LIZhi-wei 1 , WANGZhu-jun 2 , XUXu 1 , QIAOShuai 1 , MAZhi-jia 1 , WANGShu-long 1 , GAOWen-hua 1 , LANCai-xia 1
  • 1. The Emergency Department of the 253 th Hospital of PLA, Hohhot, Inner Mongolia 010051, P. R. China;
  • 2. The Emergency Center of Hohhot International Airport Corporate Limited Company, Hohhot, Inner Mongolia 010070, P. R. China;
XUXu, Email: XX6877@126.com
Severe chest-abdomen injury; Acute myocardial cell damage; Tumor necrosis factor-α; Interleukin-6; Phospholipase A2
10.7507/1002-0179.20140668
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Objective To investigate the correlation between tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), phospholipase A2 (PLA2) and myocardial cell function disorders in severe chest-abdominal injury patients. Methods Eighty-two subjects with severe chest-abdominal injury were collected from January 2009 to June 2012, of whom the trauma index were all above or equal to 17 points. As the rescue and treatment were in progress, the patients were examined for their creatine kinase-MB (CK-MB), cardiac troponin T (cTnT), TNF-α, IL-6, and PLA2 for correlation analysis. Another 82 subjects undergoing physical examination during the same time were chosen as the controls, who were again divided into myocardial cell function control group with 46 subjects and injury factors control group with 36 subjects. Results For the myocardial cell function control group, CK-MB was (8.13±3.64) U/L, and cTnT was (26.71±11.58) pg/mL; for the injury group, those two indexes were respectively (158.74±31.59) U/L and (496.25±58.46) pg/mL. For the injury factors control group, TNF-α was (1.28±0.59) ng/mL, IL-6 was (63.93±41.49) ng/mL, and PLA2 was (7.47±5.27) ng/mL; for the injury group, those three indexes were respectively (36.41±18.09) ng/mL, (393.83±143.86) ng/mL, and (41.35±14.26) ng/mL. For severer chest-abdominal injury patients, all correlation factors between CK-MB and TNF-α, IL-6, PLA2 were above 0.911, and the factors between cTnT and TNF-α, IL-6, PLA2 were all above 0.912, and all correlations were positive. Conclusion TNF-α, IL-6 and PLA2 all participate in the process of acute myocardial cell function disorders in severe chest-abdominal injury patients. Early intervention of TNF-α, IL-6, and PLA2 may reduce myocardial cell damage, and improve patients' survival rate.

Citation： LIZhi-wei, WANGZhu-jun, XUXu, QIAOShuai, MAZhi-jia, WANGShu-long, GAOWen-hua, LANCai-xia. Investigation on the Correlation between Tumor Necrosis Factor-α, Interleukin-6, Phospholipase A2 and Acute Myocardial Cell Function Disorders after Severe Chest-abdomen Injury. West China Medical Journal, 2014, 29(12): 2209-2212. doi: 10.7507/1002-0179.20140668 Copy

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