induces c-Src signaling and vascular permeability in vivo via the adaptor protein TSAd[J]. J Exp Med, 2012, 209(7):1363-1377.
11.	Mizushima.N, Komatsu M. Autophagy:enovation of cells and tissues[J]. Cell, 2011, 147(4):728-741.
12.	Lee J, Giordano S, Zhang J, et al. Autophagy, mitochondria and oxidative stress:cross-talk and redox signaling[J].Biochem J, 2012, 441(2):523-540.
13.	Wang Q, Liang B, Shirwany NA, et al. 2-deoxy-D-glucose treatment of endothelial cells induces autophagy by reactive oxygen species-mediated activation of the AMP activated protein kinase[J].Plos One, 2011, 6(2):e17234.
14.	Shen W, Tian C, Chen H, et al. Oxidative stress mediates chemerin-induced autophagy in endothelial cells[J]. Free Radic Biol Med, 2012, 55:73-82.
15.	Du J, Teng RJ, Guan T, et al. Role of autophagy in angiogenesis in aortic endothelial cells[J]. Am J Physiol Cell Physiol, 2012, 302(2):C383-C391.
16.	Alexander MR, Owens GK. Epigenetic control of smooth muscle cell differentiation and phenotypic switching in vascular development and disease[J]. Annu Rev Physiol, 2012, 74:13-40.
17.	Moraes JA, Barcellos-de-Souza P, Rodrigues G, et al. Heme modulates smooth muscle cell proliferation and migration via NADPH oxidase:a counter-regulatory role for heme oxygenase system[J]. Atherosclerosis, 2012, 24(2):394-400.
18.	Diebold I, Petry A, Burger M, et al. NOX4 mediates activation of FoxO3a and matrix metalloproteinase-2expression by urotensin-Ⅱ[J]. Mol Biol Cell, 2011, 22(22):4424-4434.
19.	Weber DS, Taniyama Y, Roci P et al.Phosphoinositidedependent kinase 1 and p21-activated protein kinase mediate reactive oxygen species-dependent regulation of plateletderived growth factor-induced smooth muscle cell migration[J]. Circ Res, 2004, 94(9):1219-1226.
20.	Seshiah PN,Weber DS,Rocic P, et al. Angiotensin Ⅱ stimulation of NAD(P)H oxidase activity:upstream mediators[J]. Circ Res, 2002, 91(5):406-413.
21.	Jagadeesha DK,Takapoo M, Banfi B, et al. Nox1 transactivation of epidermal growth factor receptor promotes N-cadherin shedding and smooth muscle cell migration[J]. Cardiovasc Res, 2012, 93(3):406-413.
22.	San Martín A, Griendling KK. Redox control of vascular smooth muscle migration[J]. Antioxid Redox Signal, 2010, 12(5):625-640.
23.	Lee MY,San Martin A, Mehta PK et al.Mechanisms of vascular smooth muscle NADPH oxidase 1(Nox1) contribution to injury-induced neointimal formation[J]. Arterioscler Thromb Vasc Biol, 2009, 29(4):480-487.
24.	Torres RA, Drake DA, Solodushko V, et al. Slingshot isoform-specific regulation of cofilin-mediated vascular smooth muscle cell migration and neointima formation[J]. Arterioscler Thromb Vasc Biol, 2011, 31(11):2424-2431.
25.	Kim JS, Huang TY, Bokoch GM, et al. Reactive oxygen species regulate a slingshot-cofilin activation pathway[J]. Mol Biol Cell, 2009, 20(11):2650-2660.
26.	Maheswaranathan M, Gole HK, Fernandez I, et al. Platelet-derived growth factor (PDGF) regulates Slingshot phosphatase activity via Nox1-dependent auto-dephosphorylation of serine 834 in vascular smooth muscle Cells[J]. J Biol Chem, 2011, 286(41):35430-35437.
27.	Zimmerman MC, Takapoo M, Jagadeesha DK, et al. Activation of NADPH oxidase 1 increases intracellular calcium and migration of smooth muscle cells[J]. Hypertension, 2011, 58(3):446-453.
28.	Schroder K, Zhang M, Benkhoff S, et al. Nox4 is a protective reactive oxygen species generating vascular NADPH oxidase[J]. Circ Res, 2012, 110(9):1217-1225.

1. Coant N, Mkaddem SB, Pedruzzi E, et al. NADPH oxidase 1 modulates WNT and NOTCH1 signaling to control the fate of proliferative progenitor cells in the colon[J]. Mol Cell Biol, 2010, 30(11):2636-2650.
2. Kajla S, Mondol AS, Nagasawa A, et al. A crucial role for Nox 1 in redox-dependent regulation of Wnt-beta-catenin signaling[J]. FASEB J, 2012, 26(5):2049-2059.
3. Carmeliet P, Jain RK. Molecular mechanisms and clinical applications of angiogenesis[J]. Nature, 2011, 473(7347):298-307.
4. Haddad P, Dussault S, Groleau J, et al. Nox2-derived reactive oxygen species contribute to hypercholesterolemia-induced inhibition of neovascularization:effects on endothelial progenitor cells and mature endothelial cells[J]. Atherosclerosis, 2011, 217(2):340-349.
5. Urao N, Inomata H, Razvi M et al. Role of nox2-based NADPH oxidase in bone marrow and progenitor cell function involved in neovascularization induced by hindlimb ischemia[J]. Circ Res, 2008, 103(2):212-220.
6. Schroeter MR, Stein S, Heida NM, et al. Leptin promotes the mobilization of vascular progenitor cells and neovascularization by NOX2-mediated activation of MMP9[J]. Cardiovasc Res, 2012, 93(1):170-180.
7. Lewandowski D, Barroca V, Ducongé F, et al. In vivo cellular imaging pinpoints the role of reactive oxygen species in the early steps of adult hematopoietic reconstitution[J]. Blood, 2010, 115(3):443-452.
8. Tojo T, Ushio-Fukai M, Yamaoka-Tojo M et al. Role of gp91phox (Nox2)-containing NADPH oxidase in angiogenesis in response to hindlimb ischemia[J]. Circulation, 2005, 111(18):2347-2355.
9. White CD, Erdemir HH, Sacks DB, et al. IQGAP1 and its binding proteins control diverse biological functions[J]. Cell Signal, 2012, 24(4):826-834.
10. Sun Z, Li X, Massena S, et al. VEGFR2 induces c-Src signaling and vascular permeability in vivo via the adaptor protein TSAd[J]. J Exp Med, 2012, 209(7):1363-1377.
11. Mizushima.N, Komatsu M. Autophagy:enovation of cells and tissues[J]. Cell, 2011, 147(4):728-741.
12. Lee J, Giordano S, Zhang J, et al. Autophagy, mitochondria and oxidative stress:cross-talk and redox signaling[J].Biochem J, 2012, 441(2):523-540.
13. Wang Q, Liang B, Shirwany NA, et al. 2-deoxy-D-glucose treatment of endothelial cells induces autophagy by reactive oxygen species-mediated activation of the AMP activated protein kinase[J].Plos One, 2011, 6(2):e17234.
14. Shen W, Tian C, Chen H, et al. Oxidative stress mediates chemerin-induced autophagy in endothelial cells[J]. Free Radic Biol Med, 2012, 55:73-82.
15. Du J, Teng RJ, Guan T, et al. Role of autophagy in angiogenesis in aortic endothelial cells[J]. Am J Physiol Cell Physiol, 2012, 302(2):C383-C391.
16. Alexander MR, Owens GK. Epigenetic control of smooth muscle cell differentiation and phenotypic switching in vascular development and disease[J]. Annu Rev Physiol, 2012, 74:13-40.
17. Moraes JA, Barcellos-de-Souza P, Rodrigues G, et al. Heme modulates smooth muscle cell proliferation and migration via NADPH oxidase:a counter-regulatory role for heme oxygenase system[J]. Atherosclerosis, 2012, 24(2):394-400.
18. Diebold I, Petry A, Burger M, et al. NOX4 mediates activation of FoxO3a and matrix metalloproteinase-2expression by urotensin-Ⅱ[J]. Mol Biol Cell, 2011, 22(22):4424-4434.
19. Weber DS, Taniyama Y, Roci P et al.Phosphoinositidedependent kinase 1 and p21-activated protein kinase mediate reactive oxygen species-dependent regulation of plateletderived growth factor-induced smooth muscle cell migration[J]. Circ Res, 2004, 94(9):1219-1226.
20. Seshiah PN,Weber DS,Rocic P, et al. Angiotensin Ⅱ stimulation of NAD(P)H oxidase activity:upstream mediators[J]. Circ Res, 2002, 91(5):406-413.
21. Jagadeesha DK,Takapoo M, Banfi B, et al. Nox1 transactivation of epidermal growth factor receptor promotes N-cadherin shedding and smooth muscle cell migration[J]. Cardiovasc Res, 2012, 93(3):406-413.
22. San Martín A, Griendling KK. Redox control of vascular smooth muscle migration[J]. Antioxid Redox Signal, 2010, 12(5):625-640.
23. Lee MY,San Martin A, Mehta PK et al.Mechanisms of vascular smooth muscle NADPH oxidase 1(Nox1) contribution to injury-induced neointimal formation[J]. Arterioscler Thromb Vasc Biol, 2009, 29(4):480-487.
24. Torres RA, Drake DA, Solodushko V, et al. Slingshot isoform-specific regulation of cofilin-mediated vascular smooth muscle cell migration and neointima formation[J]. Arterioscler Thromb Vasc Biol, 2011, 31(11):2424-2431.
25. Kim JS, Huang TY, Bokoch GM, et al. Reactive oxygen species regulate a slingshot-cofilin activation pathway[J]. Mol Biol Cell, 2009, 20(11):2650-2660.
26. Maheswaranathan M, Gole HK, Fernandez I, et al. Platelet-derived growth factor (PDGF) regulates Slingshot phosphatase activity via Nox1-dependent auto-dephosphorylation of serine 834 in vascular smooth muscle Cells[J]. J Biol Chem, 2011, 286(41):35430-35437.
27. Zimmerman MC, Takapoo M, Jagadeesha DK, et al. Activation of NADPH oxidase 1 increases intracellular calcium and migration of smooth muscle cells[J]. Hypertension, 2011, 58(3):446-453.
28. Schroder K, Zhang M, Benkhoff S, et al. Nox4 is a protective reactive oxygen species generating vascular NADPH oxidase[J]. Circ Res, 2012, 110(9):1217-1225.

Previous Article
心房钠尿肽及其受体在内耳的研究进展
Next Article
改良电休克治疗麻醉用药研究进展

West China Medical Journal

活性氧簇对创口愈合过程中血管新生的影响

Abstract Full text Figures/Tables Video References Cited by

Previous Article

Next Article

Format

Content