Common Variable Immune Deficiency Combined with Celiac Disease: A Case Report and Literatures Review_West China Medical Journal

Authors：

 ZHANGJuan ,  YANGXiao-dong , WANGYu-fang , HUQiu-fang , ZHANGYi , WULi-xue

Department of Respiratory Medicine, West China Hospital, Sichuan University, Chengdu, Sichuan 610041;

Corresponding author：

YANGXiao-dong, Email: yang-xiaodong@163.com

Keywords：

Common variable immunodeficiency; Celiac disease; Hypogammaglobulinemia; Gluten-free diet; Literature review

DOI：

10.7507/1002-0179.20150634

Video：

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Abstract Full text Figures/Tables Video References Cited by

Objective To enhance the understanding of common variable immune deficiency (CVID) combined with celiac disease in order to diagnose and treat the disease as early as possible and delay its complications through the treatment of the disease and study on related literatures. Method The experience of diagnosing and treating one case of CVID combined with celiac disease in November 2013 was reported in the present study, and the related literatures were reviewed. Results After strict gluten-free diet and infusion of intravenous immune globulin, the patient's diarrhea relieved and serum immunoglobulin elevated. Conclusions CVID is the most frequent symptomatic primary immune deficiency which is related to celiac disease closely, a gluten-sensitive condition characterized by a variable degree of villous atrophy. Once diagnosed, gluten-free diet can alleviate the symptoms.

Citation： ZHANGJuan, YANGXiao-dong, WANGYu-fang, HUQiu-fang, ZHANGYi, WULi-xue. Common Variable Immune Deficiency Combined with Celiac Disease: A Case Report and Literatures Review. West China Medical Journal, 2015, 30(12): 2208-2211. doi: 10.7507/1002-0179.20150634 Copy

1.	Herbst EW, Armbruster M, Rump JA, et al. Intestinal B cell defects in common variable immunodeficiency[J]. Clin Exp Immunol, 1994, 95(2):215-221.
2.	Cunningham-Rundles C. Clinical and immunologic analyses of 103 patients with common variable immunodeficiency[J]. J Clin Immunol, 1989, 9(1):22-33.
3.	Hammarström L, Vorechovsky I, Webster D. Selective IgA deficiency (SIgAD) and common variable immunodeficiency (CVID)[J]. Clin Exp Immunol, 2000, 120(2):225-231.
4.	Cunningham-Rundles C, Bodian C. Common variable immunodeficiency:clinical and immunological features of 248 patients[J]. Clin Immunol, 1999, 92(1):34-48.
5.	Salzer U, Warnatz K, Peter HH. Common variable immunodeficiency-an update[J]. Arthritis Res Ther, 2012, 14(5):223.
6.	Park MA, Li JT, Hagan JB, et al. Common variable immunodeficiency:a new look at an old disease[J]. Lancet, 2008, 372(9637):489-502.
7.	Cunningham-Rundles C. How I treat common variable immune deficiency[J]. Blood, 2010, 116(1):7-15.
8.	Empson M, Sinclair J, O'Donnell J, et al. The assessment and management of primary antibody deficiency[J]. NZ Med J, 2004(117):U914.
9.	Agarwal S, Cunningham-Rundles C. Assessment and clinical interpretation of reduced IgG values[J]. Ann Allergy Asthma Immunol, 2007, 99(3):281-283.
10.	Knight AK, Cunningham-Rundles C. Inflammatory and autoimmune complications of common variable immune deficiency[J]. Autoimmun Rev, 2006, 5(2):156-159.
11.	Biagi F. The significance of duodenal mucosal atrophy in patients with common variable immunodeficiency[J]. Am J Clin Pathol, 2012(138):185-189.
12.	Alarida K, Harown J, Ahmaida A, et al. Coeliac disease in Libyan children:a screening study based on the rapid determination of anti-transglutaminase antibodies[J]. Dig Liver Dis, 2011, 43(9):688-691.
13.	Aggarwal S, Lebwohl B. Green PH. Screening for celiac disease in average-risk and high-risk populations[J]. Therap Adv Gastroenterol, 2012, 5(1):37-47.
14.	Cash BD, Rubenstein JH, Young PE, et al. The prevalence of celiac disease among patients with nonconstipated irritable bowel syndrome is similar to controls[J]. Gastroenterology, 2011, 141(4):1187-1193.
15.	Book L, Zone JJ, Neuhausen SL. Prevalence of celiac disease among relatives of sib pairs with celiac disease in U.S. families[J]. Am J Gastroenterol, 2003, 98(2):377-381.
16.	姚怡然, 周力. 麦胶性肠病1例. 世界华人消化杂志[J]. 2010, 18(26):2831-2833.
17.	Washington K, Stenzel TT, Buckley RH, et al. Gastrointestinal pathology in patients with common variable immunodeficiency and X-linked agammaglobulinemia[J]. Am J Surg Pathol, 1996, 20(10):1240-1252.
18.	Catassi C, Rätsch IM, Fabiani E, et al. High prevalence of undiagnosed coeliac disease in 5280 Italian students screened by antigliadin antibodies[J]. Acta Paediatr, 1995, 84(6):672-676.
19.	Cavell B, Stenhammar L, Ascher H, et al. Increasing incidence of childhood coeliac disease in Sweden. Results of a national study[J]. Acta Paediatr, 1992, 81:589-592.
20.	Daniels JA, Lederman HM, Maitra A, et al. Gastrointestinal tract pathology in patients with common variable immunodeficiency (CVID):a clinicopathologic study and review[J]. Am J Surg Pathol, 2007, 31:1800-1812.
21.	Cataldo F, Lio D, Marino V, et al. IgG(1) antiendomysium and IgG antitissue transglutaminase (anti-tTG) antibodies in coeliac patients with selective IgA deficiency. Working Groups on Celiac Disease of SIGEP and Club del Tenue[J]. Gut, 2000, 47(3):366-369.
22.	Sollid LM, Lie BA. Celiac disease genetics:current concepts and practical applications[J]. Clin Gastroenterol Hepatol, 2005, 3(9):843-851.

1. Herbst EW, Armbruster M, Rump JA, et al. Intestinal B cell defects in common variable immunodeficiency[J]. Clin Exp Immunol, 1994, 95(2):215-221.
2. Cunningham-Rundles C. Clinical and immunologic analyses of 103 patients with common variable immunodeficiency[J]. J Clin Immunol, 1989, 9(1):22-33.
3. Hammarström L, Vorechovsky I, Webster D. Selective IgA deficiency (SIgAD) and common variable immunodeficiency (CVID)[J]. Clin Exp Immunol, 2000, 120(2):225-231.
4. Cunningham-Rundles C, Bodian C. Common variable immunodeficiency:clinical and immunological features of 248 patients[J]. Clin Immunol, 1999, 92(1):34-48.
5. Salzer U, Warnatz K, Peter HH. Common variable immunodeficiency-an update[J]. Arthritis Res Ther, 2012, 14(5):223.
6. Park MA, Li JT, Hagan JB, et al. Common variable immunodeficiency:a new look at an old disease[J]. Lancet, 2008, 372(9637):489-502.
7. Cunningham-Rundles C. How I treat common variable immune deficiency[J]. Blood, 2010, 116(1):7-15.
8. Empson M, Sinclair J, O'Donnell J, et al. The assessment and management of primary antibody deficiency[J]. NZ Med J, 2004(117):U914.
9. Agarwal S, Cunningham-Rundles C. Assessment and clinical interpretation of reduced IgG values[J]. Ann Allergy Asthma Immunol, 2007, 99(3):281-283.
10. Knight AK, Cunningham-Rundles C. Inflammatory and autoimmune complications of common variable immune deficiency[J]. Autoimmun Rev, 2006, 5(2):156-159.
11. Biagi F. The significance of duodenal mucosal atrophy in patients with common variable immunodeficiency[J]. Am J Clin Pathol, 2012(138):185-189.
12. Alarida K, Harown J, Ahmaida A, et al. Coeliac disease in Libyan children:a screening study based on the rapid determination of anti-transglutaminase antibodies[J]. Dig Liver Dis, 2011, 43(9):688-691.
13. Aggarwal S, Lebwohl B. Green PH. Screening for celiac disease in average-risk and high-risk populations[J]. Therap Adv Gastroenterol, 2012, 5(1):37-47.
14. Cash BD, Rubenstein JH, Young PE, et al. The prevalence of celiac disease among patients with nonconstipated irritable bowel syndrome is similar to controls[J]. Gastroenterology, 2011, 141(4):1187-1193.
15. Book L, Zone JJ, Neuhausen SL. Prevalence of celiac disease among relatives of sib pairs with celiac disease in U.S. families[J]. Am J Gastroenterol, 2003, 98(2):377-381.
16. 姚怡然, 周力. 麦胶性肠病1例. 世界华人消化杂志[J]. 2010, 18(26):2831-2833.
17. Washington K, Stenzel TT, Buckley RH, et al. Gastrointestinal pathology in patients with common variable immunodeficiency and X-linked agammaglobulinemia[J]. Am J Surg Pathol, 1996, 20(10):1240-1252.
18. Catassi C, Rätsch IM, Fabiani E, et al. High prevalence of undiagnosed coeliac disease in 5280 Italian students screened by antigliadin antibodies[J]. Acta Paediatr, 1995, 84(6):672-676.
19. Cavell B, Stenhammar L, Ascher H, et al. Increasing incidence of childhood coeliac disease in Sweden. Results of a national study[J]. Acta Paediatr, 1992, 81:589-592.
20. Daniels JA, Lederman HM, Maitra A, et al. Gastrointestinal tract pathology in patients with common variable immunodeficiency (CVID):a clinicopathologic study and review[J]. Am J Surg Pathol, 2007, 31:1800-1812.
21. Cataldo F, Lio D, Marino V, et al. IgG(1) antiendomysium and IgG antitissue transglutaminase (anti-tTG) antibodies in coeliac patients with selective IgA deficiency. Working Groups on Celiac Disease of SIGEP and Club del Tenue[J]. Gut, 2000, 47(3):366-369.
22. Sollid LM, Lie BA. Celiac disease genetics:current concepts and practical applications[J]. Clin Gastroenterol Hepatol, 2005, 3(9):843-851.

West China Medical Journal

Common Variable Immune Deficiency Combined with Celiac Disease: A Case Report and Literatures Review

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