超敏肌钙蛋白T与肌酸激酶同工酶在心绞痛患者中的检出水平分析_West China Medical Journal

Authors：

 罗招川 , 林良才

什邡市人民医院心血管内科（四川什邡 618400）;

Corresponding author：

Keywords：

超敏肌钙蛋白T; 肌酸激酶同工酶; 心绞痛

DOI：

10.7507/1002-0179.20160025

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目的探讨超敏肌钙蛋白T（hs-TnT）与肌酸激酶同工酶（CK-MB）在心绞痛患者血清表达的水平差异及临床意义。方法将2012年1月-2013年12月收治的168例疑似心绞痛患者，均以冠状动脉造影结果分为无或轻病变组（单支冠状动脉狭窄＜50%，64例），临界病变组（单支冠状动脉狭窄50%～70%，53例），心绞痛组（单支冠状动脉＞70%或多支冠状动脉狭窄＞50%，51例），入院后4 h抽静脉血检查hs-TnT与CK-MB，比较各组间相关数值差异。结果 hs-TnT在各组中差异有统计学意义（P＜0.05），并随冠状动脉狭窄病变程度加重而升高，CK-MB各组之间差异无统计学意义（P＞0.05）。结论 hs-TnT对心绞痛型冠状动脉粥样硬化性心脏病有预测作用，在心绞痛患者早期就能很好表达出，且随着病变程度加重，hs-TnT水平开高，CK-MB对早期心绞痛患者无显著临床意义。

Citation： 罗招川, 林良才. 超敏肌钙蛋白T与肌酸激酶同工酶在心绞痛患者中的检出水平分析. West China Medical Journal, 2016, 31(1): 98-99. doi: 10.7507/1002-0179.20160025 Copy

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3.	蔡英, 周晓茜, 于萍, 等. 血清超敏肌钙蛋白T在急性冠状动脉综合征患者中危险分层及预后价值的探讨[J]. 临床心血管病杂志, 2011, 27(7):507-510.
4.	Feng YJ, Chen C, Fallon JT, et al. Comparison of cardiac troponin I, creatine kinase-MB, and myoglobin for detection of acute ischemic myocardial injury in a swine model[J]. Am J Clin Pathol, 1998, 110(1):70-77.
5.	Sabatine MS, Morrow DA, De Lemos JA, et al. Detection of acute changes in circulating troponin in the setting of transient stress test-induced myocardial ischaemia using an ultrasensitive assay:results from TIMI 35[J]. Eur Heart J, 2009, 30(2):162-169.
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7.	Ivandic BT, Spanuth E, Kleber M, et al. High-sensitivity troponin T improves the prognostic value of N-terminal pro-B-type natriuretic peptide in patients with stable coronary artery disease:results from the LURIC Study[J]. Clin Chem Lab Med, 2011, 49(6):1053-1058.

1. Laufer EM, Mingels AM, Winkens MH, et al. The extent of coronary atherosclerosis is associated with increasing circulating levels of high sensitive cardiac troponin T[J]. Arterioscler Thromb Vasc Biol, 2010, 30(6):1269-1275.
2. 孙伟峰, 杨莉. 高敏心脏肌钙蛋白在冠状动脉粥样硬化性心脏病的研究进展[J]. 心血管病学进展, 2012, 33(6):751-754.
3. 蔡英, 周晓茜, 于萍, 等. 血清超敏肌钙蛋白T在急性冠状动脉综合征患者中危险分层及预后价值的探讨[J]. 临床心血管病杂志, 2011, 27(7):507-510.
4. Feng YJ, Chen C, Fallon JT, et al. Comparison of cardiac troponin I, creatine kinase-MB, and myoglobin for detection of acute ischemic myocardial injury in a swine model[J]. Am J Clin Pathol, 1998, 110(1):70-77.
5. Sabatine MS, Morrow DA, De Lemos JA, et al. Detection of acute changes in circulating troponin in the setting of transient stress test-induced myocardial ischaemia using an ultrasensitive assay:results from TIMI 35[J]. Eur Heart J, 2009, 30(2):162-169.
6. Sehulz O, Kromer A. Cardiac troponin I:a potential maker of exercise intolerance in patients with moderate heart failure[J]. Am Heart J, 2002, 144(2):351-358.
7. Ivandic BT, Spanuth E, Kleber M, et al. High-sensitivity troponin T improves the prognostic value of N-terminal pro-B-type natriuretic peptide in patients with stable coronary artery disease:results from the LURIC Study[J]. Clin Chem Lab Med, 2011, 49(6):1053-1058.

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超敏肌钙蛋白T与肌酸激酶同工酶在心绞痛患者中的检出水平分析

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