• Department of Nephrology, the Second Affiliated Hospital of Chongqing Medical University & the Third People's Hospital of Chengdu, Chengdu, Sichuan 610031, P. R. China;
GONGRong, Email: gongr2006@sina.com
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Objective To observe whether proteinuria is relate to the decline of residual renal function (RRF) in peritoneal dialysis (PD) patients. Methods This is a prospective cohort study including 45 PD patients (underwent PD between January 2011 and January 2013) with a 12-month follow-up. All the patients were divided into 2 groups with respect to the initial proteinuria level: massive proteinuria group A (n=20) and non-massive proteinuria group B (n=25) at baseline. We established regression models to do univariate analysis and multivariate analysis of the relationship between the decline of RRF≥50% of baseline and the indices of age, sex, PD-associated peritonitis, baseliner residual glomerular filtration rate (rGFR), initial proteinuria, and use of ACEI/ARB. Results The primary outcome (RRF>50% of baseline) at 12 months was 65% in group A, and 80% in group B (P<0.05). Based both on the results of univariate and multivariate Cox regression analysis, non-massive proteinuria and higher rGFR at baseline were factors to protect RRF from decline (P<0.05). Conclusion The study demonstrates that massive proteinuria and lower rGFR at baseline may be associated with a rapid decline of RRF in PD patients. Treatment aimed at reducing albuminuria may lead to protect RRF and improve life quality of patients.

Citation: JINLi-zhu, CHENZe-jun, GONGRong, YANGBin, SHUYing, QUANDa-yong, TONGYu-na. Effect of Proteinuria on Residual Renal Function in Peritoneal Dialysis Patients. West China Medical Journal, 2014, 29(12): 2205-2208. doi: 10.7507/1002-0179.20140667 Copy

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