Analysis of the clinical application of the reticulocyte parameters and different types of anemia in children_West China Medical Journal

Authors：

 LI Ruizhen , ZHANG Yuerong , ZENG Jiawei , LI Shuixia

Department of Clinical Laboratory, the People’s Hospital of Dujiangyan, Dujiangyan, Sichuan 611830, P. R. China;

Corresponding author：

LI Ruizhen, Email: 604641161@qq.com

Keywords：

Reticulocyte parameters; Children with different types of anemia; Automatic blood cell analyzer

DOI：

10.7507/1002-0179.201511115

Video：

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Objective To investigate the diagnostic value of the series parameters of reticulocyte in children with different types of anemia. Methods From January to August 2015, the reticulocyte parameters of 150 children with different types of anemia treated in the People’s Hospital of Dujiangyan were retrospectively analyzed. Another 150 healthy children aged 1-10 years examined in the same hospital at the same period were as the control group. Mindray BC-6900 automatic blood cell analyzer and suited reagent were used to determine the absolute value of reticulocyte (RET#), percentage of reticulocyte (RET%), immature reticulocyte ratio (IRF), low fluorescent intensity reticulocyte percentage (LFR%), moderate fluorescent intensity reticulocyte percentage (MFR%), and height fluorescent intensity reticulocyte percentage (HFR%). The data were statistically analyzed. Results Compared with the control group, RET%, RET# and IRF results in iron deficiency anemia group, hemolytic anemia group, aplastic anemia group, recent hemorrhagic anemia group, renal anemia group, leukemia and chemotherapy group had statistical difference (P<0.05). Compared with the control group, LFR%, MFR%, HFR% results in hemolytic anemia group and aplastic anemia group had statistical difference (P<0.05). LFR%, MFR% and HFR% results of other types of anemia had no statistical differences (P>0.05). Conclusion The series parameters of the reticulocyte, having an important reference value, can be used in the diagnosis of children with different types of anemia as a reference index, early diagnosis and early treatment of children with different anemia, which also can be used as a method to diagnose different types of anemia.

Citation： LI Ruizhen, ZHANG Yuerong, ZENG Jiawei, LI Shuixia. Analysis of the clinical application of the reticulocyte parameters and different types of anemia in children. West China Medical Journal, 2017, 32(7): 1033-1036. doi: 10.7507/1002-0179.201511115 Copy

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1. 安艳, 赵平. 临床检验. 2 版. 北京: 人民卫生出版社, 2008: 47.
2. 王德琴. 网织红细胞参数 IRF 的临床应用价值. 国际检验医学杂志, 2012, 33(22): 2745-2746.
3. 陈志奇. 骨髓细胞学检查在小儿贫血病因诊断中的临床价值分析. 中国实用医药, 2015, 10(14): 66.
4. 刘洋子, 宋金霞, 孙桂霞. 新生儿贫血相关因素分析及防治进展. 齐鲁护理杂志, 2013, 19(19): 62-64.
5. 陈灏珠. 实用内科学(上) . 11 版. 北京: 人民卫生出版社, 2003: 1221-1253.
6. 戈建军, 王晓卫, 戈萱. 儿童网织红细胞参考范围调查及临床应用. 中国实验诊断学, 2006,10(10): 1213-1215.
7. Harris N, Kunicka J, Kratz A. The ADVIA 2120 hematology system: flow cytometry-based analysis of blood and body fluids in the routine hematology laboratory. Lab Hematol, 2005, 11(1): 47-61.
8. 施泽瑜. 探讨血液检验在贫血鉴别诊断中的临床意义. 吉林医学, 2012, 33(30): 6626.
9. 谭维贤. 贫血鉴别诊断中血液检验的临床作用. 华夏医学, 2013, 26(1): 148-150.
10. 熊立凡. 刘成玉临床检验基础. 4 版. 北京: 人民卫生出版社, 2007: 37, 124.
11. 王瑜敏, 李小龙, 杨丽红. 网织红细胞多参数参考值调查及临床意义. 实验与检验医学, 2003, 21(6)447-448.
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13. 王晓贤. 网织红细胞多参数分析对贫血患者诊疗的意义. 齐齐哈尔医学院学报, 2011, 32(15): 2460-2461.
14. 刘锡范, 常洪军, 寻蕊蕊, 等. 未成熟网织红细胞在小儿贫血中的应用价值, 潍坊医学院学报, 2007, 29(6): 441-442.

West China Medical Journal

Analysis of the clinical application of the reticulocyte parameters and different types of anemia in children

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