Correlation of the T102C Polymorphism of Serum 5-Hydroxytryptamine and Its Receptor Gene and Suicidal Behavior by Poison in Non-depressive Patients_West China Medical Journal

Authors：

 WUPeng-qiang , CHENMei ,  HANLi-ying

Department of Hematology, Affiliated Hospital of Luzhou Medical College, Luzhou, Sichuan 646000, P. R. China;

Corresponding author：

HANLi-ying, Email: lyhanliying@sina.com

Keywords：

Suicidal behavior; Serum level of 5-hydroxytryptamine; 5-hydroxytryptamine 2A receptor; T102C polymorphism; Non-depressive patients

DOI：

10.7507/1002-0179.20150407

Video：

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Abstract Full text Figures/Tables Video References Cited by

Objective To explore the correlation of serum levels of 5-hydroxytryptamine (5-HT) and 5-HT_2A receptor gene T102C polymorphism with suicidal behavior by poison in non-depressive patients, in order to diagnose and intervene the suicidal behavior of patients as early as possible. Methods Sixty-two non-depressive patients with the behavior of suicide by poison treated between January 2013 and June 2014 were selected as patient group, and other 66 healthy persons were selected as control group. Peripheral blood in the two groups of patients were collected to test the serum levels of 5-HT with enzyme linked immunosorbent assay, and the 5-HT_2A receptor gene T102C polymorphism was detected by polymerase chain reaction-restriction fragment length polymorphism. The data were analyzed by SPSS 19.0 statistically. Results The serum level of 5-HT in the patient group was significantly lower than that in the control group (P<0.001), and the frequency of T102C genotype in the patient group was higher than the control group (χ²=5.533, P=0.013). The distribution of genotype was different, and homozygous mutations of CC in the patient group were higher than the control group (χ²=5.648, P=0.017). Conclusion The serum levels of 5-HT and 5-HT_2A receptor gene T102C polymorphism, and the frequency of T102C genotype may be related to suicidal behavior by poison in non-depressive patients.

Citation： WUPeng-qiang, CHENMei, HANLi-ying. Correlation of the T102C Polymorphism of Serum 5-Hydroxytryptamine and Its Receptor Gene and Suicidal Behavior by Poison in Non-depressive Patients. West China Medical Journal, 2015, 30(8): 1411-1414. doi: 10.7507/1002-0179.20150407 Copy

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12.	Oksenberg D, Havlik S, Peroutka SJ, et al. The third intracellular loop of the 5-hydroxytryptamine2A receptor determines effector coupling specificity[J]. J Neurochem, 1995, 64(4):1440-1447.
13.	Arias B, Gastó C, Catalán R, et al. The 5-HT(2A) receptor gene 102T/C polymorphism is associated with suicidal behavior in depressed patients[J]. Am J Med Genet, 2001, 105(8):801-804.
14.	Du L, Faludi G, Palkovits M, et al. Serotonergic genes and suicidality[J]. Crisis, 2001, 22(2):54-60.
15.	黎雪梅, 况利, 艾明. 5-羟色胺转运体基因第二内含子及启动子区多态性与自杀未遂的关联分析[J]. 重庆医科大学学报, 2010, 35(4):568-571.

1. Bleich S, Bönsch D, Rauh J, et al. Association of the long allele of the 5-HTTLPR polymorphism with compulsive craving in alcohol dependence[J]. Alcohol Alcohol, 2007, 42(6):509-512.
2. Wang SH, Zhang ZJ, Guo YJ, et al. Involvement of serotonin neurotransmission in hippocampal neurogenesis and behavioral responses in a rat model of post-stroke depression[J]. Pharmacol Biochem Behav, 2010, 95(1):129-137.
3. Marcinko D, Pivac N, Martinac M, et al. Platelet serotonin and serum cholesterol concentrations in suicidal and non-suicidal male patients with a first episode of psychosis[J]. Psychiatry Res, 2007, 150(1):105-108.
4. Audenaert K, Van Laere K, Dumont F, et al. Decreased frontal serotonin 5-HT 2a receptor binding index in deliberate self-harm patients[J]. Eur J Nucl Med, 2001, 28(2):175-182.
5. Glatz K, Mössner R, Heils A, et al. Glucocorticoid-regulated human serotonin transporter (5-HTT) expression is modulated by the 5-HTT gene-promotor-linked polymorphic region[J]. J Neurochem, 2003, 86(5):1072-1078.
6. Dodig-Curković K, Curković M, Radić J, et al. Suicidal behavior and suicide among children and adolescents-risk factors and epidemiological characteristics[J]. Coll Antropol, 2010, 34(2):771-777.
7. Oquendo MA, Placidi GP, Malone KM, et al. Positron emission tomography of regional brain metabolic responses to a serotonergic challenge and lethality of suicide attempts in major depression[J]. Arch Gen Psychiatry, 2003, 60(1):14-22.
8. Alvarez JC, Cremniter D, Lesieur P, et al. Low blood cholesterol and low platelet serotonin levels in violent suicide attempters[J]. Biol Psychiatry, 1999, 45(8):1066-1069.
9. 李华芳, 林治光, 王慧芳, 等. 自杀行为患者血小板5-HT浓度[J]. 上海精神医学, 2003, 15(1):1-3.
10. Audenaert K, Peremans K, Goethals I, et al. Functional imaging, serotonin and the suicidal brain[J]. Acta Neurol Belg, 2006, 106(3):125-131.
11. Zhang HY, Ishigaki T, Tani K, et al. Serotonin2a receptor gene polymorphism in mood disorders[J]. Biol Psychiatry, 1997, 41(7):768-773.
12. Oksenberg D, Havlik S, Peroutka SJ, et al. The third intracellular loop of the 5-hydroxytryptamine2A receptor determines effector coupling specificity[J]. J Neurochem, 1995, 64(4):1440-1447.
13. Arias B, Gastó C, Catalán R, et al. The 5-HT(2A) receptor gene 102T/C polymorphism is associated with suicidal behavior in depressed patients[J]. Am J Med Genet, 2001, 105(8):801-804.
14. Du L, Faludi G, Palkovits M, et al. Serotonergic genes and suicidality[J]. Crisis, 2001, 22(2):54-60.
15. 黎雪梅, 况利, 艾明. 5-羟色胺转运体基因第二内含子及启动子区多态性与自杀未遂的关联分析[J]. 重庆医科大学学报, 2010, 35(4):568-571.

West China Medical Journal

Correlation of the T102C Polymorphism of Serum 5-Hydroxytryptamine and Its Receptor Gene and Suicidal Behavior by Poison in Non-depressive Patients

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