Changes of Plasma Homocysteine and Peripheric Arterial Stiffness in Patients with Subclinical Hypothyroidism_West China Medical Journal

Authors：

 XIONGLu , LUOCai-dong , LIUYun-bing , WUYi , WENYu

Department of Cardiology, Mianyang Central Hospital, Mianyang, Sichuan 421000, P. R. China;

Corresponding author：

Keywords：

Subclinical hypothyroidism; Homocysteine; Brachial ankle pulse wave velocity; Arterial stiffness

DOI：

10.7507/1002-0179.20150633

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Objective To observe the changes of plasma homocysteine (Hcy) and brachial ankle pulse wave velocity (baPWV) in patients with subclinical hypothyroidism, and discuss the relationship between subclinical hypothyroidism and arterial stiffness. Method Seventy-three patients with subclinical hypothyroidism who were not treated before were divided into two groups according to thyroid stimulating hormone (TSH) level between January 2013 and June 2014. There were 35 patients in group A (4 mU/L < TSH < 10 mU/L) and 38 in group B (TSH ≥ 10 mU/L). Another 30 healthy individuals were selected as controls. Hcy and baPWV were determined in all subjects. Results Compared with the controls, patients had significantly higher level of TSH, Hcy and baPWV in group A, and had significantly higher TSH, triacylglycerol (TG), low density lipoprotein cholesterol (LDL)-C, Hcy, and baPWV in group B (P<0.05). Compared with group A, TSH, TG, LDL-C, Hcy, and baPWV in group B patiens were significantly higher (P<0.05). Pearson correlation analysis showed that Hcy was positively correlated with TSH (r=0.353, P<0.01) and baPWV was positively correlated with TSH (r=0.416, P<0.01). Conclusions Hcy level and peripheric arterial stiffness increase in patients with subclinical hypothyroidism. Both of them are correlated positively with TSH.

Citation： XIONGLu, LUOCai-dong, LIUYun-bing, WUYi, WENYu. Changes of Plasma Homocysteine and Peripheric Arterial Stiffness in Patients with Subclinical Hypothyroidism. West China Medical Journal, 2015, 30(12): 2205-2207. doi: 10.7507/1002-0179.20150633 Copy

1.	Razvi S, Weaver JU, Vanderpump MP, et al. The incidence of ischemic heart disease and mortality in people with subclinical hypothyroidism:reanalysis of the Whickham Survey cohort[J]. J Clin Endocrinol Metab, 2010, 95(4):1734-1740.
2.	Takamura N, Hayashida N, Maeda T. Risk of coronary heart disease and mortality for adults with subclinical hypothyroidism[J]. JAMA, 2010, 304(22):2481-2482; author reply 2482.
3.	Ochs N, Auer R, Bauer DC, et al. Meta-analysis:subclinical thyroid dysfunction and the risk for coronary heart disease and mortality[J]. Ann Intern Med, 2008, 148(11):832-845.
4.	Razvi S, Shakoor A, Vanderpump M, et al. The influence of age on the relationship between subclinical hypothyroidism and ischemic heart disease:a metaanalysis[J]. J Clin Endocrinol Metab, 2008, 93(8):2998-3007.
5.	中华医学会内分泌学分会《中国甲状腺疾病诊治指南》编写组. 甲状腺疾病诊治指南[J].中华内科杂志, 2007, 46(11):967-971.
6.	陈玉红, 孙玉倩, 傅雪莲. 亚临床甲状腺功能减退症与相关疾病的研究进展[J]. 中国地方病学杂志, 2012, 31(3):343-346.
7.	Velkoska Nakova V, Krstevska B, Bosevski M, et al. Dyslipidaemia and hypertension in patients with subclinical hypothyroidism[J]. Prilozi, 2009, 30(2):93-102.
8.	Maratou E, Hadjidakis DJ, Kollias A, et al. Studies of insulin resistance in patients with clinical and subclinical hypothyroidism[J]. Eur J Endocrinol, 2009, 160(5):785-790.
9.	Ashizawa K, Imaizumi M, Usa T, et al. Metabolic cardiovascular disease risk factors and their clustering in subclinical hypothyroidism[J]. Clin Endocrinol (Oxf), 2010, 72(5):689-695.
10.	张丽云. 高同型半胱氨酸血症与脑卒中的关系探讨[J]. 吉林医学, 2010, 31(22):3743-3744.
11.	Antoniades C, Antonopoulos AS, Tousoulis D, et al. Homocysteine and coronary atherosclerosis:from folate fortification to the recent clinical trials[J]. Eur Heart J, 2009, 30(1):6-15.
12.	邓宇鲲, 闫冰, 陈涛, 等. 血浆同型半胱氨酸水平与颈动脉斑块相关性的研究[J]. 中国循环杂志, 2014, 29(5):363-366.
13.	Alsulaimani S, Gardener H, Elkind MS, et al. Elevated homocysteine and carotid plaque area and densitometry in the Northern Manhattan Study[J]. Stroke, 2013, 44(2):457-461.
14.	Mcdermott MT, Ridgway EC. Subclinical hypothyroidism is mild thyroid failure and should be treated[J]. J Clin Endocrinol Metab, 2001, 86(10):4585-4590.
15.	卢海龙, 郝敬波, 时宏娟, 等. 亚临床甲减对脑梗死患者同型半胱氨酸的影响[J]. 徐州医学院学报, 2012, 32(9):595-597.

1. Razvi S, Weaver JU, Vanderpump MP, et al. The incidence of ischemic heart disease and mortality in people with subclinical hypothyroidism:reanalysis of the Whickham Survey cohort[J]. J Clin Endocrinol Metab, 2010, 95(4):1734-1740.
2. Takamura N, Hayashida N, Maeda T. Risk of coronary heart disease and mortality for adults with subclinical hypothyroidism[J]. JAMA, 2010, 304(22):2481-2482; author reply 2482.
3. Ochs N, Auer R, Bauer DC, et al. Meta-analysis:subclinical thyroid dysfunction and the risk for coronary heart disease and mortality[J]. Ann Intern Med, 2008, 148(11):832-845.
4. Razvi S, Shakoor A, Vanderpump M, et al. The influence of age on the relationship between subclinical hypothyroidism and ischemic heart disease:a metaanalysis[J]. J Clin Endocrinol Metab, 2008, 93(8):2998-3007.
5. 中华医学会内分泌学分会《中国甲状腺疾病诊治指南》编写组. 甲状腺疾病诊治指南[J].中华内科杂志, 2007, 46(11):967-971.
6. 陈玉红, 孙玉倩, 傅雪莲. 亚临床甲状腺功能减退症与相关疾病的研究进展[J]. 中国地方病学杂志, 2012, 31(3):343-346.
7. Velkoska Nakova V, Krstevska B, Bosevski M, et al. Dyslipidaemia and hypertension in patients with subclinical hypothyroidism[J]. Prilozi, 2009, 30(2):93-102.
8. Maratou E, Hadjidakis DJ, Kollias A, et al. Studies of insulin resistance in patients with clinical and subclinical hypothyroidism[J]. Eur J Endocrinol, 2009, 160(5):785-790.
9. Ashizawa K, Imaizumi M, Usa T, et al. Metabolic cardiovascular disease risk factors and their clustering in subclinical hypothyroidism[J]. Clin Endocrinol (Oxf), 2010, 72(5):689-695.
10. 张丽云. 高同型半胱氨酸血症与脑卒中的关系探讨[J]. 吉林医学, 2010, 31(22):3743-3744.
11. Antoniades C, Antonopoulos AS, Tousoulis D, et al. Homocysteine and coronary atherosclerosis:from folate fortification to the recent clinical trials[J]. Eur Heart J, 2009, 30(1):6-15.
12. 邓宇鲲, 闫冰, 陈涛, 等. 血浆同型半胱氨酸水平与颈动脉斑块相关性的研究[J]. 中国循环杂志, 2014, 29(5):363-366.
13. Alsulaimani S, Gardener H, Elkind MS, et al. Elevated homocysteine and carotid plaque area and densitometry in the Northern Manhattan Study[J]. Stroke, 2013, 44(2):457-461.
14. Mcdermott MT, Ridgway EC. Subclinical hypothyroidism is mild thyroid failure and should be treated[J]. J Clin Endocrinol Metab, 2001, 86(10):4585-4590.
15. 卢海龙, 郝敬波, 时宏娟, 等. 亚临床甲减对脑梗死患者同型半胱氨酸的影响[J]. 徐州医学院学报, 2012, 32(9):595-597.

West China Medical Journal

Changes of Plasma Homocysteine and Peripheric Arterial Stiffness in Patients with Subclinical Hypothyroidism

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