Therapeutic Effect of Glucosamine Hydrochloride Combined with Calcium and Vitamin D on Knee Osteoarthritis_West China Medical Journal

Authors：

 WangWenzhi ¹ , XuJian ¹ , WangLu ¹ , LiuZhonghua ²

1. Department of Osteoporosis, No. 4 West China Teaching Hospital, Sichuan University, Chengdu, Sichuan 610041, P. R. China;
2. Department of Geriatrics, No. 4 West China Teaching Hospital, Sichuan University, Chengdu, Sichuan 610041, P. R. China;

Corresponding author：

Keywords：

Osteoarthritis,knee; Glucosamine hydrochloride; Vitamin D; Calcium; Medication

DOI：

10.7507/1002-0179.201600321

Video：

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Objective To explore the therapeutic effect of glucosamine hydrochloride combined with calcium and vitamin D on knee osteoarthritis. Methods A total of 120 female outpatients with knee osteoarthritis from January 2014 to January 2015 were selected. The patients were randomly divided into study group and control group (60 patients in each group) according to their treatment sequence. The patients in the study group were given oral calcium citrate, alfacalcidol and glucosamine hydrochloride while those in the control group were given glucosamine hydrochloride only. Both groups were investigated and scored by Western Ontario and McMaster University Osteoarthritis Index (WOMAC) questionnaire before and three and six months after treatment. Results Three and six months after the treatment, WOMAC scores of both groups were lower than those before the treatment with significant differences (P<0.05). Three months after the treatment, WOMAC scores between the two groups didn't differ much (P>0.05), while the difference between the two groups was significant 6 months after the treatment (P<0.05). Three months after the treatment, the difference of total effective rate in the study group (43.3%) and control group (41.7%) was not significant (P>0.05), while the rate in the study group (65.0%) was obviously higher than that in the control group (46.7%) 6 months after the treatment (P<0.05). Conclusion Glucosamine hydrochloride has exact effect on knee osteoarthritis. There are differences in the therapeutic effect on knee osteoarthritis between glucosamine hydrochloride combined with calcium and vitamin D and glucosamine hydrochloride alone after six-month treatment.

Citation： WangWenzhi, XuJian, WangLu, LiuZhonghua. Therapeutic Effect of Glucosamine Hydrochloride Combined with Calcium and Vitamin D on Knee Osteoarthritis. West China Medical Journal, 2016, 31(7): 1178-1180. doi: 10.7507/1002-0179.201600321 Copy

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2.	余卫, 徐苓, 秦明伟, 等. 北京市城区老年人膝关节骨关节炎流行病学调查——与美国白种人膝关节骨关节炎的临床和X线比较分析[J]. 中华放射学杂志, 2005, 39(1):67-71.
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4.	Pendleton A, Arden N, Dougados M, et al. EULAR recommendations for the management of knee osteoarthritis:report of a task force of the Standing Committee for International Clinical Studies Including Therapeutic Trials (ESCISIT)[J]. Ann Rheum Dis, 2000, 59(12):936-944.
5.	赵鉴非, Fornasier VL. 组织形态计量学方法测定骨性关节炎股骨头骨密度[J]. 中华外科杂志, 2003, 41(5):354-358.
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8.	Bellamy N, Buchanan WW, Goldsmith CH, et al. Validation study of WOMAC:a health status instrument for measuring clinically important patient relevant outcomes to antirheumatic drug therapy in patients with osteoarthritis of the hip or knee[J]. J Rheumatol, 1988, 15(12):1833-1840.
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11.	罗群英, 廖燕群, 叶虹. 氨基葡萄糖联合醋氯酸肠溶胶囊治疗骨关节炎的疗效观察[J]. 国际医药卫生导报, 2010, 16(3):319-320.
12.	高山, 刘少楠, 王传林, 等. 盐酸氨基葡萄糖胶囊联合氯诺昔康片治疗膝骨关节炎的临床研究[J]. 国际医药卫生导报, 2013, 19(17):2728-2731.
13.	杨雪生. 硫酸氨基葡萄糖联合仙灵骨葆治疗骨关节炎临床观察[J]. 中国基层医药, 2013, 20(9):1371-1373.
14.	王昆, 朱蕾, 刘斌, 等. 硫酸氨基葡萄糖和透明质酸钠治疗髌股关节骨关节炎的研究[J]. 解剖与临床, 2008, 13(6):418-420.
15.	马哲, 冯浩, 梁佳慧. 中西医结合治疗膝关节骨性关节炎疗效观察[J]. 中国医药, 2011, 6(8):970-971.
16.	Lane NE, Gore LR, Cummings SR, et al. Serum vitamin D levels and incident changes of radiographic hip osteoarthritis:a longitudinal study[J]. Arthritis Rheum, 1999, 42(5):854-860.
17.	Sanghi D, Mishra A, Sharma AC, et al. Does vitamin D improve osteoarthritis of the knee:a randomized controlled pilot trial[J]. Clin Orthop Relat Res, 2013, 471(11):3556-3562.
18.	Laslett LL, Quinn S, Burgess JR, et al. Moderate vitamin D deficiency is associated with changes in knee and hip pain in older adults:a 5-year longitudinal study[J]. Ann Rheum Dis, 2014, 73(4):697-703.
19.	Solovieva S, Hirvonen A, Siivola P, et al. Vitamin D receptor gene polymorphisms and susceptibility of hand osteoarthritis in Finnish women[J]. Arthritis Res Ther, 2006, 8(1):R20.
20.	Khodyrev VN, Beketova NA, Kodentsova VM, et al. The influence of the vitamin-mineral complex upon the blood vitamin, calcium and phosphorus of patients with ostreoarthrosis[J]. Vopr Pitan, 2006, 75(2):44-47.

1. American College of Rheumatology Subcommittee on Osteoarthritis Guidelines. Recommendations for the medical management of osteoarthritis of the hip and knee:2000 update[J]. Arthritis Rheum, 2000, 43(9):1905-1915.
2. 余卫, 徐苓, 秦明伟, 等. 北京市城区老年人膝关节骨关节炎流行病学调查——与美国白种人膝关节骨关节炎的临床和X线比较分析[J]. 中华放射学杂志, 2005, 39(1):67-71.
3. 高万里, 吴立生, 訾金花, 等. 女性膝骨性关节与雌二醇及其代谢产物的关系[J]. 中华实验外科杂志, 2014, 31(3):662-665.
4. Pendleton A, Arden N, Dougados M, et al. EULAR recommendations for the management of knee osteoarthritis:report of a task force of the Standing Committee for International Clinical Studies Including Therapeutic Trials (ESCISIT)[J]. Ann Rheum Dis, 2000, 59(12):936-944.
5. 赵鉴非, Fornasier VL. 组织形态计量学方法测定骨性关节炎股骨头骨密度[J]. 中华外科杂志, 2003, 41(5):354-358.
6. 邱贵兴. 骨关节炎诊治指南(2007年版)[J]. 中国临床医生杂志, 2007, 27(10):793.
7. Kanis JA, Melton L, Christiansen C, et al. The diagnosis of osteoporosis[J]. J Bone Miner Res, 1994, 9(8):1137-1141.
8. Bellamy N, Buchanan WW, Goldsmith CH, et al. Validation study of WOMAC:a health status instrument for measuring clinically important patient relevant outcomes to antirheumatic drug therapy in patients with osteoarthritis of the hip or knee[J]. J Rheumatol, 1988, 15(12):1833-1840.
9. Langley GB, Sheppeard H. Problems associated with pain measurement in arthritis:comparison of the visual analogue and verbal rating scales[J]. Clin Exp Rheumatol, 1985, 2(3):231-234.
10. Reginster JY, Bruyere O, Neuprez A. Current role of glucosamine in the treatment of osteoarthritis[J]. Rheumatology (Oxford), 2007, 46(5):731-735.
11. 罗群英, 廖燕群, 叶虹. 氨基葡萄糖联合醋氯酸肠溶胶囊治疗骨关节炎的疗效观察[J]. 国际医药卫生导报, 2010, 16(3):319-320.
12. 高山, 刘少楠, 王传林, 等. 盐酸氨基葡萄糖胶囊联合氯诺昔康片治疗膝骨关节炎的临床研究[J]. 国际医药卫生导报, 2013, 19(17):2728-2731.
13. 杨雪生. 硫酸氨基葡萄糖联合仙灵骨葆治疗骨关节炎临床观察[J]. 中国基层医药, 2013, 20(9):1371-1373.
14. 王昆, 朱蕾, 刘斌, 等. 硫酸氨基葡萄糖和透明质酸钠治疗髌股关节骨关节炎的研究[J]. 解剖与临床, 2008, 13(6):418-420.
15. 马哲, 冯浩, 梁佳慧. 中西医结合治疗膝关节骨性关节炎疗效观察[J]. 中国医药, 2011, 6(8):970-971.
16. Lane NE, Gore LR, Cummings SR, et al. Serum vitamin D levels and incident changes of radiographic hip osteoarthritis:a longitudinal study[J]. Arthritis Rheum, 1999, 42(5):854-860.
17. Sanghi D, Mishra A, Sharma AC, et al. Does vitamin D improve osteoarthritis of the knee:a randomized controlled pilot trial[J]. Clin Orthop Relat Res, 2013, 471(11):3556-3562.
18. Laslett LL, Quinn S, Burgess JR, et al. Moderate vitamin D deficiency is associated with changes in knee and hip pain in older adults:a 5-year longitudinal study[J]. Ann Rheum Dis, 2014, 73(4):697-703.
19. Solovieva S, Hirvonen A, Siivola P, et al. Vitamin D receptor gene polymorphisms and susceptibility of hand osteoarthritis in Finnish women[J]. Arthritis Res Ther, 2006, 8(1):R20.
20. Khodyrev VN, Beketova NA, Kodentsova VM, et al. The influence of the vitamin-mineral complex upon the blood vitamin, calcium and phosphorus of patients with ostreoarthrosis[J]. Vopr Pitan, 2006, 75(2):44-47.

West China Medical Journal

Therapeutic Effect of Glucosamine Hydrochloride Combined with Calcium and Vitamin D on Knee Osteoarthritis

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