Efficacy of Glucosamine Hydrochloride in the Treatment of Lumbar Facet Joint Osteoarthritis_West China Medical Journal

Authors：

 ShuJianchen ,  ShiKece , ZhuYu , LiuBo

Department of Orthopedics, the People's Hospital of Leshan, Leshan, Sichuan 614200, P. R. China;

Corresponding author：

ShiKece, Email: skc841631@163.com

Keywords：

Glucosamine hydrochloride; Lumbar; Facet joint; Osteoarthritis; Lower back pain

DOI：

10.7507/1002-0179.201600319

Video：

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Objective To analyze the clinical efficacy of glucosamine hydrochloride in the treatment of lumbar facet joint osteoarthritis, in order to provide the most appropriate treatment for lumbar facet joint osteoarthritis. Methods A total of 120 patients with lumbar facet joint osteoarthritis and low back pain treated between August 2014 and August 2015 were randomly divided into three groups with 40 in each. Group A was treated with glucosamine hydrochloride; group B accepted loxoprofen-sodium; and group C was given glucosamine hydrochloride plus loxoprofen-sodium. The courses of treatment were all 8 weeks in the three groups. Follow-up lasted for 16 weeks. Oswestry disability index (ODI) and visual analogue score (VAS) of the patients were compared before treatment, 8 weeks after treatment, and 8 weeks after withdrawal. Results Three patients in group B gave up treatment due to upper gastrointestinal moderate pain after taking the drug. Another 12 patients in group B suffered from upper gastrointestinal mild discomfort, and the symptoms alleviated after accepting symptomatic treatment. There were no drug-related adverse reactions in group A and C. A total of 117 patients completed the 8-week treatment and were all followed up. Before treatment, the ODI scores and VAS scores were not significantly different among the groups (P>0.05). After treatment, the scores changed significantly in all the groups (P<0.05). At week 8 after treatment, the clinical efficacy in group B and C was superior to that in group A, and the differences were statistically significant (P<0.05), but there was no significant difference between group B and C (P>0.05). Eight weeks after withdrawal, the clinical efficacy in group A and C was better than that in group B, and the differences were statistically significant (P<0.05), but there was no significant difference between group A and C (P>0.05). Conclusion Glucosamine hydrochloride is effective for low back pain caused by lumbar facet joint osteoarthritis, which has no non-steroidal anti-inflammatory drug-related complications. It is worthy of clinical application.

Citation： ShuJianchen, ShiKece, ZhuYu, LiuBo. Efficacy of Glucosamine Hydrochloride in the Treatment of Lumbar Facet Joint Osteoarthritis. West China Medical Journal, 2016, 31(7): 1170-1173. doi: 10.7507/1002-0179.201600319 Copy

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2.	Percope DA, Campos TV, Abreu-E-Silva GM. Supplementary methods in the nonsurgical treatment of osteoarthritis[J]. Arthroscopy, 2015, 31(4):785-792.
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6.	Hochberg MC, Martel-Pelletier J, Monfort J, et al. Combined chondroitin sulfate and glucosamine for painful knee osteoarthritis:a multicentre, randomised, double-blind, non-inferiority trial versus celecoxib[J]. Ann Rheum Dis, 2016, 75(1):37-44.
7.	Celik B, Er U, SimsekS, et al. Effectiveness joint blockage for low back pain[J]. Turk Neurosurg, 2011, 21(4):467-470.
8.	Van Zundert J, Vanelderen P, Kessels A, et al. Radiofrequency treatment of facet-related pain:evidence and controversies[J]. Curr Pain Headache Rep, 2012, 16(1):19-25.
9.	孙郁雨, 崔志明. 腰椎关节突关节炎的研究进展[J]. 中国脊柱脊髓杂志, 2012, 22(1):85-88.
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11.	舒剑臣, 唐小穗. P物质、白介素6与腰椎间盘突出症所致腰腿痛的相关性研究[J]. 中国骨与关节损伤杂志, 2013, 28(9):825-827.
12.	Tant L, Gillard B, Open-Label AT, et al. Controlled pilot study of the effects of a glucosamine complex on low back pain[J]. Curr Ther Res Clin Exp, 2005, 66(6):511-521.
13.	Wilkens P, Storheim K, Scheel I, et al. No effect of 6-month intake of glucosamine sulfate on modic changes or high intensity zones in the lumbar spine:sub-group analysis of a randomized controlled trial[J]. J Negat Results Biomed, 2012, 11:13.
14.	Jacobs L, Vo N, Coelho JP, et al. Glucosamine supplementation demonstrates a negative effect on intervertebral disc matrix in an animal model of disc degeneration[J]. Spine (Phila Pa 1976), 2013, 38(12):984-990.
15.	Sodha R, Sivanadarajah N, Alam M. The use of glucosamine for chronic low back pain:a systematic review of randomised control trials[J]. BMJ Open, 2013, 3(6):pii:e001167.
16.	Stuber K, Sajko S, Kristmanson K. Efficacy of glucosamine, chondroitin, and methylsulfonylmethane for spinal degenerative joint disease and degenerative disc disease:a systematic review[J]. J Can Chiropr Assoc, 2011, 55(1):47-55.

1. Falco FJ, Manchikanti L, Datta S, et al. An update of the effectiveness of therapeutic lumbar facet joint interventions[J]. Pain Physician, 2012, 15(6):E909-E953.
2. Percope DA, Campos TV, Abreu-E-Silva GM. Supplementary methods in the nonsurgical treatment of osteoarthritis[J]. Arthroscopy, 2015, 31(4):785-792.
3. 吴子英, 李云霞, 陈世益. 氨基葡萄糖在骨关节炎治疗中的应用[J]. 上海医药, 2012, 33(15):8-11.
4. Wu D, Huang Y, Gu Y, et al. Efficacies of different preparations of glucosamine for the treatment of osteoarthritis:a meta-analysis of randomised, double-blind, placebo-controlled trials[J]. Int J Clin Pract, 2013, 67(6):585-594.
5. Henrotin Y, Mobasheri A, Marty M. Is there any scientific evidence for the use of glucosamine in the management of human osteoarthritis?[J]. Arthritis Res Ther, 2012, 14(1):201.
6. Hochberg MC, Martel-Pelletier J, Monfort J, et al. Combined chondroitin sulfate and glucosamine for painful knee osteoarthritis:a multicentre, randomised, double-blind, non-inferiority trial versus celecoxib[J]. Ann Rheum Dis, 2016, 75(1):37-44.
7. Celik B, Er U, SimsekS, et al. Effectiveness joint blockage for low back pain[J]. Turk Neurosurg, 2011, 21(4):467-470.
8. Van Zundert J, Vanelderen P, Kessels A, et al. Radiofrequency treatment of facet-related pain:evidence and controversies[J]. Curr Pain Headache Rep, 2012, 16(1):19-25.
9. 孙郁雨, 崔志明. 腰椎关节突关节炎的研究进展[J]. 中国脊柱脊髓杂志, 2012, 22(1):85-88.
10. 舒剑臣, 唐小穗, 赵京元. 腰椎间盘退变引起腰腿痛的相关化学因素研究进展[J]. 中华临床医师杂志:电子版, 2012, 6(6):1534-1537.
11. 舒剑臣, 唐小穗. P物质、白介素6与腰椎间盘突出症所致腰腿痛的相关性研究[J]. 中国骨与关节损伤杂志, 2013, 28(9):825-827.
12. Tant L, Gillard B, Open-Label AT, et al. Controlled pilot study of the effects of a glucosamine complex on low back pain[J]. Curr Ther Res Clin Exp, 2005, 66(6):511-521.
13. Wilkens P, Storheim K, Scheel I, et al. No effect of 6-month intake of glucosamine sulfate on modic changes or high intensity zones in the lumbar spine:sub-group analysis of a randomized controlled trial[J]. J Negat Results Biomed, 2012, 11:13.
14. Jacobs L, Vo N, Coelho JP, et al. Glucosamine supplementation demonstrates a negative effect on intervertebral disc matrix in an animal model of disc degeneration[J]. Spine (Phila Pa 1976), 2013, 38(12):984-990.
15. Sodha R, Sivanadarajah N, Alam M. The use of glucosamine for chronic low back pain:a systematic review of randomised control trials[J]. BMJ Open, 2013, 3(6):pii:e001167.
16. Stuber K, Sajko S, Kristmanson K. Efficacy of glucosamine, chondroitin, and methylsulfonylmethane for spinal degenerative joint disease and degenerative disc disease:a systematic review[J]. J Can Chiropr Assoc, 2011, 55(1):47-55.

West China Medical Journal

Efficacy of Glucosamine Hydrochloride in the Treatment of Lumbar Facet Joint Osteoarthritis

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