Comparison of the Curative Effect between Glucosamine Hydrochloride and Angelicae Pubescentis and Loranthi Decoction in the Treatment of Knee Osteoarthritis_West China Medical Journal

Authors：

 WenXina , LiMinqing , HeMiao , ChengXiang , GengJiabin , LiYongjia

Department of Rehabilitation of Traditional Chinese Medicine, Dazhou Central Hospital, Dazhou, Sichuan 635000, P. R. China;

Corresponding author：

Keywords：

Glucosamine hydrochloride; Osteoarthritis, knee; Angelicae pubescentis and loranthi decoction; Comparison of effect

DOI：

10.7507/1002-0179.201600221

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Objective To compare the clinical efficacy of glucosamine hydrochloride and Chinese traditional medicine of angelicae pubescentis and loranthi decoction in the treatment of knee osteoarthritis. Methods We included 142 patients with mild-to-moderate knee osteoarthritis treated between January 2014 and July 2015. The patients were randomly divided into treatment group and control group. The 72 patients in the treatment group received glucosamine hydrochloride, while the other 70 patients in the control group took oral Chinese medicine of angelicae pubescentis and loranthi decoction. The treatment course was one month. We observed the clinical curative effect of both the two groups. Results After the treatment, the difference in Visual Analogy Score (VAS) and Severity Index of Osteoarthritis (ISOA) in the two groups were significant compared with those before the treatment (P ＜ 0.05) . There were significant differences between the two groups in terms of VAS pain score, ISOA and treatment effectiveness (P ＜ 0.05) . Conclusion Glucosamine hydrochloride can obviously relieve knee osteoarthritis symptoms and improve knee function, which has a better curative effect than the traditional Chinese medicine of angelicae pubescentis and loranthi decoction.

Citation： WenXina, LiMinqing, HeMiao, ChengXiang, GengJiabin, LiYongjia. Comparison of the Curative Effect between Glucosamine Hydrochloride and Angelicae Pubescentis and Loranthi Decoction in the Treatment of Knee Osteoarthritis. West China Medical Journal, 2016, 31(5): 808-810. doi: 10.7507/1002-0179.201600221 Copy

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1. 胥少汀, 葛宝丰, 徐印坎. 实用骨科学[M]. 北京：人民军医出版社, 2009: 1337.
2. 尹群党, 藏向博. 综合疗法治疗膝关节骨性关节炎临床分析[J]. 实用中医药杂志, 2013, 12(29) : 983-985.
3. 黄伟毅, 魏秋实, 曾健英, 等. 独活寄生汤配合玻璃酸钠对膝骨关节炎生活质量的影响[J]. 广东医学, 2014, 35(15) : 2247-2450.
4. 姬登高, 张国强, 张伟. 盐酸氨基葡萄糖联合独活寄生丸治疗膝骨性关节炎临床疗效观察[J]. 中外医学研究, 2014, 12(31) : 10-12.
5. 邓中甲. 方剂学[M]. 北京：中国中医药出版社, 2004: 316.
6. 张丽秀, 钟慧, 周兆德, 等. 独活寄生汤加针刺治疗膝骨关节炎疗效观察[J]. 云南中医中药杂志, 2014, 35(6) : 29-30.
7. 陈湘鄂, 陈四海, 韩东等. 综合康复治疗膝关节骨关节炎临床观察[J]. 中华物理医学与康复杂志, 2006, 28(3) : 213-214.
8. 李磊世, 陈俊伟, 周金龙, 等. 双醋瑞因联合美洛昔康治疗膝骨关节炎临床研究[J]. 中国药物与临床, 2010, 10(1) : 91-93.
9. 石楸鸣. 独活寄生汤的药理作用及临床应用[J]. 中国医院用药评价与分析, 2010, 10(6) : 575-576.
10. 朱粟才, 许能新. 基于中医骨正筋柔理论治疗膝关节骨关节炎的疗效研究[J]. 中外医学研究, 2013, 11(1) : 33-34.
11. 黄武君, 谈志龙, 白人骁. 细胞因子与骨关节炎软骨退变的研究[J]. 中国骨伤, 2006, 19(9) : 635.
12. 李卿, 陆俊鸿, 刘韦, 等. 软骨细胞的老化对软骨蛋白聚糖代谢的影响[J]. 中国临床康复, 2003(2) : 216-218.
13. Leslie M . Knee osteoarthritis management therapiea[J]. Pain Mang Nuts, 2000, 1(2) : 51-57.
14. McAlindon TE, Lavalley MP, Gulin IP, et al. Glucosamine and chondroitin for treatment of osteoarthritis a systematic quality assessment[J]. JAMA, 2000, 283(11) : 1469-1475.
15. 许志宇, 李敏, 刘娜. 盐酸氨基葡萄糖治疗膝关节半月板的临床研究[J]. 中国中医药科技, 2014, 7(21) : 216-217.
16. 陈洁, 兰申玉, 刘伟, 等. 盐酸氨基葡萄糖与双醋瑞因治疗软骨关节炎的临床对照研究[J]. 华西医学, 2014, 29(6) : 1111-1114.
17. 何忠斌, 朱海波. 盐酸氨基葡萄糖对膝骨关节炎患者血清IL-1b、MMP-9 和TNF-α表达的影响和临床疗效[J]. 医学理论与实践,2015, (28) : 1566-1570.
18. 张百挡, 梁祖建, 张还添, 等. 盐酸/硫酸氨基葡萄糖治疗膝骨关节炎的成本效果分析[J]. 中国组织工程研究, 2012, 16(52) : 9867-9872.
19. 卢锋, 郭红卫. 盐酸氨基葡萄糖对骨关节炎作用机制的初步探讨[J]. 卫生研究, 2003, 32(6) : 594-597.
20. Da Camara CC, Dowless GV. Glucosamine sulfate for osteoarthritis[J]. Ann Phammcother, 1998, 32(5) : 580-587.
21. O’Rourke M. Determining the efficacy of glucosamine and chondroitin for osteoarthritis[J]. Nurse Prac, 2001, 26(6) : 44-46, 49-52.
22. 原巧宁, 梁淑芬, 牛洁, 等. 独活寄生汤治疗大鼠膝骨性关节炎软骨病理学分析[J]. 山西中医, 2015, 31(4) : 51-53.
23. 何时华. 膝骨关节炎的针灸治疗与康复训练[J]. 医学美学美容,2014(7) : 466.

West China Medical Journal

Comparison of the Curative Effect between Glucosamine Hydrochloride and Angelicae Pubescentis and Loranthi Decoction in the Treatment of Knee Osteoarthritis

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