腋窝逆行淋巴显影在乳腺癌手术中的应用_West China Medical Journal

Authors：

 陈洁 ¹ , 王竹 ² ,  吕青 ¹ , 杜正贵 ¹ , 谭秋文 ¹ , 王强 ² , 曾荷 ¹

1. ;
2. ;

Corresponding author：

吕青, Email: lqlq1963@163.com

Keywords：

乳腺癌; 腋窝逆行淋巴显影; 上肢淋巴水肿

DOI：

10.7507/1002-0179.201600396

Video：

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Abstract Full text Figures/Tables Video References Cited by

同侧上肢的淋巴水肿是乳腺癌腋窝处理后一种常见的，同时也是治疗非常困难的并发症。近年来新发明的腋窝逆行淋巴显影（ARM）技术能通过示踪剂显示引流同侧上肢的淋巴管及淋巴结，从而避免在行腋窝淋巴结清扫或腋窝的前哨淋巴结活体组织检查时伤及这些结构，以达到降低术后上肢淋巴水肿发生概率的目的。现有的文献资料显示，ARM在乳腺癌腋窝手术中是可行的，且ARM后保护腋窝逆行淋巴显影显示的淋巴结及其淋巴管的确能降低术后同侧上肢的淋巴水肿发生率。

Citation： 陈洁, 王竹, 吕青, 杜正贵, 谭秋文, 王强, 曾荷. 腋窝逆行淋巴显影在乳腺癌手术中的应用. West China Medical Journal, 2016, 31(8): 1458-1462. doi: 10.7507/1002-0179.201600396 Copy

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2.	朱倩男, 夏添松, 王水.逆行腋窝淋巴示踪技术预防乳腺癌术后上肢淋巴水肿[J].江苏医药, 2015, 41(1):78-80.
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8.	Ashikaga T, Krag DN, Land SR, et al. Morbidity results from the NSABP B-32 trial comparing sentinel lymph node dissection versus axillary dissection[J]. J Surg Oncol, 2010, 102(2):111-118.
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10.	Rockson SG, Rivera KK. Estimating the population burden of lymphedema[J]. Ann N Y Acad Sci, 2008, 1131:147-154.
11.	Shaw C, Mortimer P, Judd PA. Randomized controlled trial comparing a low-fat diet with a weight-reduction diet in breast cancer-related lymphedema[J]. Cancer, 2007, 109(10):1949-1956.
12.	Petrek JA, Senie RT, Peters M, et al. Lymphedema in a cohort of breast carcinoma survivors 20 years after diagnosis[J]. Cancer, 2001, 92(6):1368-1377.
13.	Thompson M, Korourian S, Henry-Tillman R, et al. Axillary reverse mapping (ARM):a new concept to identify and enhance lymphatic preservation[J]. Ann Surg Oncol, 2007, 14(6):1890-1895.
14.	Nos C, Lesieur B, Clough KB, et al. Blue dye injection in the arm in order to conserve the lymphatic drainage of the arm in breast cancer patients requiring an axillary dissection[J]. Ann Surg Oncol, 2007, 14(9):2490-2496.
15.	Boneti C, Korourian S, Bland K, et al. Axillary reverse mapping:mapping and preserving arm lymphatics may be important in preventing lymphedema during sentinel lymph node biopsy[J]. J Am Coll Surg, 2008, 206(5):1038-1044.
16.	Ikeda K, Ogawa Y, Komatsu H, et al. Evaluation of the metastatic status of lymph nodes identified using axillary reverse mapping in breast cancer patients[J]. World J Surg Oncol, 2012(10):233-239.
17.	Clough KB, Nasr R, Nos C, et al. New anatomical classification of the axilla with implications for sentinel node biopsy[J]. Br J Surg, 2010, 97(11):1659-1665.
18.	Ponzone R, Mininanni P, Cassina E, et al. Axillary reverse mapping in breast cancer:can we spare what we find?[J]. Ann Surg Oncol, 2008, 15(1):390-391.
19.	Casabona F, Bogliolo S, Valenzano Menada M, et al. Feasibility of axillary reverse mapping during sentinel lymph node biopsy in breast cancer patients[J]. Ann Surg Oncol, 2009, 16(9):2459-2463.
20.	Connor C, McGinness M, Mammen J, et al. Axillary reverse mapping:a prospective study in women with clinically node negative and node positive breast cancer[J]. Ann Surg Oncol, 2013, 20(10):3303-3307.
21.	Ochoa D, Korourian S, Boneti C, et al. Axillary reverse mapping:five-year experience[J]. Surgery, 2014, 156(5):1261-1268.
22.	Beek MA, Gobardhan PD, Klompenhouwer EG, et al. Axillary reverse mapping (ARM) in clinically node positive breast cancer patients[J]. Eur J Surg Oncol, 2015, 41(1):59-63.
23.	Fiorito S, Serafino A, Andreola F, et al. Toxicity and biocompatibility of carbon nanoparticles[J]. J Nano Sci Nanotechnol, 2006, 6(3):591-599.
24.	谢锡驹, 黄村榕, 郑伟, 等.上肢淋巴定位显影在乳腺癌ALND术中的应用价值[J].实用临床医药杂志, 2014, 18(24):43-45.
25.	陶庆松, 张亚, 杲圣, 等.腋窝逆行淋巴显影联合术中细针穿刺活检预防腋窝淋巴清扫术后上肢淋巴水肿[J].南京医科大学学报, 2015, 35(2):211-213.
26.	Nos C, Kaufmann G, Clough KB, et al. Combined axillary reverse mapping (ARM) technique for breast cancer patients requiring axillary dissection[J]. Ann Surg Oncol, 2008, 15(9):2550-2555.
27.	Britton TB, Chandra CK, Pinder SE, et al. Lymphatic drainage pathways of the breast and the upper limb[J]. Nucl Med Commun, 2009, 30(6):427-430.
28.	Samorani D, Fogacci T, Panzini I, et al. The use of indocyanine green to detect sentinel nodes in breast cancer:a prospective study[J]. Eur J Surg Oncol, 2015, 41(1):60-70.
29.	Noguchi M, Yokoi M, Nakano Y. Axillary reverse mapping with indocyanine fluorescence imaging in patients with breast cancer[J]. J Surg Oncol, 2010, 101(3):217-221.
30.	Noguchi M, Noguchi M, Nakano Y, et al. Axillary reverse mapping using fluorescence imaging system in breast cancer[J]. J Surg Oncol, 2012, 105(3):229-234.
31.	Sakurai T, Endo M, Shimizu K, et al. Axillary reverse mapping using fluorescence imaging is useful for identifying the risk group of postoperative lymphedema in breast cancer patients undergoing sentinel node biopsies[J]. J Surg Oncol, 2014, 109(6):612-615.
32.	Noguchi M, Miura S, Morioka E, et al. Is axillary reverse mapping feasible in breast cancer patients?[J]. Eur J Sueg Oncol, 2015, 41(4):442-449.

1. 吴祥德, 董守义.乳腺疾病诊治[M]. 2版.北京:人民卫生出版社, 2008:176-179.
2. 朱倩男, 夏添松, 王水.逆行腋窝淋巴示踪技术预防乳腺癌术后上肢淋巴水肿[J].江苏医药, 2015, 41(1):78-80.
3. Mansel RE, Fallowfield L, Kissin M, et al. Randomized multicenter trial of sentinel node biopsy versus standard axillary treatment in operable breast cancer:the ALMANAC Trial[J]. J Natl Cancer Inst, 2006, 98(9):599-609.
4. Leidenius M, Leivonen M, Vironen J, et al. The consequences of long-time arm morbidity in node-negative breast cancer patients with sentinel node biopsy or axillary clearance[J]. J Surg Oncol, 2005, 92(1):23-31.
5. Ronka R, von Smitten K, Tasmuth T, et al. One-year morbidity after sentinel node biopsy and breast surgery[J]. Breast, 2005, 14(1):28-36.
6. Blanchard DK, Donohue JH, Reynolds C, et al. Relapse and morbidity in patients undergoing sentinel lymph node biopsy alone or with axillary dissection for breast cancer[J]. Archives, 2003, 138(5):482-487.
7. Schijven MP, Vingerhoets AJ, Rutten HJ, et al. Comparison of morbidity between axillary lymph node dissection and sentinel node biopsy[J]. Eur J Surg Oncol, 2003, 29(4):341-350.
8. Ashikaga T, Krag DN, Land SR, et al. Morbidity results from the NSABP B-32 trial comparing sentinel lymph node dissection versus axillary dissection[J]. J Surg Oncol, 2010, 102(2):111-118.
9. Wilke LG, McCall LM, Posther KE, et al. Surgical complications associated with sentinel lymph node biopsy:results from a prospective international cooperative group trial[J]. Ann Surg Oncol, 2006, 13(4):491-500.
10. Rockson SG, Rivera KK. Estimating the population burden of lymphedema[J]. Ann N Y Acad Sci, 2008, 1131:147-154.
11. Shaw C, Mortimer P, Judd PA. Randomized controlled trial comparing a low-fat diet with a weight-reduction diet in breast cancer-related lymphedema[J]. Cancer, 2007, 109(10):1949-1956.
12. Petrek JA, Senie RT, Peters M, et al. Lymphedema in a cohort of breast carcinoma survivors 20 years after diagnosis[J]. Cancer, 2001, 92(6):1368-1377.
13. Thompson M, Korourian S, Henry-Tillman R, et al. Axillary reverse mapping (ARM):a new concept to identify and enhance lymphatic preservation[J]. Ann Surg Oncol, 2007, 14(6):1890-1895.
14. Nos C, Lesieur B, Clough KB, et al. Blue dye injection in the arm in order to conserve the lymphatic drainage of the arm in breast cancer patients requiring an axillary dissection[J]. Ann Surg Oncol, 2007, 14(9):2490-2496.
15. Boneti C, Korourian S, Bland K, et al. Axillary reverse mapping:mapping and preserving arm lymphatics may be important in preventing lymphedema during sentinel lymph node biopsy[J]. J Am Coll Surg, 2008, 206(5):1038-1044.
16. Ikeda K, Ogawa Y, Komatsu H, et al. Evaluation of the metastatic status of lymph nodes identified using axillary reverse mapping in breast cancer patients[J]. World J Surg Oncol, 2012(10):233-239.
17. Clough KB, Nasr R, Nos C, et al. New anatomical classification of the axilla with implications for sentinel node biopsy[J]. Br J Surg, 2010, 97(11):1659-1665.
18. Ponzone R, Mininanni P, Cassina E, et al. Axillary reverse mapping in breast cancer:can we spare what we find?[J]. Ann Surg Oncol, 2008, 15(1):390-391.
19. Casabona F, Bogliolo S, Valenzano Menada M, et al. Feasibility of axillary reverse mapping during sentinel lymph node biopsy in breast cancer patients[J]. Ann Surg Oncol, 2009, 16(9):2459-2463.
20. Connor C, McGinness M, Mammen J, et al. Axillary reverse mapping:a prospective study in women with clinically node negative and node positive breast cancer[J]. Ann Surg Oncol, 2013, 20(10):3303-3307.
21. Ochoa D, Korourian S, Boneti C, et al. Axillary reverse mapping:five-year experience[J]. Surgery, 2014, 156(5):1261-1268.
22. Beek MA, Gobardhan PD, Klompenhouwer EG, et al. Axillary reverse mapping (ARM) in clinically node positive breast cancer patients[J]. Eur J Surg Oncol, 2015, 41(1):59-63.
23. Fiorito S, Serafino A, Andreola F, et al. Toxicity and biocompatibility of carbon nanoparticles[J]. J Nano Sci Nanotechnol, 2006, 6(3):591-599.
24. 谢锡驹, 黄村榕, 郑伟, 等.上肢淋巴定位显影在乳腺癌ALND术中的应用价值[J].实用临床医药杂志, 2014, 18(24):43-45.
25. 陶庆松, 张亚, 杲圣, 等.腋窝逆行淋巴显影联合术中细针穿刺活检预防腋窝淋巴清扫术后上肢淋巴水肿[J].南京医科大学学报, 2015, 35(2):211-213.
26. Nos C, Kaufmann G, Clough KB, et al. Combined axillary reverse mapping (ARM) technique for breast cancer patients requiring axillary dissection[J]. Ann Surg Oncol, 2008, 15(9):2550-2555.
27. Britton TB, Chandra CK, Pinder SE, et al. Lymphatic drainage pathways of the breast and the upper limb[J]. Nucl Med Commun, 2009, 30(6):427-430.
28. Samorani D, Fogacci T, Panzini I, et al. The use of indocyanine green to detect sentinel nodes in breast cancer:a prospective study[J]. Eur J Surg Oncol, 2015, 41(1):60-70.
29. Noguchi M, Yokoi M, Nakano Y. Axillary reverse mapping with indocyanine fluorescence imaging in patients with breast cancer[J]. J Surg Oncol, 2010, 101(3):217-221.
30. Noguchi M, Noguchi M, Nakano Y, et al. Axillary reverse mapping using fluorescence imaging system in breast cancer[J]. J Surg Oncol, 2012, 105(3):229-234.
31. Sakurai T, Endo M, Shimizu K, et al. Axillary reverse mapping using fluorescence imaging is useful for identifying the risk group of postoperative lymphedema in breast cancer patients undergoing sentinel node biopsies[J]. J Surg Oncol, 2014, 109(6):612-615.
32. Noguchi M, Miura S, Morioka E, et al. Is axillary reverse mapping feasible in breast cancer patients?[J]. Eur J Sueg Oncol, 2015, 41(4):442-449.

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腋窝逆行淋巴显影在乳腺癌手术中的应用

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