Calcitonin Combined with Glucosamine Hydrochloride for the Treatment of Knee Osteoarthritis: A Randomized Controlled Study_West China Medical Journal

Authors：

 XuJian ,  WangWenzhi

Department of Osteoporosis, No. 4 West China Teaching Hospital, Sichuan University, Chengdu, Sichuan 610041, P. R. China;

Corresponding author：

WangWenzhi, Email: 1124989091@qq.com

Keywords：

Osteoarthritis,knee; Glucosamine hydrochloride; Calcitonin

DOI：

10.7507/1002-0179.201600320

Video：

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Objective To explore the efficacy of calcitonin combined with glucosamine hydrochloride on knee osteoarthritis. Methods According to Kellgren-Lawrence radiographic scoring system, 156 patients with knee osteoarthritis diagnosed from November 2014 to April 2015 were classified as mild, moderate and severe cases. All of the patients were divided into control group (treated by glucosamine hydrochloride only) and trial group (treated by calcitonin combined with glucosamine hydrochloride) via table of random sampling numbers (with 78 patients in each group). The West Ontario and Manchester University (WOMAC) score was recorded at the 6th week and the 3rd month after the medication treatment. Results In the patients with mild osteoarthritis, there were significant differences in WOMAC score of both groups at the 6th week and the 3rd month after treatment compared with those before the treatment (P<0.05); there were no significant differences between the two groups at the same time points after the treatment (P>0.05). In the patients with moderate osteoarthritis, WOMAC scores in the control group at the 3rd month differed much from that before the treatment (P<0.05); there were no significant differences between the two groups at the same time points after the treatment (P>0.05). In the patients with serious osteoarthritis, there was no significant difference in WOMAC scores in the control group after the treatment compared with that before the treatment (P>0.05); while in the trial group, the scores at the 3rd month after the treatment differed much from that before the treatment (P<0.05), and also from that in the control group (P<0.05). Conclusion For mild knee osteoarthritis, the combined treatment is not superior to the single use of glucosamine hydrochloride. For moderate knee osteoarthritis, the combined treatment has faster effect than the single use of glucosamine hydrochloride. For severe osteoarthritis, the use of single glucosamine hydrochloride is not effective, while the combination of calcitonin and glucosamine hydrochloride is effective at the 3rd month after the treatment.

Citation： XuJian, WangWenzhi. Calcitonin Combined with Glucosamine Hydrochloride for the Treatment of Knee Osteoarthritis: A Randomized Controlled Study. West China Medical Journal, 2016, 31(7): 1174-1177. doi: 10.7507/1002-0179.201600320 Copy

1.	Moskowite RW. 骨关节炎-诊断与治疗[M]. 王学谦, 娄思权, 侯筱魁, 等, 译. 天津:天津科技翻译出版公司, 2005:3-183.
2.	Cibere J, Kopec JA, Thorne A, et al. Randomized, double-blind, placebo-controlled glucosamine discontinuation trial in knee osteoarthritis[J]. Arthritis Rheum, 2004, 51(5):738-745.
3.	D'ambrosio E, Casa B, Bompani R, et al. Glucosamine sulphate:a controlled clinical investigation in arthrosis[J]. Pharmatherapeutica, 1981, 2(8):504-508.
4.	Rozendaal RM, Koes BW, Van Osch GJ, et al. Effect of glucosamine sulfate on hip osteoarthritis:a randomized trial[J]. Ann Intern Med, 2008, 148(4):268-277.
5.	Esenyel M, İçağasıoğlu A, Esenyel CZ. Effects of calcitonin on knee osteoarthritis and quality of life[J]. Rheumatol Int, 2013, 33(2):423-427.
6.	中华医学会骨科学分会. 骨关节炎诊治指南(2007年版)[J]. 中华骨科杂志, 2007, 27(10):793-796.
7.	Petersson IF, Boegård T, Saxne T, et al. Radiographic osteoarthritis of the knee classified by the Ahlbäck and Kellgren & Lawrence systems for the tibiofemoral joint in people aged 35-54 years with chronic knee pain[J]. Ann Rheum Dis, 1997, 56(8):493-496.
8.	Houpt JB, Mcmillan R, Wein C, et al. Effect of glucosamine hydrochloride in the treatment of pain of osteoarthritis of the knee[J]. J Rheumatol, 1999, 26(11):2423-2430.
9.	Burdett N, Mcneil JD. Difficulties with assessing the benefit of glucosamine sulphate as a treatment for osteoarthritis[J]. Int J Evid Based Healthc, 2012, 10(3):222-226.
10.	Felson DT. Glucosamine sulfate might have no effect on pain or structural changes associated with osteoarthritis[J]. Nat Clin Pract Rheumatol, 2008, 4(10):518-519.
11.	Kyrkos MJ, Papavasiliou KA, Kenanidis E, et al. Calcitonin delays the progress of early-stage mechanically induced osteoarthritis. In vivo, prospective study[J]. Osteoarthritis Cartilage, 2013, 21(7):973-980.
12.	Baxter E, Fraser JR, Harris GS, et al. Stimulation of glycosaminoglycan synthesis by thyrocalcitonin preparations[J]. Med J Aust, 1968, 1(6):216-217.
13.	Badurski JE, Schwamm W, Popko J, et al. Chondroprotective action of salmon calcitonin in experimental arthropathies[J]. Calcif Tissue Int, 1991, 49(1):27-34.
14.	Bassleer C, Henrotin Y, Bassleer R, et al. Three-dimensional culture model for studying human chondrocyte functions[M]. Israel:Methods used in reserach for cartilaginous tissues, 1989.
15.	李任增, 张柳, 高晓增. 降钙素对兔骨关节炎关节软骨的保护作用[J]. 中国矫形外科杂志, 2006, 14(2):121-123.
16.	Armagan O, Serin DK, Calisir C, et al. Inhalation therapy of calcitonin relieves osteoarthritis of the knee[J]. J Korean Med Sci, 2012, 27(11):1405-1410.

1. Moskowite RW. 骨关节炎-诊断与治疗[M]. 王学谦, 娄思权, 侯筱魁, 等, 译. 天津:天津科技翻译出版公司, 2005:3-183.
2. Cibere J, Kopec JA, Thorne A, et al. Randomized, double-blind, placebo-controlled glucosamine discontinuation trial in knee osteoarthritis[J]. Arthritis Rheum, 2004, 51(5):738-745.
3. D'ambrosio E, Casa B, Bompani R, et al. Glucosamine sulphate:a controlled clinical investigation in arthrosis[J]. Pharmatherapeutica, 1981, 2(8):504-508.
4. Rozendaal RM, Koes BW, Van Osch GJ, et al. Effect of glucosamine sulfate on hip osteoarthritis:a randomized trial[J]. Ann Intern Med, 2008, 148(4):268-277.
5. Esenyel M, İçağasıoğlu A, Esenyel CZ. Effects of calcitonin on knee osteoarthritis and quality of life[J]. Rheumatol Int, 2013, 33(2):423-427.
6. 中华医学会骨科学分会. 骨关节炎诊治指南(2007年版)[J]. 中华骨科杂志, 2007, 27(10):793-796.
7. Petersson IF, Boegård T, Saxne T, et al. Radiographic osteoarthritis of the knee classified by the Ahlbäck and Kellgren & Lawrence systems for the tibiofemoral joint in people aged 35-54 years with chronic knee pain[J]. Ann Rheum Dis, 1997, 56(8):493-496.
8. Houpt JB, Mcmillan R, Wein C, et al. Effect of glucosamine hydrochloride in the treatment of pain of osteoarthritis of the knee[J]. J Rheumatol, 1999, 26(11):2423-2430.
9. Burdett N, Mcneil JD. Difficulties with assessing the benefit of glucosamine sulphate as a treatment for osteoarthritis[J]. Int J Evid Based Healthc, 2012, 10(3):222-226.
10. Felson DT. Glucosamine sulfate might have no effect on pain or structural changes associated with osteoarthritis[J]. Nat Clin Pract Rheumatol, 2008, 4(10):518-519.
11. Kyrkos MJ, Papavasiliou KA, Kenanidis E, et al. Calcitonin delays the progress of early-stage mechanically induced osteoarthritis. In vivo, prospective study[J]. Osteoarthritis Cartilage, 2013, 21(7):973-980.
12. Baxter E, Fraser JR, Harris GS, et al. Stimulation of glycosaminoglycan synthesis by thyrocalcitonin preparations[J]. Med J Aust, 1968, 1(6):216-217.
13. Badurski JE, Schwamm W, Popko J, et al. Chondroprotective action of salmon calcitonin in experimental arthropathies[J]. Calcif Tissue Int, 1991, 49(1):27-34.
14. Bassleer C, Henrotin Y, Bassleer R, et al. Three-dimensional culture model for studying human chondrocyte functions[M]. Israel:Methods used in reserach for cartilaginous tissues, 1989.
15. 李任增, 张柳, 高晓增. 降钙素对兔骨关节炎关节软骨的保护作用[J]. 中国矫形外科杂志, 2006, 14(2):121-123.
16. Armagan O, Serin DK, Calisir C, et al. Inhalation therapy of calcitonin relieves osteoarthritis of the knee[J]. J Korean Med Sci, 2012, 27(11):1405-1410.

West China Medical Journal

Calcitonin Combined with Glucosamine Hydrochloride for the Treatment of Knee Osteoarthritis: A Randomized Controlled Study

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