深部脑刺激治疗肥胖症的最新进展_West China Medical Journal

Authors：

 张伊祎 ^1,2 ,  赵铁耘 ¹

1. ;
2. ;

Corresponding author：

赵铁耘, Email: zty112356@126.com

Keywords：

深部脑刺激; 肥胖; 下丘脑; 伏核

DOI：

10.7507/1002-0179.20150110

Video：

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深部脑刺激器作为可植入设备，常被称为“脑起搏器”，可对深部脑组织的特定部位提供连续脉冲刺激，即所谓的深部脑刺激（DBS）。DBS作为有效且安全的治疗复杂的、难治性神经精神疾病的手段，目前的研究提示亦可能用于治疗肥胖症。外侧下丘脑和腹侧下丘脑是大脑独立的食欲和饱食中心，伏核也与高脂高糖饮食的过量摄入有关，以这些区域为靶目标的DBS可以抑制食欲和减轻体质量。现将DBS的作用机制及治疗肥胖症的3个潜在靶点作一综述。

Citation： 张伊祎, 赵铁耘. 深部脑刺激治疗肥胖症的最新进展. West China Medical Journal, 2015, 30(2): 370-372. doi: 10.7507/1002-0179.20150110 Copy

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11.	Hetherington AW. Non-production of hypothalamic obesity in the rat by lesions rostral or dorsal to the ventro-medial hypothalamic nuclei[J]. J Comparat Neurol, 1944, 80(1):33-45.
12.	Torres N, Chabardès S, Benabid AL. Rationale for hypothalamus-deep brain stimulation in food intake disorders and obesity[J]. Adv Tech Stand Neurosurg, 2011, 36:17-30.
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14.	Brown FD, Fessler RG, Rachlin JR, et al. Changes in food intake with electrical stimulation of the ventromedial hypothalamus in dogs[J]. J Neurosurg, 1984, 60(6):1253-1257.
15.	Hamani C, Mcandrews MP, Cohn M, et al. Memory enhancement induced by hypothalamic/fornix deep brain stimulation[J]. Ann Neurol, 2008, 63(1):119-123.
16.	Berridge KC. "Liking" and "wanting" food rewards:brain substrates and roles in eating disorders[J]. Physiol Behav, 2009, 97(5):537-550.
17.	Van der Plasse G, Schrama R, van Seters SP, et al. Deep brain stimulation reveals a dissociation of consummatory and motivated behaviour in the medial and lateral nucleus accumbens shell of the rat[J]. PLoS One, 2012, 7(3):e33455.
18.	张弨, 张凯, 魏乃礼, 等. 伏隔核脑深部电刺激对大鼠肥胖症的治疗作用[J]. 吉林大学学报:医学版, 2013, 39(2):209-212.
19.	Halpern CH, Tekriwal A, Santollo J, et al. Amelioration of binge eating by nucleus accumbens shell deep brain stimulation in mice involves D2 receptor modulation[J]. J Neurosci, 2013, 33(17):7122-7129.
20.	Quaade F. Letter:stereotaxy for obesity[J]. Lancet, 1974, 1(7851):267.
21.	Tomycz ND, Whiting DM, Oh MY. Deep brain stimulation for obesity-from theoretical foundations to designing the first human pilot study[J]. Neurosurg Rev, 2012, 35(1):37-42.

1. Flegal KM, Carroll MD, Ogden CL, et al. Prevalence and trends in obesity among US adults, 1999-2000[J]. JAMA, 2002, 288(14):1723-1727.
2. Pandey S, Bhattacharya S. Impact of obesity on gynecology[J]. Womens Health (Lond Engl), 2010, 6(1):107-117.
3. Rucker D, Padwal R, Li SK, et al. Long term pharmacotherapy for obesity and overweight:updated meta-analysis[J]. Br Med J, 2007, 335(7631):1194-1199.
4. Maggard MA, Shugarman LR, Suttorp M, et al. Meta-analysis:surgical treatment of obesity[J]. Ann Intern Med, 2005, 142(7):547-559.
5. Coffey RJ. Deep brain stimulation devices:a brief technical history and review[J]. Artif Organs, 2009, 33(3):208-220.
6. Mcbriar MD, Guzik H, Shapiro S, et al. Discovery of orally efficacious melanin-concentrating hormone receptor-1 antagonists as antiobesity agents. Synthesis, SAR, and biological evaluation of bicyclo[3.1.0]hexyl ureas[J]. J Med Chem, 2006, 49(7):2294-2310.
7. Kotz CM, Teske JA, Levine JA, et al. Feeding and activity induced by orexin A in the lateral hypothalamus in rats[J]. Regul Pept, 2002, 104(1/2/3):27-32.
8. Halpern CH, Wolf JA, Bale TL, et al. Deep brain stimulation in the treatment of obesity[J]. J Neurosurg, 2008, 109(4):625-634.
9. Sani S, Jobe K, Smith A, et al. Deep brain stimulation for treatment of obesity in rats[J]. J Neurosurg, 2007, 107(4):809-813.
10. Laćan G, De Salles AA, Gorgulho AA, et al. Modulation of food intake following deep brain stimulation of the ventromedial hypothalamus in the vervet monkey[J]. J Neurosurg, 2008, 108(2):336-342.
11. Hetherington AW. Non-production of hypothalamic obesity in the rat by lesions rostral or dorsal to the ventro-medial hypothalamic nuclei[J]. J Comparat Neurol, 1944, 80(1):33-45.
12. Torres N, Chabardès S, Benabid AL. Rationale for hypothalamus-deep brain stimulation in food intake disorders and obesity[J]. Adv Tech Stand Neurosurg, 2011, 36:17-30.
13. Covalin A, Feshali A, Judy J. Deep brain stimulation for obesity control:analyzing stimulation parameters to modulate energy expenditure[C]//Neural Engineering, 2005. Conference Proceedings. 2nd International IEEE EMBS Conference on, Arlington:IEEE, 2005:482-485.
14. Brown FD, Fessler RG, Rachlin JR, et al. Changes in food intake with electrical stimulation of the ventromedial hypothalamus in dogs[J]. J Neurosurg, 1984, 60(6):1253-1257.
15. Hamani C, Mcandrews MP, Cohn M, et al. Memory enhancement induced by hypothalamic/fornix deep brain stimulation[J]. Ann Neurol, 2008, 63(1):119-123.
16. Berridge KC. "Liking" and "wanting" food rewards:brain substrates and roles in eating disorders[J]. Physiol Behav, 2009, 97(5):537-550.
17. Van der Plasse G, Schrama R, van Seters SP, et al. Deep brain stimulation reveals a dissociation of consummatory and motivated behaviour in the medial and lateral nucleus accumbens shell of the rat[J]. PLoS One, 2012, 7(3):e33455.
18. 张弨, 张凯, 魏乃礼, 等. 伏隔核脑深部电刺激对大鼠肥胖症的治疗作用[J]. 吉林大学学报:医学版, 2013, 39(2):209-212.
19. Halpern CH, Tekriwal A, Santollo J, et al. Amelioration of binge eating by nucleus accumbens shell deep brain stimulation in mice involves D2 receptor modulation[J]. J Neurosci, 2013, 33(17):7122-7129.
20. Quaade F. Letter:stereotaxy for obesity[J]. Lancet, 1974, 1(7851):267.
21. Tomycz ND, Whiting DM, Oh MY. Deep brain stimulation for obesity-from theoretical foundations to designing the first human pilot study[J]. Neurosurg Rev, 2012, 35(1):37-42.

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